scholarly journals Vitamin D binding protein polymorphysm in patients with acute coronary syndrome in kaliningrad region

2019 ◽  
Vol 16 (3) ◽  
pp. 81-87
Author(s):  
Robert S. Bogachev ◽  
Anastasia Y. Kozel ◽  
Larisa S. Litvinova ◽  
Larisa V. Mikhailova ◽  
Elena S. Shytova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Protein Gene ◽  
Malignant Tumors ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Coronary Syndrome ◽  
Binding Protein Gene

BACKGROUND: Vitamin D binding protein is a main vitamin D carrier in serum. It also has an impact on macrophagial function. Role of vitamin D and macrophages in the pathogenesis of atherosclerosis is scientifically proven but there is lack of data on vitamin D binding protein in this regard. AIMS: To evaluate the vitamin D binding protein polymorphism in patients with acute coronary syndrome without diabetes mellitus, autoimmune diseases and malignant tumors. Determine correlation, if there is, between vitamin D binding protein allele and features of acute coronary syndrome among this patient group. MATERIALS AND METHODS: It is a cross-sectional observational study. Study subjects are patients with acute coronary syndrome. Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors. In all participants were evaluated: predisposing factors for heart diseases, CBC, biochemical blood test, troponin, coronarography, echocardiography. The study lasted for 5 months from November 2017 until March 2018. Primary end point assessment of vitamin D binding protein polymorphysm in this group of patients with acute coronary syndrome by means of vitamin D binding protein gene sequencing. 50 patients were enrolled into this study who were urgently admitted to hospital and diagnosed with acute coronary syndrome. Among them 36 males and 14 females. Mean age was 60 (55;66) years. All participants were sequenced for single nucleotide polymorphysm in VDBP p.T436K (rs4588) and P.432E (rs7041). RESULTS: Gene polymorphysms of interest were found in 43 patients among 50 enrolled. Haplotype Gc1s/2 (rs7041G-rs4588A) was found in 7 (14%) patients, Gc2 (rs7041T-rs4588A) in 9 (18%) patients, Gc1s (rs7041G-rs4588C) in 20 (40%) patients, Gc1f (rs7041T-rs4588C) in 14 (28%). Coronarography showed that coronary artery occlusions obstructing more than 50% of vessel lumen was found in 16 patients; obstruction greater than 90% was seen in 8 patients; total occlusion in 4 patients. CONCLUSIONS: In patient group with acute coronary syndrome prevalence of vitamin D binding protein gene polymorphysm was high in 86% of participants. The features of Gc2 haplotype were higher frequency of recurrent myocardial infarction and total coronary artery occlusion, as well as tendency to decreased serum vitamin D3 (25(OH)D) levels.

scholarly journals Variants in Vitamin D Binding Protein Gene Are Associated With Gestational Diabetes Mellitus

Medicine ◽  
2015 ◽  
Vol 94 (40) ◽  
pp. e1693 ◽  
Author(s):  
Ying Wang ◽  
Ou Wang ◽  
Wei Li ◽  
Liangkun Ma ◽  
Fan Ping ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Protein Gene ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

Study on Vitamin D deficiency in patients of diabetes mellitus presenting with Acute Coronary syndrome in a tertiary care hospital in South India

2020 ◽  
Vol 11 (5) ◽  
pp. 49-53
Author(s):  
Archana Bhat ◽  
Arunachalam Ramachandran ◽  
Pradeep Periera ◽  
Akshatha Rao Aroor
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Vitamin D ◽  
Acute Coronary Syndrome ◽  
Coronary Artery ◽  
Vitamin D Deficiency ◽  
Coronary Syndrome ◽  
Vitamin D Levels ◽  
Luminal Stenosis ◽  
Artery Disease

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

Association of rs7041 and rs4588 polymorphisms of vitamin D binding protein gene in pulmonary tuberculosis

Meta Gene ◽  
2020 ◽  
Vol 26 ◽  
pp. 100822
Author(s):  
Murugesan Harishankar ◽  
Pavithra Sampath ◽  
Veerasamy Athikesavan ◽  
Ponnuraja Chinnaiyan ◽  
Banurekha Velayutham ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pulmonary Tuberculosis ◽  
Protein Gene ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men

2007 ◽  
Vol 19 (7) ◽  
pp. 951-960 ◽  
Author(s):  
Z. H. Al-oanzi ◽  
S. P. Tuck ◽  
S. S. Mastana ◽  
G. D. Summers ◽  
D. B. Cook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Protein Gene ◽  
Binding Protein ◽  
Microsatellite Polymorphism ◽  
Vitamin D Binding Protein ◽  
Binding Protein Gene

Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women

2020 ◽  
Vol 43 (7) ◽  
pp. 935-946 ◽  
Author(s):  
B. Rivera-Paredez ◽  
A. Hidalgo-Bravo ◽  
A. de la Cruz-Montoya ◽  
M. M. Martínez-Aguilar ◽  
E. G. Ramírez-Salazar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Postmenopausal Women ◽  
Protein Gene ◽  
Binding Protein ◽  
Common Variants ◽  
Vitamin D Binding Protein ◽  
Mexican Mestizo ◽  
Binding Protein Gene
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