25-OH-VITAMIN D IS NOT ASSOCIATED WITH COGNITIVE PERFORMANCE AMONG MEXICAN COMMUNITY-DWELLING OLDER PERSONS

2015 ◽  
pp. 1-6
Author(s):  
A.P. NAVARRETE-REYES ◽  
I. GARCÍA-MUÑOZ ◽  
J.M.A. GARCÍA-LARA ◽  
N.M. TORRES-CARRILLO ◽  
H. AMIEVA ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Performance ◽  
Latin American ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Public Health Issue ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Mexican Community ◽  
25 Oh Vitamin D

Background: Low cognitive performance has been associated with a wide array of adverse health-related outcomes in elderly populations. Recently, the effect of vitamin D on cognition has been studied; however, its benefits are still controversial. Moreover, most studies have been carried out on North-American and European populations where vitamin D deficiency could represent a greater public-health issue when compared to Latin American ones. Objective: To investigate the association between 25-OH-vitamin D and cognitive performance in Mexican community-dwelling elderly. Design, Setting and Participants: Cross-sectional study sample of 331 community-dwelling elderly aged 70 and older, participating in the Mexican Study of Nutritional and Psychosocial Markers of Frailty. Measurements: Serum 25-OH-vitamin D, cognitive performance as per the Mini-Mental State Examination (MMSE) and the IST (Isaacs Set Test), as well as several elements from the comprehensive geriatric assessment. Results: Mean age of participants was 79.3 years (SD 5.9), 54.1% were women. The mean serum 25-OH-vitamin D level was 59.0 (SD 23.3) nmol/L while mean MMSE score was 22.3 (SD 3.4) and mean IST score was 37.1 (SD 9.1). Although 25-OH-vitamin D levels were lower across all the definitions of low cognitive perfomance, the difference between groups was not statistically significant in any of them. Conclusion: No association between 25-OH-vitamin D level and cognitive performance was found in this population of Mexican community-dwelling elderly. Further investigation is required in order to clarify its existence and if so, to delineate its characteristics.

scholarly journals Vitamin D Status of Epileptic Children in India: A Prospective Cross-Sectional Study from a Tertiary Care Centre

2020 ◽  
Vol 10 (01) ◽  
pp. e87-e92
Author(s):  
Chandrika Azad ◽  
Vishal Guglani ◽  
Jasbinder Kaur ◽  
Roosy Aulakh ◽  
Sukhvinder Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Epileptic Children ◽  
25 Oh Vitamin D

AbstractVitamin D deficiency is prevalent all over the world, especially in tropical countries. In epileptics, antiepileptic drugs (AED) and associated comorbidities further impact vitamin D status. The aim of this study is to estimate the prevalence of 25(OH) vitamin D deficiency in epileptic children and evaluate probable risk factors. A cross-sectional study of 200 children between 1 and 18 years of age on AED was undertaken in the pediatric neurology clinic of a tertiary care center of Northern India. In all children, serum 25(OH) vitamin D levels, calcium, phosphorus, and alkaline phosphatase were estimated. The deficiency levels of vitamin D were categorized as: deficiency <20 ng/mL, insufficiency 20 to 30 ng/mL, and sufficiency >30 ng/mL. The potential risk factors for hypovitaminosis D, including type of epilepsy, AED regimen (specific medications, polytherapy vs. monotherapy), cerebral palsy, ambulatory status, intellectual disability, body mass index, gender, and vegetarianism were examined. Among the 200 enrolled children (60% boys), 106/200 (53%) were vitamin D deficient. There was no significant relation of vitamin D levels with gender, type of epilepsy, neurological deficit, and type of AED. An inverse relationship of higher phenytoin doses during monotherapy associated with lower vitamin D levels in monotherapy was found, thereby suggesting adverse effect of high doses of phenytoin on vitamin D levels. VDD is common among epileptic children on AED therapy. Vitamin D deficiency is common prevalent among epileptic children on AED therapy, and its detection and treatment correction should be an integral part of epilepsy management.

scholarly journals Thyroid Function and 25 (OH) Vitamin D Level among Sudanese Women in Early Pregnancy

