scholarly journals Diabetes mellitus in children and adolescents according to the Federal diabetes registry in the Russian Federation: dynamics of major epidemiological characteristics for 2013–2016

2018 ◽  
Vol 20 (6) ◽  
pp. 392-402 ◽  
Author(s):  
Ivan I. Dedov ◽  
Marina V. Shestakova ◽  
Valentina A. Peterkova ◽  
Olga K. Vikulova ◽  
Anna V. Zheleznyakova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Neuropathy ◽  
Children And Adolescents ◽  
Russian Federation ◽  
Diabetic Complications ◽  
Care Organization ◽  
Pump Therapy ◽  
Diabetes Registry ◽  
Number Of Patients ◽  
Epidemiological Characteristics

Background: The data of the register is the main source of up-to-date information about patients with diabetes mellitus (DM). Its very important for improving the quality of medical care organization. Aims: to analyze the main epidemiological DM characteristics in Russian Federation (RF) (prevalence, incidence, mortality) in children and adolescents, to assess the dynamics of these parameters for the period 2013 2016, to analyze the status of compensation for carbohydrate metabolism, therapy of DM1, prevalence of diabetic complications and the reasons for hospitalizations in these age groups. Materials and methods: The database of Federal DM registry of 81 regions was included in the online system. Results: The total number of patients under the age of 18 with DM in RF on 31.12.2016 was 33081 people, there were 95,9% (31727 people) with DM1 and 4,1% (1354 patients) with DM2. The prevalence of DM1 in 20132016 in children: 81.0 91.4 / 100 ths., in adolescents 212,8209,5 / 100 ths. The DM1 incidence/100 thousand population in 2016 in children was 14,2/100 ths., in adolescents 10,0/100 ths. HbA1c levels in DM1 was in children: 7,5% in 32%, 7,69,0% in 33%, 9% in 35% of the patients; in adolescents 7,5% in 25%, 7,69,0% in 30%, 9% in 45% of the patients. Among complications in children and adolescents with DM1, diabetic neuropathy is the most often recorded (in 10,9% of cases and 40,8%, respectively); among DM2 patients, diabetic neuropathy is registered in 4,7% and 8,8% in children and adolescents, respectively. There are associated diseases in DM2 patients arterial hypertension and dyslipidemia. 43,8% of children and 49,2% of adolescents were hospitalized in the anamnesis, most hospitalizations in 2016 (children 71,9%, adolescents 67,1%) were due to diabetes. Conclusions: It is established that in the dynamics of 20132016 the prevalence of DM1 in children continues to increase, with relatively stable indicators in adolescents. According to the register, during last two years there has been a decrease in the incidence of DM1 and, on the contrary, an increase in the prevalence/incidence of DM2 in children. Significant interregional differences in the level of incidence/prevalence have been established, especially in regions located in various geographic regions of the RF. The frequency of diabetic complications in children and adolescents with diabetes varies. There is an association of hospitalizations with higher HbA1c level. In the structure of therapy of this age group the ratio of insulin therapy in syringes-pens and pump therapy is 80.9% / 15.1% according to the register.

scholarly journals Epidemiology of diabetes mellitus in Russian Federation: clinical and statistical report according to the federal diabetes registry

2017 ◽  
Vol 20 (1) ◽  
pp. 13-41 ◽  
Author(s):  
Ivan Ivanovich Dedov ◽  
Marina Vladimirovna Shestakova ◽  
Olga Konstantinovna Vikulova
Keyword(s):  
Diabetes Mellitus ◽  
Life Span ◽  
Russian Federation ◽  
Diabetic Complications ◽  
Haemoglobin A1c ◽  
Diabetes Registry ◽  
Number Of Patients ◽  
The Russian Federation ◽  
Epidemiological Characteristics ◽  
Hba1c Levels

