scholarly journals The INSPIRE research initiative: a program for GeroScience and healthy aging research going from animal models to humans and the healthcare system

2020 ◽  
pp. 1-8
Author(s):  
P. de Souto Barreto ◽  
S. GUYONNET ◽  
I. Ader ◽  
S. Andrieu ◽  
L. Casteilla ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Care Pathway ◽  
Functional Decline ◽  
World Health ◽  
Biological Aging ◽  
Aging Research ◽  
Research Initiative ◽  
Centered Care ◽  
Clinical Gerontology ◽  
Health Organization

Aging is the most important risk factor for the onset of several chronic diseases and functional decline. Understanding the interplays between biological aging and the biology of diseases and functional loss as well as integrating a function-centered approach to the care pathway of older adults are crucial steps towards the elaboration of preventive strategies (both pharmacological and non-pharmacological) against the onset and severity of burdensome chronic conditions during aging. In order to tackle these two crucial challenges, ie, how both the manipulation of biological aging and the implementation of a function-centered care pathway (the Integrated Care for Older People (ICOPE) model of the World Health Organization) may contribute to the trajectories of healthy aging, a new initiative on Gerosciences was built: the INSPIRE research program. The present article describes the scientific background on which the foundations of the INSPIRE program have been constructed and provides the general lines of this initiative that involves researchers from basic and translational science, clinical gerontology, geriatrics and primary care, and public health.

scholarly journals The INSPIRE Bio-resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort)

2020 ◽  
pp. 1-11 ◽  
Author(s):  
S. Guyonnet ◽  
Y. Rolland ◽  
C. Takeda ◽  
P.-J. Ousset ◽  
I. Ader ◽  
...  
Keyword(s):  
Health Care ◽  
Translational Research ◽  
Healthy Aging ◽  
Care Pathway ◽  
Integrative Approach ◽  
Biological Aging ◽  
Imaging Data ◽  
Aging Research ◽  
Age Related

Background: The Geroscience field focuses on the core biological mechanisms of aging, which are involved in the onset of age-related diseases, as well as declines in intrinsic capacity (IC) (body functions) leading to dependency. A better understanding on how to measure the true age of an individual or biological aging is an essential step that may lead to the definition of putative markers capable of predicting healthy aging. Objectives: The main objective of the INStitute for Prevention healthy agIng and medicine Rejuvenative (INSPIRE) Platform initiative is to build a program for Geroscience and healthy aging research going from animal models to humans and the health care system. The specific aim of the INSPIRE human translational cohort (INSPIRE-T cohort) is to gather clinical, digital and imaging data, and perform relevant and extensive biobanking to allow basic and translational research on humans. Methods: The INSPIRE-T cohort consists in a population study comprising 1000 individuals in Toulouse and surrounding areas (France) of different ages (20 years or over - no upper limit for age) and functional capacity levels (from robustness to frailty, and even dependency) with follow-up over 10 years. Diversified data are collected annually in research facilities or at home according to standardized procedures. Between two annual visits, IC domains are monitored every 4-month by using the ICOPE Monitor app developed in collaboration with WHO. Once IC decline is confirmed, participants will have a clinical assessment and blood sampling to investigate markers of aging at the time IC declines are detected. Biospecimens include blood, urine, saliva, and dental plaque that are collected from all subjects at baseline and then, annually. Nasopharyngeal swabs and cutaneous surface samples are collected in a large subgroup of subjects every two years. Feces, hair bulb and skin biopsy are collected optionally at the baseline visit and will be performed again during the longitudinal follow up. Expected Results: Recruitment started on October 2019 and is expected to last for two years. Bio-resources collected and explored in the INSPIRE-T cohort will be available for academic and industry partners aiming to identify robust (set of) markers of aging, age-related diseases and IC evolution that could be pharmacologically or non-pharmacologically targetable. The INSPIRE-T will also aim to develop an integrative approach to explore the use of innovative technologies and a new, function and person-centered health care pathway that will promote a healthy aging.

