scholarly journals Pathogenetic aspects of hepcidin metabolism and ferrocinetics dysregulation in carbohydrate metabolism disorders

2019 ◽  
Vol 21 (6) ◽  
pp. 506-512 ◽  
Author(s):  
Tatiana V. Saprina ◽  
Anastasia P. Zima ◽  
Nadezhda N. Musina ◽  
Tatiana S. Prokhorenko ◽  
Alina V. Latypova ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Neurodegenerative Diseases ◽  
Carbohydrate Metabolism ◽  
Iron Metabolism ◽  
Metabolic Disorders ◽  
Ongoing Research ◽  
Anaemia Of Chronic Disease ◽  
Patients With Diabetes ◽  
Parkinson Diseases

Hepcidin, a hormone regulating iron metabolism, has received attention for its role in the pathogenesis of dysregulations in carbohydrate metabolism. Hepcidin disorders in patients with diabetes mellitus are bi-directional: manifesting as iron overload syndrome in cases of decreased hepcidin production and as anaemia of chronic disease in cases of hepcidin hypersecretion. However, till date, detailed analyses of mechanisms underlying hepcidin dysregulation have not been conducted nor have the interactions of ferrocinetic and carbohydrate-metabolic disorders been examined. An association between diabetes mellitus and neurodegenerative diseases as well as the role of iron metabolism in Alzheimer or Parkinson diseases is a subject of ongoing research. This review provides a summary of the current understanding of hepcidin regulation and its disorders in various diseases, including diabetes mellitus and neurodegenerative diseases. In addition, we provide an overview of the available therapies that address ferrocinetic disorders resulting from the dysregulation of hepcidin.

scholarly journals Association Study of Candidate Gene Uncoupling Protein 2 (UCP2) with Type 2 Diabetes Mellitus in the Different Population Groups of Jammu Region

2019 ◽  
Vol 16 (2) ◽  
pp. 351-357
Author(s):  
Sunil Raina ◽  
Roopali Fotra
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Disorders ◽  
Uncoupling Protein ◽  
Molecular Genetic ◽  
Promoter Polymorphism ◽  
Uncoupling Protein 2 ◽  
Population Groups ◽  
Allelic Odds Ratio

Diabetes Mellitus is a group of metabolic disorders characterized by hyperglycaemic resulting from the defects of insulin secretion, insulin action or both. The present study was conducted in order to know the molecular genetic cause of the T2DM patients belonging to the Jammu region of J&K State. Many genes have been known to be linked with the onset and progression of the T2DM therefore the present data represents the role of one of the genes Uncoupling protein 2 (UCP2) known to be strongly associated with T2DM was selected. A total of 250 confirmed cases & controls samples belonging to four population groups (Hindu, Muslim, Sikh & Christians) of Jammu region were also screened for UCP2 -866G/A promoter polymorphism (rs659366). The allelic odds ratio (OR) as observed for UCP2 -866G/A polymorphism in the four population groups showed significant association with Muslim & Sikh population groups. The study undertaken supports the findings of the previous investigations and thus is an addition to the existing literatute in support of UCP2 and T2DM.

Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat

2021 ◽  
Vol 22 ◽  
Author(s):  
Raghuvir Keni ◽  
Abinitha Sekhar ◽  
Karthik Gourishetti ◽  
Pawan Ganesh Nayak ◽  
Manas Kinra ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Meta Analysis ◽  
Primary And Secondary Prevention ◽  
Patients With Diabetes ◽  
Peripheral Cells ◽  
Intensive Statin Therapy ◽  
New Onset Diabetes Mellitus ◽  
Analysis Point ◽  
New Onset

Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's inefficient management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in with patients with diabetes. A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition.

scholarly journals Role of early screening for diabetic retinopathy in patients with diabetes mellitus: An overview

2011 ◽  
Vol 36 (4) ◽  
pp. 247 ◽  
Author(s):  
Praveen Vashist ◽  
Noopur Gupta ◽  
Sameeksha Singh ◽  
Rohit Saxena
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Early Screening ◽  
Patients With Diabetes

scholarly journals Disturbances of carbohydrate metabolism and postoperative complications after distal pancreatic resection

2020 ◽  
Vol 37 (3) ◽  
pp. 33-39
Author(s):  
V. N. Barykov ◽  
A. G. Istomin ◽  
N. V. Markina ◽  
V. L. Tyulganova
Keyword(s):  
Diabetes Mellitus ◽  
Postoperative Complications ◽  
Carbohydrate Metabolism ◽  
Pancreatic Resection ◽  
Abdominal Cavity ◽  
The Body ◽  
Total Risk ◽  
Distal Pancreatic Resection ◽  
Before And After ◽  
Patients With Diabetes

Objective. To study the state of carbohydrate metabolism in patients after distal pancreatic resection and its effect on the development of postoperative complications. Materials and methods. Over 10 years, 47 patients have been operated on with various tumors of the body/tail of the pancreas and complications of chronic pancreatitis. In 16 of them, concomitant diabetes mellitus was diagnosed before surgery, and in 31 patients, carbohydrate metabolism was normal. Results. After surgery, from a group of patients with unchanged carbohydrate metabolism, 8 (25.8 %) developed diabetes mellitus. The following postoperative complications pancreatic fistula, inflammatory infiltrates and "fluid leakages in the abdominal cavity occurred in 68 % of cases. Out of 24 patients with diabetes mellitus, complications were registered in 21 (87.5 %) and of 23 diabetes-free patients in 11 (47.8 %). Conclusions. The total risk for the development of the postoperative abdominal complications after the distal resection in patients with diabetes mellitus, diagnosed before and after the intervention, is 7.6 times higher than in patients without diabetes.

scholarly journals PSYCHOLOGICAL STUDIES OF THE MOTIVATIONAL-SEMANTIC SPHERE IN PATIENTS WITH DIABETES MELLITUS

2018 ◽  
pp. 6-9
Author(s):  
I. Burovska
Keyword(s):  
Diabetes Mellitus ◽  
Detailed Examination ◽  
Social Significance ◽  
Way Of Life ◽  
Leading Role ◽  
Patients With Diabetes ◽  
Psychological Features ◽  
Psychological Studies

The article is devoted to the study of the motivational and semantic sphere for patients with diabetes mellitus. Description of the patients’ main directions of the psychological features are distinguished. This study aims to explorer the formation of a hierarchical system of values, attitudes, experiences and motives of this category of patients. Different approaches in the study of this problem were noted, which point to the great possibilities of prevention in the process of rehabilitation in a given subject. The leading role of psychosocial factors of impairment of their mental adaptation and quality of life in patients with diabetes mellitus is determined. Conducting theoretical analysis of modern psychological studies of the motivational and semantic sphere in patients with diabetes makes it possible to identify and analyze the main directions of rehabilitation of this category of persons, to outline the main motivational components of the disease and their relationship with the semantic sphere of each particular person. The peculiarities of the motivational and semantic sphere of persons with diabetes mellitus are described. The relationship between the motivational and intellectual sphere of personality and its influence on the formation of motives are considered. The importance of life-building and the desire to adapt to a particular way of life, to increase its qualitative characteristics and social significance, to take into account the psychological characteristics of patients, are outlined. A detailed examination of the two structural components of this study (which is one of the key tasks of this topic) allows us to more closely combine them into a single entity that forms the life-orienting purposes of patients with diabetes, and draws attention to the dynamics of motivational processes that occur in individuals during the period the course of the disease and the possibility of correction of these processes. The prospects of further researches which consist in formation and modeling of holistic construct of motivational – semantic sphere in patients with diabetes mellitus are outlined.

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