scholarly journals MODERN TREATMENT APPROACHES IN PATIENTS AFTER HIP ARTHROPLASTY BASED ON ASSESSMENT OF MINERAL METABOLISM IN DIFFERENT SKELETAL SEGMENTS

2015 ◽  
Vol 18 (1) ◽  
pp. 14-17
Author(s):  
I R Gafarov ◽  
R R Yakupov ◽  
T B Minasov ◽  
T E Hairov ◽  
A R Trubin ◽  
...  
Keyword(s):  
Hip Arthroplasty ◽  
Medical Technology ◽  
Mineral Metabolism ◽  
System Level ◽  
Control Group ◽  
Bone Homeostasis ◽  
Mineral Density ◽  
Functional Rehabilitation ◽  
Positive Effect

The results of a comparative study (study group included 35 patients after hip arthroplasty, control group - 36 patients) of mineral monitoring in different skeletal segments showed that a deficit in bone mineral density is formed in operated limb and is reflected at the system level leading to various forms of suppression of bone homeostasis, which subsequently impairs the quality of life. The efficiency of the use of calcium salts in combination with alfacalcidol, and in conjunction with an active functional rehabilitation after hip arthroplasty based on clinical and radiological monitoring. Such a scheme has a positive effect on treatment outcomes when using this medical technology.

scholarly journals The Lasting Effect of Discontinuing Zoledronic Acid On Periprosthetic Bone Mineral Density Five Years After Total Hip Arthroplasty

2021 ◽  
Author(s):  
Allen Herng Shouh Hsu ◽  
Chun-Hsien Yen ◽  
Yu-Der Lu ◽  
Feng-Chih Kuo ◽  
Cheng-Ta Wu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Renal Function ◽  
Zoledronic Acid ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Control Group ◽  
Mineral Density ◽  
Short Term ◽  
Periprosthetic Bone ◽  
Lasting Effect

Abstract Background: Previous study has shown that a short-term use of zoledronic acid (ZA) after cementless total hip arthroplasty (THA) significantly increases bone mineral density (BMD) over the proximal femur and inhibits bone turnover markers (BTMs) after two years. However, could the discontinuation of ZA have a lasting effect is of interest.Method: This is an extension study of a two-year prospective randomized controlled trial on 54 cementless THA treated with either two doses of ZA or placebo. We compared BTMs [alkaline phosphatase (ALP); osteocalcin (OC); procollagen 1 intact N-terminal propeptide (P1NP)], serum calcium, renal function, radiological findings, and functional outcomes (Harris hip score and UCLA activity score) from baseline to 5 years post-THA in 49 patients, and periprosthetic BMD of the seven Gruen zones in 19 patients.Result: All patients had well-functioning hip prostheses, normal renal function, and normal serum calcium levels at 5-year follow-up. At the fifth year, the BMD levels were not statistically different between the two groups, but the change in BMD from baseline (BMD change ratios) in ZA group were significantly increased in zone 2, 4, and 6 as compared with control group. Parallel to that, in ZA group, levels of ALP were significantly lower at the fifth year; OC were significantly lower at the second and the fifth year; P1NP were significantly lower from 6 weeks to 2 years as compared with those in control group.Conclusion: This study demonstrates the lasting effect of a two-dose ZA given within one year after THA on bone metabolism and periprosthetic BMD at five years. The short-term dosing of ZA followed by a 4-year drug holiday had no adverse events and resulted in significant inhibition of periprosthetic bone loss and BTMs.Trial Registration:This extension study on a randomized, open label, single-center clinical trial was conducted under Institutional Review Board of Chang Gung Memorial Hospital Protocol Records 98-1150A3; 105-1296C1; 105-7004D, and was registered July 19th, 2016 on public registry ClinicalTrials.gov trial registration number NCT02838121.

scholarly journals Preventing Loss of Femoral Periprosthetic Bone Mineral Density in Cementless Total Hip Arthroplasty Using a Tapered Wedge Stem in Patients With Osteoporosis Treated With Denosumab: a Retrospective, Cohort Study

