scholarly journals Assessment of the physical development and metabolic status of children born to women with gestational diabetes

2021 ◽  
Vol 24 (4) ◽  
pp. 325-333
Author(s):  
A. S. Deynega (Masel) ◽  
A. S. Liskina ◽  
S. A. Valieva ◽  
I. L. Nikitina
Keyword(s):  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Perinatal Period ◽  
Physical Development ◽  
Control Group ◽  
Neonatal Hypoglycemia ◽  
Anthropometric Parameters ◽  
Postprandial Glycemia ◽  
Glucose And Lipid Metabolism ◽  
Comparison Groups

Backgraund: Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders found during pregnancy. Currently, it is relevant not only to search optimal target levels of glycemia during pregnancy, but also to study the ­effect of different glycemia levels on fetal development and further changes in glucose and lipid metabolism in children.Aims: To describe perinatal period, physical development and metabolic status of children born to women with GDM and different glucose levels during pregnancy.Materials and methods: The perinatal period features and anthropometric parameters at birth were evaluated in 300 children born to women with GDM and different levels of glycemia during pregnancy. Over the course two years, 141 children have been evaluated for physical development parameters and glucose and lipid metabolism. Fasting and postprandial glycemia was measured with glucometer for 14 days in 33 children aged 1 to 4 years.Results: The anthropometric parameters of children at birth did not differ from the parameters of the control group (p> 0.05) when during pregnancy fasting blood glucose was less than 5.1 mmol / l and 7.0 mmol / l 1 hour after a meal. The glycemia in women above this level was associated with an increase of frequency and risk of a body mass index, body mass / length ratio and head circumference “above average” in children at birth (p <0.05). With the dynamic control of anthropometric parameters up to 2 years, no differences between the comparison groups were obtained (p> 0.05). The change in metabolic parameters was represented by neonatal hypoglycemia in children of GDM group (GDM group — 23%, control group — 3.5%, p = 0.000002), the least risk of which occurred in group with the lowest fasting and postprandial glycemic values during pregnancy. Fasting glucose, and insulin levels, НOMA index, triglycerides and cholesterol, as well as monitoring fasting and postprandial glycemia for 14 days, were obtained no significant differences between the comparison groups of children (p> 0.05).Conclusions: The lowest risks of neonatal hypoglycemia and anthropometric deviations at birth were associated with the lowest glycemia levels during pregnancy, which correspond to the criteria of the Russian clinical guidelines.

scholarly journals Role of metabolic glycemic control in programming perinatal risk in gestational diabetes

2019 ◽  
pp. 218-225
Author(s):  
A. S. Masel ◽  
I. L. Nikitina ◽  
D. A. Yablunovskaya ◽  
V. Kh. Tekueva ◽  
P. V. Popova ◽  
...  
Keyword(s):  
Body Weight ◽  
Gestational Diabetes ◽  
Metabolic Control ◽  
Perinatal Period ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Group 4 ◽  
Average Body ◽  
Average Body Weight ◽  
Group 1

Purpose. Evaluate the effect of metabolic control of gestational diabetes mellitus (GDM) on the perinatal period course and anthropometric parameters of newborns.Materials and methods. 300 newborns were divided into 4 groups depending on the metabolic control of the mother. Group 1: fasting glycemia <5.1 mmol/L, 1 hour after meals <7.0 mmol/L (n = 50); Group 2: <5.3 mmol/L and <7.8 mmol/L (n = 90); Group 3: > 5.3 mmol/L and> 7.8 mmol/L (n = 46), respectively; Group 4: control (n = 114). The analysis of the perinatal period course was carried out, the anthropometric parameters were estimated according to the tables INTERGROWTH-21st.Results. Differences in the frequency of obstetric injuries, which risk is associated with «above average» body weight of the newborn (p = 0.04), were found between the GDM group and the control group (38.7 and 12.3%, respectively, p = 0.0000005). The risk of having a baby with «above average» body weight (Group 1/Group 4, OR = 1.9, p = 0.1; Gr. 2/Gr. 4, OR = 2.6, and Gr. 3/Gr. 4, OR = 3.7, p <0.05), the ratio of weight/length (Gr. 1/Gr. 4, OR = 0.9, p = 0.9; Gr. 2/Gr. 4, OR = 3.6, and Gr. 3/Gr. 4, OR = 4.9, p <0.05) and head circumference (G.1/Gr. 4, OR = 1.1, p = 0.6; Gr. 2/Gr. 4, OR = 2.5, and Gr. 3/Gr. 4, OR = 2.9, p <0.05) was higher in Groups 2 and 3 than in Group 4. In the early neonatal period with GDM, hypoglycemia was more common than in the control Group 4. The lowest risk was in Group 1 (Gr. 1/Gr. 4, OR = 4.8; Gr. 2/Gr. 4, OR = 6.7; Gr. 3/Gr. 4, OR = 7.9, р < 0,05).Conclusions. Group 1 showed the lowest frequency and risk of adverse effects, which meets the control criteria of the Russian consensus.

