scholarly journals Rare case of Cushing’s disease due to double ACTH-producing adenomas, one located in the pituitary gland and one into the stalk

HORMONES ◽  
2002 ◽  
Author(s):  
Marco Mendola ◽  
Alessia Dolci ◽  
Lanfranco Piscopello ◽  
Giustino Tomei ◽  
Dario Bauer ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Rare Case ◽  
Cushing's Disease

The corticotrophic cells of the canine pituitary gland in pituitary-dependent hyperadrenocorticism

1983 ◽  
Vol 96 (2) ◽  
pp. 303-309 ◽  
Author(s):  
A. M. McNicol ◽  
H. Thomson ◽  
C. J. R. Stewart
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease ◽  
Human Pituitary ◽  
Human Pituitary Gland ◽  
Single Entity ◽  
Pituitary Glands ◽  
Corticotrophic Cells

The distribution of specifically stained corticotrophic cells has been studied in the pituitary glands of 11 dogs with pituitary-dependent hyperadrenocorticism. The results suggest that the disease is not a single entity, and that some cases are caused by primary abnormality of the pituitary gland whereas others appear to be the result of dysfunction of the hypothalamus or central nervous system. The patterns correspond closely to those demonstrated in the human pituitary gland in Cushing's disease, and confirm that the canine disease is a useful model for the study of the pathogenesis of the variants of the condition.

Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy

1985 ◽  
Vol 143 (3) ◽  
pp. 221-223 ◽  
Author(s):  
H. Stegner ◽  
D. K. Lüdecke ◽  
M. Kadrnka-Lovrenćić ◽  
N. Stahnke ◽  
R. P. Willig
Keyword(s):  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Cushing's Disease

scholarly journals High resolution pituitary gland MRI at 7.0 tesla: a clinical evaluation in Cushing’s disease

2015 ◽  
Vol 26 (1) ◽  
pp. 271-277 ◽  
Author(s):  
Alexandra A. J. de Rotte ◽  
Amy Groenewegen ◽  
Dik R. Rutgers ◽  
Theo Witkamp ◽  
Pierre M. J. Zelissen ◽  
...  
Keyword(s):  
High Resolution ◽  
Pituitary Gland ◽  
Clinical Evaluation ◽  
Cushing’S Disease ◽  
Cushing's Disease

scholarly journals ХАРАКТЕРИСТИКА НАРУШЕНИЙ РАЗВИТИЯ ПРИ ОБЪЕМНЫХ ЗАБОЛЕВАНИЯХ ГИПОФИЗА У ДЕТЕЙ И ПОДРОСТКОВ

Innova ◽  
2019 ◽  
Vol 15 ◽  
pp. 31-34
Author(s):  
Урманова Ю.М. ◽  
◽  
Мавлонов У.Х. ◽  
Keyword(s):  
Pituitary Gland ◽  
Diabetes Insipidus ◽  
Children And Adolescents ◽  
Cushing’S Disease ◽  
Pituitary Adenomas ◽  
Developmental Disorders ◽  
Pituitary Tumors ◽  
Cushing's Disease

The aim of the study was to study the nature of developmental disorders in children and adolescents with masses of the Turkish saddle. Material and methods. 44 children and adolescents with large tumors of the Turkish saddle (TS) were under our supervision in the neuroendocrinology department of the RSNPMCE MH RUz. Of 44 sick girls there were 20, boys 24. The average age of girls was 12.1 years, boys - 12.8 years. By the nature of the pathology, the patients were divided into 5 groups: I group. - inactive pituitary adenomas (NAG) - 23 patients (52.3%); II gr. - Itsenko-Cushing's disease - 5 (11.4%); III gr. - craniopharyngioma - 6 (13.6%); IV gr. - prolactinoma - 5 b-x (11.4%); V gr. - germinoma - 5 bx (11.4%). Results. The results obtained indicate that in children and adolescents there are TJ masses of various origins: inactive pituitary adenomas (52%), craniopharyngiomas (13.6%), corticotropinomas (11.4%), prolactinomas (11.4%), and others. The presence of diabetes insipidus (8.6%) indicates the severity of panhypopituitarism that developed as a result of the tumor. Conclusions: 1) disorders of growth and puberty are the most frequent manifestations of pituitary gland masses (34.0%), 2) pituitary tumors in children and adolescents often lead to hypo- and panhypopituitarism (n = 19, or 43.2%).

