scholarly journals The «cut-off point» of vitamin D: a method of suppressing excessive secretion of PTH

2019 ◽  
Vol 16 (3) ◽  
pp. 88-93 ◽  
Author(s):  
Liudmila A. Suplotova ◽  
Valeria A. Avdeeva ◽  
Ekaterina A. Pigarova ◽  
Liudmila Ya. Rozhinskaya
Keyword(s):  
Vitamin D ◽  
Roc Analysis ◽  
Vitamin D Levels ◽  
The Subject ◽  
The Russian Federation ◽  
Excessive Secretion ◽  
Study Participants ◽  
Working Out ◽  
Pth Level

BACKGROUND: The subject of discussion is the issue of the separation point, which determines sufficient levels of vitamin D for bone health. When determining the adequate reference range of vitamin D, researchers are mainly guided by the results of research, where the level of 25(OH)D is determined, at which the PTH level decreases and reaches a plateau. AIM: To establish the cut-off point of vitamin D by suppressing excessive secretion of PTH. MATERIALS AND METHODS: Observational, single-site, single-stage, selective, uncontrolled study of the search for vitamin D levels by the effect on PTH secretion in residents of Tyumen region was conducted (n = 176). All selected study participants determined the level of 25(OH)D and PTH in serum. The calculation of the cut-off point was carried out using the method of searching for changes in the correlation dependence of PTH on the level of vitamin D, followed by verification of the data obtained using ROC analysis. RESULTS: A mathematical analysis of the dependence of 25(OH)D and PTH showed the cut-off point of vitamin D, equal to 23.6 ng/ml. CONCLUSION: The cut-off point of 23.6 ng/ml is optimal for suppressing excessive PTH secretion. The data obtained may be an incentive for further working out the cut-off point of vitamin D for the Russian population and can be used to clarify the classification of deficiency, insufficiency and optimal levels of vitamin D for the population of the Russian Federation.

scholarly journals Ain’t No Sunshine When She’s Gone: Pseudohypoparathyroidism Discovered in an Adult

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
C. R. van Rooijen ◽  
M. B. Kok ◽  
S. Simsek ◽  
F. Stam
Keyword(s):  
Vitamin D ◽  
Calcium Supplementation ◽  
Fold Increase ◽  
Target Tissue ◽  
Phosphate Excretion ◽  
Tissue Resistance ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D ◽  
Severe Hypocalcaemia ◽  
Pth Level

An 18-year-old negroid woman presented with progressive cramps in both hands. She was Jamaican and had moved to The Netherlands 8 months before. On physical examination Trousseau’s sign was positive. Laboratory analysis showed severe hypocalcaemia (1.17 mmol/L) and hyperphosphatemia (2.0 mmol/L). Urinary excretion of both calcium (0.8 mmol/day) and phosphate (5 mmol/day) was low, as is seen in hypoparathyroidism. However, the PTH level was increased (22.1 pmol/L), whereas 25-(OH)-vitamin D was low (31 nmol/L). An Ellsworth-Howard test showed only a fivefold increase in urinary phosphate excretion after administration of synthetic PTH, supporting the diagnosis pseudohypoparathyroidism. Upon treatment with calcium supplementation and alfacalcidol, her symptoms disappeared. Pseudohypoparathyroidism (PHP) is a rare hereditary disorder resembling hypoparathyroidism, although plasma PTH levels are elevated. PHP is caused by alterations in the PTH receptor, inducing target tissue resistance to PTH. This results in hypocalcaemia and hyperphosphatemia, while PTH levels are elevated. The diagnosis is confirmed by the Ellsworth-Howard test, which will show a 100-fold increase in phosphate excretion if the PTH receptor functions properly. Treatment is lifelong supplementation of calcium and alfacalcidol. In our patient, symptoms were probably evoked by the lack of sunlight in Dutch winter, decreasing vitamin D levels and thereby aggravating hypocalcaemia.

scholarly journals Prevalence and Correlation of Laryngopharyngeal Reflux in Females with Vitamin D Deficiency in a Multi-Specialty Polyclinic in New Delhi, India

