scholarly journals Contraception in obese women

2016 ◽  
Vol 13 (3) ◽  
pp. 65-69
Author(s):  
Elena Andreeva ◽  
Dar’y Sokolova ◽  
Ol'ga Grigoryan
Keyword(s):  
Reproductive Age ◽  
Modern World ◽  
Specific Method ◽  
Obese Patients ◽  
Obese Women ◽  
Overweight People ◽  
Reproductive Age Women ◽  
Carbohydrate And Lipid Metabolism ◽  
Gynecological Diseases ◽  
Selection Of

At present, the prevalence of overweight people in the world is more than 1.7 billion; 312 million people are obese. The 25% of them consist of reproductive age women. In the modern world contraception is not only the way to prevent unscheduled pregnancy but also the opportunity to treat endocrine and gynecological diseases. While choosing the method of contraception, it is important to realize it’s pharmacological effect on carbohydrate and lipid metabolism, hemocoagulation/fibrinolysis system, cardiovascular and other systems of body that are involved in cascade of pathological processes. Selection of contraception for overweight/obese patients needs an individualized approaches with evaluation of efficiency/risk for every specific method of fertility correction.

scholarly journals The role of leptin in the pathogenesis of ovarian insufficiency in obesity women

2016 ◽  
Vol 65 (3) ◽  
pp. 18-24
Author(s):  
Ekaterina М Riazantceva
Keyword(s):  
Reproductive Age ◽  
Blood Levels ◽  
Obese Women ◽  
Ovarian Dysfunction ◽  
Ovarian Insufficiency ◽  
Reproductive Age Women ◽  
Alimentary Obesity ◽  
Immunoenzymatic Assay ◽  
Follicular Stimulating Hormone

Actuality. Ovarian insufficiency can be diagnosed in more than 30% of reproductive age women with obesity. The role of leptin in the pathogenesis of ovarian insufficiency in obesity is not well understood and needs to be detalised. The aim of the study: to ivestigate the role of leptin in the pathogenesis of ovarian insufficiency in obesity. Materials and methods. 50 reproductive age females with BMI > 26.5 kg/m2 were studied. 10 healthy reproductive age females were used as control. Blood levels of leptin, gonadotropins, prolactin, sex steroid hormones were measured by immunoenzymatic assay and pelvic echoscopy were performed in all studied patients and co ntrols. Results. 72% of obese women had signs of ovarian insufficiency, such as ovarian enlargement and increased antral follicular count. The level of leptin did not correlate with the presence or absence of ovarian insufficiency in our patient group. The positive correlation between leptin level and BMI, luteinizing hormone (LG) and oestradiol and negative correlation between leptin level and follicular stimulating hormone (FSH) were revealed. Conclusion. The results of our study do not support the hyperleptinemia as the main cause of ovarian dysfunction in alimentary obesity. The most potential reason of ovarian dysfunction in these women could be ovarian or non-ovarian origin hyperoestrogenia leading to premature LG piques, and, thus, disturbing folliculogenesis in ovaria.

scholarly journals Is body mass index associated with the incidence of endometriosis and the severity of dysmenorrhoea: a case–control study in China?

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037095
Author(s):  
Yunhui Tang ◽  
Mingzhi Zhao ◽  
Luling Lin ◽  
Yifei Gao ◽  
George Qiaoqi Chen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Risk Factor ◽  
Body Mass ◽  
Case Control Study ◽  
Case Control ◽  
Normal Weight ◽  
Reproductive Age ◽  
Obese Patients ◽  
Obese Women ◽  
Control Study

ObjectiveEndometriosis is considered as a serious gynaecological disease in women at a reproductive age. Lower body mass index (BMI) is thought to be a risk factor. However, recent studies indicated that women with normal BMI were also more likely to develop endometriosis, suggesting the association with BMI is controversial. We therefore investigated the association of BMI and surgically diagnosed endometriosis in a cohort of Chinese women.DesignRetrospective case–control study.SettingTertiary hospital.Patients709 women with endometriosis and 807 age matched controls between January 2018 and August 2019.InterventionAge at diagnosis, parity, gravida, BMI and self-reported dysmenorrhoea status were collected and the association of BMI and endometriosis was analysed.Measurement and main resultsOverall, the median BMI was not different between patients and controls (21.1 kg/m2 vs 20.9 kg/m2, p=0.223). According to the BMI categories for Asians/Chinese by WHO (underweight: <18.5 kg/m2, normal weight: 18.5–22.99 kg/m2, overweight: 23–27.49 kg/m2, obese: ≥27.50 kg/m2), overall, there was no difference in the association of BMI and endometriosis (p=0.112). 60% of patients were of normal weight. However, the OR of obese patients (BMI over 27.50 kg/m2) having endometriosis was1.979 (95% CI 1.15 to 3.52, p=0.0185), compared with women with normal weight. 50.3% patients reported dysmenorrhoea, and the OR of developing severe dysmenorrhoea in obese patients (BMI over 27.50 kg/m2) was 3.64 (95% CI 1.195 to 10.15, p=0.025), compared with patients with normal weight.ConclusionOur data demonstrate that overall there was no association between BMI and the incidence of endometriosis, but there was a significant increase in the incidence of endometriosis in obese women, compared with women with normal weight. Obesity was also a risk factor for severe dysmenorrhoea.

