ASSOCIATION BETWEEN HIGH LEVELS OF PARATHYROID HORMONE AND FRAILTY: THE NEPEAN OSTEOPOROSIS AND FRAILTY (NOF) STUDY

2018 ◽  
pp. 1-5
Author(s):  
L. Murthy ◽  
P. Dreyer ◽  
P. Suriyaarachchi ◽  
F. Gomez ◽  
C.L. Curcio ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Grip Strength ◽  
Multinomial Logistic Regression ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Gait Velocity ◽  
Older Individuals ◽  
Cross Sectional ◽  
Serum Pth

Background: Frailty is associated with poor outcomes hence identification of risks factors is pivotal. Since the independent role of parathyroid hormone (PTH) in frailty remains unexplored, we aimed to determine this in a population of older individuals with a history of falling. Design: Cross-sectional study. Setting: Falls and Fracture Clinic, Nepean Hospital (Penrith, Australia). Participants: 692 subjects (mean age=79, 65% women) assessed between 2009-2015. Measurements: Assessment included clinical examination, mood, nutrition, grip strength, gait velocity, bone densitometry and posturography. Chemistry included serum PTH, calcium, vitamin D (25(OH)D3), creatinine and albumin. Normocalcemic subjects were divided into 4 groups: (1) Normal: 25(OH)D3 >50nmol/L and PTH between 1.6-6.8pmol/L; (2) PTH responsive: low 25(OH)D3 (<50nmol/L) and high PTH (>6.8pmol/L); (3) PTH unresponsive: low 25(OH)D3 and normal PTH; (4) Hyper PTH (>6.8pmol/L) with normal 25(OH)D3. Frailty was defined using Fried’s criteria. Difference between the groups was assessed using one-way ANOVA and X2 analysis. Multinomial logistic regression evaluated the association between the groups and the number of Fried’s criteria adjusted for age, BMI, renal function, 25(OH)D3 levels, and albumin. Results: 22.6% subjects had high PTH levels (>6.8pmol/L). All subjects in the high PTH groups had significantly lower grip strength, gait velocity, limits of stability, and higher BMI. The PTH responsive group had a higher risk of pre-frailty (β=3.8, 95% CI = 3.42 – 5.22, p< 0.01) and frailty (β=8.26, 95% CI = 2.8-16.1, p<0.01). The risk of frailty was also higher in the Hyper PTH group (β=2.3, 95% CI = 1.74-4.32, p<0.01). Conclusion: We have reported an independent association of high PTH levels with high number of falls and with the clinical components of physical frailty in community dwelling older persons. Our results suggest a possible role of PTH in frailty that deserves further exploration.

EDUCATIONAL INEQUALITIES AND FRAILTY IN SPAIN: WHAT IS THE ROLE OF OBESITY?

2014 ◽  
pp. 1-6
Author(s):  
S. RODRÍGUEZ LÓPEZ ◽  
P. MONTERO ◽  
M. CARMENATE
Keyword(s):  
Formal Education ◽  
Multinomial Logistic Regression ◽  
Educational Background ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Independent Effect ◽  
Cross Sectional ◽  
Self Reports ◽  
Educational Gradient

Background: Evaluate how obesity is associated with the development of frailty among older adults isimportant. However, few studies have examined the relation between obesity and frailty within differenteducational backgrounds. Objectives:This study aims to investigate the association between educational leveland frailty and to evaluate whether obesity explains any possible associations among Spanish adults. Design,participants and settings:This is a cross-sectional study including 2,319 50-years-old and older community-dwelling Spanish adults, who participated in the first wave (2004/05) of the Survey of Health, Ageing andRetirement in Europe (SHARE). Measurements:Educational differences in frailty phenotypes –defined by theSHARE’s operationalized criterion– and their association with obesity –estimated through self-reports of weightand height– were evaluated using multinomial logistic regression analyses. Results:Women experienced frailtyin a larger proportion than men (22.3% vs. 13.3%). After adjusting for all confounders, we found a markededucational gradient in frailty, where individuals with non-formal education showed increased odds of a frailtyphenotype than individuals with higher education. Moreover, obesity was significantly related to frailty and theeffect of obesity is similar at all levels of education after testing for interaction effects. Although there is amediation effect of obesity, the educational gradient in frailty is robust to controls for obesity. Conclusions:Ourfindings suggest a somehow independent effect of both educational background and obesity on frailty amongSpanish individuals. This adds to the evidence of the frailty-obesity association among different educationalbackgrounds, and has implications for future interventions leading to reduce health disparities in elders.

