scholarly journals MicroRNAs or Long Noncoding RNAs in Diagnosis and Prognosis of Coronary Artery Disease

2019 ◽  
Vol 10 (2) ◽  
pp. 353 ◽  
Author(s):  
Yuan Zhang ◽  
Lei Zhang ◽  
Yu Wang ◽  
Han Ding ◽  
Sheng Xue ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Diagnosis And Prognosis ◽  
Artery Disease

Differential Expression of Long Noncoding RNAs in Patients with Coronary Artery Disease

2021 ◽  
pp. 1-7
Author(s):  
Hamide Saygili ◽  
Ibrahim Bozgeyik ◽  
Onder Yumrutas ◽  
Erdal Akturk ◽  
Haydar Bagis
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Operating Characteristic ◽  
Obstructive Coronary Artery Disease ◽  
Noncoding Rnas ◽  
Diagnostic Value ◽  
Long Noncoding Rnas ◽  
Receiver Operating Characteristic Curves ◽  
Cardiovascular Pathologies ◽  
Artery Disease

Long noncoding RNAs (lncRNAs) constitute the largest class of noncoding RNAs and play significant roles in the development of cardiovascular pathologies. In the present study, we aimed to evaluate whether 4 candidate lncRNAs – MIAT, MEG3, MALAT1, and MCM3AP-AS1 – have distinct expression levels in patients with obstructive coronary artery disease (CAD) and reveal the diagnostic and therapeutic potentials of these lncRNAs for CAD. A total of 90 patients who subjected to coronary angiography were enrolled. Relative expression of lncRNAs were assayed using qRT-PCR methodology. As a result, <i>MIAT</i> was downregulated, while <i>MEG3</i> was upregulated in CAD patients. Receiver operating characteristic curves demonstrated that these lncRNAs have a high potential to provide sensitive and specific diagnosis of CAD. The calculated area under curve levels indicated that MIAT and MEG3 have high diagnostic value for detecting the presence of significant CAD. However, <i>MALAT1</i> and <i>MCM3AP-AS1</i> levels were not sufficiently reliable for CAD development in our cases. Here, we demonstrate that <i>MIAT</i> and <i>MEG3</i> were differentially expressed in our patients and might be promising biomarkers and therapeutic targets for CAD. These results indicate that <i>MIAT</i> and <i>MEG3</i> could play chief roles in CAD development.

MicroRNAs and Long Noncoding RNAs in Coronary Artery Disease

2020 ◽  
Vol 38 (4) ◽  
pp. 601-617
Author(s):  
Lukasz Zareba ◽  
Alex Fitas ◽  
Marta Wolska ◽  
Eva Junger ◽  
Ceren Eyileten ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas ◽  
Artery Disease

A GENETIC AND METABOLIC STUDY OF A FAMILY WITH HYPERLIPEMIA

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 566-578
Author(s):  
George Bialkin ◽  
Saul Zucker ◽  
Burton S. Sklarin ◽  
Kurt Hirschhorn ◽  
Murray Davidson
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Lipid Levels ◽  
Metabolic Study ◽  
Diagnosis And Prognosis ◽  
The Family ◽  
Artery Disease ◽  
Pathologic Physiology ◽  
Relationship Of ◽  
The Relationship

A family consisting of a mother and father, heterozygous for idiopathic hyperlipemia, and their four offspring, one heterozygous and three homozygous for the disease, are described. In addition, a fifth child who is heterozygous, born of same mother but by another incompletely studied father, is presented. The genetics of the disease in this family, and also in the general population, with emphasis on diagnosis and prognosis in heterozygotes is discussed. The interrelationship of various lipid components in serum and their metabolism are briefly reviewed. The possible defective mechanisms in hyperlipemia, the techniques for deciding on the specific defect, and their application to the members of this family are reviewed. The effect of heparin, nicotinic acid, and fat-free diets in the homozygous members of the family are evaluated and their therapeutic applications are discussed. The symptomatology, possible pathologic physiology, relationship to lipid levels in serum and occurrence of abdominal crises in some of the homozygous members of this family are pointed out. The relationship of cholesterol and triglyceride levels in serum to, and the significance of, idiopathic hyperlipemia in the genesis of, atherosclerosis and coronary artery disease is elucidated.

Assessment of coronary artery disease: imaging-guided management and therapy

ESC CardioMed ◽  
2018 ◽  
pp. 585-589
Author(s):  
Juhani Knuuti ◽  
S. Richard Underwood ◽  
Antti Saraste
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Myocardial Perfusion ◽  
Single Photon ◽  
Photon Emission ◽  
Cost Effective ◽  
Absolute Quantification ◽  
Diagnosis And Prognosis ◽  
Positron Emission ◽  
Artery Disease

Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) myocardial perfusion scintigraphy (MPS) have been validated for the diagnosis and prognosis of cardiac disease and the techniques. MPS is safe and cost-effective in a wide variety of clinical settings. The evidence for the SPECT MPS technique is broad and supports its use. Although less widely available, PET is a very accurate technique in detecting myocardial ischaemia. It allows absolute quantification of myocardial perfusion that will provide additional guidance for the therapy of coronary artery disease.

Comparison of treadmill scores with physician estimates of diagnosis and prognosis in patients with coronary artery disease

2002 ◽  
Vol 143 (4) ◽  
pp. 650-658 ◽  
Author(s):  
Michael Lipinski ◽  
Victor Froelicher ◽  
Eddie Atwood ◽  
Anna Tseitlin ◽  
Barry Franklin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diagnosis And Prognosis ◽  
Artery Disease
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