scholarly journals Stromal ovarian tecomatosis

1996 ◽  
Vol 42 (3) ◽  
pp. 40-45
Author(s):  
M. F. Maltseva ◽  
A. A. Pishchulin ◽  
M. E. Bronstein
Keyword(s):  
Polycystic Ovary ◽  
Ovarian Tissue ◽  
Treatment Options ◽  
Interstitial Tissue ◽  
Morphological Form ◽  
Ovarian Stroma ◽  
Morphological Picture ◽  
The Subject ◽  
Theca Interna ◽  
First Time

In 1942, S. Geist and J. Geines were the first to publish the unusual results of a histological examination of ovarian tissue in patients with Stein-Leventhal syndrome. They found foci of "luteinized" tecal cells, similar to theca interna folliculi cells, scattered along the ovarian "stroma" outside the follicles. The following year, L. Fraenkel in his work called these histopathological changes in ovarian hypertosis. In 1949, A. Culiner and S. Shipel used the term "hypertension syndrome" to refer to conditions in which foci of "tekomatosis", consisting of 10-30-60 individual hypertrophic and luteinized tecal cells in the ovarian "stroma", combined with the clinical picture of defemini ation and virilization. In subsequent years, due to the lack of a unified terminology in the literature, synonyms such as hypertosis, cortical stromal hyperplasia, stromal proliferation, stromal tecosis, and tecomatosis were used. R. Feinberg proposed dividing hypertosis into 3 groups, based on the predominance of cystic follicles and a thickened white membrane (mixed tecosis) with increased proliferation of the actual cells of the interstitial tissue or without it (internal tecosis). The presence of "stromal" proliferation in the absence of phenomena of cystic atresia of the follicles, he defined the term "stromal tecosis" (tekomatosis). I.V. Golubeva for the first time in our country drew attention to the clinical and hormonal features of stromal tecomatosis (ST), which was previously considered in the framework of polycystic ovary syndrome, and after 3 years M.E. Bronstein proved that this is an independent morphological form and gave a definition concepts of ST. Ovarian CT is understood as hyperplasia of the interstitial tissue of the ovaries and the appearance in it of groups of hypertrophied epithelioid cells that form foci of various sizes without any connection with follicles. The subject of this review is the consideration of the clinical and morphological picture of this disease, the features of hormonal homeostasis, modern hypotheses of the pathogenetic mechanisms of its development, as well as possible treatment options.

СОЦИАЛЬНАЯ КОНФЛИКТОЛОГИЯ: ТЕОРЕТИКО-ИСТОРИЧЕСКИЙ АСПЕКТ

2020 ◽  
Vol 15 (2) ◽  
pp. 68
Author(s):  
А. Н. Сухов
Keyword(s):  
Theory And Practice ◽  
Important Task ◽  
Social Conflicts ◽  
Psychological Approach ◽  
Structure Dynamics ◽  
History Of ◽  
The Subject ◽  
First Time

This given article reveals the topicality not only of destructive, but also of constructive, as well as hybrid conflicts. Practically it has been done for the first time. It also describes the history of the formation of both foreign and domestic social conflictology. At the same time, the chronology of the development of the latter is restored and presented objectively, in full, taking into account the contribution of those researchers who actually stood at its origins. The article deals with the essence of the socio-psychological approach to understanding conflicts. The subject of social conflictology includes the regularities of their occurrence and manifestation at various levels, spheres and conditions, including normal, complicated and extreme ones. Social conflictology includes the theory and practice of diagnosing, resolving, and resolving social conflicts. It analyzes the difficulties that occur in defining the concept, structure, dynamics, and classification of social conflicts. Therefore, it is no accident that the most important task is to create a full-fledged theory of social conflicts. Without this, it is impossible to talk about effective settlement and resolution of social conflicts. Social conflictology is an integral part of conflictology. There is still a lot of work to be done, both in theory and in application, for its complete design. At present, there is an urgent need to develop conflict-related competence not only of professionals, but also for various groups of the population.

