scholarly journals Seroprevalence and risk factors of toxoplasma gondii infection (toxoplasmosis) among hiv seropositive pregnant women in a tertiary healthcare centre, Kano, Northern Nigeria

2016 ◽  
Vol 07 (01) ◽  
Author(s):  
Yusuf A.M
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Northern Nigeria ◽  
Healthcare Centre ◽  
Tertiary Healthcare ◽  
Toxoplasma Gondii Infection ◽  
Hiv Seropositive

scholarly journals Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria

2020 ◽  
Vol 32 (3) ◽  
pp. 169-176
Author(s):  
Maryam Zakari
Keyword(s):  
Risk Factors ◽  
T Cell ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Cell Count ◽  
Education Level ◽  
Cd4 T Cell ◽  
Toxoplasma Gondii Infection ◽  
Hiv Seropositive ◽  
Cd4 T Cell Count

Background Toxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to inform clinicians about the significance of maternal toxoplasmosis in antenatal care.AimThis study aimed to determine the seroprevalence of Toxoplasma gondii infection, associated CD4+ T-cell profile and sociodemographic risk factors among pregnant women with or without HIV infection attending the University of Abuja Teaching Hospital, Abuja, Nigeria. MethodsThis hospital-based cross-sectional study involved blood samples collected from 160 HIV-infected and 160 HIV-seronegative pregnant women. These samples were analysed for anti-T. gondii (IgG and IgM) and CD4+ T-cell count using ELISA and flow cytometry, respectively. Sociodemographic variables of participants were collected using structured questionnaires. ResultsThe overall seroprevalence of anti-T. gondii IgG and IgM was 28.8% and 3.8%, respectively. The seroprevalence of anti-T. gondii IgG and IgM was 29.4% and 4.4%, respectively, among HIV-seropositive pregnant women and 28.1% and 3.1%, respectively, among HIV-seronegative women. There was no significant association between the seroprevalence of anti-T. gondii-IgG and anti-T. gondii-IgM with age, gestational age, education level, parity or place of residence of HIV-infected pregnant women (P > 0.05). However, there was significant association between the seroprevalence of anti-T. gondii-IgG (P = 0.03) and anti-T. gondii-IgM (P = 0.01) with education level. CD4+ T-cell count varied significantly between HIV-infected and HIV-uninfected pregnant women (P = 0.035). Conclusion In this study, the seroprevalence of anti-T. gondii IgG and IgM did not differ in HIV-seropositive or HIV-seronegative pregnant women. However, women with primary T. gondii and HIV coinfection had lower CD4+ T-cell count than those with toxoplasmosis monoinfection.

scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection in pregnant women from Bobo Dioulasso, Burkina Faso

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Sanata Bamba ◽  
Mamoudou Cissé ◽  
Ibrahim Sangaré ◽  
Adama Zida ◽  
Souleymane Ouattara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Burkina Faso ◽  
Pregnant Women ◽  
Bobo Dioulasso ◽  
Toxoplasma Gondii Infection

scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection among pregnant women in south western, Saudi Arabia

2012 ◽  
Vol 38 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Mona A. Almushait ◽  
Saad M. Bin Dajem ◽  
Nahla M. Elsherbiny ◽  
Mamdoh A. Eskandar ◽  
Tarik A. Al Azraqi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Saudi Arabia ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Toxoplasma Gondii Infection

scholarly journals Seroprevalence and risk factors of Toxoplasma gondii infection among pregnant women in Trinidad and Tobago

2008 ◽  
Vol 23 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Samuel Ramsewak ◽  
Randall Gooding ◽  
Koteswaramma Ganta ◽  
Nadira Seepersadsingh ◽  
Abiodun A. Adesiyun
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Trinidad And Tobago ◽  
Pregnant Women ◽  
Toxoplasma Gondii Infection

scholarly journals Seroprevalence and the associated risk factors of Toxoplasma gondii infection among pregnant women in the middle belt of Ghana

2019 ◽  
Author(s):  
DERRICK ADU MENSAH ◽  
Linda Batsa Debrah ◽  
Clement Evans Aryee ◽  
ALEXANDER YAW YAW DEBRAH
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Venous Blood ◽  
Study Participant ◽  
Antibody Concentration ◽  
Ashanti Region ◽  
Significant Difference ◽  
Toxoplasma Gondii Infection ◽  
Associated Risk Factors