scholarly journals Effects of Marine Drug Propylene Glycol Alginate Sodium Sulfate on Glucose and Lipid Metabolism in Mice

2021 ◽  
Vol 58 (2) ◽  
pp. 150-154
Author(s):  
Haiyue Liang ◽  
Qun Liu ◽  
Yonghong Xiu
Keyword(s):  
Lipid Metabolism ◽  
Blood Glucose ◽  
Sodium Sulfate ◽  
Glycosylated Hemoglobin ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Control Group ◽  
Distilled Water ◽  
Glucose And Lipid Metabolism ◽  
Propylene Glycol Alginate

Previous studies have shown that marine drug propylene glycol alginate sodium sulfate (PSS) plays important roles in human diseases. This study mainly explored the effects of PSS on hyperglycemia and hyperlipidemia in diabetic db/db mouse models. The db/db mice were randomly divided into 5 groups (n=12), which were model control group (distilled water), positive control group (metformin), PSS low, medium, and high dose groups (PSS25, PSS50, PSS100) and normal control group (C57/BL, distilled water). The mice in each group had free diet and water for 90 days. During the experiment, food intake was recorded every day and body weight was recorded weekly. In addition, fasting blood glucose and glycosylated hemoglobin levels were measured regularly. Finally, the contents of triglyceride (TG), low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c) and total cholesterol (TC) in the serum of mice were determined. PSS can significantly reduce fasting blood glucose and glycosylated hemoglobin levels in db/db mice, and improve insulin sensitivity. Moreover, PSS can reduce the fat accumulation of db/db mice and significantly improve the blood lipid level of db/db mice. PSS can significantly improve the symptoms of glucose and lipid metabolism disorders in db/db mice.

PHYSICAL DEVELOPMENT OF CHILDREN OF PRESCHOOL AGE

2020 ◽  
Vol 18 (Suppl.1) ◽  
pp. 903-907
Author(s):  
T. Traykova
Keyword(s):  
Body Weight ◽  
Physical Development ◽  
Preschool Age ◽  
Chest Circumference ◽  
Control Group ◽  
Physical Culture ◽  
Educational Content ◽  
Anthropometric Parameters ◽  
Basic Parameters ◽  
Experimental Group

Purpose of the study: To register the dynamics of the basic parameters of the physical development of children from the fourth preparatory group, as a result of the implementation of an enriched educational content in physical culture pedagogical situations. 54 girls and 67 boys were investigated and measured twice – at the beginning and at the end of the pedagogical experiment. Anthropometric parameters assessed: height, body weight, chest circumference. Methods: Theoretical analysis, pedagogical experiment, anthropometry, statistical methods. Results: Height: the highest increase in that parameter was found in the Experimental Group of boys and the smallest one – in girls of the Control group. Body weight: boys from the EG showed the highest increase, while the lowest one was found in boys from CG. Chest circumference: the greatest increase was measured in CG of, while the smallest one in the EG of girls. In conclusion, we can underline that the changes in the anthropometric parameters are due both to the laws of biological developments of children at that age, as well as to the applied enriched educational content.

Prepubertal Children Exposed to Maternal Gestational Diabetes Have Latent Low-Grade Inflammation

2018 ◽  
Vol 90 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Leena Antikainen ◽  
Jarmo Jääskeläinen ◽  
Henrikki Nordman ◽  
Raimo Voutilainen ◽  
Hanna Huopio
Keyword(s):  
Blood Pressure ◽  
Lipid Metabolism ◽  
Gestational Diabetes ◽  
Low Grade ◽  
Prepubertal Children ◽  
Glucose And Lipid Metabolism ◽  
The Metabolic Syndrome ◽  
Increased Risk ◽  
Hs Crp ◽  
Low Grade Inflammation

