scholarly journals Analysis of melatonin concentration and its correlation with ovarian disfunction among obese women of reproductive age

2021 ◽  
Vol 67 (1) ◽  
pp. 69-75
Author(s):  
R. K. Mikheev ◽  
E. N. Andreeva ◽  
E. V. Sheremetyeva ◽  
Yu. S. Absatarova ◽  
T. A. Ponomareva ◽  
...  
Keyword(s):  
Reproductive Age ◽  
Cochrane Library ◽  
Light Pollution ◽  
Free Access ◽  
Obese Women ◽  
Reproductive Disorders ◽  
Receptor Sensitivity ◽  
Women Of Reproductive Age ◽  
Mechanisms Of Development ◽  
The Impact

One of the new directions in the study of reproductive disorders in obese women is the effect and receptor sensitivity of  melatonin on the gonadotropic function of the pituitary gland and ovariogenesis, taking into account the chronology of «light pollution». At the present stage, there is very little literature on the influence of the aspects of «light pollution» on the problem of obesity and reproductive disorders in the literature. This review is an attempt to combine the above problem in terms of the impact of «light pollution» and the level of receptor sensitivity of melatonin in women of reproductive age with obesity. The literature search was carried out in Russian (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. Free access to the full text of the articles was a priority. The selection of sources was prioritized for the period from 2015 to 2019. However, given the insufficient knowledge of the chosen topic, the choice of sources was dated from 1992. The work was carried out as part of the study «Central and peripheral pathophysiological mechanisms of development of adipose tissue diseases, taking into account clinical and hormonal characteristics» 2020–2022.

scholarly journals Significance of the pineal gland hormone melatonin in maintaining the health of women of reproductive age (a review)

2020 ◽  
Vol 13 (4) ◽  
pp. 337-344
Author(s):  
M. V. Danilova ◽  
E. N. Usoltseva
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Pineal Gland ◽  
Reproductive System ◽  
Reproductive Age ◽  
Cochrane Library ◽  
Women Of Reproductive Age ◽  
The Impact ◽  
Night Shifts

Introduction. Maintaining women's reproductive health is an important task that requires safe approaches based on the pathogenesis. More and more studies address the role of the pineal gland (epiphysis) hormone melatonin (МТ) in the functioning of the reproductive system, as well as the impact of МТ deficiency on the women’s health.Aim: to analyze and summarize the available literature about the role of the pineal gland hormone МТ in the pathogenesis of gynecological diseases in women of reproductive age (infertility, endometriosis, polycystic ovary syndrome, premenstrual syndrome), and also about the impact of МТ deficiency on the health of women working night shifts.Materials and methods. The relevant publications were searched in domestic (eLibrary, CyberLeninka.ru) and international (Pubmed, Cochrane Library) databases; we looked up the materials published in the recent 7 years. In our search, we prioritized the free access to full text articles. The selection of sources was limited to the period from 2012 to 2019.Results. МТ is involved in the development of follicles by causing the oocytes maturation, promoting the development of embryos, inhibiting the synthesis of steroids in the ovaries and, therefore, reducing the level of steroids in the blood. MT delays ovarian aging through a variety of mechanisms, including the antioxidant action, the maintenance of the due length of the telomere, the upregulated expression of the aging-related SIRT genes, and also the regulation of the ribosome functioning. As MT protects germ cells from oxidative stress, it is essential for normal ovulation, fertilization and further development of the embryo; this hormone has an impact on the duration of the woman's fertility and the onset of menopause. MT has a potential therapeutic effect on endometriosis. The oncostatic role of MT in hormone-dependent breast tumors has been described. Disruption of normal MT production during night shifts is associated with the risk of developing breast cancer in shift workers. MT deficiency leads to circadian desynchronosis and may cause both somatic disorders (metabolic syndrome, obesity, oncopathology) and neuroendocrine dysregulation of the female reproductive system.Conclusion. The variety of physiological functions of the pineal gland hormone MT emphasizes the pathogenetic role of its deficiency in many gynecological and somatic diseases. Of particular relevance is the increased risk of cardiovascular disorders, the development of metabolic syndrome and breast cancer in women who work night shifts. Therefore, it is important both to maintain normal endogenous level of MT and also use its therapeutic potential to maintain the health of women of reproductive age.

scholarly journals The Impact of Bariatric Surgery on Menstrual Abnormalities—a Cross-Sectional Study

