scholarly journals Age-dependent Muscle Adaptation after Chronic Stretch-shortening Contractions in Rats

2016 ◽  
Vol 7 (1) ◽  
pp. 1 ◽  
Author(s):  
Erik P. Rader ◽  
Kayla N. Layner ◽  
Alyssa M. Triscuit ◽  
Robert D. Chetlin ◽  
James Ensey ◽  
...  
2008 ◽  
Vol 33 (6) ◽  
pp. 1181-1191 ◽  
Author(s):  
Brent A. Baker ◽  
Melinda S. Hollander ◽  
Robert R. Mercer ◽  
Michael L. Kashon ◽  
Robert G. Cutlip

This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.


2005 ◽  
Vol 37 (Supplement) ◽  
pp. S318
Author(s):  
Robert G. Cutlip ◽  
Brent A. Baker ◽  
Ken B. Geronilla ◽  
Mike L. Kashon ◽  
Zsolt Murlasits ◽  
...  

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S318
Author(s):  
Robert G. Cutlip ◽  
Brent A. Baker ◽  
Ken B. Geronilla ◽  
Mike L. Kashon ◽  
Zsolt Murlasits ◽  
...  

Author(s):  
Gladys Harrison

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.


2007 ◽  
Vol 177 (4S) ◽  
pp. 411-412
Author(s):  
Javier Miller ◽  
Angela Smith ◽  
Kris Gunn ◽  
Erik Kouba ◽  
Eric M. Wallen ◽  
...  

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