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Sachin Saini ◽  
Rahul Pandey ◽  
Navdeep Singh ◽  
Surendra Kumar Pandey ◽  
Inam Danish Khan
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tissue Injury ◽  
Laryngopharyngeal Reflux ◽  
New Delhi ◽  
Female Population ◽  
Severe Vitamin ◽  
Vitamin D Levels ◽  
The Mean ◽  
Study Participants

Background: Laryngopharyngeal Reflux (LPR) is a condition in which gastric content reflux into the larynx and pharynx. It is one of the extraesophageal manifestations of gastroesophageal reflux disease (GERD), involving the laryngeal regio. The laryngopharyngeal epithelium is more susceptible to reflux-related tissue injury than the esophageal epithelium. Objectives: This study aimed to test the hypothesis of whether severe vitamin D deficiency results in increased Laryngopharyngeal reflux (LPR) symptoms in Indian females. The objective was to find out the prevalence of LPR in the severe vitamin D deficient Indian female population. Methods: A descriptive observational study was done at a multispecialty polyclinic in New Delhi, India, over a period of one year. Based on a pilot study, a sample size of 185 individuals was taken. All females referring to the general outpatient department (OPD) with vitamin D levels below 20 ng/ml were included. The frequency of LPR symptoms in the study participants was assessed using the reflux symptom index (RSI) and reflux finding score (RFS) given for all symptomatic patients using a validated scoring system. The data were analyzed descriptively with Microsoft Excel and SPSS version 21 using appropriate tests. Results: In this study, 92% of the subjects aged more than 25 years, and the mean vitamin D level was 9.87 (± 3.425) ng/ml. Moreover, 74% of study participants had severe vitamin D deficiency (≤ 10 ng/ml). The mean RSI for our study participants was 14.54 (± 10.353). Also, the mean RFS was 1.77 (± 3.069). No significant correlation was established between the severity of vitamin D deficiency and RSI as well as RFS. The prevalence of LPR was 43%. Conclusions: Hypovitaminosis D does not have any effect on LPR in the Indian female population.

scholarly journals Official recognition of facts as an institution of international law: problems and

2020 ◽  
pp. 222-238
Author(s):  
Kira L'vovna Sazonova
Keyword(s):  
Intergovernmental Relations ◽  
Practical Interest ◽  
The State ◽  
The Status ◽  
The Subject ◽  
The Russian Federation ◽  
The Common ◽  
A Chain ◽  
Official Recognition

We are witnessing a formation of the new institution of recognition, which can be referred to as the “official recognition of facts”. Such seemingly different political themes as annexation of Crimea by the Russian Federation, the “Skripal Case”, or the status of the Golan Heights have an important common parameter – each of them has become an object of recognition by at least one country. Examination of the causal links that conduce certain countries to issuing the acts of recognition of long-past events or territorial changes are of considerable scientific and practical interest. Recognition of facts by the state is of paramount importance, as it[WU1]  is documented and reflects stance on a specific event, fact, or occurrence. Recognition ensures legitimacy for further actions of the state and initiates a chain of related political and legal events, including sanctions. Over the recent years, recognition of facts by the countries has become more frequent, and virtually becomes a means of political manipulation. Classification of the facts and events that have most often been the subject of recognition allows determining the common trends in the procedure of recognition, as well as the factors that prompt the country to resort to such step. Thus, at times strange and illogical actions of the state associated with the official recognition or non-recognition of the fact acquire a specific political and legal meaning, and allow analyzing the new strategic vectors in intergovernmental relations.  [WU1]

scholarly journals ABNORMALITY IN SERUM CALCIUM, PHOSPHATE AND VITAMIN-D LEVELS IN CHRONIC RENAL FAILURE PATIENTS: A CASE CONTROL STUDY IN THE EASTERN INDIAN POPULATION

2021 ◽  
pp. 5-7
Author(s):  
Chinmoy Ghosh ◽  
Sandip Chakraborty ◽  
Arnab Ghosh ◽  
Sayantan Dasgupta
Keyword(s):  
Vitamin D ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Calcium Phosphate ◽  
Serum Levels ◽  
Vitamin D Levels ◽  
Important Health ◽  
Calcium Phosphorus ◽  
Healthy Control ◽  
Study Participants