PREVENTION OF FRAILTY IN AGING

2017 ◽  
pp. 1-4
Author(s):  
B. Vellas ◽  
S. Sourdet
Keyword(s):  
Functional Decline ◽  
Strength Loss ◽  
The Elderly ◽  
Cellular Damage ◽  
World Health ◽  
Health Concern ◽  
National Academy Of Sciences ◽  
Definition Of ◽  
Health Organization ◽  
Academy Of Sciences

Worldwide, the number of people age 60 and older is expected to grow from nearly 900 million in 2015 to over 1.3 trillion in 2030 (1). Increased age is associated with gradual increases in molecular and cellular damage; impairment of bodily functions; decreased muscle mass and strength; loss of bone density; declining vision, hearing and cognition; multimorbidity; and frailty (2). Frailty has been conceptualized as a physiological syndrome of decreased reserve and resilience, resulting in progressive functional decline, increased vulnerability to many stressors, and an increase in negative health outcomes and dependence (3, 4). It has been recognized by the World Health Organization (2) and the U.S. National Academy of Sciences (5) as a major public health concern among the elderly, although consensus on a definition of frailty remains elusive (6). Nonetheless, research suggests that disability and dependence in the elderly may be preventable by targeting frail and pre-frail older adults (3, 7, 8).

scholarly journals 41DIFFERENCES IN PHYSICAL PERFORMANCE ACROSS A MULTI-ETHNIC COHORT OF OLDER ADULTS: INSIGHTS FROM THE HEALTHY AGING RESEARCH INITIATIVE

2017 ◽  
Vol 46 (suppl_2) ◽  
pp. ii11-ii13 ◽  
Author(s):  
H Mossop ◽  
A Granic ◽  
A A Sayer ◽  
G Engstrom ◽  
K Davies ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Performance ◽  
Healthy Aging ◽  
Aging Research ◽  
Research Initiative

scholarly journals Good practices of labor and birth care from the perspective of health professionals

2018 ◽  
Vol 71 (suppl 3) ◽  
pp. 1313-1319 ◽  
Author(s):  
Simone Barbosa Pereira ◽  
Claudia Maria Gabert Diaz ◽  
Marli Terezinha Stein Backes ◽  
Carla Lizandra de Lima Ferreira ◽  
Dirce Stein Backes
Keyword(s):  
Health Professionals ◽  
World Health ◽  
Child Health Care ◽  
Rio Grande Do Sul ◽  
Good Practices ◽  
Care Network ◽  
Biological Character ◽  
Research Initiative ◽  
Health Organization ◽  
And Child Health

ABSTRACT Objective: Determine the understanding of health professionals of an obstetric hospital regarding the good practices of labor and birth care recommended by the World Health Organization. Method: Research-initiative, with data collection between April and July 2016 using the focal group technique, with 27 health professionals of an obstetric hospital of Rio Grande do Sul with 21 hospitalization beds. Results: Three thematic categories were achieved: good obstetric practices and their meanings; from the biological character to singular and multidimensional care; from the punctual and fragmented conception to the labor and birth care network. Conclusion: Good practices, in addition to enabling rethinking the obstetric model and contributing to organize the maternal and child health care network in order to ensure access, humane care, and problem-solving capacity, also foster female protagonism.

scholarly journals Resveratrol: A Sirtuin Activator and The Fountain of Youth

2015 ◽  
Vol 7 (1) ◽  
pp. 1 ◽  
Author(s):  
Anna Meiliana ◽  
Nurrani Mustika Dewi ◽  
Andi Wijaya
Keyword(s):  
Caloric Restriction ◽  
Healthy Aging ◽  
Myocardial Infarct ◽  
Functional Decline ◽  
Steady Increase ◽  
Healthy Human ◽  
Aging Research ◽  
Human Lifespan ◽  
Age Related ◽  
Fountain Of Youth

BACKGROUND: An organism’s lifespan is inevitably accompanied by the aging process, which involves functional decline, a steady increase of a plethora of chronic diseases, and ultimately death. Thus, it has been an ongoing dream of mankind to improve healthspan and extend life.CONTENT: There are only a few proposed aging interventions: caloric restriction, exercise, and the use of low-molecular-weight compounds, including spermidine, metformin, resveratrol, and rapamycin. Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Resveratrol have been shown to prevent and reduce the severity of age-related diseases such as atherosclerosis, stroke, myocardial infarct, diabetes, neurodegenerative diseases, osteoarthritis, tumors and metabolic syndrome, along with their ability to extend lifespan.SUMMARY: The purpose of aging research is the identification of interventions that may avoid or ameliorate the ravages of time. In other words, the quest is for healthy aging, where improved longevity is coupled to a corresponding healthspan extension. It is only by extending the healthy human lifespan that we will truly meet the premise of the Roman poet Cicero: “No one is so old as to think that he may not live a year.”KEYWORDS: aging, caloric restriction, mimetic, healthspan, sirtuin activator

scholarly journals The role of the age-friendly cities movement in the framework of active aging policies against the socioeconomic risks of demographic aging

