Modeling approaches to predict human skin absorption of drugs and other chemicals

2021 ◽  
Author(s):  
◽  
Hanumanth Srikanth Cheruvu
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Modeling Approaches

Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study

2019 ◽  
Vol 32 (3) ◽  
pp. 117-124 ◽  
Author(s):  
Sébastien Grégoire ◽  
Richard Cubberley ◽  
Hélène Duplan ◽  
Joan Eilstein ◽  
Nicola J. Hewitt ◽  
...  
Keyword(s):  
Human Skin ◽  
In Vitro Test ◽  
Skin Absorption ◽  
Absorption Study ◽  
Vitro Test

scholarly journals Anti-Aging Potential of Substance P-Based Hydrogel for Human Skin Longevity

2019 ◽  
Vol 20 (18) ◽  
pp. 4453 ◽  
Author(s):  
Da Jung Kim ◽  
Song Sun Chang ◽  
Jungsun Lee
Keyword(s):  
Substance P ◽  
Human Skin ◽  
Collagen Synthesis ◽  
Skin Penetration ◽  
Dermal Fibroblasts ◽  
Toxicity Tests ◽  
Skin Absorption ◽  
Collagen Production ◽  
Anti Inflammatory

Skin aging is generally caused by a decline in the components of the extracellular matrix (e.g., collagen and elastin) and due to inflammatory phenomena. Many growth factors and peptides with cell-growth and collagen-synthesis activities have shown promise in their application in anti-aging materials. However, the effect of collagen production, without anti-inflammatory effect, and skin penetration may not be enough for their use in anti-aging agents. Previously, we reported a substance P (SP)-based hydrogel (SP gel) that had potential wound-healing activities via induction of skin cell regeneration and collagen synthesis. Here, we analyzed the anti-aging activities and skin absorption effects of SP gel to extend its characterization. Toxicity tests, performed on human dermal fibroblasts (HDFs) and on a reconstructed 3D human skin model, indicated SP gel to be safe for long-term use, without causing irritation, even at high concentrations. In-vitro analysis revealed that SP gel elicited stronger collagen production activities than SP alone, and promoted anti-inflammatory effects with increased skin absorption properties. Moreover, SP gel did not induce melanin synthesis in a keratinocyte-melanocyte co-culture system. Together, the results suggest that SP gel has potential cosmetic effects and applicability as a novel ingredient in anti-aging products.

Permeation and Skin Absorption: Reproducibility of Various Industrial Reconstructed Human Skin Models

2002 ◽  
Vol 15 (1) ◽  
pp. 18-30 ◽  
Author(s):  
C. Lotte ◽  
C. Patouillet ◽  
M. Zanini ◽  
A. Messager ◽  
R. Roguet
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Human Skin Models ◽  
Reconstructed Human Skin

In Vitro Human Skin Absorption of Solvent-Deposited Solids: Niacinamide and Methyl Nicotinate

2021 ◽  
Author(s):  
Gerald B. Kasting ◽  
Matthew A. Miller ◽  
Lijing Xu ◽  
Fang Yu ◽  
Joanna Jaworska
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Methyl Nicotinate

In vivo measurement of human skin absorption of topically applied substances by a photoacoustic technique

2002 ◽  
Vol 23 (3) ◽  
pp. 521-532 ◽  
Author(s):  
G Guti$eacute$rrez-Ju$aacute$rez ◽  
M Vargas-Luna ◽  
T C$oacute$rdova ◽  
J B Varela ◽  
J J Bernal-Alvarado ◽  
...  
Keyword(s):  
Human Skin ◽  
Photoacoustic Technique ◽  
Skin Absorption ◽  
In Vivo Measurement

Human Skin Absorption and Metabolism of the Contact Allergens, Cinnamic Aldehyde, and Cinnamic Alcohol

2000 ◽  
Vol 168 (3) ◽  
pp. 189-199 ◽  
Author(s):  
Camilla K. Smith ◽  
Caroline A. Moore ◽  
Eiram N. Elahi ◽  
Alan T.S. Smart ◽  
Sharon A.M. Hotchkiss
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Contact Allergens ◽  
Cinnamic Aldehyde ◽  
Cinnamic Alcohol

Human skin absorption of bis-2-(chloroethyl)sulphide (sulphur mustard)in vitro

2000 ◽  
Vol 20 (5) ◽  
pp. 349-355 ◽  
Author(s):  
R. P. Chilcott ◽  
J. Jenner ◽  
W. Carrick ◽  
S. A. M. Hotchkiss ◽  
P. Rice
Keyword(s):  
Human Skin ◽  
Skin Absorption ◽  
Sulphur Mustard
Sign in / Sign up

Export Citation Format

Share Document