A genome-wide approach to identify genetic determinants of skin wound healing and scar formation

2017 ◽  
Author(s):  
Betoul Baz
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Scar Formation ◽  
Genetic Determinants ◽  
Skin Wound Healing ◽  
Genome Wide ◽  
A Genome

scholarly journals Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation

2019 ◽  
Author(s):  
Chen-Chen Zhao ◽  
Lian Zhu ◽  
Zheng Wu ◽  
Rui Yang ◽  
Na Xu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Damage Model ◽  
Skin Wound ◽  
Scar Formation ◽  
Wound Dressings ◽  
Skin Damage ◽  
Skin Wound Healing ◽  
Accelerate Wound Healing ◽  
Peptide Hydrogels

Abstract Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.

scholarly journals Role of periostin in skin wound healing and pathologic scar formation

2020 ◽  
Vol 133 (18) ◽  
pp. 2236-2238
Author(s):  
Shi-Lu Yin ◽  
Ze-Lian Qin ◽  
Xin Yang
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Scar Formation ◽  
Skin Wound Healing

Scarless wound repair: a human fetal skin model

Development ◽  
1992 ◽  
Vol 114 (1) ◽  
pp. 253-259 ◽  
Author(s):  
H.P. Lorenz ◽  
M.T. Longaker ◽  
L.A. Perkocha ◽  
R.W. Jennings ◽  
M.R. Harrison ◽  
...  
Keyword(s):  
Wound Healing ◽  
Gestational Age ◽  
Animal Studies ◽  
Wound Repair ◽  
Mouse Skin ◽  
Skin Wound ◽  
Scar Formation ◽  
Fetal Skin ◽  
Skin Wound Healing ◽  
Thickness Skin

Animal studies demonstrate that the fetus heals cutaneous wounds by reformation of normal tissue architecture without scar formation. We have developed a new model to study human fetal skin wound healing. Grafts of human fetal skin placed onto athymic mice retain the morphologic features of normal development, although they differentiate at an accelerated rate when placed cutaneously compared to subcutaneously. Full-thickness skin grafts from human fetuses at 15 (n = 12), 17 (n = 11), 18 (n = 25), 19 (n = 20) and 22 (n = 13) weeks gestational age were placed onto athymic (nu/nu) mice in 2 locations: (1) cutaneously onto a fascial bed and thereby exposed to air or (2) subcutaneously in a pocket under the murine panniculus carnosus. Linear incisions were made in each graft 7 days after transplantation. Grafts were harvested at 7, 14 and 21 days postwounding and analyzed histologically for scar formation. By hematoxylin & eosin and Mallory's trichrome stains, complete epidermal and dermal graft wound healing without scar formation was demonstrated in the subcutaneous grafts at each gestational age studied. In contrast, scar was seen at all time points in the cutaneous grafts in both the incisional wound and at the interface of the fetal human skin graft and adult mouse skin, regardless of fetal skin gestational age.(ABSTRACT TRUNCATED AT 250 WORDS)

Lactobacillus rhamnosus CGMCC 1.3724 (LPR) Improves Skin Wound Healing and Reduces Scar Formation in Mice

2021 ◽  
Author(s):  
Camila Francisco Moreira ◽  
Puebla Cassini-Vieira ◽  
Maria Cecília Campos Canesso ◽  
Mariane Felipetto ◽  
Hedden Ranfley ◽  
...  
Keyword(s):  
Wound Healing ◽  
Lactobacillus Rhamnosus ◽  
Skin Wound ◽  
Scar Formation ◽  
Skin Wound Healing

Spatiotemporal manipulation of L-arginine release from bioactive hydrogels initiates rapid skin wound healing accompanied with repressed scar formation

2021 ◽  
Vol 24 ◽  
pp. 101116
Author(s):  
Zhixin Ling ◽  
Jing Deng ◽  
Zhuoran Zhang ◽  
Heyu Sui ◽  
Wenxiong Shi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Scar Formation ◽  
Skin Wound Healing

scholarly journals Calpain Activity Is Essential in Skin Wound Healing and Contributes to Scar Formation

