scholarly journals Prevalence of carbohydrate metabolism disorders in patients with new coronavirus infection

2021 ◽  
Vol 24 (3) ◽  
pp. 222-230
Author(s):  
T. N. Markova ◽  
M. A. Lysenko ◽  
A. A. Ivanova ◽  
E. S. Pavlova ◽  
A. A. Ponomareva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Carbohydrate Metabolism ◽  
Inverse Correlation ◽  
Study Groups ◽  
Postprandial Glycemia ◽  
Number Of Patients ◽  
High Prevalence ◽  
History Of ◽  
Flow Group ◽  
Coronavirus Infection

BACKGRAUND: There is evidence of a multifactorial effect of SARS-CoV2 on carbohydrate metabolism with the development of hyperglycemia and the weighting of COVID19 even in people without DM.AIMS: Assess the prevalence of disorders carbohydrate metabolism (DCM) in hospitalized patients with a new coronavirus infection without a history of DM.MATERIALS AND METHODS: Patients with PCR-confirmed diagnosis of COVID19 aged 18-75 years (n=72) without a history of diabetes were examined. Observation was carried out from the moment of hospitalization to discharge. Patients were collected anamnesis data, laboratory and instrumental studies, HbA1c, fasting plasma glucose (FPG), postprandial glycemia.RESULTS: The prevalence of DCM (HbA1c≥6%) in 72 patients with COVID19 without a history of diabetes admitted to the hospital was 41,7%, while HbA1c ≥6,5% had 8,3%. The median HbA1c in the moderate-flow group was 5,7% [5,3–6,0], and in the severe-flow group it was 6,0% [5,8–6,2] (p=0,008). Participants were divided into groups according to the level of HbA1c≥6% and < 6%. The examined patients showed a high prevalence of risk factors for developing DM: age over 45 years — 83,3%, cardiovascular diseases — 46,3%, obesity — 50%. The study groups didn’t differ statistically in terms of risk factors for DM. In the group with HbA1c≥6%, FPG≥6,1 mmol / l on the second day and postprandial glycemia ≥7,8 mmol/l were observed in more cases than in the group with HbA1c<6% (39,1% vs 12,9%, p=0,051 and 47,8% vs 3,2%, p=0,0001, respectively). The prevalence of DCM in HbA1c was higher than in FPG (41,7% vs 29,2%, p=0,006). On the seventh day, the number of patients with FPG ≥ 6,1 mmol / l in the first group decreased from 39,1% to 4,4% (p=0,01), and in the second group-from 12,9% to 9,7% (p=1,0). There was a direct correlation between the level of HbA1c and C-reactive protein (r=0,271; p=0,048), and an inverse correlation with the content of lymphocytes in the blood (r=-0,25; p=0,068).CONCLUSIONS: In patients with a new coronavirus infection without a history of DM, a high prevalence of DCM was detected — 41,7%. Against the background of comparability of the studied groups by risk factors for DM, an increase in HbA1c, FPG and postprandial glycemia is a manifestation of transient hyperglycemia. Given the high prevalence of DCM, it can be assumed that SARS-CoV2 has diabetogenic properties.

scholarly journals Relationship between serum leptin levels, non-cardiovascular risk factors and mortality in hemodialysis patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ivona Risovic ◽  
Vlastimir Vlatkovic ◽  
Snjezana Popovicpejicic ◽  
Gabrijela Malešević
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Survival Rates ◽  
Inverse Correlation ◽  
Study Groups ◽  
Mineral And Bone Disorder ◽  
Serum Leptin ◽  
Significant Difference