Background: Maternal gestational diabetes mellitus (GDM) and overweight are associated with an increased risk of obesity and the metabolic syndrome in the adult offspring. We studied the influence of maternal GDM on prepubertal children’s height, weight, body mass index (BMI), lipid and glucose metabolism, and low-grade inflammation. Methods: A cohort of 135 prepubertal Caucasian children (age range 4.4–9.7 years) was studied in a controlled cross-sectional study. Seventy-seven children had been exposed to maternal GDM, and 58 children born after a normal pregnancy served as controls. The outcomes were height, weight, BMI, blood pressure, and biochemical markers of glucose and lipid metabolism and inflammation. Results: There were no differences in height, weight, BMI, fasting serum insulin, plasma glucose, lipids, or blood pressure between the study groups. However, high-sensitivity C-reactive protein (hs-CRP) was significantly higher in the GDM group than in the controls (p = 0.001). Conclusions: Higher hs-CRP as a marker of low-grade inflammation was detected in prepubertal children exposed to maternal GDM, but no differences were seen in height, weight, BMI, or markers of glucose and lipid metabolism compared to control children. This finding may reflect an ongoing process of metabolic changes in children born after a GDM pregnancy.

scholarly journals Evaluation of physical development and state of health in ART-conceived children with retinopathy of prematurity: a population, one-time study

2020 ◽  
Vol 1 (2) ◽  
pp. 18-24
Author(s):  
Anna N. Plaksina ◽  
Olga P. Kovtun ◽  
Elena A. Stepanova ◽  
Elena A. Dugina ◽  
Valeriya A. Makutina ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
High Body Mass Index ◽  
Physical Development ◽  
Control Group ◽  
Time Study ◽  
State Of Health ◽  
Anthropometric Parameters ◽  
Increased Risk ◽  
High Bmi

Background. Assisted reproductive technology (ART) poses an increased risk for preterm birth. Women with high body mass index, who opted for ART, have the elevated levels of the insulin-like growth factor 1 (IGF-1) which is involved in the development of pathologic vasoproliferation in retinopathy of prematurity (ROP). Children with ROP are at increased risk for co-morbid pathology.Objective. The study aims at evaluating physical development and state of health in ART-conceived children with ROP.Methods. This is a population, one-time study to evaluate physical development and state of health in children with ROP. Statistical analysis was carried out using the SPSS v. 14.0 software package, and included determination of normality (Shapiro-Wilk test), descriptive statistics (М — mean value, σ — standard deviation of the mean), and non-parametric methods (Mann-Whitney U-test, Z-test of a proportion).Results. The anthropometric characteristics of infants with ROP did not differ from those in spontaneously conceived babies. Children with ROP born to mothers with high BMI had lower anthropometric parameters (p < 0.001) and required longer dynamic follow-up while being diagnosed as “risk group for ROP”. A significantly higher number (a total of 65) of nosologies has been revealed in the ART-conceived infants. Statistically significant predominant diagnoses (p = 0.0047) included dwarfism and obesity despite the absence of anthropometric differences at birth (p = 0.123).Conclusion. The ART-conceived infants with ROP at birth do not differ in their physical development from infants in the general population, however, on prospective follow-up the former developed dwarfism and obesity significantly more often. Children born to mothers with high BMI have significantly lower parameters of weight and height, and require longer follow-up period while being diagnosed with ROP. The ART-conceived infants with ROP have co-morbid pathology significantly more often than children with ROP in the control group.

scholarly journals Effects of Olanzapine on Bone Mineral Density, Glucose, and Lipid Metabolism in Schizophrenia Patients

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Mining Liang ◽  
Beibei Zhang ◽  
Lu Deng ◽  
Rong Xu ◽  
Haishan Wu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lipid Metabolism ◽  
Bone Mineral ◽  
Treated Group ◽  
Control Group ◽  
Mineral Density ◽  
Insulin Levels ◽  
Glucose And Lipid Metabolism ◽  
History Of ◽  
Drug Naïve