scholarly journals Community-dwelling Older Individuals using Day Services: Prevalence and Associations Between Walking, Toe-grip Strength, and Foot Problems -Cross-sectional Study-

2020 ◽  
Author(s):  
Kashiko Fujii ◽  
Takuyuki Komoda ◽  
Ikumi Honda ◽  
Nozomi Kawabe ◽  
Ryouhei Nishimura ◽  
...  
Keyword(s):  
Grip Strength ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
P Value ◽  
Older Individuals ◽  
Cross Sectional ◽  
Term Care ◽  
Foot Problems ◽  
The Right ◽  
Toe Deformity

Abstract Background: Foot disorders in older individuals contribute to balance, posture, and gait instability, causing a decrease in activity of daily living and quality of life. However, the existing foot problems of older individuals in the community have not been studied well in Japan.Method: This cross-sectional study analyzed the foot-related data of 176 frail, old-aged participants who attended day service centers in Japan. Foot conditions were assessed and measured from various aspects, as was weight distribution to the floor. Multiple regression analysis was used to find foot item variables that correlated with toe-grip strength and walking speed.Results: Prevalence of skin dryness and suspected and existing nail fungal infection was high in both sexes regardless of care level. Prevalence rate of toe deformity and arch deformity was significantly higher in men and women requiring long-term care, respectively. The multiple regression analysis using stepwise method indicated the right toe-grip strength had a statistically significant association with the arch deformity, suspected or existing nail fungal infection, and nail thickness of the right sided foot (p-value, 0·012, 0·034, 0·040 respectively). Coefficients of all independent variables were negative. Any independent variables were not selected from the left foot. The corn, callus and toe deformity of right sided foot was significantly associated with walking test (p-value, 0·026, 0·033 respectively).Conclusions: Our study supported that individuals requiring more long-term care tend to have more foot problems. Some specific conditions were associated with toe-grip force and walking speed. This finding contributes to future strategies to protect foot health for community-dwelling older individuals, particularly the frail population. Trial registration: Not Applicable

The Relationship between Dental Findings and Tongue Pressure: A Survey of 745 Community-Dwelling Adults and Elderly Persons in Japan

Gerontology ◽  
2021 ◽  
pp. 1-8
Author(s):  
Kensuke Tashiro ◽  
Sakiko Soutome ◽  
Madoka Funahara ◽  
Yumiko Kawashita ◽  
Masayasu Kitamura ◽  
...  
Keyword(s):  
Propensity Score ◽  
Grip Strength ◽  
Propensity Score Matching ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Tongue Pressure ◽  
Elderly Persons ◽  
Cross Sectional ◽  
Number Of Teeth ◽  
The Relationship

Introduction: Reduced tongue pressure is one of the causes of dysphagia. The purpose of this study was to investigate the relationship between dental findings and tongue pressure, and whether prosthetic treatment prevents reduced tongue pressure. Methods: This was a cross-sectional study. Participants were 745 community-dwelling adults and elderly persons in the Goto Islands in Nagasaki, who underwent a health checkup for residents in 2015 and 2016. Data were collected on gender; age; grip strength; hemoglobin; Creatinine (Cr); glycated hemoglobin (HbA1c); history of stroke; smoking, drinking, exercise, and walking habits; number of teeth; wearing of removable dentures; functional units of natural teeth (n-FTUs), fixed prostheses (nif-FTUs), and removable dentures (t-FTUs); and tongue pressure. The associations between each variable and tongue pressure were examined using multiple regression analysis. Next, those with 3 or fewer n-FTUs were selected, and differences in tongue pressure were compared between those with 3 or fewer nif-FTUs and those with 4 or more nif-FTUs, using a propensity score matching method. Results: Male gender, weak grip strength, low HbA1c, no drinking, and a low number of teeth were independent factors significantly associated with lower tongue pressure. Among participants with 3 or fewer n-FTUs, the 43 with 4 or more nif-FTUs showed significantly higher tongue pressure than the 43 with 3 or fewer nif-FTUs after propensity score matching, although the number of t-FTUs was not associated with tongue pressure. Discussion/Conclusion: Tooth loss was significantly associated with lower tongue pressure. It was suggested that fixed prosthesis treatment might prevent the reduction of tongue pressure, but removable dentures did not have such an effect.

scholarly journals Is there an association between ageist attitudes and frailty?