scholarly journals Extrapituitary Parasellar Microadenoma in Cushing’s Disease

1999 ◽  
Vol 84 (8) ◽  
pp. 2912-2923 ◽  
Author(s):  
Ryszard M. Pluta ◽  
Lynnette Nieman ◽  
John L. Doppman ◽  
Joseph C. Watson ◽  
Nancy Tresser ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Cushing’S Disease ◽  
Anterior Lobe ◽  
Empty Sella ◽  
Cushing's Disease ◽  
Pars Tuberalis ◽  
Serial Sections ◽  
Resonance Imaging ◽  
High Incidence ◽  
Acth Secreting

Negative sellar exploration (despite the results of endocrine evaluation indicating Cushing’s disease), the high incidence of failure of total hypophysectomy, and remission of Cushing’s syndrome after unsuccessful hypophysectomy and sellar irradiation suggest that the etiology of refractory Cushing’s disease, in some patients, lies near the sella but not in the pituitary gland. We present 5 patients, out of 626 who received surgery for Cushing’s disease, in whom an ACTH-secreting extrapituitary parasellar adenoma was identified: 2 after unsuccessful total hypophysectomy for the treatment of refractory Cushing’s disease, 2 after unsuccessful hemihypophysectomy (the first, 2 yr before treatment at the NIH for Nelson’s syndrome; and the second, with recurrent Cushing’s disease 5 yr after negative transsphenoidal exploration), and 1 with a preoperative diagnosis of an intraclival microadenoma, which was cured by resection of the tumor. In all cases, an extrapituitary parasellar microadenoma was confirmed unequivocally as the cause of the disease, by negative pathology of the resected pituitary gland (patients 1, 2, 3, and 5), and/or the remission of the disease after selective resection of the extrasellar adenoma (patients 3, 4, and 5). Three of 5 patients had a partial empty sella. These patients support the thesis that ACTH-secreting tumors can arise exclusively from remnants of Rathke’s pouch, rather than from the adenohypophysis (anterior lobe or pars tuberalis of the pituitary gland) and can be a cause of Cushing’s disease. In the sixth presented case, an extrapituitary tumor was suspected at surgery after negative pituitary exploration, but serial sections of the hemihypophysectomy specimen revealed a microscopic focus of tumor at the margin of the resected gland. This case demonstrates the importance of negative pituitary histology to establish the presence of an extrapituitary parasellar tumor as an exclusive source of ACTH, and it supports the value of clinical outcome to establish the diagnosis with selective adenomectomy of an extrapituitary parasellar tumor. In patients with negative pituitary magnetic resonance imaging, especially in the presence of a partial empty sella, the diagnostic and surgical approach in Cushing’s disease should consider the identification and resection of extrapituitary parasellar adenoma, which can avoid total hypophysectomy, as was possible in 3 of our 5 patients.

CHROMOPHOBE ADENOMAS OF THE PITUITARY GLAND IN CUSHING'S DISEASE

1969 ◽  
Vol 62 (4) ◽  
pp. 647-652 ◽  
Author(s):  
J. Lindholm ◽  
P. Rasmussen ◽  
O. Korsgaard
Keyword(s):  
Pituitary Gland ◽  
Cushing’S Disease ◽  
The Other ◽  
Cushing's Disease ◽  
Chromophobe Adenoma

ABSTRACT Two patients with concurrent Cushing's disease and chromophobe adenoma of the pituitary gland are presented. In one case the tumour was present before adrenalectomy, in the other it was not recognized until after adrenalectomy. The characteristic symptoms and findings are described – including the results of corticotrophin determinations in the blood. Some aspects of the treatment of Cushing's disease are discussed.

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