scholarly journals Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice

2021 ◽  
Vol 12 (2) ◽  
pp. 371
Author(s):  
Huijuan Shu ◽  
Zhongxin Guo ◽  
Xiangren Chen ◽  
Shuya Qi ◽  
Xinxin Xiong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cognitive Deficits ◽  
Intracerebral Transplantation

Icariin improves cognitive deficits and activates quiescent neural stem cells in aging rats

2012 ◽  
Vol 142 (3) ◽  
pp. 746-753 ◽  
Author(s):  
Bin Wu ◽  
Yang Chen ◽  
Jianhua Huang ◽  
You Ning ◽  
Qin Bian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Cognitive Deficits ◽  
Aging Rats

scholarly journals Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X Syndrome

2022 ◽  
Author(s):  
Sahar Javadi ◽  
Yue Li ◽  
Jie Shen ◽  
Lucy Zhao ◽  
Yao Fu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Young Adult ◽  
Neural Stem Cells ◽  
Fragile X Syndrome ◽  
Cognitive Deficits ◽  
Fragile X ◽  
Therapeutic Effects ◽  
Mature Adult ◽  
Mature Adults ◽  
Deficient Mice

Background: Fragile X syndrome (FXS), the most prevalent inherited intellectual disability and one of the most common monogenic form of autism, is caused by a loss of FMRP translational regulator 1 (FMR1). We have previously shown that FMR1 represses the levels and activities of ubiquitin ligase MDM2 in young adult FMR1-deficient mice and treatment by a MDM2 inhibitor Nutlin-3 rescues both hippocampal neurogenic and cognitive deficits in FMR1-deficient mice when analyzed shortly after the administration. However, it is unknown whether Nutlin-3 treatment can have long-lasting therapeutic effects. Methods: We treated 2-month-old young adult FMR1-deficient mice with Nutlin-3 for 10 days and then assessed the persistent effect of Nutlin-3 on both cognitive functions and adult neurogenesis when mice were 6-month-old mature adults. To investigate the mechanisms underlying persistent effects of Nutlin-3, we analyzed proliferation and differentiation of neural stem cells isolated from these mice and assessed the transcriptome of the hippocampal tissues of treated mice. Results: We found that transient treatment with Nutlin-3 of 2-month-old young adult FMR1-deficient mice prevents the emergence of neurogenic and cognitive deficits in mature adult FXS mice at 6-month of age. We further found that the long-lasting restoration of neurogenesis and cognitive function might not be mediated by changing intrinsic properties of adult neural stem cells. Transcriptomic analysis of the hippocampal tissue demonstrated that transient Nultin-3 treatment leads to significant expression changes in genes related to extracellular matrix, secreted factors, and cell membrane proteins in FMR1-deficient hippocampus.

scholarly journals Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S487
Author(s):  
Seonghee Jung ◽  
Seongwon Choe ◽  
Hanwoong Woo ◽  
Hyeonjeong Jeong ◽  
Hyun-Kyu An ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Chronic Stress ◽  
Cognitive Deficits ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis

scholarly journals Amelioration of Penetrating Ballistic-Like Brain Injury Induced Cognitive Deficits after Neuronal Differentiation of Transplanted Human Neural Stem Cells

2017 ◽  
Vol 34 (11) ◽  
pp. 1981-1995 ◽  
Author(s):  
Markus S. Spurlock ◽  
Aminul I. Ahmed ◽  
Karla N. Rivera ◽  
Shoji Yokobori ◽  
Stephanie W. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Brain Injury ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Cognitive Deficits ◽  
Human Neural Stem Cells

scholarly journals Histopathological and Behavioral Improvement of Murine Mucopolysaccharidosis Type VII by Intracerebral Transplantation of Neural Stem Cells

2006 ◽  
Vol 13 (3) ◽  
pp. 548-555 ◽  
Author(s):  
Yasuyuki Fukuhara ◽  
Xiao-Kang Li ◽  
Yusuke Kitazawa ◽  
Masumi Inagaki ◽  
Kentaro Matsuoka ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Mucopolysaccharidosis Type ◽  
Intracerebral Transplantation ◽  
Behavioral Improvement
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