Thermodynamics in Geochemistry

1993 ◽  
Author(s):  
Greg M. Anderson ◽  
David A. Crerar
Keyword(s):  
Teaching Experience ◽  
Graduate Level ◽  
Years Of Teaching Experience ◽  
The Subject ◽  
First Time

This textbook and reference outlines the fundamental principles of thermodynamics, emphasizing applications in geochemistry. The work is distinguished by its comprehensive, balanced coverage and its rigorous presentation. The authors bring years of teaching experience to the work, and have attempted to particularly address those areas where other texts on the subject have provided inadequate coverage. A thorough review of the necessary mathematics is presented early on, both as a refresher for those with a background in university calculus, and for the benefit of those coming to the subject for the first time. The text is written for students in advanced undergraduate or graduate-level geochemistry as well as for all researchers in this field.

Anisotropic Elasticity

1996 ◽  
Author(s):  
T. T. C. Ting
Keyword(s):  
Composite Materials ◽  
Elastic Constants ◽  
Piezoelectric Materials ◽  
Anisotropic Materials ◽  
Anisotropic Elasticity ◽  
Stress Singularities ◽  
Comprehensive Survey ◽  
The Subject ◽  
Key Topics ◽  
First Time

Anisotropic Elasticity offers for the first time a comprehensive survey of the analysis of anisotropic materials that can have up to twenty-one elastic constants. Focusing on the mathematically elegant and technically powerful Stroh formalism as a means to understanding the subject, the author tackles a broad range of key topics, including antiplane deformations, Green's functions, stress singularities in composite materials, elliptic inclusions, cracks, thermo-elasticity, and piezoelectric materials, among many others. Well written, theoretically rigorous, and practically oriented, the book will be welcomed by students and researchers alike.

scholarly journals COT-13 Current situation and problems of cancer genomic profiling test in Kyoto University Hospital

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii22-ii22
Author(s):  
Yoshiki Arakawa ◽  
Junko Suga ◽  
Yukinori Terada ◽  
Kohei Nakajima ◽  
Masahiro Tanji ◽  
...  
Keyword(s):  
Treatment Options ◽  
Insurance Coverage ◽  
Germline Mutations ◽  
University Hospital ◽  
Genomic Profiling ◽  
Test Results ◽  
Final Test ◽  
First Time ◽  
To Receive ◽  
Secondary Finding

Abstract Objective: Kyoto University Hospital has introduced the cancer genomic profiling tests, Oncoprime in 2015, Guardant360 in 2018, which are not under insurance coverage, FoundationOne CDx(F1CDx) and OncoGuide NCC Oncopanel system(NCC OP) in 2019, which received approval for insurance coverage for the first time in Japan. We investigated the results of cancer genomic profiling test under insurance coverage in our hospital. Methods: A special facility for the cancer genomic profiling tests was produced. To perform the cancer genomic profiling test, an outpatient must visit the facility three times (learning, ordering of the test, and getting the results). The expert panels decide the final test results and treatment options with the all information of the patients. Results: From November 2019 to March 2020, 51 and 9 patients were tested with F1CDx and NCC OP, respectively. 16 patients (31%) of F1CDX and 2 patients (22%) of NCC OP got treatment recommendations from the expert panels. However, only 5 patients (9.8%) of F1CDX and 1 patient (11%) of NCC OP received the treatments. The secondary finding suspecting germline mutations was found in 8 patients of F1CDX. Conclusion: After the approval the cancer genomic profiling tests with insurance coverage in Japan, it becomes easy for the patients to perform the test and get the genetic information of the tumor. However, it remains not easy to receive the recommended drugs because of several limitations of their usages.

scholarly journals Per Ravenna trecentesca: nuove proposte per l’assetto architettonico di Santa Maria in Porto Fuori

2019 ◽  
Vol 82 (1) ◽  
pp. 3-31
Author(s):  
Fabio Massaccesi
Keyword(s):  
Fourteenth Century ◽  
Second World War ◽  
World War ◽  
The Subject ◽  
First Time ◽  
Santa Maria ◽  
Second World ◽  
The Church

Abstract This contribution intends to draw attention to one of the most significant monuments of medieval Ravenna: the church of Santa Maria in Porto Fuori, which was destroyed during the Second World War. Until now, scholars have focused on the pictorial cycle known through photographs and attributed to the painter Pietro da Rimini. However, the architecture of the building has not been the subject of systematic studies. For the first time, this essay reconstructs the fourteenth-century architectural structure of the church, the apse of which was rebuilt by 1314. The data that led to the virtual restitution of the choir and the related rood screen are the basis for new reflections on the accesses to the apse area, on the pilgrimage flows, and on the view of the frescoes.