2020 ◽  
Vol 30 (11) ◽  
pp. 4505-4509
Author(s):  
Anna Różańska-Walędziak ◽  
Paweł Bartnik ◽  
Joanna Kacperczyk-Bartnik ◽  
Krzysztof Czajkowski ◽  
Maciej Walędziak
Keyword(s):  
Bariatric Surgery ◽  
Menstrual Cycle ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Obese Women ◽  
Sectional Study ◽  
Cross Sectional ◽  
Contraception Use ◽  
Before And After ◽  
The Impact

Abstract Introduction Obesity is associated with hyperestrogenism along with other hormonal abnormalities affecting the menstrual cycle. The most effective and decisive method of obesity treatment is bariatric surgery. The aim of this study was to analyze the impact of bariatric surgery on menstrual cycle, the incidence of menstrual abnormalities, hyperandrogenism manifestation, and contraception use. Materials and Methods It was a cross-sectional study of 515 pre-menopausal women who had undergone bariatric surgery between 1999 and 2017 in a bariatric center. Data was collected via anonymous questionnaire, and the questions covered a 1-year period before the surgery and the last year before questionnaire completion. Results Before the surgery, 38.6% of the patients reported irregular menstruations in comparison with 25.0% after bariatric surgery (RR = 0.65; 95%CI 0.53–0.79). The mean number of menstruations per year did not differ before and after surgery (10.2 ± 3.9 vs 10.4 ± 3.3; p < .45). There were no statistically significant differences in terms of prolonged menstruations, acne, and hirsutism prevalence. A total of 14.4% of patients before surgery reported estrogen-based contraception use in comparison with 15.0% after the surgery (p < .95). There were no significant differences in the frequency of OC use (11.0% before surgery vs 13.6% 12 months after the surgery vs 11.5% at the moment of survey administration; p < 0.46). Conclusion Bariatric surgery improves the regularity of the menstrual cycle in obese women in reproductive age. The lack of any changes in the combined hormonal contraception (CHC) use, especially OC, before and after bariatric surgery may be a result of a possibly low level of contraception counseling.

scholarly journals Sexual Function in Women With and Without Female Genital Mutilation in Reproductive Age in South of Iran

2021 ◽  
Author(s):  
Mahshid Bokaie ◽  
Samaneh Hatefi ◽  
Shahnaz Mojahed ◽  
Nasibeh Roozbeh
Keyword(s):  
Sexual Function ◽  
Female Genital Mutilation ◽  
Reproductive Age ◽  
Public Health Issue ◽  
P Value ◽  
Women Of Reproductive Age ◽  
Genital Mutilation ◽  
Significant Difference ◽  
The Impact ◽  
Female Genital

Abstract Objectives: Female genital mutilation (FGM) is an important public health issue, especially in developing countries and it is still done in some parts of Iran. This study aimed to investigate the effect of FGM on the sexual function of women of reproductive age in Hormozgan province/IRAN.Study design: This study is a descriptive-analytical case-control study that was conducted in 2020 on 209 married women of reproductive age (15-49) in rural areas of Minab and Sirik counties in Hormozgan province/IRAN. Main outcome measures: The reliable and valid questionnaire FSFI for assessing female sexual function in the two groups was used after to obtain informed and voluntary consent from all participants and data with SPSS v: 16 software and with using descriptive/ Analytical statistics tests with a significant level of 0.05 were examined. Results: There is a significant difference between mutilated and non-mutilated women in the total score of sexual function(22.18±3.23 versus 23.41±2.52 respectively, p=0.023) and the domains of lubrication(3.04±0.62 versus 3.3±0.53 respectively, P=0.000), orgasm(3.81±0.63 versus 4.08±0.47 respectively, P=0.003), and sexual satisfaction(5.09±0.1 versus 5.37±0.87 respectively, P=0.017) But in the domains of desire, arousal, and pain in the two groups was no significant difference(P-value>0.05). Conclusion: FGM maybe leads to sexual dysfunction. Although most women were reluctant to perform mutilation on their daughters, more educational Actions are suggested to educate women about the impact of female mutilation on their sexual function. Counseling programs are also recommended to improve the sexual function of mutilated women.

scholarly journals HIV and infertility: neuro-endocrine and metabolic aspects

2021 ◽  
Vol 12 (4) ◽  
pp. 73-80
Author(s):  
O. Ya. Leshchenko ◽  
E. V. Genich ◽  
M. A. Darenskaya ◽  
L. I. Kolesnikova
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Reproductive Age ◽  
Neuroendocrine Regulation ◽  
Reproductive Disorders ◽  
Sociological Study ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Prognostic Assessment ◽  
Hormonal Levels

