scholarly journals COVID-19 and kidneys

2020 ◽  
Vol 23 (3) ◽  
pp. 235-241
Author(s):  
M. S. Shamkhalova ◽  
N. G. Mokrysheva ◽  
M. V. Shestakova
Keyword(s):  
Kidney Tissue ◽  
Cell Aggregation ◽  
Organ Damage ◽  
Evidence Base ◽  
Acute Renal Injury ◽  
Red Blood Cell Aggregation ◽  
Kidney Involvement ◽  
Autopsy Data ◽  
Extracorporeal Therapy ◽  
Epithelium Cells

COVID-19 poses a real threat to patients with comorbid conditions such as diabetes mellitus (DM), hypertension, cardiovascular, renal or hepatic disorders. Kidney damage is very likely in people with diabetes who have undergone a new infection, and the risk of developing acute renal injury is associated with mortality. Potential mechanisms of kidney involvement in theclinical picture of the disease may include cytokine damage, cross-organ damage, and systemic effects that determine the treatment strategy. These mechanisms are closely interrelated and are important for individuals on extracorporeal therapy and kidney transplants. Autopsy data provide evidence of SARS-CoV-2 virus invasion into kidney tissue with damage to tubular epithelium cells and podocytes, and red blood cell aggregation in severely COVID-19 patients. By including individuals with chronic kidney disease in planned COVID-19 research protocols, an evidence base for effective and safe treatments can be generated.

scholarly journals Epidemiological, clinical and morphological aspects of kidney damage in COVID-19

2021 ◽  
Vol 10 (3) ◽  
pp. e17-e17
Author(s):  
Batir Daminov ◽  
Sherzod Abdullaev ◽  
Olimkhon Sharapov ◽  
Ranokhon Igamberdieva
Keyword(s):  
Kidney Tissue ◽  
Organ Damage ◽  
Evidence Base ◽  
Kidney Damage ◽  
Erythrocyte Aggregation ◽  
Morphological Aspects ◽  
Research Protocols ◽  
Kidney Involvement ◽  
Autopsy Data ◽  
Extracorporeal Therapy

The mini-review presents modern data on the epidemiology, clinical and morphological aspects of kidney damage in COVID-19. Potential mechanisms of kidney involvement in the clinical picture of the disease may include cytokine damage, cross-organ damage, and systemic effects that determine the treatment strategy. These mechanisms are closely interrelated and are especially important for individuals undergoing extracorporeal therapy and kidney transplants. Autopsy data provide evidence of SARS-CoV-2 virus invasion into kidney tissue with damage to tubular epithelial cells and podocytes, and erythrocyte aggregation in persons with severe COVID-19. By including people with chronic kidney disease in planned COVID-19 research protocols, an evidence base for effective and safe treatments can be generated.

Effects on Erythrocyte Aggregation and Blood Coagulation from Iohexol Solutions with and without Sodium Chloride

1995 ◽  
Vol 36 (2) ◽  
pp. 204-209
Author(s):  
C.-M. Chai ◽  
T. Almén ◽  
P. Aspelin ◽  
L. Bååth
Keyword(s):  
Sodium Chloride ◽  
Blood Coagulation ◽  
Glucose Solution ◽  
Cell Aggregation ◽  
Test Solution ◽  
Erythrocyte Aggregation ◽  
Cell Aggregates ◽  
Red Cell ◽  
Red Blood Cell Aggregation ◽  
Osmotic Effects

Solutions of the nonionic monomeric contrast medium iohexol (300 mg I/ml) with and without added NaCl were investigated for effects on red blood cell aggregation and blood coagulation. Three volumes of a test solution were mixed in test tubes with one volume of human blood. During 30 min samples of the mixture were taken for investigation. Six test solutions were used: 1) iohexol, 2) iohexol+glucose 280 mM, 3) iohexol+NaCl 150 mM, 4) glucose 280 mM, 5) glucose 140 mM+NaCl 75 mM, 6) NaCl 150 mM. Test solutions with NaCl caused no aggregation. Test solutions without NaCl always caused macroscopic red cell aggregates. These aggregates always disappeared when saline was added to the sample. The macroscopic red cell aggregates could be dispersed to microscopic aggregates by shaking the test tubes. During the next 30 min macroscopic aggregates returned in the glucose solution but not in the iohexol solutions. In 30 min, blood mixed with iohexol solutions never coagulated while blood layered on top of the same iohexol solutions always coagulated. Blood mixed with solutions 5 and 6, both without iohexol, always coagulated. It is concluded that adding 150 mM NaCl to iohexol did not eliminate its ability to antico-agulate whole blood, but inhibited its ability to aggregate red cells. This inhibition was not caused by the osmotic effects of the added NaCl.

