Self-nonself recognition: genomic and transcriptomic insights from the sponge aggregation factors

Faculty Opinions recommendation of Self/nonself recognition in ascidian fertilization: vitelline coat protein HrVC70 is a candidate allorecognition molecule.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022197.251759 ◽

2004 ◽

Author(s):

Masaru Nonaka

Keyword(s):

Coat Protein ◽

Nonself Recognition ◽

Vitelline Coat

Download Full-text

Self- and nonself recognition during hyphal interactions in Rosellinia necatrix

Journal of General Plant Pathology ◽

10.1007/s10327-015-0622-y ◽

2015 ◽

Vol 81 (6) ◽

pp. 420-428 ◽

Cited By ~ 1

Author(s):

Takahiro Uwamori ◽

Kanako Inoue ◽

Chiaki Kida ◽

Yuichi Morita ◽

Pyoyun Park ◽

...

Keyword(s):

Rosellinia Necatrix ◽

Nonself Recognition

Download Full-text

Allogeneic resorption in colonial protochordates: Consequences of nonself recognition

Developmental & Comparative Immunology ◽

10.1016/0145-305x(92)90002-t ◽

1992 ◽

Vol 16 (4) ◽

pp. 275-286 ◽

Cited By ~ 37

Author(s):

Baruch Rinkevich ◽

Irving L. Weissman

Keyword(s):

Nonself Recognition

Download Full-text

Self-nonself Recognition through B-Cell Antigen Receptor

How the Immune System Recognizes Self and Nonself ◽

10.1007/978-4-431-73884-8_4 ◽

2008 ◽

pp. 99-132

Author(s):

Daisuke Kitamura

Keyword(s):

B Cell ◽

Antigen Receptor ◽

B Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Nonself Recognition

Download Full-text

The effect of mixing on glutenin particle properties: aggregation factors that affect gluten function in dough

Journal of Cereal Science ◽

10.1016/j.jcs.2004.09.009 ◽

2005 ◽

Vol 41 (1) ◽

pp. 69-83 ◽

Cited By ~ 75

Author(s):

Clyde Don ◽

Wim J. Lichtendonk ◽

Johan J. Plijter ◽

Ton van Vliet ◽

Rob J. Hamer

Keyword(s):

Particle Properties ◽

Aggregation Factors

Download Full-text

VIB-1 Is Required for Expression of Genes Necessary for Programmed Cell Death in Neurospora crassa

Eukaryotic Cell ◽

10.1128/ec.00253-06 ◽

2006 ◽

Vol 5 (12) ◽

pp. 2161-2173 ◽

Cited By ~ 59

Author(s):

Karine Dementhon ◽

Gopal Iyer ◽

N. Louise Glass

Keyword(s):

Cell Death ◽

Programmed Cell Death ◽

Neurospora Crassa ◽

Filamentous Fungi ◽

Somatic Growth ◽

Genetic Differences ◽

Extracellular Proteases ◽

Hyphal Fusion ◽

Expression Of Genes ◽

Nonself Recognition

ABSTRACT Nonself recognition during somatic growth is an essential and ubiquitous phenomenon in both prokaryotic and eukaryotic species. In filamentous fungi, nonself recognition is also important during vegetative growth. Hyphal fusion between genetically dissimilar individuals results in rejection of heterokaryon formation and in programmed cell death of the fusion compartment. In filamentous fungi, such as Neurospora crassa, nonself recognition and heterokaryon incompatibility (HI) are regulated by genetic differences at het loci. In N. crassa, mutations at the vib-1 locus suppress nonself recognition and HI mediated by genetic differences at het-c/pin-c, mat, and un-24/het-6. vib-1 is a homolog of Saccharomyces cerevisiae NDT80, which is a transcriptional activator of genes during meiosis. For this study, we determined that vib-1 encodes a nuclear protein and showed that VIB-1 localization varies during asexual reproduction and during HI. vib-1 is required for the expression of genes involved in nonself recognition and HI, including pin-c, tol, and het-6; all of these genes encode proteins containing a HET domain. vib-1 is also required for the production of downstream effectors associated with HI, including the production of extracellular proteases upon carbon and nitrogen starvation. Our data support a model in which mechanisms associated with starvation and nonself recognition/HI are interconnected. VIB-1 is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in nonself recognition and death in N. crassa.

Download Full-text

Antimicrobial Peptides, Polymorphic Toxins, and Self-Nonself Recognition Systems in Archaea: an Untapped Armory for Intermicrobial Conflicts

mBio ◽

10.1128/mbio.00715-19 ◽

2019 ◽

Vol 10 (3) ◽

Cited By ~ 13

Author(s):

Kira S. Makarova ◽

Yuri I. Wolf ◽

Svetlana Karamycheva ◽

Dapeng Zhang ◽

L. Aravind ◽

...

Keyword(s):

Antimicrobial Peptides ◽

Comparative Genomic ◽

Protein Families ◽

Bacterial Genomes ◽

Uncharacterized Protein ◽

Genomic Locus ◽

Genomic Analyses ◽

Nonself Recognition ◽

Guilt By Association ◽

Recognition Systems

ABSTRACTNumerous, diverse, highly variable defense and offense genetic systems are encoded in most bacterial genomes and are involved in various forms of conflict among competing microbes or their eukaryotic hosts. Here we focus on the offense and self-versus-nonself discrimination systems encoded by archaeal genomes that so far have remained largely uncharacterized and unannotated. Specifically, we analyze archaeal genomic loci encoding polymorphic and related toxin systems and ribosomally synthesized antimicrobial peptides. Using sensitive methods for sequence comparison and the “guilt by association” approach, we identified such systems in 141 archaeal genomes. These toxins can be classified into four major groups based on the structure of the components involved in the toxin delivery. The toxin domains are often shared between and within each system. We revisit halocin families and substantially expand the halocin C8 family, which was identified in diverse archaeal genomes and also certain bacteria. Finally, we employ features of protein sequences and genomic locus organization characteristic of archaeocins and polymorphic toxins to identify candidates for analogous but not necessarily homologous systems among uncharacterized protein families. This work confidently predicts that more than 1,600 archaeal proteins, currently annotated as “hypothetical” in public databases, are components of conflict and self-versus-nonself discrimination systems.IMPORTANCEDiverse and highly variable systems involved in biological conflicts and self-versus-nonself discrimination are ubiquitous in bacteria but much less studied in archaea. We performed comprehensive comparative genomic analyses of the archaeal systems that share components with analogous bacterial systems and propose an approach to identify new systems that could be involved in these functions. We predict polymorphic toxin systems in 141 archaeal genomes and identify new, archaea-specific toxin and immunity protein families. These systems are widely represented in archaea and are predicted to play major roles in interactions between species and in intermicrobial conflicts. This work is expected to stimulate experimental research to advance the understanding of poorly characterized major aspects of archaeal biology.

Download Full-text