scholarly journals Peculiarities of presentation and evolution over time of Hashimoto’s thyroiditis in children and adolescents with Down’s syndrome

HORMONES ◽  
2015 ◽  
Author(s):  
Tommaso Aversa ◽  
Mariacarolina Salerno ◽  
Giorgio Radetti ◽  
Maria Faienza ◽  
Lorenzo Iughetti ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Hashimoto’S Thyroiditis ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Hashimoto's Thyroiditis ◽  
Over Time

scholarly journals Diet quality and well-being in children and adolescents: the UP&DOWN longitudinal study

2018 ◽  
Vol 121 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Laura Esteban-Gonzalo ◽  
Anne I. Turner ◽  
Susan J. Torres ◽  
Irene Esteban-Cornejo ◽  
José Castro-Piñero ◽  
...  
Keyword(s):  
Secondary School ◽  
Negative Affect ◽  
Primary School ◽  
Positive Affect ◽  
Children And Adolescents ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Well Being ◽  
School Girls

AbstractThe present study examined the association between high-quality diet (using the Mediterranean diet (MD) as an example) and well-being cross-sectionally and prospectively in Spanish children and adolescents. Participants included 533 children and 987 adolescents at baseline and 527 children and 798 adolescents at 2-year follow-up, included in the UP&DOWN study (follow-up in schoolchildren and adolescents with and without Down’s syndrome). The present study excluded participants with Down’s syndrome. Adherence to an MD was assessed using the KIDMED index. Well-being was measured using the Positive and Negative Affect Schedule and the KIDSCREEN-10 questionnaire. Associations between MD adherence and well-being were assessed using multi-level, mixed-effects linear regression. At baseline, MD adherence was positively related to health-related quality of life in secondary school girls and boys (β=0·41,se0·10,P<0·001;β=0·46,se0·10,P<0·001, respectively) and to positive affect in secondary school girls and boys (β=0·16,se0·05,P=0·006;β=0·20,se0·05,P<0·001, respectively) and in primary school boys (β=0·20,se0·08,P=0·019). At 2-year follow-up, MD adherence was negatively related to negative affect in secondary school adolescent girls and boys (β=–0·15,se0·07,P=0·047;β=–0·16,se0·06,P=0·019, respectively), and MD adherence was associated with higher positive affect scores in secondary school girls (β=0·30,se0·06,P<0·001) and in primary school boys (β=0·20,se0·09,P=0·023). However, MD adherence at baseline did not predict well-being indicators at 2-year follow-up. In conclusion, higher MD adherence was found to behave as a protective factor for positive well-being in cross-sectional analysis.

scholarly journals Thyroid function in children and adolescents with Hashimoto's thyroiditis after l-thyroxine discontinuation

2017 ◽  
Vol 6 (4) ◽  
pp. 206-212 ◽  
Author(s):  
Giorgio Radetti ◽  
Mariacarolina Salerno ◽  
Chiara Guzzetti ◽  
Marco Cappa ◽  
Andrea Corrias ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Outcome Measure ◽  
Hashimoto's Thyroiditis ◽  
Pediatric Endocrinology ◽  
Normal Range ◽  
Discontinuation Of Treatment ◽  
One Year ◽  
Serum Tsh

Objective Thyroid function may recover in patients with Hashimoto’s thyroiditis (HT). Design To investigate thyroid function and the need to resume l-thyroxine treatment after its discontinuation. Setting Nine Italian pediatric endocrinology centers. Patients 148 children and adolescents (25 m and 123 f) with HT on treatment with l-thyroxine for at least one year. Intervention and main outcome measure Treatment was discontinued in all patients, and serum TSH and fT4 concentrations were measured at the time of treatment discontinuation and then after 2, 6, 12 and 24 months. Therapy with l-thyroxine was re-instituted when TSH rose >10 U/L and/or fT4 was below the normal range. The patients were followed up when TSH concentrations were between 5 and 10 U/L and fT4 was in the normal range. Results At baseline, TSH was in the normal range in 139 patients, and was between 5 and 10 U/L in 9 patients. Treatment was re-instituted after 2 months in 37 (25.5%) patients, after 6 months in 13 patients (6.99%), after 12 months in 12 patients (8.6%), and after 24 months in an additional 3 patients (3.1%). At 24 months, 34 patients (34.3%) still required no treatment. TSH concentration >10 U/L at the time of diagnosis was the only predictive factor for the deterioration of thyroid function after l-thyroxine discontinuation. Conclusions This study confirms that not all children with HT need life-long therapy with l-thyroxine, and the discontinuation of treatment in patients with a TSH level <10 U/L at the time of diagnosis should be considered.

Psychiatric Disorders in Mildly and Severely Mentally Retarded Urban Children and Adolescents: Epidemiological Aspects

1986 ◽  
Vol 149 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Christopher Gillberg ◽  
Eva Persson ◽  
Marianne Grufman ◽  
Ulla Themnér
Keyword(s):  
Mental Retardation ◽  
Children And Adolescents ◽  
Psychiatric Disorders ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Mentally Retarded ◽  
Urban Children ◽  
Psychiatric Condition ◽  
Child Population ◽  
Mentally Retarded Children

A total of 149 children aged 13–17 years were examined. 83 were mildly and 66 severely mentally retarded. These children, especially the severely retarded ones, are representative of all mentally retarded children born in 1966–1970 and living in Göteborg, Sweden. 64% of the severely mentally retarded and 57% of the mildly mentally retarded children were suffering from a handicapping psychiatric condition. Autism-like ‘psychotic behaviour’ was common in the severely retarded. 0.2% of the total child population aged 13–17 years suffering from the combination of mental retardation and ‘psychotic behaviour’. Epilepsy was associated with psychiatric abnormality, but Down's syndrome was generally not so associated.

Serial Microbiota Analysis after Fecal Microbiota Transplantation in a Child with Down's Syndrome

2017 ◽  
Vol 14 (03) ◽  
pp. 136-139
Author(s):  
Lisethe Meijer ◽  
Clementien Vermont ◽  
Andries Budding ◽  
Chris Mulder ◽  
Tim Meij ◽  
...  
Keyword(s):  
Fecal Microbiota Transplantation ◽  
Diversity Index ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Fecal Microbiota ◽  
Recurrent Clostridium Difficile Infection ◽  
Microbiota Analysis ◽  
Before And After ◽  
Immunocompromised State ◽  
Over Time

AbstractFecal microbiota transplantation (FMT) is a very effective treatment for recurrent Clostridium difficile infection (CDI) in adults. However, there is a paucity of data on FMT in children and associated microbiome changes in this particular group. We describe a child with Down's syndrome and intracranial malignancy, who received FMT for recurrent CDI. Detailed microbiota analysis before and after FMT, and pre- and post-recurrence, linked to microbial communities in the donor feces showed that the patient developed a unique microbiota profile after FMT which was very stable over time despite CDI recurrence and subsequent fidaxomicin therapy. Bacteroidetes were stably acquired from donor feces, while Firmicutes, Actinobacteria, Fusobacteria, Verrucomicrobia, and Proteobacteria were unique to the patient. The diversity of microbiota of the patient increased from a Shannon diversity index of 2.08 pre-FMT to 3.12 post-FMT. Our findings underscore that patients with Down's syndrome may well tolerate and benefit from FMT even in a severely immunocompromised state.

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