scholarly journals The effect of Nauclea latifolia leaf extract on some biochemical parameters in streptozotocin diabetic rat models

2015 ◽  
Vol 06 (03) ◽  
Keyword(s):  
Biochemical Parameters ◽  
Leaf Extract ◽  
Diabetic Rat ◽  
Rat Models ◽  
Streptozotocin Diabetic Rat ◽  
Nauclea Latifolia

Effects of soursop leaf extract and physical training on decreasing oxidative stress and pancreatic histopathology in diabetic rat models

2020 ◽  
Vol 23 (03) ◽  
pp. 84-95
Author(s):  
Retno Yulianti ◽  
Citra Ayu Aprilia ◽  
Erna Harfiani ◽  
Khariri Khairi
Keyword(s):  
Oxidative Stress ◽  
Physical Training ◽  
Leaf Extract ◽  
Diabetic Rat ◽  
Rat Models

Polyol pathway activity in streptozotocin-diabetic rat lens

1989 ◽  
Vol 49 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Hong-Ming Cheng ◽  
Keiko Hirose ◽  
Hua Xiong ◽  
R.Gilberto González
Keyword(s):  
Polyol Pathway ◽  
Diabetic Rat ◽  
Pathway Activity ◽  
Streptozotocin Diabetic Rat

scholarly journals Up-regulation of kinin B1 receptor in the lung of streptozotocin-diabetic rat: autoradiographic and functional evidence

2003 ◽  
Vol 138 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Rose Mari J Vianna ◽  
Brice Ongali ◽  
Domenico Regoli ◽  
João Batista Calixto ◽  
Réjean Couture
Keyword(s):  
Diabetic Rat ◽  
B1 Receptor ◽  
Kinin B1 Receptor ◽  
Streptozotocin Diabetic Rat

Expression of chaperonin 60 in the hippocampus of the streptozotocin diabetic rat

Neuroreport ◽  
2006 ◽  
Vol 17 (3) ◽  
pp. 239-242 ◽  
Author(s):  
Jiang Yuan ◽  
Brian J. Young ◽  
Ryan D. Martinus
Keyword(s):  
Diabetic Rat ◽  
Chaperonin 60 ◽  
Streptozotocin Diabetic Rat

scholarly journals Toxicological assessment of the methanolic leaf extract of Bridelia ferrugelia

2018 ◽  
Vol 7 (5) ◽  
pp. 419-424
Author(s):  
Abiodun Olusoji Owoade ◽  
◽  
Adewale Adetutu ◽  
Augustine Ikhueoya Airaodion ◽  
Olufemi Ogundeji Ogundipe ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Leaf Extract ◽  
Blood Lipids ◽  
Lipid Levels ◽  
Toxicological Evaluation ◽  
Toxicological Assessment ◽  
Acute Group ◽  
Male Wistar Rats ◽  
Dose Dependent Decrease ◽  
Dose Dependent

This study evaluated the acute and subacute toxicity effects of Bridelia ferrugelia leaf extract. Observation of the acute group showed that LD50 of the extract is greater than 2000 mg/kg. The subacute investigation was determined by administering 200 mg/kg, 400 mg/kg and 600 mg/kg of the methanolic leaf extract to male Wistar rats for 28 days with distilled water as a control. Haematological and biochemical parameters, as well as lipid levels of vital organs, were examined. Toxicological evaluation of the extract did not produce any significant change in haematological and biochemical parameters in rats. In addition, blood lipids levels were not significantly affected, while dyslipidaemia effect observed in some vital organs were found to be nonlipotoxic. Administration of Bridelia ferrugelia at a dose of 200, 400 and 600 mg/kg for 28 days resulted in reduction of cardiac cholesterol level by 37.16%, 39.36% and 17.64% respectively, reduction of pulmonary cholesterol by 22.17%, 28.08% and 6.24 % respectively and dose-dependent decrease in pulmonary triglyceride level by 16.17, 29.14 and 54.25% respectively. This study indicates that Bridelia ferrugelia extract administered at 200, 400 and 600 mg/kg did not show any toxic effect on the parameters investigated in rats. Thus, the extract can be considered safe when administered orally

scholarly journals Skrining Mekanisme Kerja Daun Malaka (Phyllanthus emblica L.) Sebagai Antidiabetes

