scholarly journals Gallstone disease as a clinical marker of metabolic syndrome

2018 ◽  
Vol 15 (3) ◽  
pp. 3-8
Author(s):  
Andrey A. Svistunov ◽  
Miсhail A. Osadchuk ◽  
Natalia V. Kireeva ◽  
Alexey M. Osadchuk
Keyword(s):  
Metabolic Syndrome ◽  
Prognostic Model ◽  
Clinical Medicine ◽  
Gallstone Disease ◽  
Acute Cholangitis ◽  
Economic Losses ◽  
Additional Risk ◽  
The Metabolic Syndrome ◽  
Life Threatening ◽  
Complications Of Cholelithiasis

The prevalence of cholelithiasis, its close pathogenetic connection with metabolic syndrome, high frequency of surgical intervention, significant economic losses put forward this comorbid pathology in a number of leading problems of modern clinical medicine. The factors associated with the metabolic syndrome not only increase the risk of developing cholelithiasis, but also form the basis of non-drug and drug therapy. Metabolic syndrome often determines the occurrence of three common and potentially life-threatening complications of cholelithiasis: acute cholecystitis, acute cholangitis and biliary pancreatitis. Therefore, the solution of this problem is associated with the need for early detection of additional risk factors for cholelithiasis, optimization of the early diagnostic and prognostic model of existing multi-organ pathology with the aim of reducing the progression of the disease and its complications. The data obtained in recent years on the human genome with metabolic syndrome and cholelithiasis make it possible to predict the development of comorbid pathology and to fully ensure the effectiveness of primary prevention.

scholarly journals The Metabolic Syndrome Is Associated with Complicated Gallstone Disease

2011 ◽  
Vol 25 (5) ◽  
pp. 274-276 ◽  
Author(s):  
Naim Ata ◽  
Metin Kucukazman ◽  
Bunyamin Yavuz ◽  
Hakan Bulus ◽  
Kursat Dal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Gallstone Disease ◽  
Clinical Importance ◽  
Model Assessment ◽  
Biochemical Tests ◽  
The Metabolic Syndrome ◽  
Number Of Patients ◽  
Significant Difference

BACKGROUND: Gallstone disease (GD) is a common condition worldwide. Several studies demonstrated that the presence of gallstones is strongly associated with cardiovascular disease. The metabolic syndrome is a highly prevalent cardiovascular condition.OBJECTIVE: To examine the relationship between complicated GD (CGD) and the metabolic syndrome or its components.METHODS: Two hundred seventeen patients with gallstones were examined. All patients underwent biliary ultrasonography after a complete medical history and laboratory examination. Data collection for the diagnosis of metabolic syndrome included measurements of waist circumference, blood pressure and lipids, and biochemical tests.RESULTS: Of the 217 patients examined, 115 patients (53%) had CGD and 102 patients (47%) had uncomplicated GD (UCGD). There was a significant difference between the number of patients with large gallstones in the CGD and UCGD groups (n=14 [12%] versus n=2 [2%], respectively; P=0.004). Metabolic syndrome, diabetes mellitus and large waist circumference were more prevalent in the CGD group than in the UCGD group. Homeostatic model assessment of insulin resistance scores were higher in the CGD group than in UCGD group (2.51 [95% CI 0.57 to 23.90] versus 2.20 [95% CI 0.09 to 8.87], respectively; P=0.032). Logistic regression analysis revealed that the presence of metabolic syndrome (OR 1.434; 95% CI 1.222 to 1.846, P=0.014), diabetes mellitus (OR 1.493; 95% CI 1.255 to 1.953; P=0.035) and large gallstones (OR 1.153; 95% CI 1.033 to 1.714; P=0.017) were independent predictors of CGD.CONCLUSION: Results of the present study demonstrated that metabolic syndrome, diabetes and gallstone size were associated with CGD. Further prospective studies are needed to understand the clinical importance of this association.

scholarly journals Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease: A Dynamic and Life-Threatening Triad

2011 ◽  
Vol 2011 ◽  
pp. 1-16 ◽  
Author(s):  
Mário Raimundo ◽  
José António Lopes
Keyword(s):  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Treatment Options ◽  
Therapeutic Interventions ◽  
Global Public Health ◽  
The Metabolic Syndrome ◽  
High Prevalence ◽  
Life Threatening