Abstract Introduction. Hemodialysis (HD) patients have higher mortality rate than the general population. Recent studies indicate a significant role of non-cardiovascular risk factors in for mortality in HD patients. Leptin is protein hormone and may indicate malnutrition in HD patients. Its role in mortality in these patients is being examined. This study aimed to investigate the correlation between serum leptin levels and non-cardiovascular risk factors and relationship between leptin level and mortality in HD patients. Methods The prospective study included 93 patients on maintenance HD and follow-up period was 12 months. We measured leptin level and evaluated non-cardiovascular risk factors: nutritional status, anemia, volemia, parameters of mineral and bone disorder. Results. Out of 93 patients 9 died during study and 1 underwent kidney transplantation. Malnutrition and hypervolemia were two main non-cardiovascular risk factors among deceased subjects. Leptin showed a significant direct correlation with nutritional BMI (r = 0.72, P <0.001), fat tissue index (r = 0.74, P <0.001) and statistically significant inverse correlation with leantissue index (r = -0.349, P <0.05) and inverse correlation with volemic parameters (overhydration / extracellular water ratio (r = -0.38, P <0.001), but no association with anemia and mineral bone parameters was observed. Elevated leptin levels were associated with better survival. However, no statistically significant difference in survival rates was observed between the study groups (Log-Rank P =0.214, Breslow P =0.211, Tarone-Ware P=0.212). Conclusion: Deceased patients had significantly lower leptin values. Leptin was associated with two non-cardiovascular risk factors for mortality: malnutrition and hypervolemia.

scholarly journals Major clinical risk factors for seizures in febrile children aged 6 to 60 months.

2020 ◽  
Vol 27 (05) ◽  
pp. 891-894
Author(s):  
Shahid Ishaq ◽  
Ejaz Mazari ◽  
Fazal ur Rehman
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Febrile Seizures ◽  
Study Groups ◽  
Clinical Risk Factors ◽  
P Value ◽  
Chi Square ◽  
Clinical Risk ◽  
Significant Difference ◽  
History Of

Objectives: Febrile seizures (FS) are the most common type of seizures and typically transpire in children with ages from 6 to 60 months. This study was planned to find out major clinical risk factors for seizures in febrile children who were aged 6 to 60 months. A total of 100 febrile children aged 6 to 60. Study Design: Analytical Study. Setting: Department of Neurology, Children’s Hospital and the Institute of Child Health, Multan. Period: From 1st April 2018 to 31st December 2018. Material & Methods: Group A had 40 children with febrile seizures while group B had 60 febrile children but without seizures. Demographic features along with family history of (H/O) epilepsy as well as family history of febrile seizure, types of seizure and infection diseases were noted and analyzed using SPSS version 20. Odds ratio was calculated for various risk factors. Chi square test was applied and P value < 0.05 was considered as significant. Results: Out of a total of 100 children, there were 54 (54.0%) male and 46 (46.0%) female. There was no statistical difference in terms of gender between the two groups (p value = 0.566). Overall, mean age of the children was 26.02 months with standard deviation of 13.4 months. There were 28 (70.0%) children who reported with simple seizures while complex seizures were found in 12 (30.0%) cases. Statistically significant difference (p value = 0.001) was seen in terms of types of infections between the two study groups. When risk of seizures for various risk factors was calculated, family H/O FS, family H/O epilepsy, and upper RTI were as 14, 7 and 3 times respectively and turned out to be the major risk factors for seizures in febrile children. Conclusions: Family H/O FS, family H/O epilepsy and upper RTIs are the major risk factors related with seizures in febrile children. Measures to prevent these risk factors can decrease the burden of FS in our population.

scholarly journals Profile of Ectopic Pregnancy at Kathmandu Model Hospital

2016 ◽  
Vol 10 (2) ◽  
pp. 10-13
Author(s):  
HK Pradhan ◽  
G Dangal ◽  
A Karki ◽  
R Shrestha ◽  
K Bhattachan
Keyword(s):  
Risk Factors ◽  
Ectopic Pregnancy ◽  
Discharge Summary ◽  
Reproductive Age ◽  
Emergency Laparotomy ◽  
Average Hospital ◽  
Pain Abdomen ◽  
Number Of Patients ◽  
History Of ◽  
Age Range

