Pituitary-adrenocortical system
with experimental hereditary hypertension
An experimental study of hypertension is the main way to discover the mechanisms of formation, flow patterns and the search for ways to prevent one of the most common human diseases. The most interesting in this aspect are genetic models [19], since heredity plays a significant role in the pathogenesis of hypertension. In most of these models created on rats by their long-term selection for high blood pressure (BP), its increase occurs spontaneously, that is, almost independently of environmental influences, and is determined mainly by the animals genotype (lines GH, LH, MSN and SHR ) In such rats, hypertension is irreversible; its formation is inevitable for all individuals without exception.