scholarly journals N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model

2018 ◽  
Vol 9 (4) ◽  
pp. 664 ◽  
Author(s):  
Aurore Marie ◽  
Johann Meunier ◽  
Emilie Brun ◽  
Susanna Malmstrom ◽  
Veronique Baudoux ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Memory Impairment ◽  
Samp8 Mouse ◽  
Age Related ◽  
Age Related Hearing Loss

SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss

2014 ◽  
Vol 51 ◽  
pp. 8-14 ◽  
Author(s):  
Hao Xiong ◽  
Min Dai ◽  
Yongkang Ou ◽  
Jiaqi Pang ◽  
Haidi Yang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Auditory Cortex ◽  
Sirt1 Expression ◽  
Age Related ◽  
Age Related Hearing Loss

Oxidative Stress, Inflammation, and Autophagic Stress as the Key Mechanisms of Premature Age-Related Hearing Loss in SAMP8 Mouse Cochlea

2012 ◽  
Vol 16 (3) ◽  
pp. 263-274 ◽  
Author(s):  
Julien Menardo ◽  
Yong Tang ◽  
Sabine Ladrech ◽  
Marc Lenoir ◽  
François Casas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hearing Loss ◽  
Samp8 Mouse ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals RNA-seq analysis of potential lncRNAs for age-related hearing loss in a mouse model

Aging ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 7491-7510 ◽  
Author(s):  
Tong Zhao ◽  
Xiuzhen Liu ◽  
Zehua Sun ◽  
Jinjin Zhang ◽  
Xiaolin Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Rna Seq ◽  
Age Related ◽  
Age Related Hearing Loss

Differential Expression of Bcl-2 in the Cochlea and Auditory Cortex of a Mouse Model of Age-Related Hearing Loss

2016 ◽  
Vol 21 (5) ◽  
pp. 326-332 ◽  
Author(s):  
Qiuhong Huang ◽  
Hao Xiong ◽  
Haidi Yang ◽  
Yongkang Ou ◽  
Zhigang Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mouse Model ◽  
Auditory Cortex ◽  
Hair Cells ◽  
Spiral Ganglion ◽  
Outer Hair Cells ◽  
Protective Effects ◽  
Age Related ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

Bcl-2, the first gene shown to be involved in apoptosis, is a potent regulator of cell survival and known to have protective effects against a variety of age-related diseases. However, the possible relationship between hearing and Bcl-2 expression in the cochlea or auditory cortex of C57BL/6 mice, a mouse model of age-related hearing loss, is still unknown. Using RT-PCR, immunohistochemistry, and Western blot analysis, our results show that Bcl-2 is strongly expressed in the inner hair cells and spiral ganglion neurons of young mice. In addition, moderate Bcl-2 expression is also detected in the outer hair cells and in the neurons of the auditory cortex. A significant reduction of Bcl-2 expression in the cochlea or auditory cortex is also associated with elevated hearing thresholds and hair cell loss during aging. The expression pattern of Bcl-2 in the peripheral and central auditory systems suggests that Bcl-2 may play an important role in auditory function serving as a protective molecule against age-related hearing loss.

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