scholarly journals Specific features of peripheral blood lymphocytes immunophenotype in pregnant women with chronic periodontitis

2015 ◽  
Vol 10 (2) ◽  
Author(s):  
Viktoria Prohodnaya
Keyword(s):  
Pregnant Women ◽  
Chronic Periodontitis ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Blood Lymphocytes

G1691A MUTATION OF  F5 GENE AND PREECLAMPSIA

2014 ◽  
pp. 13-19
Author(s):  
Ngoc Thanh Cao ◽  
Thi Minh Thi Ha ◽  
Viet Nhan Nguyen ◽  
Vu Quoc Huy Nguyen ◽  
Duy Tran
Keyword(s):  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Pregnant Women ◽  
Peripheral Blood ◽  
Factor V Leiden ◽  
Peripheral Blood Lymphocytes ◽  
Factor V ◽  
Blood Lymphocytes ◽  
Mutation Carriers ◽  
Pcr Rflp

Background:G1691A mutation of F5 gene is a risk factor of thrombosis and endothelial dysfunction causing preeclampsia (PE). This study aimed to (1) determine the rate of 1691GG, 1691GA and 1691AA genotypes of F5 gene in preeclamptic and normotensive pregnant women, and (2) survey the association between G1691A mutation of F5 gene and preeclampsia. Patients and methods: 73 preeclamptic pregnant women and 292 normotensive pregnant women were determined G1691A genotypes of F5 gene by PCR-RFLP in with DNA samples extracted from peripheral blood lymphocytes. Results:100% normotensive pregnant women were 1691GG genotype. In the group of preeclamptic pregnant women, the rate of 1691GA genotype and 1691GG were 4.1% and 95.9%, respectively. G1691A mutation was a risk factor of preeclampsia, with OR = 29.04, 95%CI = 1.48-558.72. The rate of G1691A mutation carriers in mild PE group was 0%, in severe PE was 7.7% and in eclampsia was 100%. Conclusion:There was the association between G1691A mutation and the development and severity of preeclampsia. Keywords: Preeclampsia, G1691A mutation, factor V Leiden, F5 gene.

scholarly journals Association between inherited thrombophilia in pregnancy and micronucleus frequency in peripheral blood lymphocytes

2017 ◽  
Vol 20 (2) ◽  
pp. 11-18 ◽  
Author(s):  
GM Šošić ◽  
N Jović ◽  
B Rakić ◽  
A Dimitrijević ◽  
M Varjačić
Keyword(s):  
Pregnant Women ◽  
Peripheral Blood ◽  
First Trimester ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Case Group ◽  
Endogenous Factors ◽  
Blood Lymphocytes ◽  
The Individual ◽  
The Impact

Abstract The aim of this study was to determine possible predictors of an increased frequency of micronucleus (MN) and the impact of thrombophilia on the chromosomal instability in peripheral blood lymphocytes (PBL) of pregnant women in their first trimester. This study was designed as a case-control study on 74 pregnant women. It was performed in the gestational age of 11 to 14 weeks, when blood samples were collected and incubated for 72 hours. The individual MN frequency in PBL was measured by cytokinesis-block micronucleus (CBMN) assay. Women were grouped in control group [≤4 MN/1000 binucleated (BN) cells] and case group (>4 MN/1000 BN cells). Potential mutagenic effects of exogenous/endogenous factors in pregnant women were analyzed. By analyzing the given results, it can be concluded that pregnant women with thrombophilia have 26.69-times more chance of having a frequency of >4 MN/1000 BN than pregnant women with no thrombophilia. Our research was primarily aimed at showing that the presence of thrombophilia was a statistically important predictor of an increased MN frequency in pregnant women and it can predict about one-third of the total variance in MN frequency in the studied population.

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