scholarly journals PPARγ Agonists: Emergent Therapy in Endometriosis

2021 ◽  
Vol 14 (6) ◽  
pp. 543
Author(s):  
Alexandre Vallée ◽  
Jean-Noël Vallée ◽  
Alain Le Blanche ◽  
Yves Lecarpentier
Keyword(s):  
Uterine Cavity ◽  
Reproductive Age ◽  
New Agents ◽  
Reproductive Age Women ◽  
Gynecological Diseases ◽  
Pparγ Agonists ◽  
Adhesion And Invasion

Endometriosis is one of the major gynecological diseases of reproductive-age women. This disease is characterized by the presence of glands and stroma outside the uterine cavity. Several studies have shown the major role of inflammation, angiogenesis, adhesion and invasion, and apoptosis in endometriotic lesions. Nevertheless, the mechanisms underlying endometriotic mechanisms still remain unclear and therapies are not currently efficient. The introduction of new agents can be effective by improving the condition of patients. PPARγ ligands can directly modulate these pathways in endometriosis. However, data in humans remain low. Thus, the purpose of this review is to summarize the potential actions of PPARγ agonists in endometriosis by acting on inflammation, angiogenesis, invasion, adhesion, and apoptosis.

scholarly journals Effect of obesity on ovarian reserve parameters in mid-reproductive age women

F1000Research ◽  
2012 ◽  
Vol 1 ◽  
pp. 43 ◽  
Author(s):  
Hanan Altaee ◽  
Zaid Abdul Majeed Al-Madfai ◽  
Zainab Hassan Alkhafaji
Keyword(s):  
Body Weight ◽  
Ovarian Reserve ◽  
Antral Follicle ◽  
Antral Follicle Count ◽  
Reproductive Age ◽  
Obese Women ◽  
Blood Samples ◽  
Reproductive Age Women ◽  
Significant Difference ◽  
Early Follicular Phase

Background: The initiation and maintenance of reproductive functions are related to an optimal body weight in women. Body weight affects the ovarian reserve, which is basically an estimate of how many oocytes (eggs) are left in the ovaries.Objective: To study the relationship between obesity and serum and ultrasound markers of ovarian reserve in mid-reproductive age women (21–35 years old).Patients and methods: Twenty participants (“obese”) had a body mass index (BMI) of 30 to 35 kg/m2 and another 20 participants (“non-obese”) had a BMI 20–29 kg/m2. The obese women had a mean age of 27.9 years and the non-obese women had a mean age of 29.5 years. Blood samples were collected from all participants, anthropometric measurements were calculated, and transvaginal ultrasonography was performed to measure the antral follicle count (AFC) during the early follicular phase. The blood samples were assayed for antimüllerian hormone (AMH), follicle-stimulating hormone (FSH) and estradiol (E2).Results: There was no significant difference between the two groups regarding ovarian reserve markers and there is no significant correlation between these markers and BMI, except for serum E2 in the obese group.Conclusion: Obesity has no effect on the levels of serum FSH, AMH, or AFC indicating that obesity is unlikely to affect ovarian reserve in the mid-reproductive age group.

scholarly journals Features of the hormonal profile in obese reproductive-age women

2020 ◽  
Vol 5 (3) ◽  
pp. 77-84
Author(s):  
N. V. Artymuk ◽  
O. A. Tachkova ◽  
N. A. Sukhova
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Dehydroepiandrosterone Sulfate ◽  
Reproductive Age ◽  
Obese Women ◽  
Women Of Reproductive Age ◽  
Hormonal Profile ◽  
Reproductive Age Women

