scholarly journals Activities of antioxidant defense enzymes in children with insulin-dependent diabetes mellitus

1994 ◽  
Vol 40 (5) ◽  
pp. 7-9
Author(s):  
L. N. Scherbachyova ◽  
N. B. Lebedev ◽  
A. P. Knyazeva ◽  
B. P. Mischenko
Keyword(s):  
Glutathione Peroxidase ◽  
Antioxidant Defense ◽  
Insulin Dependent Diabetes Mellitus ◽  
Antioxidant Defense System ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Informative Marker ◽  
Antioxidant Defense Enzymes ◽  
The Status ◽  
Insulin Dependent

Activities of superoxide dismutase and glutathione peroxidase were measured in 60 children aged 5 to 15 with insulin-dependent diabetes of various degrees of compensation and duration. Measurements of glutathione peroxidase were found to be the most informative marker of the status of antioxidant defense system.

scholarly journals Lipid peroxidation and the state of the antioxidant defense system in patients with insulin-dependent diabetes mellitus

1997 ◽  
Vol 43 (5) ◽  
pp. 16-19
Author(s):  
O. N. Nikiforov ◽  
O. V. Sazonova ◽  
L. Ya. Sukhanova ◽  
L. G. Knyazkova ◽  
V. A. Galenok
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Insulin Dependent Diabetes Mellitus ◽  
Antioxidant Defense System ◽  
Conjugated Dienes ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Defense System ◽  
Insulin Dependent

Lipid peroxidation and status of the antioxidant defense were followed up in 24 patients with insulin-dependent diabetes over the course of treatment. Serum malonic dialdehyde was reliably (2.7 times) increased during the decompensation stage. Accumulation of conjugated dienes was not seen in all the patients; it depended on the content of free fatty acids. Their level decreased 1.1-1.3 times with depletion of the oxidation substrate. Variously directed changes of catalase activity were observed during the decompensation stage in the presence of a reliable (1.6 times) depression of ceruloplasmin, this reflecting various stages of adaptation of the antioxidant defense system. The level of malonic di aldehyde decreased after normalization of carbohydrate metabolism, but failed to reach the control values; a trend to recovery of the antioxidant composition was observed. The findings indicate disorders in the relationships between lipid peroxidation and antioxidant defense. Approaches to development of individual treatments and methods of correction are discussed.

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Interquartile Range ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Intergroup Comparison ◽  
Median Plasma ◽  
Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent
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