Aim. We analysed the main epidemiological characteristics of diabetes mellitus (DM) in the Russian Federation (prevalence, incidence, mortality and mean life span), degree of diabetes control, and prevalence of diabetic complications (retinopathy, nephropathy, and diabetic foot syndrome and macrovascular pathology) according to the federal DM registry. Materials and methods. The database of the federal DM registry of 79 regions was included using the online system until 31.12.2016. Results. TThe total number of patients with DM in the Russian Federation on 31.12.2016 was 4.348 million (2.97% of the population), comprising 4 million patients with DM2 (92%), 255,000 with type 1 diabetes (T1DM) (6%), and 75,000 with other types of DM (2%). DM prevalence per 100,000 population was as follows: T1DM, 164.19/100,000; type 2 diabetes (T2DM), 2637.17/100,000; and other types of DM, 50.62/100. The incidence per 100,000 population was as follows: T1DM, 16.15/100,000; T2DM, 154.9/100,000; and other types of DM, 8.65/100,000. Mortality per 100,000 population was as follows: T1DM, 2.1/100,000; T2DM, 60.29/100,000; and other types of DM, 0.57/100,000. Mortality decreased in patients with T1DM by 6.6% and with T2DM by 3.6%. Mean life span in patients with T1DM was 50.3 years for men and 58.5 years for women. Mean life span in patients with T2DM was 70.1 years for men and 75.5 years for women. Glycated haemoglobin A1c (HbA1c) levels in T1DM was 7% in 33.4%, 7%7.9% in 28.3%, 8%8.9% in 16.2%, and 9.0% in 22.1% of patients. HbA1c levels in T2DM was 7% in 52.1%, 7%7.9% in 29.1%, 8%8.9% in 10%, and 9.0% in 8.7% of patients. Conclusions. This study evaluated the increase in DM prevalence in the Russian Federation in 2016 and in the dynamics of 20132016, which was mainly due to T2DM. An increase in patients with a target HbA1c level 7% and a decrease in the proportion of patients with severe uncontrolled DM was observed; however, the treatment effectiveness of this key indicator was unsatisfactory, i.e. less than a third of the patients with DM. In the dynamics of 20132016, an increase in mean life span for patients with T2DM and mortality reduction in patients with T1DM and T2DM was observed. The frequency of diabetic complications varied widely, which may reflect differences in the quality of specialised care in different regions.

scholarly journals Diabetes mellitus in Russian Federation: prevalence, morbidity, mortality, parameters of glycaemic control and structure of glucose lowering therapy according to the Federal Diabetes Register, status 2017

2018 ◽  
Vol 21 (3) ◽  
pp. 144-159 ◽  
Author(s):  
Ivan I. Dedov ◽  
Marina V. Shestakova ◽  
Olga K. Vikulova ◽  
Anna V. Zheleznyakova ◽  
Michail А. Isakov
Keyword(s):  
Diabetes Mellitus ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Life Expectancy ◽  
Russian Federation ◽  
Diabetic Coma ◽  
Glucose Lowering ◽  
Number Of Patients ◽  
Diabetes Register ◽  
Epidemiological Characteristics