2018 ◽  
Vol 6 (3) ◽  
pp. 488-492
Author(s):  
Imad R. Musa ◽  
Duria A. Rayis ◽  
Mohmamed A. Ahmed ◽  
Ammar H. Khamis ◽  
Abubakr M. Nasr ◽  
...  
Keyword(s):  
Vitamin D ◽  
Thyroid Function ◽  
Early Pregnancy ◽  
Cross Sectional Study ◽  
The Body ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
The Mean ◽  
25 Oh Vitamin D

AIM: A cross-sectional study was conducted at Saad Abualila Hospital (Khartoum, Sudan) to evaluate the vitamin D levels and thyroid function among pregnant Sudanese women (132) in early pregnancy.METHODS: A cross-sectional study was conducted at Saad Abualila hospital (Khartoum, Sudan) during the period from March to July 2015. Women who were in early pregnancy with a singleton pregnancy were approached to participate in the study after signing informed consent. A sample size of 132 participants was calculated guided by the normal interval of thyroid function in Sudanese women in the first trimester and not the level of 25(OH) vitamin D. The 25 - hydroxyvitamin D (25 (OH) vitamins levels were measured using an electrochemiluminescence immunoassay on an Elecsys 2010 Analyzer (Roche Diagnostics, Mannheim, Germany).RESULTS: The mean (SD) of age, gravidity and gestational age was 27.6 (5.5) years, 2.2 (1.6) and 10.4 (2.2) weeks, respectively. The mean (SD) of the body mass index (BMI) and haemoglobin was 27.1 (5.2) kg/m2 and 10.8 (1.1) g/dl, respectively. Median (interquartile) values of TSH, FT3, and FT4 were 1.164 IU/ml (0.079 -2.177 IU/ml), 4.639 nmol/l (3.843 - 6.562 nmol/l), and 16.86 pmol/l (13.02 - 31.48 pmol/l), respectively. There was no significant correlation between vitamin D levels and TSH, FT3 and FT4CONCLUSION: There is no correlation between 25 (OH) vitamin D levels and thyroid function during early pregnancy among Sudanese pregnant women, despite prevalent vitamin D deficiency among these women.

scholarly journals Vitamin D deficiency in children with bronchial asthma in southern Jordan: a cross-sectional study

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052097424
Author(s):  
Enas Al-Zayadneh ◽  
Nedal Awad Alnawaiseh ◽  
Salma Ajarmeh ◽  
Areej Hamed Altarawneh ◽  
Eman M Albataineh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bronchial Asthma ◽  
Asthma Severity ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Objectives To assess serum 25-hydroxycholecalciferol (25-OH vitamin D) levels in Jordanian children with bronchial asthma, and to examine correlations between 25-OH vitamin D levels and asthma severity and control. Methods A cross-sectional study was conducted at the Paediatric Chest Clinic, Al-Karak Governmental Hospital, Southern Jordan, between May 2015 and February 2016. Serum 25-hydroxyvitamin D level was determined in children aged 1–14 years diagnosed with bronchial asthma (6–14 years) or recurrent wheezing episodes (<6 years). Asthma severity was determined based on the Global Initiative for Asthma assessment, the Asthma Control Test, and the Childhood Asthma Control Test. Demographic and clinical characteristics were compared between patients with low and normal 25-OH vitamin D levels, and correlations between asthma severity and 25-OH vitamin D level were assessed. Results Out of 98 included children, 25-OH vitamin D levels were deficient and insufficient in 41 (41.8%) and 34 (34.7%) children, respectively. Only 23 (23.5%) had sufficient 25-OH vitamin D levels. A significant correlation was found between severity of asthma symptoms and 25-OH vitamin D deficiency. Conclusion 25-OH vitamin D deficiency is highly prevalent in Jordanian children with bronchial asthma and correlates significantly with asthma severity.

scholarly journals The Association of 25 (OH) Vitamin D Levels and Severity and Outcome of COVID-19: A Cross-sectional Study

