scholarly journals Cushing’s syndrome due to bilateral oncocytic adrenal tumor

2020 ◽  
Vol 66 (3) ◽  
pp. 47-55
Author(s):  
Ekaterina I. Kim ◽  
Elizaveta O. Mamedova ◽  
Liliya S. Selivanova ◽  
Svetlana A. Buryakina ◽  
Natalya P. Gorbunova ◽  
...  
Keyword(s):  
Adrenal Tumor ◽  
Malignant Tumors ◽  
Malignant Potential ◽  
Adrenal Tumors ◽  
Uncertain Malignant Potential ◽  
Immunohistochemical Examination ◽  
Epithelial Neoplasms ◽  
Second Tumor ◽  
Bilateral Adrenal Tumors ◽  
Excessive Accumulation

Cushings syndrome accounts for approximately 2030% of endogenous hypercortisolism cases, and adrenal involvement can be either unilateral or bilateral. Cushings syndrome due to bilateral adrenal tumors is extremely rare. Adrenal oncocytomas are another rare cause of endogenous hypercortisolism: about 13 cases are described in the literature. Oncocytomas are rare epithelial neoplasms, characterized by abnormally excessive accumulation of defective mitochondria in the cytoplasm of cells, and make up 1.8% of all adrenal neoplasms. We describe a 58-year old patient with Cushings syndrome and bilateral adrenal tumors. Multispiral computed tomography of the adrenals showed signs suspicious of lipid-poor atypical adenomas or malignant tumors. Surgical treatment was the method of choice, and the larger tumor was excised first. Due to the absence of remission of endogenous hypercortisolism the excision of the second tumor was performed. Morphological and immunohistochemical examination confirmed the diagnosis of bilateral oncocytic adrenocortical tumors with uncertain malignant potential. Cases of bilateral hormone-producing adrenal oncocytomas have not been described in the literature.

scholarly journals Large non-functional adrenocortical oncocytoma with uncertain malignant potential: case report and review of literature

2020 ◽  
Vol 7 (7) ◽  
pp. 2414
Author(s):  
Praveen Kumar Yadav ◽  
Arshad Hasan ◽  
Anunay Singh ◽  
Gaurab Kundu ◽  
M. Faizul Haque ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Clinical Manifestations ◽  
Malignant Potential ◽  
Diagnostic Tools ◽  
Adrenal Tumors ◽  
Uncertain Malignant Potential ◽  
Contrast Enhanced ◽  
Urinary Tract Symptoms ◽  
Potential Case ◽  
Enhanced Computed Tomography

Adrenocortical oncocytomas are a very rare group of adrenal tumors. Unless functional, these tumors are incidentally diagnosed for clinical manifestations that are unrelated to the adrenal gland. The majority of these oncocytomas are benign and nonfunctional. Very few cases of uncertain malignant potential are reported. Here we present such a rare case of a 60 years old man presenting with voiding lower urinary tract symptoms but on contrast enhanced computed tomography (CECT) abdomen and pelvis a fairly large well defined heterogeneously enhancing retroperitoneal mass lesion with calcifications in the left anterior pararenal space (measuring 10.8×9.7×9 cm) was detected. On excision a well encapsulated solid mass of size approximately 12×10×9 cm was present in left suprarenal region. Histopathological examination confirmed the diagnosis of adrenocortical oncocytoma with uncertain malignant potential. As the incidence of adrenal oncocytoma is less, the knowledge regarding its clinical pattern, confirmatory imaging or histopathological diagnostic tools and chances of recurrence or turning malignant is limited.

Ultrastructure of Cryptorchidism and Seminoma

1981 ◽  
Vol 39 ◽  
pp. 540-541
Author(s):  
Shirley Siew ◽  
Susan C. James
Keyword(s):  
Malignant Tumors ◽  
Frozen Section ◽  
Malignant Potential ◽  
Genetic Influences ◽  
Endocrine Gland ◽  
Medial Aspect ◽  
Left Testis ◽  
Bilateral Orchiectomy

Testicular maldescent is the most common endocrine gland abnormality, as 2.7% of mature neonates are cryptorchid. The significant complications are that there is a disturbance of normal maturation which results in diminished fertility and there is an increase in the malignant potential which is 35 times greater in the undescended than the descended testis. It is considered that genetic influences may be of etiological importance and recurrence has been described in some families. It is of interest, that the case reported here has 2 siblings who have also presented with cryptorchidism and malignant tumors.The propositus is 14 years old. He is well developed (described by some as obese) and shows normal secondary male characteristics except for an immature scrotum. Laparotomy showed both testes to be intraabdominal. A hard nodule (0.5cm) was palpated on the medial aspect of the left testis. Frozen section showed the presence of seminoma and bilateral orchiectomy was performed.