Aims: The study was done to analyze the epidemiology, diagnosis and treatment aspect of patients with ectopic pregnancy at Kathmandu Model Hospital.Methods: This was a retrospective study of patients with ectopic pregnancy who received treatment at Kathmandu Model Hospital from January 2008 to September 2015. Data were analyzed from patient records and discharge summary. Delivery number was obtained from maternity record.Results: There were 61 cases of ectopic pregnancy with the hospital incidence of 1.46%. Highest number of patients 20 (32.79%) were in the age range of 28-32 years. Most of the patients were nullipara 22 (36.06%) or with parity two 20 (32.79%). Some risk factors were found in 29 (47.54%) cases. The commonest risk factor was pelvic inflammatory disease in 12 (19.67%). All presented with pain abdomen, 48 (78.68%) had per vaginal bleeding, 17 (27.87%) presented in shock. Cervival excitation was present in 38 (62.29%). Urine for pregnancy test was positive in all and 37 (60.66%) had ultrasonography. Ten (16.39%) patients underwent emergency laparoscopic surgery and 40 (65.57%) had emergency laparotomy. Salpingectomy was required in 53 (86.89%) cases. The average hospital stay was 5 days.Conclusions: The study showed that ectopic pregnancy could occur at any reproductive age without obvious risk factors. Although not all patients gave history of amenorrhoea, pain abdomen was present in all.

scholarly journals Outcomes of Percutaneous Nephrolithotomy in Patients with Previous Ipsilateral Open Renal Stone Surgery

2020 ◽  
Vol 18 (2) ◽  
pp. 277-281
Author(s):  
Robin Bahadur Basnet ◽  
Anil Shrestha ◽  
Parash Mani Shrestha ◽  
Biswa Raj Joshi
Keyword(s):  
Percutaneous Nephrolithotomy ◽  
Open Surgery ◽  
Renal Stone ◽  
Standard Technique ◽  
Study Groups ◽  
Average Hospital ◽  
Number Of Patients ◽  
History Of ◽  
Renal Stone Surgery ◽  
First Time

Background: Nephrolithiais is a recurrent disease. Recent advances have enabled stone surgeries to be performed by minimal invasive techniques; but still a large number of patients present with history of ipsilateral open renal stone surgery. Previous scar to the kidney and overlying muscles are fraught with possibility of increased complications. This study was conducted to evaluate the perioperative results of percutaneous nephrolithotomy in patients with a history of open stone surgery and to compare with those undergoing percutaneous nephrolithotomy for the first time.Methods: A retrospective study of all the percutaneous nephrolithotomy performed by standard technique within four years at Bir Hospital was made. Patients were divided into those undergoing percutaneous nephrolithotomy for the first time and those who had undergone open renal stone surgery in the past. Preoperative and intraoperative variables were recorded and postoperative stone free status and complications were evaluated. Results: Six hundred and twenty seven patients; out of 691, who had undergone percutaneous nephrolithotomy were included. Demographic variables and stone characteristics were similar in the two study groups. percutaneous nephrolithotomy was found to be statistically similar in the two groups in terms of the number of tracts made (p= 0.1642) and operative time (0.9197). Exit strategies were similar in both groups. Stone free rate was 83.33% in patients undergoing percutaneous nephrolithotomy for first time and 82.08% in those with history of open surgery. Average hospital stay was 3 days in both groups. Although the group with history of previous surgery had significantly more complications (p= 0.0207), Clavien grading was similar in the two groups.Conclusions: This study shows that the rate of complications is more in patients with history of open surgery, most complications are minor, not requiring intensive management. percutaneous nephrolithotomy is efficient and safe in patients with history of open renal stone surgery. Keywords: Complications; open renal stone surgery; percutaneous nephrolithotomy

scholarly journals Pathogenic NOTCH3 Variants Are Frequent Among the Korean General Population

2021 ◽  
Vol 7 (6) ◽  
pp. e639
Author(s):  
Chul-Hoo Kang ◽  
Young Mee Kim ◽  
Yang-Ji Kim ◽  
Su-Jeong Hong ◽  
Do Yoon Kim ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Genome Project ◽  
Jeju Island ◽  
Cross Sectional ◽  
Genome Database ◽  
Pathogenic Variants ◽  
Number Of Patients ◽  
High Prevalence ◽  
History Of ◽  
Reference Genome Database

