EDITORIAL : DEMENTIA PREVENTION STRATEGIES – BEYOND THE RANDOMIZED CONTROLLED TRIAL?

2014 ◽  
pp. 1-3
Author(s):  
E. Richard ◽  
C. Brayne
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Prevention Strategies ◽  
Randomized Controlled ◽  
Dementia Prevention

scholarly journals Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index

2021 ◽  
Author(s):  
Kay Deckers ◽  
Sebastian Köhler ◽  
Tiia Ngandu ◽  
Riitta Antikainen ◽  
Tiina Laatikainen ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Dementia Prevention ◽  
Prevention Potential

scholarly journals Effect of Positive Events Recording Based on Positive Psychology on Healthy Behaviours and Readmission Rate of Patients After PCI: A Study Protocol for a Prospective, Randomized Controlled Trial

2021 ◽  
Author(s):  
Yao yao Hu ◽  
Xin Jiang ◽  
Fang ying Mao ◽  
Jing Zhang ◽  
Lin Liu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Positive Psychology ◽  
Readmission Rate ◽  
Controlled Trial ◽  
Intervention Group ◽  
Control Group ◽  
Prevention Strategies ◽  
Positive Events ◽  
Randomized Controlled ◽  
New Ideas

Abstract Background: Unhealthy behaviours of coronary heart disease (CHD) patients are closely related to the occurrence of major heart events, which increases the readmission rate and brings heavy economic burden to families and society. Therefore, it is necessary for health care workers to take active preventive and therapeutic measures to keep or establish healthy behaviours of patients. Positive psychological intervention has been proved to be effective, but it has not been reported in the field of CHD in China. The purpose of this study is to explore the effects of positive events recording based on positive psychology on the healthy behaviours, readmission rate and anxiety of patients with CHD, in order to provide new ideas for the development of secondary prevention strategies for CHD.Methods: This is a prospective, single-center, randomized controlled trial (RCT). The subjects will be enrolled from the Department of Cardiology, the First Affiliated Hospital of Soochow University. There are 80 cases in total, according to the random number table, the subjects are randomly divided into the intervention group (n=40) and the control group (n=40). The patients in the intervention group will receive the intervention of recording positive events once a week for 3 months, while the patients in the control group receive conventional nursing, and each group will be followed up for 6 months. The primary outcomes will include healthy behaviours, readmission rate and anxiety, the secondary outcomes will include psychological capital, subjective well-being and corresponding clinical laboratory indicators. The protocol was approved by the Medical Ethics Committee of Soochow University (approval No. SUDA20200604H01) and is performed in strict accordance with the Declaration of Helsinki formulated by the World Medical Association. All participants provide written informed consent.Discussion: This study will verify whether positive events recording based on positive psychology can make patients maintain healthy behaviours, reduce readmission rate and improve anxiety after PCI. Then, this study will provide new ideas and references for the development of secondary prevention strategies for patients with CHD. Trial registration: Chinese Clinical Trials Registry, 2000034538. Registered on 10 July 2020.

scholarly journals Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index

2020 ◽  
Vol 16 (S10) ◽  
Author(s):  
Kay Deckers ◽  
Sebastian Koehler ◽  
Tiia Ngandu ◽  
Frans RJ Verhey ◽  
Miia Kivipelto ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Dementia Prevention ◽  
Prevention Potential

scholarly journals The Japan-Multimodal Intervention Trial for Prevention of Dementia (J-MINT): The Study Protocol for an 18-Month, Multicenter, Randomized, Controlled Trial

2021 ◽  
pp. 1-12
Author(s):  
T. Sugimoto ◽  
T. Sakurai ◽  
H. Akatsu ◽  
T. Doi ◽  
Y. Fujiwara ◽  
...  
Keyword(s):  
Older Adults ◽  
Randomized Controlled Trial ◽  
Study Protocol ◽  
Controlled Trial ◽  
Private Enterprises ◽  
Intervention Trial ◽  
Multimodal Intervention ◽  
Randomized Controlled ◽  
Dementia Prevention ◽  
Secondary Outcomes

Background/Objectives: The Japan-multimodal intervention trial for prevention of dementia (J-MINT) is intended to verify the effectiveness of multi-domain interventions and to clarify the mechanism of cognitive improvement and deterioration by carrying out assessment of dementia-related biomarkers, omics analysis and brain imaging analysis among older adults at high risk of dementia. Moreover, the J-MINT trial collaborates with partnering private enterprises in the implementation of relevant interventional measures. This manuscript describes the study protocol. Design/Setting: Eighteen-month, multi-centered, randomized controlled trial. Participants: We plan to recruit 500 older adults aged 65-85 years with mild cognitive impairment. Subjects will be centrally randomized into intervention and control groups at a 1:1 allocation ratio using the dynamic allocation method with all subjects stratified by age, sex, and cognition. Intervention: The multi-domain intervention program includes: (1) management of vascular risk factors; (2) group-based physical exercise and self-monitoring of physical activity; (3) nutritional counseling; and (4) cognitive training. Health-related information will be provided to the control group every two months. Measurements: The primary and secondary outcomes will be assessed at baseline, 6-, 12-, and 18-month follow-up. The primary outcome is the change from baseline to 18 months in a global composite score combining several neuropsychological domains. Secondary outcomes include: cognitive change in each neuropsychological test, incident dementia, changes in blood and dementia-related biomarkers, changes in geriatric assessment including activities of daily living, frailty status and neuroimaging, and number of medications taken. Conclusions: This trial that enlist the support of private enterprises will lead to the creation of new services for dementia prevention as well as to verify the effectiveness of multi-domain interventions for dementia prevention.

Determinants of Dropout and Nonadherence in a Dementia Prevention Randomized Controlled Trial: The Prevention of Dementia by Intensive Vascular Care Trial

2017 ◽  
Vol 65 (7) ◽  
pp. 1505-1513 ◽  
Author(s):  
Cathrien R. L. Beishuizen ◽  
Nicola Coley ◽  
Eric P. Moll van Charante ◽  
Willem A. Gool ◽  
Edo Richard ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Dementia Prevention

A Randomized Controlled Trial of Fall Prevention Strategies in Old Peoples’ Homes

Gerontology ◽  
2000 ◽  
Vol 46 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Marion E.T. McMurdo ◽  
Angela M. Millar ◽  
Fergus Daly
Keyword(s):  
Randomized Controlled Trial ◽  
Fall Prevention ◽  
Controlled Trial ◽  
Prevention Strategies ◽  
Randomized Controlled
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