2021 ◽  
Author(s):  
Keiji Kamo ◽  
Hiroaki Kijima ◽  
Koichiro Okuyama ◽  
Tetsuya Kawano ◽  
Nobutoshi Seki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Total Hip Arthroplasty ◽  
Bone Mineral ◽  
Hip Arthroplasty ◽  
Stress Shielding ◽  
Control Group ◽  
Mineral Density ◽  
Total Hip ◽  
Cementless Total Hip Arthroplasty ◽  
Periprosthetic Bone Mineral Density

Abstract Background: Bone mineral density (BMD) of the proximal femur around the stem decreases due to stress shielding after cementless total hip arthroplasty (THA). When severe stress shielding occurs, the risk of periprosthetic femoral fractures increases, and this bone loss can also increase the difficulty of future revision THA. Denosumab is known to improve the quality and strength of cortical bone in the proximal femurs of patients with osteoporosis. The purpose of this study was to investigate whether denosumab prevents loss of proximal femoral periprosthetic BMD in cementless THA using a tapered wedge stem in patients with osteoporosis.Methods: Sixty-three consecutive patients who had undergone unilateral primary THA using a tapered wedge stem were included in this retrospective study. Twenty-four patients who received denosumab for osteoporosis were the denosumab group, and the 39 without denosumab were the control group. At 2 weeks, 6 months, and 12 months after THA, bone turnover markers and femoral periprosthetic BMD were measured.Results: BMD in zone 1 was significantly increased from baseline at both 6 and 12 months after THA in the denosumab group and significantly decreased in the control group. BMD in zone 7 was significantly decreased compared to baseline at both 6 and 12 months after THA in the control group, but not in the denosumab group. The use of denosumab for THA patients with osteoporosis was independently related to preventing loss of periprosthetic BMD of the femur at 12 months after surgery in zones 1 and 7 on multivariate analysis.Conclusions: Denosumab significantly increased proximal femoral periprosthetic BMD in zone 1 and prevented loss of BMD in zone 7 in patients with osteoporosis after cementless THA using a tapered wedge stem at both 6 and 12 months after surgery.

scholarly journals Influence of probiotic and prebiotic on meat quality of broiler chicken carcasses

2021 ◽  
Vol 32 ◽  
pp. 04009
Author(s):  
Irina Chervonova
Keyword(s):  
Meat Quality ◽  
Broiler Chickens ◽  
Broiler Chicken ◽  
First Grade ◽  
Control Group ◽  
Muscle Weight ◽  
The Third ◽  
The Impact ◽  
Positive Effect

The article presents the results of studying the impact of the spore-forming probiotic “Olin” and the prebiotic “Eсofiltrum” on the meat quality of broiler chicken carcasses of the Ross-308 cross. In the course of the research, it has been found that the inclusion of these preparations in the broiler diet has a positive effect on the studied indicators: the pre-slaughter weight increased by 4.3-5.7%, the weight of the gutted carcass by 4.6-6.2%, the muscle weight 4.8-6.5%, the weight of the loin muscles by 5.7-8.2%. The ratio of edible parts to inedible parts is 4.14 in the third experimental group, 4.08-in the second, and 4.04-in the control. Based on the results of the anatomical cutting of broiler carcasses and according to the fatness indicators the poultry carcasses of the third and second experimental groups, 87.5% and 87.2%, respectively, belong to the first grade, and the yield of the first grade carcasses is 86.2% in the control group. Meat products obtained from both the control poultry and the poultry of both experimental groups has no off-aroma odor and taste, the meat is juicy, tender and aromatic. The products obtained from broiler chickens, whose ration includes the probiotic “Olin” and the prebiotic “Ecofiltrum”, do not have any deviations from the established standards and norms. During the research, it has been found that the use of the studied drugs has a positive effect on the meat quality of poultry carcasses. However, broiler chickens receiving the probiotic “Olin” has more pronounced meat qualities.

scholarly journals DON-induced changes in bone homeostasis in mink dams

2017 ◽  
Vol 61 (3) ◽  
pp. 357-362 ◽  
Author(s):  
Ewa Tomaszewska ◽  
Piotr Dobrowolski ◽  
Siemowit Muszyński ◽  
Krzysztof Kostro ◽  
Iwona Taszkun ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Bone Mineral ◽  
Wall Thickness ◽  
Vertical Wall ◽  
Control Group ◽  
Bone Homeostasis ◽  
Mineral Density ◽  
Cross Sectional ◽  
Final Body Weight ◽  
Induced Changes