ObjectiveThis study aimed to determine the frequency of pathogenic NOTCH3 variants among Koreans.MethodsIn this cross-sectional study, we queried for pathogenic NOTCH3 variants in 2 Korean public genome databases: the Korean Reference Genome Database (KRGDB) and the Korean Genome Project (Korea1K). In addition, we screened the 3 most common pathogenic NOTCH3 variants (p.Arg75Pro, p.Arg544Cys, and p.Arg578Cys) for 1,000 individuals on Jeju Island, where the largest number of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) have been reported in Korea.ResultsThe pathogenic NOTCH3 variant (p.Arg544Cys) was found in 0.12% of sequences in the KRGDB, and 3 pathogenic variants (p.Arg75Pro, p.Arg182Cys, and p.Arg544Cys) were present in 0.44% of the Korea1K database. Of the 1,000 individuals on Jeju Island, we found 2 cysteine-altering NOTCH3 variants (p.Arg544Cys variant in 9 and p.Arg578Cys in 1 individual) in 1.00% of the participants (95% confidence interval: 0.48%–1.83%). The presence of cysteine-altering NOTCH3 variants was significantly associated with a history of stroke (p < 0.001).DiscussionPathogenic NOTCH3 variants are frequently found in the general Korean population. Such a high prevalence of pathogenic variants could threaten the brain health of tens of thousands to hundreds of thousands of older adults in Korea.

scholarly journals Medical and social factors of the possibility of spreading coronavirus infection among fertile aged women

2021 ◽  
pp. 8-14
Author(s):  
V.V. Podolskyi ◽  
Y.H. Antypkin ◽  
Vl.V. Podolskyi ◽  
T.R. Umanets ◽  
T.M. Kaminska ◽  
...  
Keyword(s):  
Risk Factors ◽  
Social Factors ◽  
Odds Ratio ◽  
Age Groups ◽  
Upper Respiratory Tract ◽  
Female Population ◽  
Younger Women ◽  
History Of ◽  
Risk Of Disease ◽  
Coronavirus Infection

Research objective: to determine the risk factors for the spread of coronavirus infection among women of fertile age.Materials and methods. Authors analyzed the medical records (case histories and questionnaires) of 60 women of fertile age who were treated for coronavirus disease. After analysis of medical and social factors women were divided into age groups. Analysis of risk factors for coronavirus disease was determined by calculating the odds ratio according to Wald at p < 0.05.Results. Evaluation of the odds ratio of the COVID-19 chances depending on the nature of work of women of different ages showed that with intense work the risk of disease increases 2.5 times in the age group up to 30 years, which also confirms the analysis of previous indicators, that younger women with moderate workloads have more opportunities to attend mass events and crowds. In the structure of extragenital diseases in women with coronavirus disease, the chances of disease increased 2.6 times in those women who had a history of chronic tonsillitis. Among the history of infectious diseases, the chance ratio of coronavirus disease was increased in women over 30 years of age who had pertussis. Such data may indicate a similar mechanism of development of these diseases, because the causative agent of pertussis also penetrates the upper respiratory tract and may be accompanied by neurological symptoms – the appearance of seizures and bronchospasm.Conclusions. The data obtained in this way allow us to separate a narrower cohort of women of fertile age who may develop coronavirus disease. This will further allow developing proposals for a more efficient distribution of vaccines among the female population of Ukraine and reduce the prevalence of coronavirus infection.

scholarly journals KARAKTERISTIK INDEKS MASSA TUBUH DAN JENIS KELAMIN PASIEN HIPERTENSI DI RS IBNU SINA MAKASSAR NOVEMBER 2018

2021 ◽  
Vol 7 (2) ◽  
pp. 64
Author(s):  
Rachmat Faisal Syamsu ◽  
Siska Nuryanti ◽  
Muhammad Yastrib Semme
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Nutritional Status ◽  
High Blood Pressure ◽  
Sodium Intake ◽  
Sampling Technique ◽  
The Body ◽  
Number Of Patients ◽  
High Prevalence ◽  
Male Patients