Abstract Background Exposure to Toxoplasma gondii infection is prevalent in up to 90% of the world’s population. Severe infections can be fatal and deforming in neonates. Cats serve as reservoirs for T. gondii infections. Even though many Ghanaians have cats as pets in their homes only few studies have been undertaken to assess the prevalence of the disease in Ghana. The objective of the study was to determine the seroprevalence of T. gondii infection and its associated risk factors among pregnant women seeking antenatal care at the Goaso Municipal Hospital, in Asunafo North District of the Ahafo Region and the St. Michael’s Catholic Mission Hospital in the Bosomtwe District in the Ashanti Region of Ghana. Methods A cross-sectional study involving 266 (146 from Asunafo North District and 120 from Bosomtwe District) pregnant women who consented to participate in the study was undertaken. To gather information on associated risk factors, structured questionnaire was administered to the participants. In addition, 3 mls of venous blood was collected from each participant for anti-T. gondii IgG and anti-T. gondii IgM antibody analyses using ELISA. Results A total of 64.3% (171/266) of the study participant were positive for anti-T. gondii IgG and 26.3% (70/266) were positive for anti-T. gondii IgM antibodies. This signifies that 64.3% of the study population have been exposed to the infection and 26.3% were actively infected. There were no differences (P=0.383) between the overall T. gondii seroprevalences in the two Districts. There was a significant difference between antibody concentration levels and age in the Bosomtwe District in Ashanti Region. No association (OR<1) was found between the seroprevalences and the suspected risk factors assessed in this study. Conclusion The study showed that the seroprevalence of T. gondii among pregnant women visiting the two health facilities in the two Regions was higher compared to the 30%-65% reported as the global population infection status. This study provides baseline data for future studies in the other Districts and Regions in the country to ascertain the overall seroprevalence in Ghana.

scholarly journals Seroprevalence and Risk Factors of Toxoplasma gondii Infection among Pregnant Women in Kumasi: A Cross-Sectional Study at a District-Level Hospital, Ghana

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Bhavana Singh ◽  
Linda Batsa Debrah ◽  
Godfred Acheampong ◽  
Alexander Yaw Debrah
Keyword(s):  
Risk Factors ◽  
Secondary Education ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elisa Technique ◽  
Toxoplasma Gondii Infection ◽  
Level Hospital

Background. This study investigated the prevalence and risk factors of Toxoplasma gondii infection among pregnant women in a district-level hospital in Ghana and compared the diagnostic performance of the rapid diagnostic test (RDT) and enzyme-linked immunosorbent assay (ELISA) for T. gondii diagnosis. Method. This cross-sectional study included 400 consecutive consenting women in their first-trimester stage of pregnancy. A validated well-structured closed-ended questionnaire was used to collect sociodemographic data and possible risk factors of each participant. Blood samples were collected for analysis of T. gondii IgG and IgM using the commercial ELISA Kit and RDT. Results. Seroprevalence of toxoplasmosis was 21.5% and 57.3% based on the RDT and ELISA technique, respectively. Secondary education ( cOR = 1.9 , 95% CI (1.1-3.1), and p = 0.020 ) and contact with cats ( cOR = 1.7 , 95% CI (1.1-2.8), and p = 0.030 ) were significant predictors of T. gondii infection, with the former being the only independent risk factor for T. gondii infection ( aOR = 1.8 , 95% CI (1.0-3.0), and p = 0.034 ) by the ELISA method. The sensitivity, specificity, and area under the curve (AUC) of RDT-IgM against ELISA were 42.9%, 95.9%, and 0.694, respectively, whereas those of RDT-IgG were 31.0%, 91.2%, and 0.611, respectively. The diagnostic consistency between the two methods was fair for both RDT-IgM ( κ = 0.304 ) and RDT-IgG ( κ = 0.201 ). Conclusion. The prevalence of T. gondii infection among pregnant women at Kumasi is 21.5% and 57.3% based on the RDT and ELISA technique, respectively. Secondary education and contact with cats were the major risk factors of T. gondii infection. Using ELISA as the reference, the RDT used in this study for the diagnosis of T. gondii infection has low sensitivity, and therefore, it is unreliable. However, this finding does not invalidate all RDTs because there are several other brands of RDT with good sensitivity and specificity. Further studies to ascertain the performance of other commercially available RDT kits are needed.

scholarly journals Sero–Prevalence, and Associated Risk Factors of Toxoplasma gondii Infection in Pregnant Women and HIV/AIDS Patients in Selected Cities of Ethiopia

2014 ◽  
Vol V (10) ◽  
pp. 17-29 ◽  
Author(s):  
Anteneh HAILU HAILU ◽  
Kassahun NEGASHE NEGASHE ◽  
Aweke TASE TASEW ◽  
Medhint GETACH GETACHEW ◽  
Tesfaye SISAY SISAY ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Aids Patients ◽  
Women And Hiv ◽  
Toxoplasma Gondii Infection ◽  
Associated Risk Factors ◽  
Hiv Aids
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