scholarly journals The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy

2015 ◽  
Vol 18 (4) ◽  
pp. 66-71 ◽  
Author(s):  
Vadim V. Klimontov ◽  
Natalia E. Myakina
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Blood Glucose ◽  
Insulin Therapy ◽  
Glucose Variability ◽  
High Blood Glucose ◽  
Interstitial Glucose ◽  
Bolus Insulin ◽  
Basal Bolus

Aim. To assess the relationship of glucose variability (GV) and renal function in patients with type 2 diabetes on basal-bolus insulin therapy.Materials and methods. We observed 101 females with type 2 diabetes, aged 47–79 years, with a glomerular filtration rate (GFR) 30 mL/min/1.73 m2. Insulin was combined with metformin in 45 of these women. The mean glucose and standard deviation, continuous overlapping net glucose action, lability index, J-index, low blood glucose index (LBGI), high blood glucose index (HBGI), M-value and mean absolute glucose (MAG) were calculated based on the results of blinded continuous glucose monitoring. The prevalence of episodes of low interstitial glucose (3.9 and 2.8 mmol/L) of at least 20-min duration was estimated.Results. Patients with a GFR of 30–44 mL/min/1.73 m2 had significantly lower HBGI, J-index, MAG and M-value compared with those with better filtration (all p 0.05); LBGI was not dependent on GFR. The GFR values were weakly and positively correlated with HBGI, J-index, M-value and MAG. Multiple regression analysis showed that GFR is an independent predictor of MAG (p = 0.04). No significant differences were found in the prevalence of episodes of low interstitial glucose between patients with different GFR ranges.Conclusions. GV parameters are related to renal function in type 2 diabetic women on basal-bolus insulin therapy. Patients with stage 3b chronic kidney disease have reduced GV, predominantly in the hyperglycaemic band, compared with those with better filtration.

Gender differences in the blood glucose type 2 diabetes patients with combination rapid and long acting insulin therapy

2021 ◽  
Vol 32 (4) ◽  
pp. 567-570
Author(s):  
Dinda M. N. Ratri ◽  
Arina D. Puspitasari ◽  
Cahyo W. Nugroho ◽  
Budi Suprapti ◽  
Suharjono ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Insulin Therapy ◽  
Target Range ◽  
Bolus Insulin ◽  
Glycemic Outcomes ◽  
Basal Bolus

Abstract Objectives Previous research suggests that there may be intergender differences in the profile of glycemic control achievable during the treatment of type 2 diabetes mellitus. This preliminary study was conducted to determine differences in glycemic outcomes in type 2 diabetes mellitus patients amongst men and women in an Indonesian hospital. Methods The study was conducted at the outpatient internal medicine polyclinic of Universitas Airlangga Teaching Hospital Surabaya. This observational prospective cohort study examining outcomes for 64 patients (32 men and 32 women) treated with insulin therapy. The primary outcome measure was the extent to which subjects achieved concordance with the target blood glucose parameters based on the American Diabetes Association (ADA) guidance. Results After 3 months of combination basal-bolus insulin treatment, the proportion of subjects who had fasting blood glucose values in the target range did not increase for either gender. For women, there was a significantly higher proportion of subjects who achieved a postprandial glucose value within the target range (p=0.04) Conclusions In this study, patients achieved postprandial glycemic outcomes for women but not men. More research is required to elucidate the possible intergender difference in results for subjects treated with basal-bolus insulin for type 2 diabetes mellitus.

Switching to basal-bolus insulin therapy is effective and safe in long-term type 2 diabetes patients inadequately controlled with other insulin regimens

2013 ◽  
Vol 60 (5) ◽  
pp. 249-253
Author(s):  
Irene Vinagre ◽  
Juan Sánchez-Hernández ◽  
José Luis Sánchez-Quesada ◽  
Miguel Ángel María ◽  
Alberto de Leiva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Bolus Insulin ◽  
Basal Bolus ◽  
Term Type ◽  
Diabetes Patients

GLP-1 receptor agonist added to insulin versus basal-plus or basal-bolus insulin therapy in type 2 diabetes: A systematic review and meta-analysis

2018 ◽  
Vol 35 (1) ◽  
pp. e3082 ◽  
Author(s):  
Marco Castellana ◽  
Angelo Cignarelli ◽  
Francesco Brescia ◽  
Luigi Laviola ◽  
Francesco Giorgino
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Receptor Agonist ◽  
Meta Analysis ◽  
Bolus Insulin ◽  
Basal Bolus

scholarly journals U-500 Insulin as a Component of Basal Bolus Insulin Therapy in Type 2 Diabetes

2012 ◽  
Vol 14 (6) ◽  
pp. 505-507 ◽  
Author(s):  
Jolene Brown Lowery ◽  
Amy C. Donihi ◽  
Mary T. Korytkowski
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Bolus Insulin ◽  
Basal Bolus

scholarly journals Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy

2015 ◽  
Vol 62 (2) ◽  
pp. 209-216 ◽  
Author(s):  
Seiya Shimoda ◽  
Mina Okubo ◽  
Kotaro Koga ◽  
Taiji Sekigami ◽  
Junji Kawashima ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Insulin Requirement ◽  
Bolus Insulin ◽  
Basal Bolus

Efficacy, usability and sequence of operations of a workflow-integrated algorithm for basal-bolus insulin therapy in hospitalized type 2 diabetes patients

2013 ◽  
Vol 16 (2) ◽  
pp. 137-146 ◽  
Author(s):  
J. K. Mader ◽  
K. M. Neubauer ◽  
L. Schaupp ◽  
T. Augustin ◽  
P. Beck ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Bolus Insulin ◽  
Basal Bolus ◽  
Diabetes Patients
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