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Douglas Salguero ◽  
Juliana Ferri-Guerra ◽  
Nadeem Y. Mohammed ◽  
Dhanya Baskaran ◽  
Raquel Aparicio-Ugarriza ◽  
...  
Keyword(s):  
Older Adults ◽  
Logistic Regression ◽  
Multinomial Logistic Regression ◽  
Frailty Index ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Outcome Variable ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Frailty Status

Abstract Background Frailty is defined as a state of vulnerability to stressors that is associated with higher morbidity, mortality and healthcare utilization in older adults. Ageism is “a process of systematic stereotyping and discrimination against people because they are old.” Explicit biases involve deliberate or conscious controls, while implicit bias involve unconscious processes. Multiple studies show that self-directed ageism is a risk factor for increased morbidity and mortality. The purpose of this study was to determine whether explicit ageist attitudes are associated with frailty in Veterans. Methods This is a cross-sectional study of Veterans 50 years and older who completed the Kogan’s Attitudes towards Older People Scale (KAOP) scale to assess explicit ageist attitudes and the Implicit Association Test (IAT) to evaluate implicit ageist attitudes from July 2014 through April 2015. We constructed a frailty index (FI) of 44 variables (demographics, comorbidities, number of medications, laboratory tests, and activities of daily living) that was retrospectively applied to the time of completion of the KAOP and IAT. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by multinomial logistic regression models with frailty status (robust, prefrail and frail) as the outcome variable, and with KAOP and IAT scores as the independent variables. Age, race, ethnicity, median household income and comorbidities were considered as covariates. Results Patients were 89.76% male, 48.03% White, 87.93% non-Hispanic and the mean age was 60.51 (SD = 7.16) years. The proportion of robust, pre-frail and frail patients was 11.02% (n = 42), 59.58% (n = 227) and 29.40% (n = 112) respectively. The KAOP was completed by 381 and the IAT by 339 participants. In multinomial logistic regression, neither explicit ageist attitudes (KAOP scale score) nor implicit ageist attitudes (IAT) were associated with frailty in community dwelling Veterans after adjusting for covariates: OR = .98 (95% CI = .95–1.01), p = .221, and OR:=.97 (95% CI = .37–2.53), p = .950 respectively. Conclusions This study shows that neither explicit nor implicit ageist attitudes were associated with frailty in community dwelling Veterans. Further longitudinal and larger studies with more diverse samples and measured with other ageism scales should evaluate the independent contribution of ageist attitudes to frailty in older adults.

scholarly journals Correlation Between Serum Parathormone Levels With Urinary Magnesium Excretion In Patients With Non-Dialytic Chronic Kidney Disease

2020 ◽  
Author(s):  
Raimunda Sheyla Carneiro Dias ◽  
Dyego José Araújo Brito ◽  
Joyce Santos Lages ◽  
Alcione Miranda Santos ◽  
Elisangela Milhomen Santos ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Parathyroid Hormone ◽  
Kidney Disease ◽  
Serum Calcium ◽  
Mineral Metabolism ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
Magnesium Excretion ◽  
Serum Pth

