scholarly journals Renal concentration capacity in primary hyperparathyroidism

2015 ◽  
Vol 12 (3) ◽  
pp. 36-40
Author(s):  
Svetlana Sergeevna Mirnaya ◽  
Elizaveta Oktaevna Mamedova ◽  
Natalya Georgievna Mokrysheva ◽  
Ludmila Yakovlevna Rozhinskaya ◽  
Ivan Ivanovich Dedov
Keyword(s):  
Primary Hyperparathyroidism ◽  
Urine Osmolality ◽  
Mild Form ◽  
Blood Osmolality ◽  
The Third ◽  
High Prevalence

Aim. To evaluate the renal concentration capacity in patients with mild and severe primary hyperparathyroidism (pHPT).Materials and methods. The study included 77 patients (median age 57 years [52;61]) with pHPT, first group was comprised of patients with mild form (n=23), second group contained patients with severe pHPT without nephrolithiasis (n=28) and the third group contained patients with pHPT and nephrolithiasis (n=26). Osmolality index was calculated as urine osmolality to blood osmolality ratio. Renal concentration capacity impairment was diagnosed with osmolality index less than 2.Results. Osmolality index in patients with pHPT was low with median 1,66 [1,38;2,1]. We found a high prevalence of renal concentration capacity impairment in patients with pHPT, that was 71,4%. Regardless of presence of nephrolithiasis both patients with mild and severe pHPT had similar prevalence (70%, 75% and 69,2% respectively).Conclusions. Renal concentration impairment is common in mild and severe pHPT. The findings of this study necessitate for measurement of urine osmolality or osmolality index in all patients with pHPT.Комбинированную терапию ожирения (диета, физические нагрузки + прием орлистата) в течение 7 ± 1 месяцев получали 15 пациентов первой группы (СОАС), 5 – во второй (инсомния) и 8 пациентов без нарушений сна. При сравнении групп не выявлено статистически значимых различий по числу пациентов, принимающих медикаментозную терапию ожирения           (р 0,05). Через 7 ± 1 месяцев лечения ожирения среднее снижение МТ у больных с синдромом инсомнии составило –2,5 [–4; 0] кг, у больных с СОАС –7 [–18; –2] кг, у пациентов без нарушений сна –6,5 [–12;  –2,25] кг. 

scholarly journals Nephrolithiasis in primary hyperparathyroidism: a contemporary look

2014 ◽  
Vol 11 (3) ◽  
pp. 3-8 ◽  
Author(s):  
Elena Viktorovna Peretokina ◽  
Natalya Georgievna Mokrysheva
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Peptic Ulcer ◽  
Primary Hyperparathyroidism ◽  
Current Knowledge ◽  
Indications For Surgery ◽  
Medical Doctors ◽  
Mild Form ◽  
Ulcer Disease ◽  
High Prevalence

Primary hyperparathyroidism (PHPT) has attracted a growing attention of medical doctors of different specialties in the last few years. The ability to predict the risk of the development of visceral manifestations (nephrolithiasis, nephrocalcinosis, cardiovascular disease, peptic ulcer disease) in the mild asymptomatic PHPT can define indications for conservative treatment of such patients because of the high prevalence of the mild form of the disease. Nephrolithiasis is one of the most common manifestations of the PHPT and is one of the indications for surgery. Mechanisms of nephrolithiasis and nephrocalcinosis in PHPT remain unclear and many investigations are devoted to studying the possible predictors of its development. In this paper we review the current knowledge of nephrolithiasis, clinical features and risk factors of its development in patients with PHPT.

scholarly journals Sleep Quality of Hospitalized Patients, Contributing Factors, and Prevalence of Associated Disorders

2020 ◽  
Vol 2020 ◽  
pp. 1-7 ◽  
Author(s):  
Santi Kulpatcharapong ◽  
Pol Chewcharat ◽  
Kiat Ruxrungtham ◽  
Sutep Gonlachanvit ◽  
Tanisa Patcharatrakul ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Light Exposure ◽  
Hospitalized Patients ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
The Third ◽  
High Prevalence ◽  
Internal Medicine Wards ◽  
At Home

