scholarly journals Rates of physical development as a marker of the quality of metabolic control in children and adolescents with diabetes mellitus

1994 ◽  
Vol 40 (6) ◽  
pp. 10-12
Author(s):  
N. B. Lebedev
Keyword(s):  
Diabetes Mellitus ◽  
Growth Rate ◽  
Children And Adolescents ◽  
Insulin Dependent Diabetes Mellitus ◽  
Physical Development ◽  
Dependent Diabetes Mellitus ◽  
Childhood And Adolescence ◽  
Insulin Dependent ◽  
The Mean

Physical development of 710 children and adolescents with insulin-dependent diabetes mellitus (IDDM) was studied over time. The patients were divided into 3 groups: with growth rate above the 25th percentile of the age norm, with growth rate below the 10th percentile of the norm, and with growth rales between the 10th and 25th percentiles of age norm. Analysis showed that (a) the presence of manifest decompensation higher than 12 %, frequent ketoacidosis episodes is a factor of high risk of reduction of physical development rate in children and adolescents with IDDM; (b) the mean statistical rates of diabetic adolescents growth are characterized by delayed (by 1 to 2 years vs. the norm) pubertal growth skip, and this growth skip in the patients is more levelled and stretched in time, and in some cases is virtually nor manifest; (c) if good compensation is attained and maintained after previous prolonged decompensation, compensating growth rates may develop in patients of both sexes both in childhood and adolescence.

Erythrocyte Insulin Binding in Insulin-Dependent Diabetes Mellitus: Lack of Relationship to Duration and Control of Diabetes in Children and Adolescents

PEDIATRICS ◽  
1980 ◽  
Vol 66 (3) ◽  
pp. 385-390
Author(s):  
Michael S. Kappy ◽  
Leslie P. Plotnick ◽  
Joann C. Findlay ◽  
Richard D. Kayne
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Binding ◽  
Diabetic Control ◽  
Insulin Dependent Diabetes ◽  
Liver Fat ◽  
Dependent Diabetes Mellitus ◽  
Control Of Diabetes ◽  
Insulin Dependent

Insulin binding was measured in the erythrocytes (RBCs) of four children and 12 adolescents with insulin-dependent diabetes mellitus in the basal (fasting, nonketotic) state. Children and adolescents with insulin-dependent diabetes mellitus showed normal binding of insulin to their RBCs when expressed as the total insulin bound over the physiologic range of insulin concentrations. The insulin receptor concentration and receptor binding affinity for insulin were also normal. These parameters of insulin binding were not correlated with either the duration of diabetes or the degree of diabetic control in the patients. Since insulin binding by erythrocytes has been shown to reflect binding by traditional target tissues (liver, fat), the data suggest that alterations in binding of insulin to cells in children and adolescents with insulin-dependent diabetes mellitus probably play little, if any, role in the response of these patients to exogenous insulin or in the control of their glucose metabolism in the basal state.

Insulin-dependent Diabetes Mellitus

1994 ◽  
Vol 15 (4) ◽  
pp. 137-148
Author(s):  
Leslie Plotnick
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Plasma Glucose ◽  
Behavioral Problems ◽  
Insulin Dependent Diabetes Mellitus ◽  
Health Care Team ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Insulin Dependent

Insulin-dependent diabetes mellitus (IDDM) is a chronic, serious disease in children and adolescents. Its diagnosis is straightforward and rarely subtle. The major challenges of this disease for the child, family, and health-care team involve long-term management of medical and metabolic factors as well as psychological and behavioral concerns. While developments in the past 10 to 15 years have made metabolic control technically possible, psychological stresses and behavioral problems often interfere with metabolic goals. There are few, if any, other diseases that require such intensive and extensive self-care skills. Definitions Diabetes generally is classified in two types. Type I, or IDDM, is seen mostly in younger people (children and adolescents). It previously was called juvenile onset or ketosisprone. Insulin deficiency characterizes IDDM, and patients need exogenous insulin for survival. Type II, or non-IDDM (NIDDM), previously called adult or maturity onset, is the type seen most commonly in older people and in obesity and is not discussed in this review. To make a diagnosis of diabetes, a child must have either classic symptoms with a random plasma glucose above 200 mg/dL or specific plasma glucose levels before and after a standard glucose load if asymptomatic. The diagnosis of IDDM usually is clear-cut.

Serum Angiogenin Levels in Children and Adolescents with Insulin-Dependent Diabetes Mellitus

1998 ◽  
Vol 43 (6) ◽  
pp. 798-800 ◽  
Author(s):  
Ariadne Malamitsi-Puchner ◽  
Angeliki Sarandakou ◽  
Chrysoula Dafogianni ◽  
John Tziotis ◽  
Christos S Bartsocas
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent
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