AbstractIntroduction: The aim of the study was to investigate the mechanical and geometric properties as well as bone tissue and mineral density of long bones in mink dams exposed to deoxynivalenol (DON) since one day after mating, throughout gestation (ca. 46 d) and lactation to pelt harvesting. Material and Methods: Thirty clinically healthy multiparous minks (Neovison vison) of the standard dark brown type were used. After the mating, the minks were randomly assigned into two equal groups: nontreated control group and DON group fed wheat contaminated naturally with DON at a concentration of 1.1 mg·kg-1of feed. Results: The final body weight and weight and length of the femur did not differ between the groups. However, DON contamination decreased mechanical endurance of the femur. Furthermore, DON reduced the mean relative wall thickness and vertical wall thickness of the femur, while vertical cortical index, midshaft volume, and cross-sectional moment of inertia increased. Finally, DON contamination did not alter bone tissue density, bone mineral density, or bone mineral content, but decreased the values of all investigated structural and material properties. Conclusion: DON at applied concentration probably intensified the process of endosteal resorption, which was the main reason for bone wall thinning and the weakening of the whole bone.

Surveying the Ashes: Experience from the 2007 Peloponnese Wildfires Six Months after the Disaster

2011 ◽  
Vol 26 (2) ◽  
pp. 79-89 ◽  
Author(s):  
Vasiliki Papanikolaou ◽  
Gloria R Leon ◽  
John Kyriopoulos ◽  
Jeffrey Levett ◽  
Eleftherios Pallis
Keyword(s):  
Health Status ◽  
Group Living ◽  
Total Sample ◽  
Psychological Status ◽  
Control Group ◽  
Subjective Perception ◽  
The Government ◽  
Perception Of Health ◽  
Positive Effect

AbstractIntroduction: Major disasters disrupt the infrastructure of communities and have lasting psychological, economic, and environmental effects on the affected areas. The psychological status and community effects of the devastating 2007 wildfires on the Peloponnese Peninsula of Greece were assessed six months following the disaster.Methods:Adult inhabitants, 18–65 years of age, living in villages affected by the wildfires were selected randomly and compared with a demographically similar group living in neighboring villages that were unaffected by the fires. Regions were chosen based on the extent of fire damage in that area. There were 409 participants in the fire group, and 391 in the control group. Participants completed a questionnaire that included the SCL-90-R symptom checklist, a subjective perception of health status, and a series of items assessing views about current problems, personal values, and trust in different institutions.Results:The fire group scored significantly higher on psychological distress compared to the control group. Both groups viewed their health status in the previous year as better than at the present time. There were few significant differences between groups in the designation of regional problems, attitudes, and values. In the total sample, 41.6% listed unemployment, and 15.0% listed poverty as the most important problem in their region. The Church was indicated as the most trusted institution by 36.7% of the group and the Government by 13.3%. A total of 30.2% did not have a trusted institution.Conclusions:The hardiness and resilience of the fire-impacted group was evident. However, an improvement in economic conditions is needed to maintain the health and enhance the quality of life of the population living in the Peloponnese region. This improvement likely would have a positive effect on the attitude of trust in government institutions.

scholarly journals Study on the combination of brief psychodynamic psychotherapy with Viagra in the treatment of non-organic ED

2020 ◽  
Vol 33 (5) ◽  
pp. e100184
Author(s):  
Zhihang Zhang ◽  
Xiang Gao ◽  
Ying Zhou ◽  
Chao Yu ◽  
Jittikorn Pimolsettapun ◽  
...  
Keyword(s):  
Treatment Group ◽  
Clinical Efficacy ◽  
Psychodynamic Psychotherapy ◽  
Control Group ◽  
Chinese Men ◽  
Oral Medications ◽  
Psychotherapeutic Interventions ◽  
Optimal Efficiency ◽  
Positive Effect

