scholarly journals The relationship of total body composition with bone mineral density in postmenopausal women with type 2 diabetes

2015 ◽  
Vol 18 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Vadim Valer'evich Klimontov ◽  
Olga Nikolaevna Fazullina
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Total Body Composition ◽  
Total Body ◽  
The Relationship

Aim. To determine the relationship between bone mineral density (BMD) and total body composition in postmenopausal women with type 2 diabetes. Materials and Methods. The study included 78 women, from 50 to 70 years of age (median 63 years). Twenty women had normal body mass index (BMI), 29 ones were overweight and 29 had obesity. The body composition and BMD was studied by dual-energy X-ray absorptiometry. Results. Women with normal BMD had higher BMI, total and truncal fat mass, as well lean mass as compared to women with osteoporosis and osteopenia (all p

scholarly journals The Effect of a Long-Term, Community-Based Exercise Program on Bone Mineral Density in Postmenopausal Women with Pre-Diabetes and Type 2 Diabetes

2014 ◽  
Vol 43 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Marieni Bello ◽  
Maria Cirilo Sousa ◽  
Gabriel Neto ◽  
Leonardo Oliveira ◽  
Ialuska Guerras ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Exercise Program ◽  
Mineral Density ◽  
Community Based ◽  
The Impact

Abstract The aim of this study was to evaluate the impact of a community-based exercise program on bone mineral density and body composition in postmenopausal women with pre-diabetes and type 2 diabetes. Twenty postmenopausal women (aged 61.3 ± 6.0 years) with pre-diabetes and type 2 diabetes were randomly assigned to a community-based exercise program group (n=10) or a control group (n=10). The community-based exercise program was multicomponent, three days per week for 32 weeks, and included walking, resistance and aquatic exercises. Body composition and bone mineral density were measured pre and post-training by dual X-ray absorptiometry. In the exercise group significant increases were found in the ward’s triangle bone mineral density (+7.8%, p=0.043), and in fat-free mass (+2.4%, p=0.018). The findings suggest that regular multicomponent training is effective in preventing osteoporosis and sarcopenia among postmenopausal women with pre-diabetes and type 2 diabetes.

The relationship between body composition and bone mineral density in men with type 2 diabetes mellitus

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S414
Author(s):  
Zhi-qing You ◽  
Yong Wan ◽  
Ying Cheng ◽  
Hong-mei Lang ◽  
Jing Fu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Composition ◽  
Bone Mineral ◽  
Mineral Density ◽  
The Relationship

The Association of Omentin Levels in Non-Diabetic Postmenopausal Women with Bone Mineral Density and Total Body Composition

2015 ◽  
Vol 3 (2) ◽  
pp. 51
Author(s):  
Tulay Ozlu ◽  
Hakan Sarman ◽  
Aytekin Alcelik ◽  
Cengiz Isik ◽  
Selma Yazıcı ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Total Body Composition ◽  
Total Body

scholarly journals Associations of polymorphisms in the gene promoters of cytokines and matrix metalloproteinases with bone mineral density in postmenopausal type 2 diabetic women

2018 ◽  
Vol 21 (1) ◽  
pp. 26-33
Author(s):  
Olga N. Fazullina ◽  
Vadim V. Klimontov ◽  
Vladimir I. Konenkov ◽  
Alla V. Shevchenko ◽  
Viktor F. Prokoviev ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Matrix Metalloproteinases ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Additive Model ◽  
Gene Promoters ◽  
Mineral Density ◽  
Type 2 Diabetic

Background. Osteoporosis and type 2 diabetes are common comorbidities in postmenopausal women. An important role in the bone remodeling over the menopausal transition can be played by cytokines and matrix metalloproteinases (MMPs). It was shown that allelic variants in polymorphic positions of the genes of cytokines and MMPs affect the expression of these molecules under normal and pathological conditions. Aims. To examine associations between polymorphisms in the gene promoters of cytokines (TNFA, IL1B, IL4, IL6, IL10, VEGFA) and MMPs (MMP2, MMP3, MMP9) with bone mineral density (BMD) in postmenopausal women with type 2 diabetes. Materials and methods. We studied 197 Caucasian diabetic women, from 50 to70 years of age. An examination of BMD in the spine, proximal femur and forearm was performed by DEXA. Thirteen polymorphisms in the promoters of TNFA: -238 A/G (rs361525), -308 A/G(rs1800629) and -863 C/A (rs1800630), IL1B: -31 C/T (rs1143627), IL4: -590 C/T (rs2243250), IL6: -174 C/G (rs1800795), IL10: -592 C/A (rs1800872) and -1082 A/G (rs1800896), VEGFA: -2578 C/A (rs699947) and +936 C/T (rs3025039), MMP2: -1306 C/T (rs243865), MMP3: -1171 5A/6A (rs3025058) and MMP9: -1562 C/T (rs3918242), were investigated. Results. Seventy-three women had normal BMD, in 90 ones we revealed osteopenia, and 34 women had osteoporosis. Age, BMI and smoking were strongest predictors of BMD in multivariate regression analysis (p0.0001, p=0.003 and p=0.01, respectively). In the additive model, C allele and CC genotype in MMP9 -1562 position were associated with low BMD (OR 2.16, p=0.0007 and OR 2.02, p=0.0008, respectively). Association of the polymorphism with BMD remained significant after adjustment for clinical risk factors (p0.001). Twelve combinations of genotypes, associated positively with low BMD, were revealed by bioinformatic analysis (all p0.005). The СС genotype in position -1562 of MMP9, CC genotype in position -863 of TNFA, GG genotype in position -308 of TNFA, and AA genotype in position -1082 of IL10 were the most prevalent variants in these combinations. Conclusions. Variability in the gene promoters of cytokines and MMPs may confer individual susceptibility to osteoporosis in postmenopausal type 2 diabetic women.

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