2021 ◽  
Author(s):  
Maryam Vasheghani ◽  
Nasrin Jannati ◽  
Parvaneh Baghaei ◽  
Mitra Rezaei ◽  
Majid Marjani
Keyword(s):  
Vitamin D ◽  
Severe Disease ◽  
Serum Levels ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Icu Admission ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Abstract BackgroundCoronavirus disease 2019 (COVID-19) is a pandemic disease. Experiments with influenza and severe acute respiratory syndrome (SARS) have shown supplemental vitamin D can reduce the risk of infection and death.AimThis study was performed to evaluate the relationship between vitamin D levels and the severity and outcome of admitted patients with COVID-19.Material and MethodsThis cross-sectional study was performed on COVID-19 cases diagnosed by examining RT-PCR assay for SARS-CoV-2 or a set of symptoms and typical findings in lung CT scan. Based on clinical and radiologic characteristics, the patients were categorized as mild, moderate, severe, and critical. Calcium, phosphorus, albumin, creatinine, and serum 25 hydroxy vitamin D were measured and their correlation with the severity and outcome were analyzed.ResultsFrom May 1 to June 31, 2020, 508 patients ((442 patients in general wards and 66 patients in intensive care unit (ICU)) were included in this study. The participants were 56±17 years old (mean ±SD) (range from 14 to 95 years) and 52% were male. According to the past medical history, 190 (37.4%) of them had comorbidity. Concerning severity, 13.2%, 42.3%, 35.4%, and 9.1% had the mild, moderate, severe, and critical disease, respectively. The in-hospital mortality rate was 10.8%. In the multivariate regression analysis, age had a positive correlation and use of vitamin D supplement, serum level of 25 OH vitamin D, calcium, and albumin had a negative correlation with disease severity and admission to ICU. Poor outcome was inversely related to serum levels of vitamin D, calcium, albumin, and renal function. Vitamin D deficiency increased the rate of ICU admission by 2.7 times (95%CI=1.288-5.91, P=0.009).ConclusionIn patients who are hospitalized due to COVID-19, low 25-hydroxyvitamin D, hypocalcemia, and hypoalbuminemia are associated with severe disease, ICU admission, and an increase in mortality.

scholarly journals Vitamin D Status in Mothers and their Newborns at a Tertiary Care Centre in Mumbai: A Cross-sectional Study

2020 ◽  
Author(s):  
Avinash L Sangle ◽  
Amol P Jaybhaye ◽  
Ravindra Y Chittal ◽  
Deepak Ugra
Keyword(s):  
Vitamin D ◽  
Cross Sectional Study ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
High Prevalence ◽  
25 Oh Vitamin D ◽  
Pregnant Mothers

Introduction: Indian population has a paradoxically high prevalence of vitamin D deficiency. Maternal vitamin D levels are related to outcomes of pregnancy for mother and foetus. To understand the need for screening and appropriate management decisions, data is needed from various regions of India to explore the magnitude of the problem. Aim: To evaluate the vitamin D levels in pregnant mothers and their newborns at a hospital catering to the affluent population in Mumbai. Materials and Methods: A cross-sectional study was conducted from August to December 2012. A 100 women of Indian origin, between 20-45 years of age and their newborns who were delivered at the Lilavati Hospital and Research Centre in Mumbai were included. Determination of 25 hydroxy (OH) vitamin D, serum calcium, albumin concentration was done in mothers just before delivery and newborns venous cord blood at the time of delivery. Pearson’s correlation test was used for determining relation between maternal and newborns vitamin D levels and Chi-square test for association of maternal vitamin D levels with their sun exposure and newborns birth weight. Results: The distribution of serum 25 (OH) vitamin D status in mothers was 75 deficient (75%), 13 insufficient (13%) and 12 sufficient (12%). Mean serum 25 (OH) vitamin D in mothers was 15.09 ng/mL. The distribution of serum 25 (OH) vitamin D levels in newborns were 78 deficient (78%), 13 insufficient (13%) and 9 sufficient (9%). Mean serum 25 (OH) vitamin D in neonates was 13.82 ng/mL. There was strong correlation between maternal and newborns serum 25 (OH) vitamin D levels with a Pearson correlation coefficient value of 0.94 and the p-value of <0.001. Conclusion: There was a high prevalence of vitamin D deficiency in pregnant mothers associated with hypovitaminosis D in newborns in this hospital-based study catering to affluent population from Mumbai.

scholarly journals Vitamin D status in 3-6-year-old children of Mananthavady ICDS block in Wayanad, Kerala, India

2018 ◽  
Vol 5 (4) ◽  
pp. 1226
Author(s):  
Arif Mohamed Khan ◽  
T. G. Sindhu ◽  
M. Vijayakumar
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Cross Sectional Study ◽  
Tribal Community ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
High Prevalence ◽  
25 Oh Vitamin D ◽  
Kerala State