BackgroundErectile dysfunction (ED) has gradually become an important issue that seriously affects the quality of life of Chinese men. In addition to classic oral medications, psychotherapeutic interventions are increasingly being used in the treatment of ED.AimThis study aims to investigate the clinical efficacy of brief psychodynamic psychotherapy (BPP) plus Viagra in the treatment of non-organic ED.MethodsWe initiated this study via a controlled, prospective experimental design with initial optimal efficiency standard greater than 10%. On the standard, 63 patients were enrolled who were assigned to control or treatment group. The control group (including 33 cases) received Viagra treatment for 2 months, and the treatment group (including 30 cases) was cured with BPP plus Viagra. After the treatments, the clinical efficacy was assessed using the International Erectile Function Index (IIEF-5) score, the Self-rating Anxiety Scale (SAS), Sexual Satisfaction (SS) score and Erection Hardness Score (EHS).ResultsIn the comparison of efficacy, pretreatment and post-treatment within each group, the two groups showed improvements in IIEF, SAS scores, SS, and EHS (treatment group: PIIEF<0.001, PSAS<0.001, PSS<0.001, PEHS<0.001; control group: PIIEF<0.001, PSAS<0.001, PSS<0.001, PEHS<0.001). Furthermore, the treatment group presented better performances in IIEF (p=0.040), SAS (p=0.006), SS scores (p=0.045) and EHS (p=0.041) than the control group.ConclusionThe combination of BPP with Viagra has positive effect on the treatment of non-organic ED.

Physical Activity in Women with Breast Cancer and Those After Mastectomy

2020 ◽  
Vol 62 (2) ◽  
pp. 103-107
Author(s):  
Patrycja Gierszon ◽  
Agata Stachura ◽  
Magdalena Paziewska ◽  
Marzena Samardakiewicz ◽  
Marzena Furtak-Niczyporuk
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Physical Fitness ◽  
The Body ◽  
Mineral Density ◽  
Professional Literature ◽  
Mammary Gland Cancer ◽  
The Impact ◽  
Positive Effect

Mammary gland cancer, commonly known as breast cancer, is the most common malignancy in women in Poland. The occurrence of the disease and its treatment are associated with a decrease in physical fitness and endurance of the body, and also make it difficult to meet basic life needs and result in a deterioration in the quality of life. The aim of the study is to present physical activity in women with breast cancer and after mastectomy. Analysis of professional literature and available research results in patients undergoing oncological therapy in the treatment of breast cancer indicates the need for them to undertake physical activity and physiotherapy in order to minimize the effects of chemotherapy, radiotherapy, and mastectomy. Analysis of studies in terms of the impact of physical activity on the rehabilitation and recovery of patients with breast cancer showed a significant impact of physical fitness on bone mineral density as the most important factor in the development and maintenance of normal bone metabolism. Physical exercises have also been shown to have a positive effect on patients during and after treatment. Regular physical exercise in women treated for cancer is essential and has a significant impact on reducing muscle deficits and the entire skeletal system.

scholarly journals A twelve-week randomized controlled study of the cognitive-behavioral Integrated Psychological Therapy program: positive effect on the social functioning of schizophrenic patients

2007 ◽  
Vol 29 (2) ◽  
pp. 140-147 ◽  
Author(s):  
Marilene Zimmer ◽  
Adriana Veríssimo Duncan ◽  
Daniela Laitano ◽  
Eloisa Elena Ferreira ◽  
Paulo Belmonte-de-Abreu
Keyword(s):  
Quality Of Life ◽  
Social Functioning ◽  
Outcome Measures ◽  
Social Adjustment ◽  
Cognitive Behavioral ◽  
Control Group ◽  
Occupational Functioning ◽  
Treatment As Usual ◽  
Positive Effect