Hypertension, commonly referred to as high blood pressure, is a global health problem in Indonesia because of its high prevalence, although it varies in different countries. In Indonesia, hypertension is found in 83 per 1000 household members. The majority of high blood pressure increases with the presence of risk factors such as; Age, lack of exercise / physical activity, genetic factors and family history, body weight/obesity, sodium intake, alcohol consumption, smoking, stress. This study is a descriptive design using an observational approach to describe the characteristics of the risk factors for the Body Mass Index (BMI) and the gender of hypertension patients at Ibnu Sina Hospital for November 2018. The sampling technique used the total sampling technique with a complete sample size of 26 people. The results showed that the gender characteristics of hypertension sufferers showed that the number of female patients (16 people) was more than that of male patients (10 people). And the attributes of BMI in patients with hypertension found that the number of patients with normal nutritional status (13 people) was the most compared to another nutritional status.

Prevalence of Risk Factors of Major NonCommunicable Diseases among Adolescents of Higher Secondary Schools of Kaski, District

2018 ◽  
Vol 16 (3) ◽  
pp. 307-312
Author(s):  
Dipendra Kumar Yadav ◽  
Bhoopendra Sharma ◽  
Naveen Shrestha ◽  
Isha Karmacharya ◽  
Saroj Yadav
Keyword(s):  
Risk Factors ◽  
Family History ◽  
Secondary Students ◽  
Disease Risk ◽  
Communicable Disease ◽  
Noncommunicable Diseases ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
High Prevalence ◽  
History Of

Background: The main aim of this study is to determine the prevalence of major Non communicable disease risk factors among higher secondary school students.Methods: A cross-sectional study was conducted among higher secondary students of grade 11 and 12 of Kaski district in Nepal. The study period was from July 2016 to June 2017. Total sample 640 higher secondary students were recruited through two-stage cluster sampling. Self-administrated questionnaire was used for the data collection tool along with other tools which were used such as UNICEF electronic weighing scale, stature meter and mechanical aneroid sphygmomanometer. Ethical approval was obtained from IRC, Pokhara University. Data were entered into EpiData software and analysis was performed with the help of the Statistical Package for Social Science (SPSS).Results:  The prevalence of smoking was 6.1% which was high in male (11.9%) than female (0.6%). Alcohol consumption practice among the adolescents was 18.9%. Family history of hypertension was seen higher than family history of diabetes.The prevalence of hypertension was 11.7%.High prevalence of abnormal values of systolic and diastolic BP was found in male than female students. Overweight was seen in 6.1% students. Prevalence of obesity was almost equal in both groups.Conclusions: There is high prevalence of smoking, alcoholism among adolescents. Hypertension was more common than diabetes among adolescents.

ANTEPARTUM DEPRESSIVE SYMPTOMS AND ASSOCIATED RISK FACTORS AMONG ANTENATAL WOMEN IN NORTHERN KERALA- A HOSPITAL BASED STUDY

2021 ◽  
pp. 4-6
Author(s):  
Babitha E K ◽  
Geethakumary. V P ◽  
Harish. M Tharayil
Keyword(s):  
Risk Factors ◽  
Depressive Symptoms ◽  
Well Being ◽  
Perinatal Period ◽  
Antenatal Depression ◽  
Antenatal Depressive Symptoms ◽  
High Prevalence ◽  
History Of ◽  
Associated Risk Factors ◽  
Antepartum Depressive Symptoms

Depression is the most frequent psychiatric disorder that women face throughout their perinatal period. As the pregnancy proceeds, the risk of antenatal depression rises, and clinically severe depressive symptoms are quiet common in last trimesters. The present study aimed to identify the prevalence of antenatal depressive symptoms (APDS) and its associated risk factors among pregnant women attending Antenatal outpatient department (OPD) at Institute of Maternal and child health (IMCH) ,Kozhikode. Two hundred antenatal women were screened for APDS using Edinburgh Postnatal Depression Screening Scale (EPDS). The prevalence of APDS among antenatal women was 40.5% .History of illness in present pregnancy, previous pregnancy, fetal well- being, history of mental illness, fear of birth and social support were signicantly associated with APDS. Pregnancy has a high prevalence of depressive symptoms, necessitating frequent screening during antenatal checkup to detect APDS and integrating mental health service with perinatal car

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