scholarly journals A Prototyping of Penile Tumescence Continuous Observation Device

2020 ◽  
Vol 9 (0) ◽  
pp. 167-171
Author(s):  
Seiji Matsumoto ◽  
Yasuhito Takeuchi
Keyword(s):  
Continuous Observation ◽  
Penile Tumescence

scholarly journals An in vivo model allowing continuous observation of human vascular formation in the same animal over time

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yohei Tsukada ◽  
Fumitaka Muramatsu ◽  
Yumiko Hayashi ◽  
Chiaki Inagaki ◽  
Hang Su ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Blood Vessels ◽  
Human Blood ◽  
Molecular Mechanisms ◽  
Human Tumor ◽  
Continuous Observation ◽  
In Vivo Models ◽  
Cranial Window ◽  
Pathological Conditions

AbstractAngiogenesis contributes to numerous pathological conditions. Understanding the molecular mechanisms of angiogenesis will offer new therapeutic opportunities. Several experimental in vivo models that better represent the pathological conditions have been generated for this purpose in mice, but it is difficult to translate results from mouse to human blood vessels. To understand human vascular biology and translate findings into human research, we need human blood vessel models to replicate human vascular physiology. Here, we show that human tumor tissue transplantation into a cranial window enables engraftment of human blood vessels in mice. An in vivo imaging technique using two-photon microscopy allows continuous observation of human blood vessels until at least 49 days after tumor transplantation. These human blood vessels make connections with mouse blood vessels as shown by the finding that lectin injected into the mouse tail vein reaches the human blood vessels. Finally, this model revealed that formation and/or maintenance of human blood vessels depends on VEGFR2 signaling. This approach represents a useful tool to study molecular mechanisms of human blood vessel formation and to test effects of drugs that target human blood vessels in vivo to show proof of concept in a preclinical model.

Haemorheological Effects on Thrombocyte Adhesion and Aggregation Found Under Controlled Flow Conditions

1979 ◽  
Author(s):  
P.D. Richardson
Keyword(s):  
Rate Of Change ◽  
Continuous Observation ◽  
Flow Conditions ◽  
Wide Range ◽  
Stream Migration ◽  
Local Shear ◽  
Videotape Recording ◽  
Controlled Flow ◽  
A Site

Thrombocyte adhesion and aggregation in a vessel or on a chamber wall can be measured most readily if the flow is controlled and steady, and continuous observation is used. Videotape recording is very helpful for subsequent quantification of the dynamics. The adhesion of each thrombocyte can occur for a finite time interval:this interval has been observed to have a wide range. Platelets which escape often leave open a site which attracts other platelets preferentially. The rate of change of adhesion density (platelets/mm2) is affected by the local shear rate and the shear history upstream. Aggregation is affected similarly, and also proceeds with some platelet turnover. The role of erythrocytes in facilitating cross-stream migration of thrombocytes (which can enhance the growth rate of large thrombi) appears due in part to convective flow fields induced by the motion of erythrocytes in a shear flow, which can be demonstrated theoretically and experimentally. Observations of the phenomenlogy of adhesion and aggregation under controlled flow conditions and comparison with fLu id-dynamically based theory allows representation in terras of a small number of parameters with prospects of prediction of behaviour over a wide range of haemodynamic conditions; biochemical changes lead to changes in values of the parameters, so that activating agents and inhibiting agents modify values in different directions.

A continuous observation of photon emission

1991 ◽  
Vol 29 (2) ◽  
pp. 213-225 ◽  
Author(s):  
V.P. Belavkin ◽  
P. Staszewski
Keyword(s):  
Photon Emission ◽  
Continuous Observation

scholarly journals A quantum particle undergoing continuous observation

1989 ◽  
Vol 140 (7-8) ◽  
pp. 359-362 ◽  
Author(s):  
V.P. Belavkin ◽  
P. Staszewski
Keyword(s):  
Quantum Particle ◽  
Continuous Observation
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