Background. Data in the literature has shown poor sleep quality to be frequently observed in hospitalized patients and known to be associated with poor treatment outcome. Many factors may impact poor sleep quality, and there is currently limited available data. We aim to determine the prevalence of poor sleep quality and associated factors in patients admitted to internal medicine wards as well as the change of sleep quality over time after admission. Methods. An analytic observational study was conducted at the internal medicine wards at the King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Patients were personally interviewed to evaluate the history of sleep quality at home, sleep quality after the first and the third days of admission, and potential associated factors. The Pittsburgh Sleep Quality Index and screening questionnaires for the common diseases associated with poor sleep quality were also utilized. The logistic regression analysis was used to determine the independent factors which led to poor sleep quality. Results. Data were collected from 96 patients during the period of June 2015 to February 2016. The mean age of the patients was 50.8±16.7 years, and 51% were male. Infectious disease was the most common principal diagnosis accounted for 29.2%. The results show high prevalence of poor sleep quality after the first night of admission compared to baseline sleep quality at home (50% vs. 18.8%; p<0.001). After 3 days of admission, the prevalence of poor sleep quality was reduced to the level close to baseline sleep quality at home (28.1% vs. 18.8%; p=0.13). Multivariate analysis demonstrated that light exposure and pain were the main independent factors for poor sleep quality on the first day (odds ratio 6.68; 95% CI 2.25-19.84) and on the third day (odds ratio 3.47; 95% CI 1.24-9.71), respectively. Conclusions. This is the first study conducted on the sleep quality of hospitalized patients that included the follow-up period during hospital admission. Our study demonstrated high prevalence of poor sleep quality in hospitalized patients on the first day. Interestingly, the sleep quality was partly improved during hospitalization. Light exposure and pain were demonstrated to be the factors associated with poor sleep quality.

scholarly journals Nonalcoholic steatohepatitis in posttransplantation liver: Review article

2018 ◽  
Vol 64 (2) ◽  
pp. 187-194 ◽  
Author(s):  
Antônio Ricardo Cardia Ferraz de Andrade ◽  
Helma P. Cotrim ◽  
Paulo L. Bittencourt ◽  
Carolina G. Almeida ◽  
Ney Christian Amaral Boa Sorte
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Clinical Characteristics ◽  
Metabolic Disorders ◽  
Patient Survival ◽  
De Novo ◽  
Review Article ◽  
Liver Transplants ◽  
The Third ◽  
High Prevalence ◽  
The World

Summary Introduction: Nonalcoholic steatohepatitis (NASH) associated or not with cirrhosis is the third leading indication for liver transplantation (LT) around the world. After transplants, NASH has a high prevalence and occurs as both recurrent and de novo manifestations. De novo NASH can also occur in allografts of patients transplanted for non-NASH liver disease. Objective: To evaluate recurrent or de novo NASH in post-LT patients. Method: A literature review was performed using search engines of indexed scientific material, including Medline (by PubMed), Scielo and Lilacs, to identify articles published in Portuguese and English until August 2016. Eligible studies included: place and year of publication, prevalence, clinical characteristics, risk factors and survival. Results: A total of 110 articles were identified and 63 were selected. Most of the studies evaluated recurrence and survival after LT. Survival reached 90-100% in 1 year and 52-100% in 5 years. Recurrence of NAFLD (steatosis) was described in 15-100% and NASH, in 4-71%. NAFLD and de novo NASH were observed in 18-67% and 3-17%, respectively. Metabolic syndrome, diabetes mellitus, dyslipidemia and hypertension were seen in 45-58%, 18-59%, 25-66% and 52-82%, respectively. Conclusion: After liver transplants, patients present a high prevalence of recurrent and de novo NASH. They also show a high frequence of metabolic disorders. Nevertheless, these alterations seem not to influence patient survival.

scholarly journals Renal stones and calcifications in patients with primary hyperparathyroidism: associations with biochemical variables

2012 ◽  
Vol 166 (6) ◽  
pp. 1093-1100 ◽  
Author(s):  
Jakob Starup-Linde ◽  
Elin Waldhauer ◽  
Lars Rolighed ◽  
Leif Mosekilde ◽  
Peter Vestergaard
Keyword(s):  
Primary Hyperparathyroidism ◽  
Renal Stones ◽  
Spiral Ct ◽  
University Hospital ◽  
Plasma Creatinine ◽  
Ct Scans ◽  
Cross Sectional ◽  
Biochemical Variables ◽  
Plasma Creatinine Level ◽  
High Prevalence