Offshore Claims and Problems in the North Sea

1965 ◽  
Vol 59 (3) ◽  
pp. 505-522 ◽  
Author(s):  
Richard Young
Keyword(s):  
North Sea ◽  
Large Scale ◽  
Geneva Convention ◽  
Legal Principles ◽  
The North ◽  
Legal Problems ◽  
The North Sea ◽  
The Subject ◽  
First Time ◽  
Economic Considerations

The possible presence of very large petroleum and natural gas reserves in the area beneath the North Sea is currently the subject of intense investigation. If confirmed, as seems likely in at least some localities, this occurrence will raise legal problems of considerable interest and complexity. For the North Sea is not merely an oilfield covered by water: for centuries it has been one of the world's major fishery regions and the avenue to and from the world's busiest seaports. Thus all three of the present principal uses of the sea—fishing, navigation, and the exploitation of submarine resources—promise to meet for the first time on a large scale in an area where all are of major importance. The process of reconciling the various interests at stake will provide the first thoroughgoing test of the adequacy and acceptability of the general principles laid down in the 1958 Geneva Convention on the Continental Shelf and should add greatly to the practice and precedents available in this developing branch of the law. In the present article an attempt is made to review some of the geographical and economic considerations involved in the North Sea situation, to note some of the technical and legal developments that have already taken place, and to consider these elements in the light of the various interests and legal principles concerned.

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome

2011 ◽  
Vol 23 (4) ◽  
pp. 520 ◽  
Author(s):  
Yun Liu ◽  
Hong Jiang ◽  
Ling-Yun He ◽  
Wu-Jian Huang ◽  
Xiao-Yu He ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Early Stage ◽  
Uncoupling Protein ◽  
Serum Insulin ◽  
Ovarian Tissue ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Ovary Syndrome ◽  
Protein Levels

Polycystic ovary syndrome (PCOS) may result from hypersensitivity to insulin, which is negatively regulated by uncoupling protein (UCP)-2. Because cholesterol side-chain cleavage enzyme (CYP11A1) is closely linked to PCOS, the expression of UCP-2 and CYP11A1 in ovarian tissues from PCOS patients was examined in the present study. Twelve PCOS patients with hyperandrogenaemia who underwent laparoscopic ovarian wedge resection and 12 age-matched control patients who underwent contralateral ovarian biopsy were enrolled in the study. UCP-2 expression in early stage (primordial, primary and secondary) and late stage (sinus and mature) follicles was examined using immunohistochemistry, whereas UCP-2 and CYP11A1 mRNA and protein levels in ovarian tissue were determined using quantitative reverse transcription–polymerase chain reaction and western blot analyses, respectively. UCP-2 expression increased significantly with follicular development in both control and PCOS tissue, with expression in early stage follicles from PCOS patients significantly greater than that in controls. In addition, both UCP-2 and CYP11A1mRNA and protein levels, mean fasting blood glucose concentrations and fasting serum insulin levels were significantly higher in PCOS patients compared with the control group. Finally, a significant correlation between UCP-2 and CYP11A1 expression was found in PCOS but not control patients. In conclusion, in PCOS patients, there was a correlation between UCP-2 and CYP11A1 expression, which was significantly higher than in the control group. These changes in UCP-2 and CYP11A1 expression may mediate follicle development in PCOS.

Introducing Politics to the Undergraduate A Novel Approach

1983 ◽  
Vol 37 ◽  
pp. 10-12
Author(s):  
Kent Morrison
Keyword(s):  
Political Science ◽  
Science Class ◽  
Formal Study ◽  
Novel Approach ◽  
The Subject ◽  
First Time

What to teach the first-time student in a political science class? Perhaps more importantly, what to teach the undergraduate whose only experience with political science, and the formal study of politics, will be the introduction they receive in our classes?Owing to the peculiarities of our discipline, the “Introduction to Political Science” class is often just that: a tour through all the major gardens in the discipline, describing to students what is done among scholars and practicioners in the various fields, giving them an overall view of what we do, how we do it, and in the process perhaps making a case for the significance of our discipline, our research, and perhaps even the subject itself — politics.