Aim. To explore whether olanzapine alters bone mineral density (BMD), glucose, and lipid metabolism in schizophrenia patients. Methods. This study enrolled 150 patients diagnosed with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), including 101 patients who had over 6-month history of olanzapine use (olanzapine-treated group) and 49 patients who had no history of antipsychotic use (first episode drug-naïve group). 71 subjects with age- and gender-matched healthy volunteers (healthy control group) were also enrolled. All study subjects were from the Chinese Han population recruited in the Second Xiangya Hospital from January 2015 to January 2016. Demographic and physical examination data were collected from all subjects. BMD measurements of the radius+ulna, lumbar spine (L1-4), and left hip were performed via a dual-energy X-ray absorptiometry test. Serum lipid, glucose, and insulin levels were analyzed. Psychopathology profiles in all enrolled schizophrenia patients were assessed by the positive and negative syndrome scale (PANSS). Results. There was no significant difference in age, gender, activity intensity, smoking, or drinking among the three groups. In the majority of evaluated bone areas, the BMD values in olanzapine-treated or drug-naïve patients were lower than those in the control group. However, BMD values in the drug-naïve group showed no difference or even decreased as compared with those in the olanzapine-treated group. Among the olanzapine-treated group, although not observed in every tested region, a positive correlation was found of BMI or HOMA-IR with BMD. Stepwise multiple linear regression analysis revealed independent predictive factors associated with BMD in groups/subgroups of schizophrenia patients or healthy controls, including gender, TG, BMI, body weight, HOMA-IR, and FBG. Conclusions. Schizophrenia, but not the long-term use of olanzapine, correlates with BMD loss in schizophrenia patients. Elevated BMI, TG, FBG, and insulin levels might protect these patients against bone degradation. Our work provides new information to improve the understanding, prevention, and treatment of osteoporosis in schizophrenia patients.

scholarly journals Correlation of maternal serum fetuin/alpha2-HS-glycoprotein concentration with maternal insulin resistance and anthropometric parameters of neonates in normal pregnancy and gestational diabetes

2002 ◽  
pp. 243-248 ◽  
Author(s):  
L Kalabay ◽  
K Cseh ◽  
A Pajor ◽  
E Baranyi ◽  
GM Csakany ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gestational Diabetes ◽  
Pregnant Women ◽  
Normal Pregnancy ◽  
Tnf Alpha ◽  
Control Group ◽  
Anthropometric Parameters ◽  
Necrosis Factor Alpha ◽  
C Peptide ◽  
Glucose Ratio

OBJECTIVE: Human fetuin/alpha(2)-HS-glycoprotein (AHSG) is a 49 kDa serum and tissue protein which is a natural inhibitor of insulin receptor signaling. We investigated serum AHSG levels during pregnancy and whether the protein is involved in insulin resistance observed in healthy pregnant women and patients with gestational diabetes. DESIGN: One hundred and four healthy pregnant women and 23 of their neonates, 30 patients with gestational diabetes and their neonates and 30 healthy age-matched non-pregnant females as a control group were investigated in a case-control cross-sectional study. METHODS: Serum AHSG was determined by radial immunodiffusion. RESULTS: We observed an increase of serum AHSG concentration in the second and third trimesters. Gestational diabetes patients had significantly higher AHSG levels than healthy pregnant women and non-pregnant controls. There was a highly significant positive correlation between serum AHSG concentration and indirect parameters of insulin resistance, i.e. tumor necrosis factor-alpha (TNF-alpha), leptin, C-peptide and C-peptide/blood glucose ratio. There was also a negative correlation between maternal AHSG, TNF-alpha, leptin levels and head circumference, body length and body weight of newborns. CONCLUSION: AHSG, TNF-alpha and leptin may contribute to insulin resistance during normal pregnancy and gestational diabetes. AHSG along with these cytokines may also negatively regulate neonatal skeletal development.

scholarly journals Evaluation of physical development and state of health in ART-conceived children with retinopathy of prematurity: a population, one-time study

2020 ◽  
Vol 1 (2) ◽  
pp. 18-24
Author(s):  
Anna N. Plaksina ◽  
Olga P. Kovtun ◽  
Elena A. Stepanova ◽  
Elena A. Dugina ◽  
Valeriya A. Makutina ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
High Body Mass Index ◽  
Physical Development ◽  
Control Group ◽  
Time Study ◽  
State Of Health ◽  
Anthropometric Parameters ◽  
Increased Risk ◽  
High Bmi