2020 ◽  
Vol 17 (3) ◽  
pp. 847-863
Author(s):  
Aykut Aydın ◽  
Muharrem Es
Keyword(s):  
Social Security ◽  
Living Arrangements ◽  
Capital Accumulation ◽  
Healthy Aging ◽  
World Health ◽  
Active Aging ◽  
Education Policies ◽  
Demographic Aging ◽  
Health Organization ◽  
The Individual

Aging, a common problem in almost all countries, both developed and developing, is expressed in terms of a decrease in global birth and death rates or, from a different perspective, an increase in mean life expectancy. Demographic aging, which may be regarded as both a threat and an opportunity, affects a very broad sphere, including basic health, the economy, social security, the saving-consumption balance, living arrangements, urbanization, and the family structure, and therefore brings different disciplines together. Looked at in greater detail, it is a subject that requires reflection and planning since it affects such areas as change in a country’s population structure, economic growth, labor markets, labor supply and productivity, development policies, public borrowing, health and social security policies, education policies, and urbanization policies. The fact that demographic aging is a common problem of both developed and developing countries raises the question of active and healthy aging policies. These policies are thought to play an important role in measures created or potentially created by aging. Discovery of the importance of individual capital accumulation and wide social capital has prepared the dissemination of active-healthy aging policies out of the idea that investment in individuals’ health, education, and participation opportunities will benefit both the individual and the community. The emergence of the ‘Age-Friendly Cities’ movement initiated by the World Health Organization is one concrete outcome of these policies. The first section of this study will discuss the concept of demographic aging and its relationship with active-healthy aging. The economic and social effects of demographic aging will then be discussed. Another section of the study will discuss the concept of age-friendly cities, their relationship with active aging, and their role against the impacts of demographic aging.

scholarly journals The Road to Healthy Ageing: What Has Indonesia Achieved So Far?

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3441
Author(s):  
Ray Wagiu Basrowi ◽  
Endang Mariani Rahayu ◽  
Levina Chandra Khoe ◽  
Erika Wasito ◽  
Tonny Sundjaya
Keyword(s):  
Healthy Aging ◽  
Adult Population ◽  
Aging Population ◽  
The Elderly ◽  
World Health ◽  
Nutrition Status ◽  
The Road ◽  
The World ◽  
Key Issues ◽  
Health Organization

The World Health Organization (WHO) has projected that the world should prepare for an aging society. As the fourth most populous country in the world, the elderly population in Indonesia is also continuously growing. In 2010, the proportion of the elderly group was merely 5%, and it is expected to increase to 11% in 2035. Understanding the current situation of the adult population in Indonesia would be crucial to prepare for the future aging population. This article analyzed the current socio-demographic status, nutrition status, nutrient intake, and health profile of the current Indonesian adult population through a literature review. The key issues to prepare for healthy aging in Indonesia are summarized. Acknowledging the profile of the adult and senior adult population in Indonesia will provide beneficial information for all stakeholders in preparing Indonesia for a better healthy aging population with improved quality of life.

scholarly journals INTEREST GROUP SESSION—EPIDEMIOLOGY OF AGING: BIOSOCIAL RESEARCH ON BRAIN AGING AND BIOLOGICAL AGING

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S348-S348
Author(s):  
Daniel W Belsky
Keyword(s):  
Life Course ◽  
Cognitive Aging ◽  
Brain Aging ◽  
Functional Decline ◽  
Biological Aging ◽  
Social Psychological ◽  
Aging Research ◽  
System Integrity ◽  
Organ Systems ◽  
The Brain