Objective: to establish a correlation of the main neuroendocrine and metabolic parameters associated with infertility and to provide a prognostic assessment of reproductive disorders in HIV-infected women, stages 4.Materials and methods. Cross-sectional, cohort, clinical and sociological study of fertility of 83 women of reproductive age with HIV, stages 4.Results. The most significant indicators of lipid peroxidation and neuroendocrine regulation systems have been established in patients with HIV infection and reproductive disorders, which will make it possible to predict these disorders in the future. Decreased ovarian reserve, ovarian steroid function, increased pituitary prolactinergic function are associated with a deficiency of a number of antioxidants (retinol, tocopherol, superoxide dismutase) and the development of oxidative stress with a predominant accumulation of intermediate lipid peroxidation products in HIV-infected women with infertility.Conclusion. The pathogenetically substantiated principle of the correction of antioxidant status is the use of a-tocopherol and retinol preparations and the correction of hormonal levels in HIV-infected women with reproductive disorders.

THE NATURE OF REPRODUCTIVE DISORDERS IN WOMEN WITH HYPERANDROGENISM SYNDROMEq

2021 ◽  
Vol 2 (4) ◽  
pp. 13-16
Author(s):  
M. M Asatova ◽  
◽  
S. M. Safoeva
Keyword(s):  
Laboratory Data ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Reproductive Disorders ◽  
Menstrual Disorders ◽  
Women Of Reproductive Age ◽  
Perinatal Center ◽  
Androgen Secretion ◽  
The City ◽  
Anovulatory Infertility

PCOS occupies a leading place in the population of women with clinical manifestations of excessive androgen secretion and is detected in 72.1-82% of cases, while among women with anovulatory infertility-in 55-91% of cases (Lizneva D. (2016). The criteria, prevalence and phenotypes of PCOS. Fertil.Steril., 106 (1), 6-15). The article discusses the results of a study conducted based on the City Perinatal Center of Tashkent to study the frequency and nature of reproductive disorders in women with symptoms of hyperandrogenism. The study involved women of reproductive age with various menstrual disorders and infertility. The analysis of anamnestic, subjective and objective, clinical and laboratory data of patients was carried out

The impact of probiotic supplementation on metabolic health in healthy women of reproductive age: a systematic review

2020 ◽  
Vol 11 (12) ◽  
pp. 10279-10289
Author(s):  
David F. Byrne ◽  
Aisling A. Geraghty ◽  
Cara A. Yelverton ◽  
Eileen F. Murphy ◽  
Douwe Van Sinderen ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Disease Risk ◽  
Metabolic Health ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Preventative Measure ◽  
Probiotic Supplementation ◽  
Healthy Women ◽  
The Impact

Products containing probiotics are targeted at healthy or at-risk individuals as a preventative measure to minimise disease risk.

scholarly journals Double Burden of Malnutrition among Chinese Women of Reproductive Age and Their Social Determinants

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3102
Author(s):  
Jingqi Song ◽  
Ji Zhang ◽  
Wafaie Fawzi ◽  
Yangmu Huang
Keyword(s):  
Normal Weight ◽  
Overweight And Obesity ◽  
Living Environment ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Double Burden ◽  
Community Factors ◽  
Wide Range ◽  
Double Burden Of Malnutrition ◽  
The Impact

This study aimed to examine the impact of a wide range of demographic, socioeconomic, and community factors on the double burden of malnutrition among women of reproductive age using longitudinal data. We used data about 11,348 women of reproductive age who participated in the China Health and Nutrition Survey (CHNS), a longitudinal survey, between 1989 and 2015. Nutritional outcomes were categorized into four groups, namely underweight, normal weight, overweight, and obesity, with normal weight as reference. A multinomial logit model was fitted due to geographic clustering and repeated observations of individuals. The prevalence of underweight decreased over time from 1991 but has tended to rise again since 2004, while the prevalence of overweight/obesity continued to rise between 1991 and 2015. Improved individual factors, socioeconomic status, and community urbanization reduced the risk of underweight but elevated the risk of overweight and obesity. The medium levels, rather than the highest levels, of household income and community urbanization are associated with a higher risk of overweight and obesity. The notable increase in underweight prevalence is a cause for concern to be addressed along with efforts to curb the rising tide of overweight. In order to enhance the nutritional status of women of reproductive age, it is essential to improving the community environment, levels of education, and living environment from a wider context. Long-term and targeted plans are urgently needed for nutrition improvements among the different populations.