Background: Despite plenty of sunlight, vitamin D deficiency has been reported in both urban and rural population in India. This study was conducted to estimate the prevalence of Vitamin D deficiency in children between 3-6 years of age group belonging to Mananthavady ICDS block of Wayanad and to identify the sociodemographic variables affecting its level.Methods: This descriptive cross-sectional study was conducted from December 2014 to June 2015. 140 children were selected from 20 Anganawadis in Mananthavady ICDS block in Wayanad district of Kerala state by random methods. After taking relevant history and conducting detailed clinical examinations, blood samples were taken to assess 25(OH) Vitamin D, calcium, phosphorous and alkaline phosphatase levels. Statistical analysis was done using PASW software. Calculations of means were done using descriptive statistics and comparative analysis was done using independent T test.Results: Out of the 140 children 51 belonged to tribal community. The mean 25(OH) Vitamin D level was 22.7ng/ml. 47.1% of the population had deficient, 35% insufficient and 17.9% adequate Vitamin D levels. There was no statistically significant difference in Vitamin D levels between children of tribal and non-tribal community. There was significant increase in Vitamin D levels during summer when compared to that of winter and autumn seasons.Conclusions: There is a high prevalence of vitamin D deficiency among the rural children of 3-6-year age of Mananthavadi ICDS block. The Vitamin D levels were almost equal between the tribal and non-tribal children. Vitamin D levels are significantly higher during summer when compared to other seasons.

scholarly journals Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 347
Author(s):  
Carlo De Matteis ◽  
Lucilla Crudele ◽  
Marica Cariello ◽  
Stefano Battaglia ◽  
Giuseppina Piazzolla ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Inverse Association ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Vitamin D Levels ◽  
25 Oh Vitamin D

Vitamin D deficiency is often linked with Metabolic Syndrome, both being more frequent with ageing and associated with an increase inflammatory state. Recently, monocytes-to-high density lipoprotein (HDL) ratio (MHR) has emerged as a powerful index to predict systemic inflammation. In this cross-sectional study, we investigated the association between circulating vitamin D level (25-OH vitamin D) and inflammatory status in a population of 1048 adult individuals. Our study reveals an inverse association between 25-OH vitamin D levels and MHR in the overall population. When the population is stratified by gender, waist circumference, and body mass index (BMI), we observed that while in men this relation is strongly significative only in condition of central obesity, in women a lifelong negative correlation exists between circulating 25-OH vitamin D and MHR and it is independent of the metabolic status. These observations underscore the relevance of circulating biomarkers such as MHR in the prediction of systemic inflammatory conditions sustained by vitamin D deficiency also in healthy and young women.

scholarly journals High prevalence of peripheral neuropathy in multiple myeloma patients and the impact of vitamin D levels, a cross-sectional study

2021 ◽  
Author(s):  
B. E. Oortgiesen ◽  
J. A. Kroes ◽  
P. Scholtens ◽  
J. Hoogland ◽  
P. Dannenberg - de Keijzer ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Clinical Trial Registration ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Vitamin D Levels ◽  
The Impact

Abstract Purpose Peripheral neuropathy (PN) is common in patients with multiple myeloma (MM). We hypothesized that the relationship between hypovitaminosis D and PN described in diabetes mellitus patients may also be present in MM patients. Methods To study this potential association, we assessed the incidence of hypovitaminosis D (vitamin D < 75 nmol/L [= 30 ng/mL]) in smouldering and active MM patients in two Dutch hospitals. Furthermore, a validated questionnaire was used to distinguish different PN grades. Results Of the 120 patients included between January 2017 and August 2018, 84% had an inadequate vitamin D level (median vitamin D level 49.5 nmol/L [IQR 34–65 nmol/L]; mean age: 68 years [SD ± 7.7]; males: 58%). PN was reported by 69% of patients (n = 83); however, of these 83 patients, PN was not documented in the medical records of 52%. An association was found between lower vitamin D levels and higher incidence of PN in the total population (P = 0.035), and in the active MM patients (P = 0.016). Conclusion This multi-centre cohort study showed that PN and hypovitaminosis D are common in MM patients, and addressing low vitamin D levels in the treatment of MM patients might be beneficial in reducing the risk of PN. More attention for PN is warranted, as PN is underreported by clinicians. Further research is needed to fully understand the implications of vitamin D in the development of PN in patients with MM. Clinical trial registration Netherland Trial Register NL5835, date of registration July 28, 2016

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