BACKGROUND: The enormous social lesion caused by high prevalence of diabetes mellitus (DM) determines the state importance of clinical and epidemiological monitoring organization. AIMS: To analyze epidemiological characteristics (prevalence, mortality, morbidity), the level ofHbA1c, evaluate the therapy in Russian Federation in 20132017. METHODS: We have used the database of the Russian Federal Diabetes register 81 regions included in the online register system. RESULTS: The total number of patients with DM was 4,498m. (3.06% RF population), including: Type 1 (T1) 5,7% (0,26 m), T2 92,1% (4,15m), other DM types 1,9% (83,8 ths). Distribution male/female: T1 53.5%/46.5%, T2 29%/71%, other DM types 24%/76%. The proportion of men decreases with aging. Number of patients 65 years was 2.293.520, including T1 21.97ths (3.6%), T2 2m271.5ths (54.7%). The prevalence 20132017 per 100,000 population was as follows: T1 159,8169,6; T2 2455.32775.6; other DM types 51,265,8. Morbidity: T1 9,87,0; T2 226,7185,2; other DM types 7,812,4. The structure of causes of death 20132017: T1: diabetic coma 2,01,5%, myocardial infarction 4,04,4%, cerebral circulation disorders 8,27,6%, cardiovascular insufficiency 18,516,4%, chronic renal failure 6,16,0%; T2 0,20,2%, 4,54,5%, 12,712,2%, 29,028,6%, 1,21,8%, respectively. Mortality: T1 2.3; T2 68.4, other DM types 0,8. Life expectancy (average age of death of patients): T1 male 50.350.2, female 60.257.2; T2 69.870.3, 75.175.9 respectively. The number of patients with targetHbA1clevel 7%: T1 22.334.0%, T2 38.052.4%;HbA1c9.0%: T1 29.221.1%, T2 12.68.8%. The most commonly prescribed classes of glucose lowering medications (GLM) in 2017: in monotherapy Metformin (57.3%), Sulfonilurea (SU) (41,1%); in combination of 2 GLM: Metformin+SU 92,58% Metformin+iDPP-4 5.63%; 3 or more GLM: Metformin+SU+iDPP-4 83,9%, Metformin+SU+iSGLT-2 8.98%. The proportion of patients on aGPP-1 therapy is 0.01%. CONCLUSIONS: We observed the growth of prevalence of DM in Russian Federation and decrease in registered morbidity rate; an increase in life expectancy in T2; decrease in mortality due to diabetic coms and stable mortality rate from cardiovascular events (heart attack, stroke, cv deficiency), gangrene, chronic renal failure in both types of DM; a steady improvement in glycemic control. In the structure of T2 therapy the oral GLMs are dominated, especially Metformin and SU. In the dynamics the prescription of Metformin, insulin, iDPP-4, iSGLT-2 has increased, the proportion of SU has decreased.

scholarly journals The use of ultra-short acting insulin preparations for insulin pumps

2012 ◽  
Vol 58 (3) ◽  
pp. 46-50
Author(s):  
E A Andrianova
Keyword(s):  
Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Pump ◽  
Age Groups ◽  
Insulin Pump Therapy ◽  
Insulin Pumps ◽  
Pump Therapy ◽  
Short Acting ◽  
Acting Insulin ◽  
Short Acting Insulin

The data on the efficacy of using ultra-short acting insulin preparations in insulin pumps for children and adolescents presenting with diabetes mellitus. Insulin pump therapy in the patients of these age groups is finding an increasingly wider application as being more convenient for the users and leading to the improvement of glycemic control. One of the main advantages of modern insulin pump therapy is the possibility to maximally imitate the physiological profile of insulin secretion. The flexibility of both basal and bolus dosing regimens of insulin administration can be further increased by using ultra-short acting insulin preparations in insulin pumps. The choice of any of the three currently available analogs of ultra-short acting insulin guarantees their identical efficacy and safety in the children and adolescents with type 1 diabetes mellitus. They can be recommended as insulins of choice for the use in pump therapy

Clinical and epidemiological characteristics of diabetic nephropathy in children and adolescents in Moscow with insulin-dependent diabetes mellitus

2019 ◽  
Vol 44 (2) ◽  
pp. 3-6
Author(s):  
G. I. Sivous ◽  
E. P. Kasatkina ◽  
V. N. Sokolovskaya ◽  
L. N. Samsonova ◽  
N. P. Gerasimova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Children And Adolescents ◽  
Disease Duration ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Lipid Disorders ◽  
Chronic Hyperglycemia ◽  
Insulin Dependent ◽  
Epidemiological Characteristics

A total of 166 patients (72 males and 94 females) with insulindependent diabetes mellitus (IDDM) aged 5 to 21 years with disease duration of 1 to 18 years were examined in order to assess the clinical picture and epidemiology of diabetic nephropathy (DN) in children and adolescents in Moscow. Microalbuminuria (MAU)*was the criterion of DN. DN was diagnosed in 75 (45.7%) of patients: in 64 (85.3%) at the MAU stage and in 11 (14.6%)) at the stage of proteinuria. There were no cases with the nephrotic syndrome or chronic renal insufficiency. The minimal duration of IDDM in adolescents with MAU was about 2 years, in those with proteinuria about 5 years. All patients with DN were pubertal or postpubertal. The incidence of DN did not depend on the sex, age, or pubertal status. DN risk factors in these patients were chronic hyperglycemia, total and prepubertal duration of diabetes, hereditary predisposition to arterial hypertension, and lipid disorders. Therefore, prepubertal children with disease duration of 5 years and adolescents with disease duration of 1 year since IDDM manifestation are to be screened for DN.