Abstract Background: Disorders of mineral metabolism occur in most patients with chronic kidney disease (CKD). The aim of this work was to correlate serum parathyroid hormone (PTH) levels with urinary magnesium excretion in patients with non-dialysis CKD.Methods: Cross-sectional study with patients with CKD undergoing non-dialysis treatment in stages 3A, 3B and 4. Concentrations of creatinine, magnesium, calcium, phosphorus, parathyroid hormone (PTH), 25-hydroxyvitamin D [25(OH)D] and alkaline phosphatase (ALP) were determined in blood samples. The assessment of urinary magnesium levels was performed by means of total daily excretion and by the excretion fraction (FEMg). Results: The study evaluated 163 patients with a mean age of 60.7 ± 11.7 years and 51.0% were male. In the highest quartile of PTH (> 89.5pg / ml), the mean levels of FEMg and ALP were higher (p <0.05), as well as the levels of serum calcium and eGFR were lower (p <0.05). In the unadjusted regression analysis, the following variables were related to serum PTH levels: FEMg (odds ratio (OR) = 1.12; 95% confidence intervals (CI): 1.02–1.23), Calcium (OR = 0.45; 95% CI: 0.22-0.90), ALP (OR = 1.02; 95% CI: 1.00-1.03) and eTFG (OR = 0.92; 95% CI: 1.00-1.03). After an adjusted analysis, only one FEMg and ALP will remain correlated with PTH. Conclusion: In patients with non-dialysis CKD, with higher levels of PTH, higher mean columns of ALP and FEMg, and lower levels of serum calcium and eGFR. FEMg and ALP were some variables that remained associated with PTH.

scholarly journals Prevalence and Potential Predictors of Frailty among Community-Dwelling Older Persons in Northern Thailand: A Cross-Sectional Study

2020 ◽  
Vol 17 (11) ◽  
pp. 4077 ◽  
Author(s):  
Payom Thinuan ◽  
Penprapa Siviroj ◽  
Peerasak Lerttrakarnnon ◽  
Thaworn Lorga
Keyword(s):  
Older Persons ◽  
Multinomial Logistic Regression ◽  
Developed Countries ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Sectional Study ◽  
Cross Sectional ◽  
Slow Walking ◽  
Arm Circumference ◽  
Lower Education

This study aimed to determine the prevalence and associated factors of frailty among Thai older persons. A cross-sectional study was conducted with a representative sample of 1806 older persons aged 60 years or older. Frailty was assessed by Fried’s frailty phenotypes, which consists of five criteria, namely, unintended weight loss, exhaustion, slow walking, weak handgrip and decreased physical activity. Older people who met 3 in 5, 1–2 in 5, and none of the criteria were considered frail, pre-frail and non-frail respectively. The prevalence was calculated and multinomial logistic regression was performed. Prevalence rates of frailty, pre-frailty and non-frailty were 13.9% (95% CI 9.9 to 18.8), 50.9% (95% CI 47.5 to 54.1) and 35.1% (95% CI 31.5 to 39.9), respectively. Increasing age, lower education, having no spouse, poorer health perception, increasing number of comorbidities, osteoarthritis and smaller mid-arm circumference increased the risk of frailty (p < 0.001). The prevalence of geriatric frailty syndrome in this study was much higher than that of developed countries but was lower than that of less developed countries. Factors associated with frailty reflect common characteristics of disadvantaged older persons in Thailand.

scholarly journals Serum 25(OH)D Level and Parathyroid Hormone in Chinese Adult Population: A Cross-Sectional Study in Guiyang Urban Community from Southeast of China

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Zhang Qiao ◽  
Shi Li-xing ◽  
Peng Nian-chun ◽  
Xu Shu-jing ◽  
Zhang Miao ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Adult Population ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Cluster Sampling ◽  
Cross Sectional ◽  
The Mean ◽  
Serum Pth

Objective. To evaluate vitamin D status and serum parathyroid hormone (IPTH) of healthy adults living in Guiyang.Design and Participants. We conducted a cross-sectional evaluation in the General Community in Guiyang by cluster sampling method. The data was a part of 1510 participants (634 men, 876 women) aged 20–79 years median 45.2 years from November 2009 to February 2010 in Guiyang Health Measures Survey.Measurements. Aradioimmunoassay was used to measure the level of 25-hydroxyvitamin D [25(OH)D] and intact parathyroid hormone (iPTH).Results.The mean serum 25(OH)D level was (20.4 ± 9.0) ng/mL and the highest level among participants aged 40–59 years (22.8 ng/mL). The mean serum PTH level was (32.1 ± 13.7) pg/mL and the lowest level among participants aged 40–50 years (30.8 ng/mL). Serum 25(OH)D was below 50 nmol/liter in 52.3%, below 75 nmol/liter in 84.6%, and above 75 nmol/liter in 15.4% of the respondents. Secondary hyperparathyroidism was 5.4% (5.4% among men and 4.6% among women). The prevalence of secondary hyperparathyroidism increased (5.8%, 6.5%, and 7.1%, resp.) with decreasing serum 25(OH)D levels among subjects who were 30 to 20, 19.9 to 10, and <10 ng/mL, respectively. Serum 25(OH)D was inversely associated with serum PTH.Conclusions. Vitamin D insufficiency and its complication of secondary hyperparathyroidism are common.