scholarly journals A Pilot Study on the Impact of Accelerometer Data Reduction Algorithm Selection and the Potential Implications on Behavior Change Recommendations (OR08-03-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Annie Lin ◽  
Dana Larsen ◽  
Ashley Hsu ◽  
Sarah Luna ◽  
Steven Chin ◽  
...  
Keyword(s):  
Behavior Change ◽  
Data Reduction ◽  
Reproductive Age ◽  
Moderate Intensity ◽  
Accelerometer Data ◽  
Women Of Reproductive Age ◽  
Algorithm Selection ◽  
Bivariate Correlation ◽  
Se 33 ◽  
The Impact

Abstract Objectives Physical activity (PA) estimates obtained from recent accelerometer data reduction algorithms have not been compared in women of reproductive-age, a population more likely to engage in unstructured and intermittent PA (such as household cleaning, walking) than men. We investigated whether the accelerometer data from the Crouter, Sasaki and Santos-Lozano algorithms: 1) reported significantly different PA estimates; 2) interacted with weight and age to modify PA estimates; and 3) provided different prevalence of adults meeting PA guidelines. Methods At least four days of accelerometer data were collected from 29 women, ages 18 to 38 years, and processed through three algorithms using an Excel model that automatically removed non-wear data and simultaneously calculated PA estimates [i.e., wear minutes, metabolic equivalent minutes (MET-min)]. A combination of mixed-effects linear regression models and bivariate correlation analyses were used to examine associations between accelerometer data with weight, age, and clinical markers of metabolic status across algorithms. Results The Crouter algorithm estimated significantly more wear minutes in Moderate intensity compared to the Sasaki and Santos-Lozano algorithms [+384 (SE 33) and+356 (SE 33) minutes, respectively]. There were significant interactions between Crouter estimates of Sedentary/Light and Moderate wear minutes with weight and age (all Pinteraction ≤ 0.001, Santos-Lozano algorithm as the reference). Algorithm selection also provided inconsistent findings in the prevalence of adults meeting PA guidelines. Conclusions Recently proposed data reduction algorithms varied in their PA estimates in women of reproductive age. Algorithm selection interacted with weight and age to influence PA estimates and provided inconsistent classification of those who met PA guidelines. Thus, depending on the algorithm selected, behavior change recommendations might differ for each individual due to varying PA estimations. Larger sample sizes are needed to confirm these findings. Funding Sources This research is partially supported by the Cornell University Human Ecology Alumni Association. The first author is currently being supported by the National Institutes of Health.

scholarly journals Impact of hypocaloric dietary intervention on ovulation in obese women with PCOS

Reproduction ◽  
2017 ◽  
Vol 153 (1) ◽  
pp. R15-R27 ◽  
Author(s):  
Brittany Y Jarrett ◽  
Marla E Lujan
Keyword(s):  
Weight Loss ◽  
Dietary Intervention ◽  
Polycystic Ovary ◽  
Reproductive Function ◽  
Antral Follicle ◽  
Reproductive Age ◽  
Obese Women ◽  
Dietary Interventions ◽  
Wide Range ◽  
The Impact

Polycystic ovary syndrome (PCOS) is a common cause of ovulatory dysfunction affecting women of reproductive age. Obesity and insulin resistance are thought to potentiate disruptions in antral follicle development that result in chronic anovulation, and as such, have become important therapeutic targets of dietary interventions aimed at weight loss. Caloric restriction has been shown to promote sporadic ovulation in obese women with PCOS, but improvements have occurred across a wide range of patients and little has been garnered about the factors that distinguish responders from non-responders. Further, few studies have evaluated the likelihood for modest weight loss to restore normal ovulatory cyclicity in PCOS. Consensus regarding the impact of dietary intervention on ovulation has been limited by variability in the measures used to characterize and report ovulatory status across studies. In response, this review provides an assessment of the evidence surrounding the effectiveness of hypocaloric dietary intervention to normalize ovulatory function in PCOS. The impact of physiological vs methodological factors on the evaluation of ovulatory status is discussed, and recommendations to strengthen future studies in this area are provided. Ultimately, further research is needed to understand the optimal dietary or lifestyle approaches that promote ovulation and sustained improvements in reproductive function in PCOS.

Sign in / Sign up

Export Citation Format

Share Document