Chronic renal failure (CRF) is one of the most important health problems in our population. From the early stages of the disease progression, the activation of Vitamin D in kidney is affected, resulting in abnormality in the regulation of calcium and phosphate homeostasis in the blood. In the present study, 30 Chronic Renal Failure patients visiting Nephrology OPD and 30 age and sex matched volunteers were studied. Serum levels of Urea, Creatinine, Calcium, Phosphate and Vitamin D were measured in the study participants. The data after statistical analysis showed signicantly higher levels of Phophate and signicantly lower levels of Calcium and Vitamin D in the CRF patients in comparison to healthy control subjects. Phosphate and Vitamin D also shows signicant correlation with serum creatinine levels in the CRF patients. The present study conrms the abnormality in Calcium-Phosphorus metabolism as a complication of CRF in our population, and highlights the importance of regularly measuring these parameters in CRF patients and possible need of taking corrective measures in this regard.

scholarly journals Diagnostic performance of the calcium/phosphate ratio for primary hyperparathyroidism in southwest China

2021 ◽  
Author(s):  
Mengting Yin ◽  
Qianhui Liu ◽  
Qingzhong Wang ◽  
Yong He ◽  
Guixing Li
Keyword(s):  
Calcium Phosphate ◽  
Primary Hyperparathyroidism ◽  
Diagnostic Performance ◽  
Roc Analysis ◽  
Operating Characteristic ◽  
Southwest China ◽  
Biochemical Marker ◽  
25 Oh Vitamin D ◽  
Study Participants ◽  
Pth Level

Background: The diagnosis of primary hyperparathyroidism (PHPT) remains a challenge because of increased asymptomatic PHPT or patients with normocalcaemic PHPT (NPHPT). In addition, some primary hospitals in China have no equipment to measure PTH levels. Therefore, an additional, simple, and inexpensive laboratory biochemical marker is urgently needed. The calcium/phosphate (Ca/P) ratio and chloride/phosphate (Cl/P) ratio have been proposed as suitable tools to diagnose PHPT in Europe; however, the Ca/P ratio has never been tested in China. We aimed to conduct a confirmatory study to explore the diagnostic performance of the Ca/P ratio for PHPT in China. Methods: From January 2015 to December 2020, a total of 155 patients who underwent parathyroidectomy (143 PHPT patients and 12 NPHPT patients) and 153 controls were enrolled in this single-center, retrospective study. Serum calcium, phosphate, parathyroid hormone, 25-OH vitamin D, chloride, ALT, AST, eGFR, and creatinine levels were recorded for all the study participants. Pairwise comparisons were made between groups, and the diagnostic performance of the Ca/P ratio was determined using receiver operating characteristic (ROC) analysis. Results: Patients with PHPT had a higher Ca/P ratio than controls (P < 0.001). A Ca/P ratio above 2.94 with a sensitivity of 95.5% and specificity of 98.7% can distinguish PHPT patients from healthy individuals. This index was positively correlated with the PTH level (r = 0.875, P < 0.001). Conclusion: The Ca/P ratio is an ideal and inexpensive indicator for diagnosing PHPT in China when using a cutoff value of 2.94.

scholarly journals A Practical Mathematic Method to Predict and Manage Hypocalcemia After Parathyroidectomy and Thyroidectomy

2019 ◽  
Vol 129 (1) ◽  
pp. 70-77
Author(s):  
Changxing Liu ◽  
Liyang Tang ◽  
Pedram Goel ◽  
Tamara Chambers ◽  
Niels Kokot ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Level ◽  
Tertiary Care ◽  
Clinical Information ◽  
Care Hospital ◽  
Postoperative Hypocalcemia ◽  
Good Reliability ◽  
Primary Treatment Modality ◽  
Vitamin D Levels ◽  
Pth Level