Aim. To assess the hormonal profile features in obese reproductive-age women. Materials and Methods. We consecutively enrolled 163 women of reproductive age (140 women with body mass index ≥ 30 kg/m2 and 23 women with normal body mass index) who have been admitted to Podgorbunskiy Regional Emergency Medicine Hospital. All patients of both groups underwent general and gynecological examination. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone, free triiodothyronine, total and free thyroxine, cortisol, leptin, immunoreactive insulin, and progesterone were assessed on days 5-6 and 21-22 of the menstrual cycle. Results. Obese women of reproductive age were characterised by higher values of LH, LH/ FSH ratio, testosterone, estradiol, estrone, leptin, IRI and by lower levels of FSH and progesterone compared with normal weight women. A direct correlation was found between the level of leptin and estrone (r = 0.21, p = 0.014), insulin resistance (r = 0.18, p = 0.039), triglycerides (r = 0.20, p = 0.030), and low-density lipoprotein cholesterol (r = 0.22, p = 0.016). There was a statistically significant inverse correlation between the level of leptin and high-density lipoprotein cholesterol (r = -0.18, p = 0.043). A direct correlation was established between insulin and LH (r = 0.24, p = 0.030), testosterone (r = 0.32, p = 0.037), dehydroepiandrosterone sulfate (r = 0.56, p = 0.003), insulin resistance (r = 0.95, p < 0.001), cholesterol (r = 0.20, p = 0.024), triglycerides (r = 0.29, p < 0.001). Conclusion. Obese women of reproductive age have certain hormonal features that underlie menstrual and reproductive disorders in these patients.

Screening Tool for Bleeding Disorders in Women with Menorrhagia: Evaluation in a Prospective US Multi-Site Cohort.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1237-1237
Author(s):  
Claire S. Philipp ◽  
Ambarina Faiz ◽  
Vanessa Byams ◽  
Connie H. Miller ◽  
John A. Heit ◽  
...  
Keyword(s):  
Primary Care ◽  
Black Women ◽  
Primary Care Physicians ◽  
Screening Tool ◽  
Reproductive Age ◽  
Adult Women ◽  
Bleeding Disorders ◽  
Reproductive Age Women ◽  
Testing And Evaluation ◽  
Selection Of

Abstract Menorrhagia is a common clinical problem among reproductive age women and annually 5% of reproductive age women seek medical attention, usually with gynecologists and other primary care physicians, for this symptom. Since underlying bleeding disorders are common in women presenting with menorrhagia, and referral for comprehensive hemostatic testing of substantial numbers of women with otherwise unexplained menorrhagia is problematic from the public health and cost perspective, a short, easy-to-administer screening tool comprised of 8 questions for identifying women with menorrhagia for hemostatic evaluation was previously developed (Am J Ob Gyn2008;198:e1–163e8). In the present study, the validity of the screening tool was evaluated in a multi-site, prospectively recruited cohort of women with menorrhagia. 232 women with menorrhagia age 18 and older with a pictorial blood assessment chart (PBAC) score &gt; 100 were recruited from 5 US centers as potential subjects for a prospective cross-over study for evaluation of intranasal DDAVP versus tranexamic acid. All subjects underwent comprehensive laboratory testing for bleeding disorders, including VWF, platelet aggregation/ATP release, and factor assays. Study participants were administered a questionnaire which included the 8 screening tool questions in 4 categories, including history of duration and severity of menorrhagia, anemia treatment, excessive bleeding with hemostatic challenges, and family diagnosis of bleeding disorder. A screening tool was considered positive if there was a positive response for any of the questions in the four categories. Sensitivity of the screening tool with 95% confidence interval was calculated for bleeding disorders and also separately for low VWF (ristocetin cofactor &lt; 50%), and platelet function defects.217 women with menorrhagia including 78% white and 16% black women with complete data were evaluated. In this population, a positive screening tool had a sensitivity of 89% (95% CI, 83–93) for bleeding disorders, 89% for platelet function defects (95% CI, 82–94), and 73% for low VWF (95% CI, 39–94). The sensitivity for bleeding disorders was 87% (95% CI, 79–92) among white women and 94% (95% CI, 79–99) among black women. Adding a PBAC score &gt; 185 increased the sensitivity of the screening tool for bleeding disorders to 95% (95% CI, 90–98). Using a multi-site US population of adult women with menorrhagia, this study confirms the benefit of a short screening tool to assist primary care physicians in the selection of women with menorrhagia to refer for comprehensive hemostatic testing and evaluation. population of adult women with menorrhagia, this study confirms the benefit of a short screening tool to assist primary care physicians in the selection of women with menorrhagia to refer for comprehensive hemostatic testing and evaluation.

Folate Status and Depressive Symptoms in Reproductive-Age Women

2011 ◽  
Vol 7 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Hiroko Watanabe ◽  
Takashi Sugiyama ◽  
Hiromitsu Chihara ◽  
Hideoki Fukuoka
Keyword(s):  
Depressive Symptoms ◽  
Reproductive Age ◽  
Folate Status ◽  
Reproductive Age Women
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