scholarly journals Prevention and treatment of late complications of diabetes in children and adolescents

2000 ◽  
Vol 46 (1) ◽  
pp. 3-7
Author(s):  
E. P. Kasatkina ◽  
E. A. Odud ◽  
I. G. Sichinava ◽  
G. I. Sivous ◽  
S. E. Doll
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Diabetic Complications ◽  
Insulin Dependent Diabetes Mellitus ◽  
Late Complications ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Complications Of Diabetes ◽  
Prevention And Treatment ◽  
Insulin Dependent

The most important problem of modern clinical diabetology is the prevention and treatment of late complications of diabetes. Until recently, it was believed that the prevention and treatment of diabetic microvascular lesions was mainly a problem for endocrinologists. However, to date it has been reliably established that diabetic complications not only develop more often in patients with insulin-dependent diabetes mellitus (IDDM) in childhood, but are also widespread among children and especially adolescents [1, 2].

Erythrocyte Insulin Binding in Insulin-Dependent Diabetes Mellitus: Lack of Relationship to Duration and Control of Diabetes in Children and Adolescents

PEDIATRICS ◽  
1980 ◽  
Vol 66 (3) ◽  
pp. 385-390
Author(s):  
Michael S. Kappy ◽  
Leslie P. Plotnick ◽  
Joann C. Findlay ◽  
Richard D. Kayne
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Binding ◽  
Diabetic Control ◽  
Insulin Dependent Diabetes ◽  
Liver Fat ◽  
Dependent Diabetes Mellitus ◽  
Control Of Diabetes ◽  
Insulin Dependent

Insulin binding was measured in the erythrocytes (RBCs) of four children and 12 adolescents with insulin-dependent diabetes mellitus in the basal (fasting, nonketotic) state. Children and adolescents with insulin-dependent diabetes mellitus showed normal binding of insulin to their RBCs when expressed as the total insulin bound over the physiologic range of insulin concentrations. The insulin receptor concentration and receptor binding affinity for insulin were also normal. These parameters of insulin binding were not correlated with either the duration of diabetes or the degree of diabetic control in the patients. Since insulin binding by erythrocytes has been shown to reflect binding by traditional target tissues (liver, fat), the data suggest that alterations in binding of insulin to cells in children and adolescents with insulin-dependent diabetes mellitus probably play little, if any, role in the response of these patients to exogenous insulin or in the control of their glucose metabolism in the basal state.

Insulin-dependent Diabetes Mellitus

1994 ◽  
Vol 15 (4) ◽  
pp. 137-148
Author(s):  
Leslie Plotnick
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Plasma Glucose ◽  
Behavioral Problems ◽  
Insulin Dependent Diabetes Mellitus ◽  
Health Care Team ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Type I ◽  
Insulin Dependent

Insulin-dependent diabetes mellitus (IDDM) is a chronic, serious disease in children and adolescents. Its diagnosis is straightforward and rarely subtle. The major challenges of this disease for the child, family, and health-care team involve long-term management of medical and metabolic factors as well as psychological and behavioral concerns. While developments in the past 10 to 15 years have made metabolic control technically possible, psychological stresses and behavioral problems often interfere with metabolic goals. There are few, if any, other diseases that require such intensive and extensive self-care skills. Definitions Diabetes generally is classified in two types. Type I, or IDDM, is seen mostly in younger people (children and adolescents). It previously was called juvenile onset or ketosisprone. Insulin deficiency characterizes IDDM, and patients need exogenous insulin for survival. Type II, or non-IDDM (NIDDM), previously called adult or maturity onset, is the type seen most commonly in older people and in obesity and is not discussed in this review. To make a diagnosis of diabetes, a child must have either classic symptoms with a random plasma glucose above 200 mg/dL or specific plasma glucose levels before and after a standard glucose load if asymptomatic. The diagnosis of IDDM usually is clear-cut.

Serum Angiogenin Levels in Children and Adolescents with Insulin-Dependent Diabetes Mellitus

1998 ◽  
Vol 43 (6) ◽  
pp. 798-800 ◽  
Author(s):  
Ariadne Malamitsi-Puchner ◽  
Angeliki Sarandakou ◽  
Chrysoula Dafogianni ◽  
John Tziotis ◽  
Christos S Bartsocas
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent
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