Objective: Prediction and early intervention for hypocalcemia following parathyroidectomy and total thyroidectomy can decrease hospital cost and prevent severe hypocalcemia-related complications. This study aims to predict the severity of hypocalcemia after parathyroidectomy or thyroidectomy and to stratify patients into groups with different levels of risk for developing severe hypocalcemia, so that higher risk patients may be monitored more closely and receive earlier interventions. Methods: This was a retrospective cohort study of 100 patients with primary hyperparathyroidism who underwent parathyroidectomy as the primary treatment modality at a tertiary care hospital. Clinical information, including demographic information, perioperative PTH and calcium levels, vitamin D levels, weight of the pathologic glands removed, gland pathology, and re-admission rates, were retrieved. Statistical analysis was performed to analyze the association between collected variables and percentage of calcium drop following parathyroidectomy with statistical significant set at P-values <0.05. Results: Age, sex, and vitamin D level provided very minimal information to quantify risks of postoperative hypocalcemia. The percentage of decrease from preoperative PTH level to the lowest PTH level after the removal of the abnormal gland(s) is the most significant predicting factor for the severity of postoperative hypocalcemia. There is a mathematic regressional correlation between them. A formula was generated to quantify this linear relationship between them, and the nadir calcium can be calculated as [Formula: see text], where Canadir = the lowest postoperative calcium level, and PTHintraop = PTH level 15 minutes after removal of the abnormal gland, with the value of R2 > 0.7. The formula has been tested primarily in our patient population with good reliability. Conclusions: The highest preoperative, lowest postoperative, and change in PTH level can help us reliably calculate the trend of postoperative calcium level. Decision to pursue early interventions can be made based on the calculated result from the formula we obtained.

Low vitamin B12 level and vitamin D level adversely affect on cochlear health in women

2020 ◽  
Vol 90 (3-4) ◽  
pp. 333-338
Author(s):  
Isil Karaer ◽  
Yahya Akalın
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Otoacoustic Emissions ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Cochlear Function ◽  
Distortion Product ◽  
Vitamin D Levels ◽  
Study Participants ◽  
Low Serum

Abstract. The aim of this study is to examine the association between low serum vitamin B12 levels and low serum vitamin D levels and cochlear health in women. A prospective case–control study was carried out in the Department of Otolaryngology, Malatya Training and Research Hospital between 2017–2018. Thirty (30) patients with vitamin B12 deficiency (a mean age of 32.5 ± 1.7 years(y) women); 30 patients with vitamin D deficiency (a mean age of 32.3 ± 1.58 y women) and 30 controls (a mean age of 27.8 ± 1.48 y women) were recruited. The study participants have no evidence of symptomatic hearing loss. Transiently evoked otoacoustic emissions (TEOAEs) and distortion product otoacoustic emissions (DPOAEs) of the study participants were recorded. A comparative analysis of the parameters revealed that results at TEOAE 1,2,3,4 kHz (p = 0.013, p = 0.002, p = 0.001, p = 0.001, respectively) and at DPOAE 1, 2, 6 kHz ( p < 0.001, p < 0.001, p = 0.002, respectively) were somewhat lower in patients with vitamin B12 deficient group when compared with the controls. Moreover, TEOAE 3,4 kHz (p = 0.005, p = 0.013 respectively) and DPOAE 1,2,6 kHz (p = 0.005, p = 0.01, p = 0.031, respectively) were lower in the vitamin D deficiency group compared with the controls. There was a significant association between both vitamin B12 deficiency and vitamin D deficiency and cochlear health. Patients with vitamin B12 and vitamin D deficiency should be evaluated for cochlear function.

Dictionary on the Subject of Anti-Corruption

2016 ◽  
Author(s):  
Nikolay Vlasyenko ◽  
Artem Tsirin ◽  
YEkatyerina Spyektor ◽  
Natalya Povetkina ◽  
Zarina Bedoeva ◽  
...  
Keyword(s):  
Foreign Language ◽  
Educational Process ◽  
Educational Institutions ◽  
Government Agencies ◽  
Russian Society ◽  
Educational Support ◽  
Scientific Institutions ◽  
The Subject ◽  
The Russian Federation

Currently, the problem of combating corruption is in the center of attention of Russian society and the state. The legal and organizational framework for combating corruption has been formed. Anti-corruption legislation is constantly being improved, becoming more holistic and systematic, so further classification of its concepts is required. The Glossary contains more than 500 terms of Russian and foreign language origin, which are basic in the practice of combating corruption and are used in criminal, administrative and financial law of Russia; it guides the reader in a complex system of modern legal categories related to anti-corruption topics; uses the tools of international agreements ratified by the Russian Federation; it will help clarify the conceptual apparatus of normative legal acts and eliminate contradictions in existing documents. The publication is intended to be used in the educational process in the framework of scientific and educational support for combating corruption. For employees of scientific institutions and government agencies, teachers, students, postgraduates of higher educational institutions and practicing lawyers.

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