scholarly journals Leydig cell clustering and Reinke crystal distribution in relation to hormonal function in adult patients with testicular dysgenesis syndrome (TDS) including cryptorchidism

HORMONES ◽  
2017 ◽  
Vol 15 (4) ◽  
pp. 518-526 ◽  
Author(s):  
Rikke R Soerensen ◽  
Trine H Johannsen ◽  
Niels E Skakkebaek ◽  
Ewa Rajpert-De Meyts
Keyword(s):  
Leydig Cell ◽  
Adult Patients ◽  
Testicular Dysgenesis Syndrome ◽  
Hormonal Function ◽  
Cell Clustering ◽  
Testicular Dysgenesis

Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the testis

Apmis ◽  
2003 ◽  
Vol 111 (1) ◽  
pp. 1-11 ◽  
Author(s):  
NIELS E. SKAKKEBAEK ◽  
METTE HOLM ◽  
CHRISTINA HOEI-HANSEN ◽  
NIELS JORGENSEN ◽  
EWA RAJPERT-DE MEYTS
Keyword(s):  
Adult Patients ◽  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

scholarly journals Testicular Dysgenesis Syndrome and Leydig Cell Function

2008 ◽  
Vol 102 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Ulla Nordström Joensen ◽  
Niels Jørgensen ◽  
Ewa Rajpert-De Meyts ◽  
Niels Erik Skakkebaek
Keyword(s):  
Leydig Cell ◽  
Cell Function ◽  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis ◽  
Leydig Cell Function

scholarly journals Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence

2009 ◽  
Vol 20 (3) ◽  
pp. 139-145 ◽  
Author(s):  
Guo-Xin Hu ◽  
Qing-Quan Lian ◽  
Ren-Shan Ge ◽  
Dianne O. Hardy ◽  
Xiao-Kun Li
Keyword(s):  
Leydig Cell ◽  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

scholarly journals Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: a role for estradiol

Reproduction ◽  
2012 ◽  
Vol 144 (6) ◽  
pp. 747-761 ◽  
Author(s):  
Gary R Klinefelter ◽  
John W Laskey ◽  
Witold M Winnik ◽  
Juan D Suarez ◽  
Naomi L Roberts ◽  
...  
Keyword(s):  
Leydig Cell ◽  
Semen Quality ◽  
Testicular Dysgenesis Syndrome ◽  
Pathway Network ◽  
Diethylhexyl Phthalate ◽  
Fetal Testis ◽  
Testosterone Production ◽  
Testicular Dysgenesis ◽  
Significant Research ◽  
Dehp Exposure

Significant research has been focused on phthalate-induced alterations in male reproductive development. Studies on rodents have prompted the notion that a syndrome exists in the human male which includes phenotypic alterations such as hypospadias, cryptorchidism, poor semen quality, and even testicular cancer. Each phenotype in this ‘testicular dysgenesis syndrome’ is predicated on reduction in testosterone production by the fetal Leydig cell. We sought to examine the relationship between dysgenesis and steroidogenic capacity in the fetal rat testis more stringently by incorporating lower exposures than those typically used, conducting a comprehensive, non-targeted quantitative evaluation of the fetal testis proteome, and relating alterations in individual proteins to the capacity of the fetal Leydig cell to produce testosterone, and histopathology of the fetal testis. Pregnant dams were dosed orally from gestation day (GD) 13–19 with 0, 10, or 100 mg diethylhexyl phthalate (DEHP)/kg body weight per day. Each endpoint was represented by 16 l. Clustering of Leydig cells occurred before any significant decrease in the capacity of the GD19 Leydig cell to produce testosterone. At 100 mg DEHP/kg, testosterone production was reduced significantly, Leydig cell clusters became quite large, and additional dysgenetic changes were observed in the fetal testis. Of 23 proteins whose expression was altered significantly at both DEHP exposure levels, seven were found to be correlated with and predictive of the quantified endpoints. None of these proteins have been previously implicated with DEHP exposure. Notably, pathway analysis revealed that these seven proteins fit a pathway network in which each is regulated directly or indirectly by estradiol.

Testicular dysgenesis syndrome: foetal origin of adult reproductive problems

2009 ◽  
Vol 71 (4) ◽  
pp. 459-465 ◽  
Author(s):  
Christine Wohlfahrt-Veje ◽  
Katharina M. Main ◽  
Niels Erik Skakkebaek
Keyword(s):  
Testicular Dysgenesis Syndrome ◽  
Testicular Dysgenesis

scholarly journals Identification of a Novel Androgen Receptor Mutation in a Family With Multiple Components Compatible With the Testicular Dysgenesis Syndrome

2013 ◽  
Vol 98 (6) ◽  
pp. 2223-2229 ◽  
Author(s):  
Grete Lottrup ◽  
Anne Jørgensen ◽  
John E. Nielsen ◽  
Niels Jørgensen ◽  
Morten Duno ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Testicular Dysgenesis Syndrome ◽  
Multiple Components ◽  
Testicular Dysgenesis
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