Primary adrenal lymphoma in an HIV patient: a rare case of bilateral adrenal tumors

2018 ◽  
Author(s):  
Maria Mavromati ◽  
Olivier Nawej ◽  
Olga Tsopra ◽  
Heba Al-Alwan ◽  
Francois Jornayvaz ◽  
...  
Keyword(s):  
Rare Case ◽  
Adrenal Tumors ◽  
Primary Adrenal Lymphoma ◽  
Adrenal Lymphoma ◽  
Bilateral Adrenal Tumors

Large Oncocytic Adrenocortical Tumor with Uncertain Malignant Potential

2018 ◽  
Author(s):  
Betul Aydin Buyruk ◽  
Goknur Yorulmaz ◽  
Belgin Efe ◽  
Bartu Badak ◽  
Deniz Arik ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Adrenocortical Tumor ◽  
Uncertain Malignant Potential

Stanford parameters stratify the risk of recurrence in gynecologic smooth muscle tumors of uncertain malignant potential (STUMP)

Apmis ◽  
2021 ◽  
Author(s):  
Antonio Travaglino ◽  
Antonio Raffone ◽  
Annarita Gencarelli ◽  
Carola Caldarelli ◽  
Marcello Granata ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Malignant Potential ◽  
Uncertain Malignant Potential ◽  
Risk Of Recurrence ◽  
Smooth Muscle Tumors

Recurrent Prostatic Stromal Tumor of Uncertain Malignant Potential Combined with Concurrent Prostatic Adenocarcinoma: An Unusual Case

2021 ◽  
pp. 1-5
Author(s):  
Zhen Zhang ◽  
Chaozhao Liang
Keyword(s):  
Transurethral Resection ◽  
Unusual Case ◽  
Malignant Potential ◽  
Prostatic Adenocarcinoma ◽  
Stromal Tumor ◽  
Simultaneous Occurrence ◽  
Uncertain Malignant Potential ◽  
Unique Case ◽  
Neoplastic Lesions

Prostatic stromal tumor of uncertain malignant potential (STUMP), characterized by an atypical, unique stromal proliferation of the prostate, is often difficult to be differentiated from other nonepithelial neoplastic lesions. We present a unique case of recurrent STUMP after transurethral resection of the prostate (TURP) with concurrent prostatic adenocarcinoma. Patients diagnosed with prostatic STUMP should be followed up closely, for it may recur and invade adjacent organs after TURP shortly. Concurrent prostatic adenocarcinoma can be found in STUMP patients, and there may be some potential mechanisms which promote the simultaneous occurrence of the 2 tumors.

Unusual morphological features of uterine leiomyomas treated with progestogens

2011 ◽  
Vol 64 (6) ◽  
pp. 485-489 ◽  
Author(s):  
Clinton Boyd ◽  
W Glenn McCluggage
Keyword(s):  
Smooth Muscle ◽  
Mitotic Activity ◽  
Intrauterine Device ◽  
Malignant Potential ◽  
Morphological Features ◽  
Uterine Leiomyomas ◽  
Pathological Features ◽  
Uncertain Malignant Potential ◽  
Smooth Muscle Tumour ◽  
Benign Leiomyoma

BackgroundUterine leiomyomas are extremely common in surgical pathology practice and in the vast majority there are no issues in diagnosis. Progestogens are widely prescribed drugs for a variety of indications, including abnormal uterine bleeding, and are often given to women with leiomyomas but the pathological features of leiomyomas treated with progestogens are poorly described.MethodsWe report the pathological features in eight cases of uterine leiomyomas in women who had been treated with oral progestogens or a progestogen-containing intrauterine device; all cases were received in consultation because the features raised concern for leiomyosarcoma, smooth muscle tumour of uncertain malignant potential or a benign leiomyoma with unusual features. Additionally, we reviewed a series of cases of uterine leiomyomas (n=99) in women who exhibited progestogenic effects in the endometrium.ResultsThe morphological features in the consult cases, which were widespread and marked and which varied somewhat from case to case, included small and/or large areas of infarct-type necrosis (sometimes mimicking coagulative tumour cell necrosis) with surrounding increased cellularity, mitotic activity, nuclear pyknosis, cytoplasmic eosinophilia, epithelioid morphology, stromal oedema, haemorrhage, and myxoid change and infiltration by CD56 positive granulated lymphocytes. Sometimes the features resulted in an almost deciduoid appearance. Similar features were present to a minor degree in significant numbers of the additional series of cases.ConclusionsPathologists should be aware of these progestogen-associated features when reporting uterine leiomyomas whether or not the clinician has indicated that the woman is taking progestogens since otherwise a diagnosis of leiomyosarcoma or smooth muscle tumour of uncertain malignant potential may be rendered. Useful features in suggesting a benign leiomyoma, in addition to recognition of the morphological features described which, in combination, are characteristic of progestogens, are the lack of true nuclear atypia and the low mitotic activity away from the abnormal areas.

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