Abstract Our aging global population presents a new set of challenges for public health. Individual-disease focused models are becoming outmoded as geriatricians recognize multimorbidity and frailty as the central challenges in preserving health for older adults. Evidence from research into the biology of aging suggests that a set of common cellular-level processes underpin decline in system integrity that induces vulnerability to disease across multiple organ systems, including the brain. In parallel, research in life-course gerontology indicates that the roots of aging-related decline in system integrity extend from early life and encompass histories of social, psychological, and biochemical exposures. The research presented in this symposium aims to integrate these emerging paradigms in aging research by mapping connections among measures of aging in the brain and body and social, psychological, and nutrition exposures. Our symposium focuses on (1) links between social-psychological determinants of health and biological aging in the brain and body; and (2) social and behavioral protective factors that may buffer emerging biological risk in aging. The overarching goal of this symposium is to introduce an approach to gerontology that integrates geroscience with life-course social and psychiatric epidemiology to advance understanding of cognitive aging and functional decline, and ultimately identify novel interventions to extend healthy lifespan.

scholarly journals Human Factors and Peri-operative Safety: Compliance with Five Steps to Safer Surgery (5STSS) Protocols at an NHS Hospital during the SARS-CoV2 Pandemic1 - Human Factors Implications

2021 ◽  
Vol 6 (02) ◽  
pp. 114-122
Author(s):  
Dr Asekhame Oise Isemede ◽  
Dr Sarah O. Beckley
Keyword(s):  
Human Factors ◽  
Care Pathway ◽  
National Standards ◽  
World Health ◽  
Safety Standards ◽  
Time Out ◽  
Retrospective Audit ◽  
Operative Care ◽  
Care Guidelines ◽  
Health Organization

The five steps to safer surgery processes are essential standards for the delivery of safe surgery. The steps are Team Brief, World Health Organization (WHO) - Sign In, Time Out, Sign Out and Team Debrief. With increased anxieties and other disruptive human factors associated with the COVID-19 pandemic capable of negatively affecting care standards, this audit of compliance with the five steps to safer surgery was done to determine if peri-operative safety standards have been maintained or not during the COVID-19 pandemic1 at the Trust. Methods: A retrospective audit of completeness of documentations of the above five steps (used as proxy for compliance) obtained from electronic medical records of a sample of patients who had surgical procedures during the COVID-19 pandemic1 (Part A) and a survey of peri-operative staff on COVID-19 and peri-operative care (Part B) were carried out after approval by the audit department of the Trust. Results: Compliance with Team Briefs, WHO - Sign In, Time Out and Sign Out were comparable to 2019 audit and national standards but there was a fall in compliance with Team Debrief from 100% (pre-COVID-19 audit) to 52%. Fear of getting infected with COVID-19 and lack of suitable care guidelines were found to be potent anxiety factors for the majority of respondents, all the respondents supported a review of the current peri-operative care pathway. Conclusion: All causes including human factors contributing directly or indirectly to the fall in standards seen in this audit need to be explored and strategies (solutions) such as development of new peri-operative care pathways capable of improving team resilience for more effective and safer peri-operative care should be urgently considered.

scholarly journals Benefits of physical activity on elderly

2021 ◽  
Vol 9 (18) ◽  
pp. 25-33
Author(s):  
Esther Lizbeth Islas-Cruz
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Old Age ◽  
Healthy Aging ◽  
Healthy Lifestyle ◽  
Muscle Tone ◽  
The Elderly ◽  
World Health ◽  
Health Organization

Introduction: The increase in the Elderly population as the main characteristic of the demographic transition brings with it multiple challenges for public health. As part of the public politics of the World Health Organization (WHO) on healthy aging, Physical Activity (PA) is relevant, being the subject of multiple studies about its benefits on the quality of life of older people. The adoption of a healthy lifestyle at an early age and even in old age, which includes PA, favors the quality of life of the subjects and a healthy aging. Method: This article is a systematic review of the Pubmed, Google Schoolar, Elsevier, Scielo and Redalyc index. Using the keywords, 132 related articles were found, however, according to the inclusion and exclusion criteria, 120 articles were discarded, leaving 12 studies for review. Results: 72% of the studies showed benefits at a physical level: PA in old age improves strength, balance, flexibility and muscle tone. It is also related to a significant reduction in arterial stiffness. 11% of the investigations refer to improvements in the psychoemotional sphere: PA generates positive feelings such as happiness or good self-perception. And 17% of the articles focused on quality of life: PA favors the perception of better quality of life. Conclusion: Physical activity improves health in the physical, mental and social spheres of older adults, improving their quality of life and promoting healthy aging.

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