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e37084 ◽  
Author(s):  
Dany Nassar ◽  
Emmanuel Letavernier ◽  
Laurent Baud ◽  
Selim Aractingi ◽  
Kiarash Khosrotehrani
Keyword(s):  
Wound Healing ◽  
Skin Wound ◽  
Scar Formation ◽  
Calpain Activity ◽  
Skin Wound Healing

scholarly journals Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Mengna Duan ◽  
Yan Zhang ◽  
Haiyang Zhang ◽  
Yupeng Meng ◽  
Ming Qian ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Clinical Setting ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β1 ◽  
Skin Wound ◽  
Scar Formation ◽  
Dermal Fibroblasts ◽  
Skin Wound Healing ◽  
Tgf Β1

Abstract Background Scar formation, which may be caused by myofibroblast aggregations, is the greatest challenge during skin wound healing in the clinical setting. Studies have indicated that epidermal stem cells (EPSC) improve wound healing and reduce scar formation. Methods We investigated the therapeutic effects of EPSC-derived exosomes (EPSC-Exos) on skin wound healing in a skin-defect rat model. We also examined the roles of EPSC-Exos-specific microRNAs in inhibiting the differentiation of human dermal fibroblasts (HDF) into myofibroblasts. Results We found that EPSC-Exos increased the wound healing rate and reduced scar formation in rats. Also, EPSC-Exos improved the regeneration levels of skin appendages, nerves and vessels, as well as the natural distribution of collagen. Furthermore, we found these functions may be achieved by inhibiting the activity of transforming growth factor-β1 (TGF-β1) and its downstream genes. The results showed that some specific microRNAs, including miR-16, let-7a, miR-425-5p and miR-142-3p, were enriched in EPSC-Exos. EPSC-Exos-specific microRNAs, especially miR-425-5p and miR-142-3p, played vital roles in inhibiting myofibroblast differentiation via reducing the TGF-β1 expression in dermal fibroblasts. Conclusion We found a novel function of EPSC-Exos-specific microRNAs, suggesting that EPSC-Exos might represent a strategy to prevent scar formation during wound healing in the clinical setting.

miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-β1/Smad/CTGF signaling pathway

2017 ◽  
Vol 95 (4) ◽  
pp. 437-442 ◽  
Author(s):  
Jingdong Guo ◽  
Quan Lin ◽  
Ying Shao ◽  
Li Rong ◽  
Duo Zhang
Keyword(s):  
Wound Healing ◽  
Signaling Pathway ◽  
Inhibitory Effect ◽  
Negative Control ◽  
Skin Wound ◽  
Scar Formation ◽  
Skin Wound Healing ◽  
Morphologic Alteration ◽  
Great Pain ◽  
Tgf Β1

The hypertrophic scar is a medical difficulty of humans, which has caused great pain to patients. Here, we investigated the inhibitory effect of miR-29b on scar formation. The scalded model was established in mice and miR-29b mimics or a negative control was subcutaneously injected into the injury skin. Then various molecular biological experiments were performed to assess the effect of miR-29b on scar formation. According to our present study, first, the results demonstrated that miR-29b was down-regulated in thermal injury tissue and miR-29b treatment could promote wound healing, inhibit scar formation, and alleviate histopathological morphologic alteration in scald tissues. Additionally, miR-29b treatment suppressed collagen deposition and fibrotic gene expression in scar tissues. Finally, we found that miR-29b treatment inhibited the TGF-β1/Smad/CTGF signaling pathway. Taken together, our data suggest that miR-29b treatment has an inhibitory effect against scar formation via inhibition of the TGF-β1/Smad/CTGF signaling pathway and may provide a potential molecular basis for future treatments for hypertrophic scars.

scholarly journals Curbing Inflammation in Skin Wound Healing: A Review

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Rodrigo G. Rosique ◽  
Marina J. Rosique ◽  
Jayme A. Farina Junior
Keyword(s):  
Wound Healing ◽  
Inflammatory Process ◽  
Chronic Wounds ◽  
Healing Process ◽  
Skin Wound ◽  
Scar Formation ◽  
Medical Problems ◽  
Skin Wound Healing ◽  
Skin Scar

Wound healing is a complex regulated process that results in skin scar formation in postnatal mammals. Chronic wounds are major medical problems that can confer devastating consequences. Currently, there are no treatments to prevent scarring. In the early fetus wounds heal without scarring and the healing process is characterized by relatively less inflammation compared to adults; therefore, research aimed at reducing the inflammatory process related to wound healing might speed healing and improve the final scar appearance.

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