The metabolic syndrome (MS) and chronic kidney disease (CKD) have both become global public health problems, with increasing social and economic impact due to their high prevalence and remarkable impact on morbidity and mortality. The causality between MS and CKD, and its clinical implications, still does remain not completely understood. Moreover, prophylactic and therapeutic interventions do need to be properly investigated in this field. Herein, we critically review the existing clinical evidence that associates MS with renal disease and cardiovascular disease, as well as the associated pathophysiologic mechanisms and actual treatment options.

scholarly journals Prospects of creating a new medicine based on biologically active substances of bearberry leaves for correction of the metabolic syndrome

2021 ◽  
pp. 54-61
Author(s):  
N. Chaika ◽  
O. Koshovyi ◽  
M. Mazen ◽  
A. Kravchenko ◽  
A. Kovalyova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Metabolic Disorders ◽  
Gallstone Disease ◽  
Herbal Medicines ◽  
Biologically Active ◽  
Hypolipidemic Activity ◽  
Large Set ◽  
Dry Extract ◽  
The Metabolic Syndrome

Topicality. The metabolic syndrome is pathogenetically interrelated metabolic disorders in the condition of a sick person. A large set of factors is involved in its occurrence. Risk factors include genetic predisposition, overeating, insulin resistance, obesity, bad habits, hypodynamics, stress and unfavorable environmental conditions. First of all, defects of the lipid and carbohydrate metabolism provoke a cascade of genetic, metabolic, hormonal, nervous, inflammatory and other reactions and disorders in cells, tissues and organs, causing the metabolic syndrome and associated diseases, such as diabetes, kidney and gallstone disease, hypertension, platelet hyperaggregation, etc. Therefore, the rational use of synthetic and herbal medicines in the complex correction of these disorders can slow down the development of the metabolic syndrome. Aim. To develop the method for obtaining a dry modified extract from bearberry, study its chemical composition, hypoglycemic and hypolipidemic activity in order to determine the prospects of its use for the correction of the metabolic syndrome. Materials and methods. The study object was a dry extract of bearberry leaves modified with cysteine. HPLC and spectrophotometry were used to analyze the extract obtained. The hypoglycemic and hypolipidemic activity of dry extracts of bearberry was studied in rats with insulin resistance. Results and discussion. The method for obtaining a dry modified extract from bearberry leaves was developed by adding cysteine. Phenologlycoside (arbutin), 2 phenolic acids (gallic and ellagic), 6 flavonoids, 8 saponins were identified in the extract, and their quantitative content was determined. Hyperoside and catechin were dominant among flavonoids, and ursolic acid, uvaol, and lupeol prevailed among saponins. The content of the main groups of phenolic compounds was determined in the extract by spectrophotometry. The introduction of the dry extract from bearberry leaves modified with cysteine has a normalizing effect on metabolic disorders on the background of a high-fructose diet; therefore, it can be a promising agent for the correction of the metabolic syndrome. Conclusions. As a result of the research conducted, a new dry extract from bearberry leaves modified with cysteine has been created. The phytochemical composition, hypoglycemic and hypolipidemic activities of the extract have been studied, indicating the prospects for its use to correct the metabolic syndrome.

The predictors of cholelithiasis in female patients with metabolic syndrome

Open Medicine ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. 108-114 ◽  
Author(s):  
Doina-Clementina Cojocaru ◽  
Florin Mitu ◽  
Cristina Dascălu ◽  
Alina Manole ◽  
Corina Dima-Cozma
Keyword(s):  
Metabolic Syndrome ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Female Gender ◽  
Abdominal Ultrasound ◽  
Liver Function Tests ◽  
Lean Body Weight ◽  
Binary Logistic Regression Model ◽  
Female Patients ◽  
The Metabolic Syndrome