"Itzt kommen die Soldaten"

2019 ◽  
Author(s):  
Tilman Venzl
Keyword(s):  
Literary History ◽  
18Th Century ◽  
Military History ◽  
Form And Function ◽  
Social Structural ◽  
History Of ◽  
The Subject ◽  
And Function ◽  
The Military ◽  
First Time

In the 18th century, as many as 300 German-language plays were produced with the military and its contact and friction with civil society serving as focus of the dramatic events. The immense public interest these plays attracted feeds not least on the fundamental social structural change that was brought about by the establishment of standing armies. In his historico-cultural literary study, Tilman Venzl shows how these military dramas literarily depict complex social processes and discuss the new problems in an affirmative or critical manner. For the first time, the findings of the New Military History are comprehensively included in the literary history of the 18th century. Thus, the example of selected military dramas – including Lessing's Minna von Barnhelm and Lenz's Die Soldaten – reveals the entire range of variety characterizing the history of both form and function of the subject.

Impacts of Metformin on Local Ovarian Cell Tissue of Rats with Polycystic Ovary Syndrome and Intestinal Flora Under Aerobic Exercise

2021 ◽  
Vol 11 (12) ◽  
pp. 2381-2388
Author(s):  
Xiao Yan
Keyword(s):  
Growth Factor ◽  
Polycystic Ovary Syndrome ◽  
Aerobic Exercise ◽  
Polycystic Ovary ◽  
Ovarian Tissue ◽  
Ovary Syndrome ◽  
Ovarian Cell ◽  
Expression Levels ◽  
Cell Tissue ◽  
Igf I

In order to explore the possible treatment mechanism of metformin on the local ovarian cell tissue of rats with polycystic ovary syndrome (PCOS), 35 female clean sterile rats were selected as the research objects in this study, and randomly divided a PCOS model group (PCOS MG) (25 rats) and a control group (CG) (10 rats). After the modelling was completed, 5 rats were randomly selected to evaluate the modelling effect. When the success rate was higher than 80%, the remaining model rats were divided into two groups randomly, namely the (PCOS MG) (10 rats) and the treatment group (TG) (10 rats). Hematoxylin-eosin (HE) staining was performed on ovarian tissue of the rat, and the ovarian tissue structure was observed under light microscope. Immunohistochemistry was used to detect the distribution and expression levels of tumour necrosis factor-α (TNF-α), insulin-like growth factor-I (IGF-I), and connective tissue growth factor (CTGF) on the ovaries of rats in each group. It was found by observing the vaginal smear under the microscope that the rats in the (PCOS MG) had lost the regular estrous cycle, suggesting that there was no ovulation. The expression levels of TNF-α and CTGF in rats in the (PCOS MG) were greatly higher than those in the CG (P < 0.05); compared with the (PCOS MG), the expression levels of TNF-α and CTGF in the TG were decreased observably (P < 0.05). IGF-I was mainly expressed in granulosa cells (GCs) and follicular membrane cells (FMCs) of the ovarian tissue. The expression level of IGF-I in ovarian GCs in rats in the (PCOS MG) was significantly higher than that in the CG (P < 0.05). The expression level of IGF-I in GCs in the TG was lower significantly than that in the (PCOS MG) (P < 0.05). By comparing with rats in the CG, the rats in the (PCOS MG) had obviously decreased Actinobacteria and Betaproteobacteria in the intestinal tract, and the proportion of Firmicutes in the intestine was significantly increased; the amount of butyric acid in the faeces of rats with aerobic exercise was obviously higher than that in the (PCOS MG), because exercise increased the proportion of intestinal butyric acid-producing bacteria. Conclusion: metformin combined with aerobic exercise can treat the PCOS by regulating serum hormone levels and the expression levels of TNF-α, IGF-I, and CTGF.

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