Evaluating the Relationship Between Olfactory Function and Loneliness in Community-Dwelling Individuals: A Cross-sectional Study

2020 ◽  
pp. 194589242095836
Author(s):  
Vincent M. Desiato ◽  
Zachary M. Soler ◽  
Shaun A. Nguyen ◽  
Craig Salvador ◽  
Jonathan B. Hill ◽  
...  
Keyword(s):  
Los Angeles ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Olfactory Function ◽  
Olfactory Discrimination ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Vas Scores ◽  
The Relationship

Background Olfactory dysfunction (OD) has been reported to impact social interactions. However, the relationship between OD and loneliness has received little attention. The purpose of this study was to determine the association between OD and loneliness, controlling for patient factors. Methods Subjects without otolaryngic complaints were enrolled and olfactory function was assessed using: Sniffin’ Sticks test to measure threshold, discrimination and identification (TDI), Questionnaire of Olfactory Disorders Negative Statements (QOD-NS) and 9 – item Olfactory-Visual Analogue Scale (VAS). Loneliness was assessed using the De Jong Gierveld (DJG) and University of California Los Angeles (UCLA) loneliness scales. Bivariate analysis was performed followed by regression analysis, controlling for confounders. Results In total, 221 subjects were included with a mean age of 50.5 years (range 20 to 93), 133 (60.2%) females and 161 (72.9%) white. Mean TDI score was 29.3 (7.0) and 49.5% of the cohort was dysosmic. Using DJG, 36.4% of the cohort were classified as lonely, whereas 35.0% were lonely using UCLA. Olfactory measures were significantly associated with DJG, including TDI (β = −0.03, p = 0.050), olfactory discrimination (β = −0.111, p = 0.005), QOD-NS (β = 0.058, p < 0.001) and olfactory-VAS (β = 0.032, p < 0.001). UCLA scores were significantly associated with QOD-NS (PR 1.061 [CI 1.018–1.107], p = 0.005) and olfactory-VAS scores (PR 1.027, [CI 1.007–1.049], p = 0.009). After controlling for confounders, the association between DJG and olfactory discrimination, as well as DJG and olfactory-VAS remained significant. Conclusions In this community-based sample of older adults, both OD and loneliness were common. Those subjects with worse olfactory function were more likely to report loneliness. Further research is necessary to establish causality, as well as explore the role of depression.

scholarly journals Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity

2011 ◽  
Vol 27 (10) ◽  
pp. 1997-2008 ◽  
Author(s):  
Carolline de Araújo Mariz ◽  
Maria de Fátima P. Militão de Albuquerque ◽  
Ricardo Arraes de Alencar Ximenes ◽  
Heloísa Ramos Lacerda de Melo ◽  
Francisco Bandeira ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Multinomial Logistic Regression ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
Lifestyle Changes ◽  
Reference Level ◽  
Older Individuals ◽  
Cross Sectional ◽  
Cd4 Cell Count

A cross-sectional study was conducted using body mass index (BMI) to estimate the prevalence of thinness and overweight/obesity and associated factors in 2,018 individuals with HIV/AIDS attending health services referral centers. The dependent variable was classified as thinness, overweight/obesity and eutrophy. Multinomial logistic regression analyses were performed considering eutrophy as the reference level. The prevalence of thinness was 8.8% and of overweight/obesity, 32.1%. The variables associated with thinness were anemia and CD4 cell count < 200mm³. The variables associated with risk of overweight/obesity were age > 40 years and diabetes, and the variables identified as decreasing likelihood of overweight/obesity were having no long-term partner, smoking, presence of an opportunistic disease, anemia, and albumin levels < 3.5mg/dL. The main nutritional problem observed in this population was overweight and obesity, which were much more prevalent than thinness. Older individuals with diabetes should be targeted for nutritional interventions and lifestyle changes.

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