AbstractCholesterol gallstone disease is often associated with the metabolic syndrome. Female gender is an unmodifiable risk factor for cholelithiasis and, in its turn, the metabolic syndrome features a sexual dimorphism which warns that a global approach might overlook important discrimination. We carried out a retrospective analytical case-control study in order to perform a comparative analysis between two groups of female patients with metabolic syndrome and gallstones (n=60) or without gallstones (n=65). All the patients were investigated by abdominal ultrasound and met at least three criteria for the diagnosis of metabolic syndrome. Cases and controls were compared regarding anthropometric measurements, a complex lipid profile, and liver function tests. The risks associated with the likelihood of gallstones were estimated by means of cross-tabulation. In order to rank the significant variables we developed a binary logistic regression model which identified lean body weight ≤ 46.44 kg (OR 0.165; 95% CI 0.045–0.611; P = 0.007), total cholesterol ≥ 4.9 mmol/L (OR 15.948; 95% CI 2.700–94.205; P = 0.002), and direct bilirubin > 5.1 µmol/L (OR 0.056; 95% CI 0.013–0.235; P < 0.001), as variables with significant probability of association with the risk of gallstones in women with metabolic syndrome.

scholarly journals Risk of target organ damage in patients with arterial hypertension and various numbers of metabolic syndrome components

2014 ◽  
Vol 11 (1) ◽  
pp. 40-44
Author(s):  
Yu V Zhernakova ◽  
G Kh Sharipova ◽  
I E Chazova
Keyword(s):  
Metabolic Syndrome ◽  
Arterial Hypertension ◽  
Clinical Medicine ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Cardiovascular Complications ◽  
Target Organ ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Metabolic Syndrome Components

The metabolic syndrome is one of most socially significant and strategic problems of clinical medicine. It is known that metabolic syndrome promotes earlier and more expressed target organ damage in patients with arterial hypertension. However, correlation of the number of metabolic syndrome components with target organ damage, selection of metabolic syndrome components, influencing expressiveness on target organ damage, are studied insufficiently. In this study it is determined that with the elevating number of the metabolic syndrome components, the frequency and expressiveness of heart, kidney and vessel damage, accompanied by the increased risk of development of cardiovascular complications, increase in patients with the maximum number of the metabolic syndrome components. Moreover, it is revealed that the relative risk of simultaneous damage of heart, kidneys and vessels in patients with arterial hypertension and metabolic syndrome, apart from high blood pressure and abdominal obesity is associated with the increase of fasting glucose level.

Is Hyperhomocysteinemia an Additional Risk Factor of the Metabolic Syndrome?

2006 ◽  
Vol 4 (3) ◽  
pp. 185-195 ◽  
Author(s):  
J.-M. Garcin ◽  
S. Cremades ◽  
C. Garcia-Hejl ◽  
L. Bordier ◽  
O. Dupuy ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Additional Risk Factor ◽  
Additional Risk ◽  
The Metabolic Syndrome

scholarly journals The Association Between Gallstone Disease and Metabolic Syndrome Related Abnormalities: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Peiwu Jiang ◽  
Zhongkai Ni ◽  
Shifei Huang ◽  
Xiaowen Li ◽  
Ye Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Metabolic Syndrome ◽  
English Language ◽  
Metabolic Diseases ◽  
Meta Analysis ◽  
Gallstone Disease ◽  
Cross Sectional Study ◽  
Cochrane Library ◽  
Cross Sectional ◽  
The Metabolic Syndrome

Abstract BackgroundBile excretion is one of an important metabolite excretion pathway of human body. In recent years, it has been reported that metabolic diseases are associated with the occurrence of GSD (Gallstone Disease). The main purpose of this systematic review is to examine the relationship between metabolic syndrome and cholelithiasis, including components of the metabolic syndrome such as abnormal blood glucose regulation, hyperlipidemia, and obesity.MethodsPubmed, Cochrane library and embase were searched for all English language articles for the following relevant keywords: Metabolic Syndrome, Reaven Syndrome X, Biliary Calculi, Cholelithiasis Gallstones. Case-control study, cross-sectional study and cohort study were included .Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were calculated. The pooled mean differences of the outcome measures were compared between patients with and without MetS.ResultsAfter screening, a total of 5 cross-sectional studies and 1 cohort studies were included in the meta-analysis. The 6 studies evaluated a total of 49101 people，of whom 9055 had MS and 2308 had GSD. There is a significant correlation between MS and GSD (z=6.65, p = 0.000), and it’s more significant in female. All studies displayed increasing odds of GSD with increasing number of MetS traits, where patients with three or more MetS traits tended to have a higher prevalence of nephrolithiasis.ConclusionsOur review shows a definite association of MetS with GSD, and the more the components of MetS, the higher the prevalence of GSD. Although not as obvious as women, men also support this conclusion.

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