Background. Assisted reproductive technology (ART) poses an increased risk for preterm birth. Women with high body mass index, who opted for ART, have the elevated levels of the insulin-like growth factor 1 (IGF-1) which is involved in the development of pathologic vasoproliferation in retinopathy of prematurity (ROP). Children with ROP are at increased risk for co-morbid pathology.Objective. The study aims at evaluating physical development and state of health in ART-conceived children with ROP.Methods. This is a population, one-time study to evaluate physical development and state of health in children with ROP. Statistical analysis was carried out using the SPSS v. 14.0 software package, and included determination of normality (Shapiro-Wilk test), descriptive statistics (М — mean value, σ — standard deviation of the mean), and non-parametric methods (Mann-Whitney U-test, Z-test of a proportion).Results. The anthropometric characteristics of infants with ROP did not differ from those in spontaneously conceived babies. Children with ROP born to mothers with high BMI had lower anthropometric parameters (p < 0.001) and required longer dynamic follow-up while being diagnosed as “risk group for ROP”. A significantly higher number (a total of 65) of nosologies has been revealed in the ART-conceived infants. Statistically significant predominant diagnoses (p = 0.0047) included dwarfism and obesity despite the absence of anthropometric differences at birth (p = 0.123).Conclusion. The ART-conceived infants with ROP at birth do not differ in their physical development from infants in the general population, however, on prospective follow-up the former developed dwarfism and obesity significantly more often. Children born to mothers with high BMI have significantly lower parameters of weight and height, and require longer follow-up period while being diagnosed with ROP. The ART-conceived infants with ROP have co-morbid pathology significantly more often than children with ROP in the control group.

scholarly journals Physical development of primary school-age orphan boys with mental retardation

2020 ◽  
Vol 28 (1) ◽  
pp. 30-36
Author(s):  
Elizaveta S. Ovcharenko ◽  
Vera V. Fefelova ◽  
Edward V. Kasparov ◽  
Tatyana P. Koloskova ◽  
Olga V. Smirnova ◽  
...  
Keyword(s):  
Mental Retardation ◽  
Primary School ◽  
Sharp Decrease ◽  
Well Being ◽  
Physical Development ◽  
Residential Home ◽  
Control Group ◽  
School Age ◽  
Anthropometric Parameters ◽  
Primary School Age

Mental retardation is considered one of the most common pathologies of children's mental development. Parameters of physical development are actively used as informative markers of health status, social and hygienic well-being both in norm and in various pathologies. At the same time, not enough attention is given to orphans with intellectual disabilities in this context. Aim. To study the parameters of physical development in primary school-age boys with mental retardation brought up in a specialized orphanage. Materials and Methods. 34 Boys (7-11 years old) were examined. Of these, 20 children with a diagnosis of moderate mental retardation (F71) were brought up in a specialized children's home for mentally retarded children (without parental care). The control group included 14 intellectually healthy boys of the same age who were brought up in an orphanage of a physiological type. Anthropometric parameters (body length, body weight, chest and head circumference, cross-section diameter of the chest), sthenia index, level of physical development, and Quetelet II index were studied. Results. The data obtained indicate a sharp decrease in parameters that characterize physical development of orphan boys with mental retardation in comparison with intellectually healthy orphan boys. Since children were in the same social and hygienic conditions, the identified features may be due to the combined influence of the presence of deviations in the intellectual deve-lopment of children and upbringing in a residential home. Conclusion. The results obtained determine the need for closer medical and hygienic support for orphans with mental retardation.

scholarly journals Nutritional status of children with infantile cerebral palsy

2021 ◽  
Vol 1 (1) ◽  
pp. 82-88
Author(s):  
Z. F. Mavlyanova
Keyword(s):  
Cerebral Palsy ◽  
Nutritional Status ◽  
Group Versus ◽  
Physical Development ◽  
Control Group ◽  
Spastic Diplegia ◽  
Fatty Tissue ◽  
Healthy Children ◽  
Anthropometric Parameters ◽  
Rate Of Increase

Purpose of the study. Reveal the typical disorders of nutritional status and identify characteristic disorders of the physical development of patients with cerebral palsy.Materials and methods. The features of the nutritional status of 128 children with various forms of cerebral palsy and 20 healthy children aged 3 to 14 years were studied. Physical development was assessed using standard public anthropometric parameters: weight, height, measurement of the circumference of the upper and lower extremities, determination of the thickness of the skin-fat fold using an electronic caliper according to the Durnin-Womersly method, as well as the calculated indices of Rohrer, Pigne, Vervac.Results. In children with cerebral palsy in compare with healthy children a decrease in the rate of increase in muscle mass, the absence of significant changes in the severity of subcutaneous fatty tissue and various variants of disharmonious types of development with characteristic anthropometric features were determined (85.9% in the main group versus 5% in the control group; Р <0.001). The most prominent disorders of the nutritional status were observed in patients with double hemiplegia and hyperkinetic form of cerebral palsy and were significant in relation to patients with hemiparetic, atonic-astatic forms and spastic diplegia (P <0.05–0.001)

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