scholarly journals Pituitary-adrenocortical system with experimental hereditary hypertension

1993 ◽  
Vol 39 (6) ◽  
pp. 52-55
Author(s):  
E. V. Naumenko

An experimental study of hypertension is the main way to discover the mechanisms of formation, flow patterns and the search for ways to prevent one of the most common human diseases. The most interesting in this aspect are genetic models [19], since heredity plays a significant role in the pathogenesis of hypertension. In most of these models created on rats by their long-term selection for high blood pressure (BP), its increase occurs spontaneously, that is, almost independently of environmental influences, and is determined mainly by the animals genotype (lines GH, LH, MSN and SHR ) In such rats, hypertension is irreversible; its formation is inevitable for all individuals without exception.

2021 ◽  
Vol 15 (10) ◽  
pp. 484-490
Author(s):  
Linda Nazarko

The number of adults with high blood pressure, hypertension, is increasing globally and nationally. Hypertension increases the risk of an individual developing life-changing, long-term conditions. This article, the fourth in a series, explores the diagnosis and treatment of hypertension and the consequences of unmanaged hypertension. It explains how readers can remain healthy and well by reducing the risks of hypertension and managing it well.


2005 ◽  
Vol 33 (05) ◽  
pp. 787-795 ◽  
Author(s):  
Shih-Ching Ho ◽  
Yueh-Feng Ho ◽  
Tzung-Hsien Lai ◽  
Tsu-Hwie Liu ◽  
Rey-Yih Wu

Recent findings of a link between high blood pressure (BP) and dementia have given new prospects. The aim of this study is to analyze a mixture of Chinese herbs, Tianma Gouteng Decoction (TGD), which was traditionally used to treat hypertension, and investigate its relation to ameliorating cognitive impairment. We discovered that TGD also had properties involving enhancement of memory acquisition (learning) skills in mice, but not memory consolidation. It was observed that TGD could prolong the step-through latency at doses of 1.0 and 2.5 g/kg on passive avoidance task in mice. TGD could be developed further to treat mice with amnesia, which was induced by scopolamine at the same dose under long-term (8 days) administration.


1977 ◽  
Vol 30 (2) ◽  
pp. 115-119 ◽  
Author(s):  
R. Frankham

SUMMARYAn experimental evaluation of Robertson's (1970) theory concerning optimum intensities of selection for selection of varying durations has been carried out using published results from a long term selection study in Drosophila. Agreement of predicted rankings of treatments with expectations was excellent for low values of t/T (generations/total number scored) but poor for larger values of t/T. This was due to the 20% selection intensity treatments responding worse than expected and the 40% treatments relatively better than expected. Several possible reasons for the discrepancies exist but the most likely explanation is considered to be the greater reduction in effective population size due to selection in treatments with more intense selection.


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