Identification of genes driving endocrine tumour development

2017 ◽  
Author(s):  
Jessica Harris
Keyword(s):  
Endocrine Tumour ◽  
Tumour Development

Severe Head Injury linked to Subsequent Development of Malignant Brain Tumour within a Short Period- A Case Report

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Head Injury ◽  
Brain Tumour ◽  
Severe Head Injury ◽  
Case Reports ◽  
Subsequent Development ◽  
Malignant Brain Tumour ◽  
Tumour Development ◽  
Short Period ◽  
The Brain

There have been a few case reports of head injury leading to brain tumour development in the same region as the brain injury. Here we report a case where the patient suffered a severe head injury with contusion. He recovered clinically with conservative management. Follow up Computed Tomography scan of the brain a month later showed complete resolution of the lesion. He subsequently developed malignant brain tumour in the same region as the original contusion within a very short period of 15 months. Head injury patients need close follow up especially when severe. The link between severity of head injury and malignant brain tumour development needs further evaluation. Role of anti-inflammatory agents for prevention of post traumatic brain tumours needs further exploration.

P15 Gastrointestinal tumour development in irradiated neonatal and adult ApcMin/+ CHB6 F1 mice.

2001 ◽  
Vol 199 (1-2) ◽  
pp. 225-225
Author(s):  
M. ELLENDER ◽  
M. BARR ◽  
O. HOUGHTON ◽  
J. D. HARRISON ◽  
K. E. CARR
Keyword(s):  
Tumour Development

scholarly journals Fusion of immortalized myoblasts induces genomic instability that drives tumour development and progression

2019 ◽  
Vol 30 ◽  
pp. v703-v704
Author(s):  
C. Merle ◽  
J. Baud ◽  
N. Thebaud ◽  
T. Lesluyes ◽  
G. Pérot ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Tumour Development

scholarly journals ROS and TGFβ: from pancreatic tumour growth to metastasis

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Chao-Hui Chang ◽  
Siim Pauklin
Keyword(s):  
Tumour Growth ◽  
Cancer Metastasis ◽  
Transforming Growth Factor ◽  
Cancer Therapeutics ◽  
Transforming Growth Factor Β ◽  
Ductal Adenocarcinoma ◽  
Cellular Processes ◽  
Tumour Development ◽  
Pancreatic Tumour ◽  
Tgfβ Signalling

AbstractTransforming growth factor β (TGFβ) signalling pathway switches between anti-tumorigenic function at early stages of cancer formation and pro-tumorigenic effects at later stages promoting cancer metastasis. A similar contrasting role has been uncovered for reactive oxygen species (ROS) in pancreatic tumorigenesis. Down-regulation of ROS favours premalignant tumour development, while increasing ROS level in pancreatic ductal adenocarcinoma (PDAC) enhances metastasis. Given the functional resemblance, we propose that ROS-mediated processes converge with the spatial and temporal activation of TGFβ signalling and thereby differentially impact early tumour growth versus metastatic dissemination. TGFβ signalling and ROS could extensively orchestrate cellular processes and this concerted function can be utilized by cancer cells to facilitate their malignancy. In this article, we revisit the interplay of canonical and non-canonical TGFβ signalling with ROS throughout pancreatic tumorigenesis and metastasis. We also discuss recent insight that helps to understand their conflicting effects on different stages of tumour development. These considerations open new strategies in cancer therapeutics.

The effect of surgical wounding on tumour development

1999 ◽  
Vol 25 (3) ◽  
pp. 231-243 ◽  
Author(s):  
S.O.P. Hofer ◽  
G. Molema ◽  
R.A.E.C. Hermens ◽  
H.J. Wanebo ◽  
J.S. Reichner ◽  
...  
Keyword(s):  
Tumour Development
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