A Particle Dynamic Model of Red Blood Cell Aggregation Kinetics

2009 ◽  
Vol 37 (11) ◽  
pp. 2299-2309 ◽  
Author(s):  
Marianne Fenech ◽  
Damien Garcia ◽  
Herbert J. Meiselman ◽  
Guy Cloutier
Keyword(s):  
Blood Cell ◽  
Dynamic Model ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Aggregation Kinetics ◽  
Particle Dynamic ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

scholarly journals MYELODYSPLASTIC SYNDROMES AND IRON CHELATION THERAPY

2017 ◽  
Vol 9 (1) ◽  
pp. e2017021 ◽  
Author(s):  
Emanuele Angelucci ◽  
Silvana Anna Maria Urru ◽  
Federica Pilo ◽  
Alberto Piperno
Keyword(s):  
Iron Overload ◽  
Myelodysplastic Syndromes ◽  
Tissue Damage ◽  
Clinical Evidence ◽  
New Technologies ◽  
Iron Chelation ◽  
Organ Damage ◽  
Evidence Base ◽  
Toxic Damage ◽  
The Relationship

Over recent decades we have been fortunate to witness the advent of new technologies and of an expanded knowledge and application of chelation therapies to the benefit of patients with iron overload. However, extrapolation of learnings from thalassemia to the myelodysplastic syndromes (MDS) has resulted in a fragmented and uncoordinated clinical evidence base. We’re therefore forced to change our understanding of MDS, looking with other eyes to observational studies that inform us about the relationship between iron and tissue damage in these subjects. The available evidence suggests that iron accumulation is prognostically significant in MDS, but levels of accumulation historically associated with organ damage (based on data generated in the thalassemias) are infrequent. Emerging experimental data have provided some insight into this paradox, as our understanding of iron-induced tissue damage has evolved from a process of progressive bulking of organs through high-volumes iron deposition, to one of ‘toxic’ damage inflicted through multiple cellular pathways. Damage from iron may therefore occur prior to reaching reference thresholds, and similarly, chelation may be of benefit before overt iron overload is seen. In this review, we revisit the science and clinical evidence for iron overload in MDS to better characterise the iron overload phenotype in these patients, which is distinct from the classical transfusional and non-transfusional iron overload syndrome. We hope this will provide a conceptual framework to better understand the complex associations between anemia, iron and clinical outcomes, to accelerate progress in this area.

scholarly journals Сосудистая проницаемость и микрогемореология при системной склеродермии: возможности метода конъюнктивальной микроскопии

2020 ◽  
pp. 23-28
Keyword(s):  
Systemic Sclerosis ◽  
Blood Cell ◽  
Key Words ◽  
Vascular Permeability ◽  
Red Blood Cell ◽  
Cell Aggregation ◽  
Control Group ◽  
Age Group ◽  
Red Blood Cell Aggregation ◽  
Blood Cell Aggregation

In this article, the authors draw attention of readers to the capabilities of the conjunctival microscopy (CM) the method for studying the processes of vascular permeability and microhemorheology in patients with systemic sclerosis (SS). An original simultaneous examination of 48 patients with SS (mean age 51±1,7 years) and a comparable age group (4,74±2,3 years) of the control group of people without any diseases that might affect microcirculation (MC) by the CM-method was performed. The results demonstrated high informativeness of the CM-method in the diagnostics and assessment of vascular permeability and intravascular red blood cell aggregation (RBCA) in SS. The main changes in MC during SS revealed by the CM-method are the increase in vascular permeability and enhancement of RBCA in all types of microvessels. Key words: vascular permeability, intravascular red blood cell aggregation, conjunctival microscopy, systemic sclerosis.

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