scholarly journals Development of computational tools for analysis of polyploid plant genomes with application to hexaploid sweetpotato

2019 ◽  
Author(s):  
Chenxi Zhou
Keyword(s):  
Computational Tools ◽  
Plant Genomes ◽  
Polyploid Plant

scholarly journals Impact of transposable elements on polyploid plant genomes

2017 ◽  
Vol 120 (2) ◽  
pp. 195-207 ◽  
Author(s):  
Carlos M. Vicient ◽  
Josep M. Casacuberta
Keyword(s):  
Transposable Elements ◽  
Plant Genomes ◽  
Polyploid Plant

Assembly of whole-chromosome pseudomolecules for polyploid plant genomes using outbred mapping populations

2020 ◽  
Vol 52 (11) ◽  
pp. 1256-1264
Author(s):  
Chenxi Zhou ◽  
Bode Olukolu ◽  
Dorcus C. Gemenet ◽  
Shan Wu ◽  
Wolfgang Gruneberg ◽  
...  
Keyword(s):  
Plant Genomes ◽  
Polyploid Plant ◽  
Mapping Populations

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

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