OBJECTIVES: The present study was designed to evaluate the effect of twelve weekly sessions of the cognitive-behavioral program originally known as the Integriertes Psychologisches Therapieprogramm für Schizophrene Patienten, designated the Integrated Psychological Therapy (IPT) program in English, on cognition, social adjustment and quality of life in schizophrenic outpatients, comparing it to the effect of treating such patients as usual. METHOD: Fifty-six adult outpatients (from 18 to 65 years of age) with ICD-10-based diagnoses of schizophrenia were randomly assigned to two different groups: active intervention (IPT group); and treatment as usual (control group). Outcome measures were quality of life (as determined using the WHOQOL-Bref), cognition (Mini-Mental State Examination and Word Recall Test), global functioning (DSM-IV Global Assessment of Functioning Scale), social functioning (Social and Occupational Functioning Assessment Scale) and social adjustment (Social Adjustment Scale). RESULTS: The findings suggest that, in comparison with treatment as usual (control group), the twelve-session IPT program had a positive effect on several outcome measures: cognition in the domains of spatiotemporal orientation (p = 0.051) and memory (p = 0.031); overall social adjustment (p = 0.037), leisure/social life (p = 0.051) and family relations (p = 0.008); overall functioning (p = 0.000); social-occupational functioning (p = 0.000); and quality of life in the psychological domain (p = 0.021). CONCLUSIONS: The twelve-session cognitive-behavioral IPT intervention demonstrated superiority over treatment as usual in its effects on cognition, social adjustment and quality of life. Studies involving larger samples, longer follow-up periods and additional outcome measures are needed in order to assess the specific effects on dimensions of social functioning, cognitive functioning and quality of life in patients with schizophrenia.

Sleep disturbance in family caregivers of children who depend on medical technology

2017 ◽  
Vol 103 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Krista Keilty ◽  
Eyal Cohen ◽  
Karen Spalding ◽  
Eleanor Pullenayegum ◽  
Robyn Stremler
Keyword(s):  
At Risk ◽  
Family Caregivers ◽  
Medical Technology ◽  
Depressive Symptomatology ◽  
Sleep Diary ◽  
Control Group ◽  
Healthy Children ◽  
Daytime Function

ObjectivesFamily caregivers of children who depend on medical technology (CMT) provide highly skilled care up to 24 hours per day. Sleep disruption places family caregivers at risk for poor health and related outcomes that threaten their long-term caregiving capacity. Few studies exist that have measured sleep in family caregivers, and most have relied entirely on subjective measures.MethodsIn a prospective cohort study, family caregivers of CMT (n=42) and caregivers of healthy children (n=43) were recruited. Actigraphy data and a concurrent sleep diary were collected for 6 days/7 nights. Measures of sleep quality, depression, sleepiness, fatigue and quality of life were also administered.ResultsFamily caregivers of CMT averaged fewer hours of sleep per night (mean (SD)) (6.56 ± 1.4 vs 7.21 ± 0.6, p=0.02) of poorer quality (7.75 ± 2.9 vs 5.45 ± 2.8, p<0.01) than the control group. Three times as many family caregivers of CMT scored in the range for significant depressive symptomatology (12(33%) vs 4(10%), p=0.01) and experienced excessive daytime sleepiness (16(38%) vs 5(12%), p<0.01). Fatigue was also more problematic among family caregivers of CMT (22.12 ± 9.1 vs 17.44 ± 9.0, p=0.02).ConclusionsFamily caregivers of CMT are at risk of acute and chronic sleep deprivation, psychological distress and impaired daytime function that may threaten their capacity for sustained caregiving. Family caregivers of CMT may be important targets for screening for sleep disorders and the development of novel sleep-promoting interventions.

Data Acquisition for Assessment of Medical Technology: Methods Other than Technical Trials

1986 ◽  
Vol 2 (1) ◽  
pp. 27-38 ◽  
Author(s):  
Lincoln E. Moses
Keyword(s):  
Quality Of Life ◽  
Data Acquisition ◽  
Training Program ◽  
Surgical Procedure ◽  
Educational Program ◽  
Medical Technology ◽  
Control Group ◽  
Medical Technologies ◽  
Safety Effectiveness

The term “assessment of medical technologies” does not appear to have a unique meaning that always applies to its use. It seems wise, then, to state what will be meant by the term in this chapter. “Medical technology” is regarded here as including drugs, devices, procedures, (whether preventive, diagnostic, or therapeutic) that bear more or less directly on patients. Thus, an educational program for patients might be a technology, but a training program for dietitians would not. A surgical procedure or a prosthesis would; but a scale for assessing quality of life would not. “Assessment,” as used here, refers to a complex set of activities that comprise data acquisition, analysis, and interpretation concerning properties of medical technologies. Assessment tends to be comparative, either explicitly (as to a control group) or implicitly (as looking toward “usual experience”). In any case, the goal of assessment is to increase understanding of such properties of a medical technology as its applicability, convenience, efficacy, safety, effectiveness, cost, etc.

Sign in / Sign up

Export Citation Format

Share Document