The psychiatric services of Saratov region and directions of its’ improvement (Clinical, statistical and epidemiological aspects)

2017 ◽  
Vol 41 (S1) ◽  
pp. S568-S569
Author(s):  
Y. Barylnik ◽  
D. Samoylova ◽  
S. Pakhomova ◽  
J. Abrosimova ◽  
E. Kolesnichenko ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Russian Federation ◽  
Psychiatric Services ◽  
Saratov Region ◽  
The Past ◽  
Number Of Patients ◽  
Competing Interest ◽  
Services Effectiveness ◽  
Epidemiological Characteristics

IntroductionThe determining of the actual number of people with mental disorders and their spreading by nosology still remains actual, especially according to different regions.ObjectivesThe determining of the psychiatric services effectiveness in Saratov region on the basis of comprehensive analysis of its’ clinical, statistical and epidemiological characteristics.MethodsThe analysis of mental state indicators based on the example of adults’ schizophrenia Saratov region in dynamics for 10 years (2005–2015) in comparison with Russian Federation.ResultsOver the past 10 years the number of clinically supervised patients with schizophrenia decreased at 0.9% in the city and 2.2% in region population. This is consistent with the tendency of schizophrenia morbidity in Russian Federation over the same period. The number of supervised adult patients with primary diagnosed schizophrenia in Russia remained at the same level and amounted to 10.8 per 100 thousand population. At the same time the noticeable fluctuations in the number of this patients’ category were observed in Saratov and Saratov region. Over the past 10 years, the proportion of patients with primary diagnosed schizophrenia disability in the class structure of mental disorders is quite high, averaging of 41.1% in Saratov region. Analyzing the number of patients with re-confirmed disabilities the gradual decline from 1846 to 755 people (at 59.1%) was found.ConclusionsThe mental health analysis of Saratov region population allows to suggest the long-term forecast of mental disorders’ morbidity, to analyze the level of disability due to schizophrenia, to develop recommendations for the optimal regional model of psychiatric services.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals The Effectiveness and Durability of an Early Insulin Pump Therapy in Children and Adolescents with Type 1 Diabetes Mellitus

2014 ◽  
Vol 16 (11) ◽  
pp. 735-741 ◽  
Author(s):  
Davide Brancato ◽  
Mattia Fleres ◽  
Vito Aiello ◽  
Gabriella Saura ◽  
Alessandro Scorsone ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Insulin Pump ◽  
Insulin Pump Therapy ◽  
Pump Therapy

scholarly journals National register of diabetes mellitus in Russian Federation.

2015 ◽  
Vol 18 (3) ◽  
pp. 5-22 ◽  
Author(s):  
Ivan Ivanovich Dedov ◽  
Marina Vladimirovna Shestakova ◽  
Olga Konstantinovna Vikulova
Keyword(s):  
Diabetes Mellitus ◽  
Russian Federation ◽  
Diabetic Complications ◽  
Diabetes Care ◽  
Research Centre ◽  
Reference Center ◽  
Epidemiological Monitoring ◽  
Diabetes Register ◽  
Related Mortality ◽  
Online Software

Clinical and epidemiological monitoring of diabetes in Russian Federation (RF) is carried out by the National diabetes register, which methodological and organizational reference center is Federal Endocrinology Research Centre. Since 2014 initiated the translation the National diabetes register on online software system in order to increase the effectiveness of the register as a scientific and analytical platform. The article include the analysis of DM prevalence, incidence,DM-related mortality,the prevalence of diabetic complications and analysis of effectiveness of diabetes care (included HbA1c) and according to the data of online register.

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