2018 ◽  
Vol 1 (3) ◽  
pp. 106-110
Author(s):  
Novi Irwan Fauzi ◽  
Seno Aulia Ardiansyah ◽  
Saeful Hidayat
Keyword(s):  
Mechanism Of Action ◽  
Inhibitory Activity ◽  
Leaf Extract ◽  
Test Method ◽  
Diabetic Rat ◽  
Phyllanthus Emblica ◽  
Insulin Sensitizer ◽  
Water Fraction

Daun malaka (Phyllanthus emblica L.) mempunyai potensi digunakan sebagai alternatif obat antidiabetes. Daun malaka menunjukkan efek hipoglikemia pada tikus yang diinduksi aloksan. Namun, mekanisme kerjanya belum diketahui pasti. Penelitian ini dilakukan dalam rangka skrining mekanisme kerja daun malaka sebagai antidiabetes. Skrining mekanisme kerja dilakukan terhadap fraksi air daun malaka melalui uji aktivitas inhibisi enzim α-glukosidase serta α-amilase secara in vitro dan pengujian aktivitas insulin-sensitizer terhadap ekstrak daun malaka dengan metode tes toleransi insulin secara in vivo. Fraksi air daun malaka menunjukkan aktivitas inhibisi terhadap enzim α-glukosidase serta α-amilase dengan nilai IC50 (Inhibitor Concentration 50) pada kedua enzim tersebut berturut-turut adalah 0,87% dan 8,64% b/v. Pada uji aktivitas insulin sensitizer, pemberian ekstrak daun malaka dapat meningkatkan sensitivitas insulin pada tikus diabet dengan kondisi resistensi insulin. Nilai KTTI pada kelompok tikus diabet yang diberi ekstrak daun malaka dosis 100 dan 500 mg/kgbb tikus (74,89 dan 75,57) lebih tinggi dibandingkan kelompok tikus diabet (38,41) dan kadar glukosa darah yang lebih rendah selama interval waktu pengukuran. Daun malaka telah diketahui mampu meningkatkan sekresi insulin dan pada penelitian ini menunjukkan aktivitas inhibisi enzim α-glukosidase serta α-amilase secara in vitro dan menunjukkan aktivitas insulinsensitizer pada tikus diabet dengan kondisi resistensi insulin.   Malaka leaf (Phyllanthus emblica L.) has the potential to be used as an alternative antidiabetic drug. Malacca leaves showed hypoglycemia effect in rat induced by alloxan. However, the mechanism of action is not yet known. This study was conducted to evaluate the mechanism of action of Malaka leaves as antidiabetic. Screening of the mechanism of action was carried out on the water fraction of Malaka leaf  byinhibitory activity examination  on α-glucosidase and α-amylase by in vitro studyand Evaluation of insulin-sensitizer activity of Maaka leaf leaf extract was conducted by invivo  insulin tolerance test method. Malaka leaf water fraction showed inhibitory activity against the α-glucosidase and α-amylase with IC50 values ​​(Inhibitory Concentration 50)  of0.87% and 8.64% b / v on both enzyme, respectively. The evaluation of insulin sensitizer revelead that administration ofMalaka  leaf extract can increase insulin sensitivity in diabetic rat with insulin resistance.KTTI values ​​in diabetic rats given malaka extract  at the dose of 100 and 500 mg / kg BW (74.89 and 75.57) were higher than diabetics rat (38.41) and the extract also decrease blood glucose levels during measurement time intervals . Malaka leafhas been known to increase insulin secretion and the study showedthe  inhibitory activity on α-glucosidase and α-amylase by in vitro study and showed insulinsensitizer activity in diabetic rat with insulin resistance.

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