ObjectiveTo study the prevalence of renal stones and nephrocalcinosis in patients with primary hyperparathyroidism (PHPT) and to appraise biochemical variables as risk factors for developing renal calcifications.DesignCross-sectional.Materials and methodsAll patients (n=177) undergoing diagnostic evaluation and surgery for PHPT at Aarhus University Hospital between 2007 and 2009. All patients underwent routine spiral CT scans of the abdomen to determine the presence or absence of renal calcifications.ResultsA total of 45 patients (25.4%, 95% confidence intervals: 19.0–31.4%) had renal stones (15.3%) and/or renal calcifications (10.2%) on the CT scans. Compared with those without calcification (n=132), the group with calcification had a significantly lower plasma creatinine level (67.0±25.1 vs 74.6±17.5 μmol/l, 2P=0.03). Moreover, CaE was higher in PHPT patients with renal calcification than in PHPT patients without (0.91±0.28 vs 0.74±0.40 mmol/mmol, 2P=0.02). The other measured or derived biochemical variables were similar in the two groups. No biochemical variable was predictive for renal calcifications in a multiple regression analysis.ConclusionWe found a high prevalence of renal calcifications among PHPT patients but no deterioration of renal function. The occurrence of calcifications was related to low plasma creatinine and a high urine calcium/creatinine ratio. However, biochemical markers in general were poor predictors for the risk of renal stones or nephrocalcinosis indicating that routine image diagnostics may be needed for the identification of these complications in order to establish indication for surgery and ensure proper treatment.

scholarly journals Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl− oxalate transporter in patients with primary hyperparathyroidism

2009 ◽  
Vol 160 (2) ◽  
pp. 283-288 ◽  
Author(s):  
S Corbetta ◽  
C Eller-Vainicher ◽  
M Frigerio ◽  
R Valaperta ◽  
E Costa ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Kidney Stones ◽  
Healthy Subjects ◽  
Polymorphic Variant ◽  
Gene Encoding ◽  
Stone Formers ◽  
High Prevalence ◽  
Urine Oxalate ◽  
Design And Methods ◽  
Oxalate Metabolism

ObjectivePrimary hyperparathyroidism (PHPT) is often complicated by kidney stones. Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT as well as in idiopathic stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism.Design and methodsWe tested the hypothesis that the 206M polymorphic variant of SLC26A6 gene might contribute to the risk of kidney stones in PHPT. DNA samples from 145 PHPT patients and 129 age- and sex-matched healthy subjects were genotyped.ResultsThe homozygous 206V genotype was the most frequent both in PHPT patients and controls (79.3 and 74.4%), while heterozygosity for the 206M allele was detected in 20.0 and 23.3% respectively. The homozygous 206M genotype was extremely rare, occurring in 0.7 and 2.3% of PHPT and healthy subjects respectively. In the PHPT cohort, the prevalence of urolithiasis did not differ between the V/V and V/M+M/M groups and urine oxalate excretions did not correlate with the genotype. Considering the subset of PHPT stone formers (n=74), calciuria was lower in V/M+M/M patients with respect to V/V stone-formers (4.40±1.88 vs 5.92±2.62 mg/kg per 24 h; mean±s.d., P=0.034). Finally, the SLC26A6 206M alleles were significantly related to the presence of hypertension (73.3 vs 47.8%), showing an OR of 4.8.ConclusionsThough the SLC26A6 206M polymorphism did not correlate with kidney stone development in PHPT patients, PHPT stone-formers harbouring the M allele had a lower hypercalciuria. This observation and the high prevalence of hypertension associated with the 206M polymorphism need further investigation.

scholarly journals High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT)

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Victoria Mendoza-Zubieta ◽  
Gloria A Gonzalez-Villaseñor ◽  
Guadalupe Vargas-Ortega ◽  
Baldomero Gonzalez ◽  
Claudia Ramirez-Renteria ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Primary Hyperparathyroidism ◽  
Adult Patients ◽  
High Prevalence

Preoperative Normal Level of Parathyroid Hormone Signifies an Early and Mild Form of Primary Hyperparathyroidism

2003 ◽  
Vol 27 (4) ◽  
pp. 481-485 ◽  
Author(s):  
Anders Bergenfelz ◽  
Pia Lindblom ◽  
Birger Linderg�rd ◽  
Stig Valdemarsson ◽  
Johan Westerdahl
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Normal Level ◽  
Mild Form
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