Neuropsychological Correlates of Cortical Miswiring: A Case Series in Corpus Callosum Dysgenesis

2019 ◽  
Author(s):  
◽  
Jacquelyn Knight
Keyword(s):  
Corpus Callosum ◽  
Case Series ◽  
Neuropsychological Correlates

scholarly journals Relevance of CSF, Serum and Neuroimaging Markers in CNS and PNS Manifestation in COVID-19: A Systematic Review of Case Report and Case Series

2021 ◽  
Vol 11 (10) ◽  
pp. 1354
Author(s):  
Sanjiti Podury ◽  
Samiksha Srivastava ◽  
Erum Khan ◽  
Mihir Kakara ◽  
Medha Tandon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Case Report ◽  
Corpus Callosum ◽  
Neurological Complication ◽  
Case Series ◽  
Transverse Myelitis ◽  
Acute Disseminated Encephalomyelitis ◽  
Neurological Manifestations ◽  
Comprehensive Review ◽  
Inflammatory Disorders

Background: The data on neurological manifestations in COVID-19 patients has been rapidly increasing throughout the pandemic. However, data on CNS and PNS inflammatory disorders in COVID-19 with respect to CSF, serum and neuroimaging markers is still lacking. Methods: We screened all articles resulting from a search of PubMed, Google Scholar and Scopus, using the keywords “SARS-CoV-2 and neurological complication”, “SARS-CoV-2 and CNS Complication” and “SARS-CoV-2 and PNS Complication” looking for transverse myelitis, vasculitis, acute disseminated encephalomyelitis, acute hemorrhagic necrotizing encephalitis (AHNE), cytotoxic lesion of the corpus callosum (CLOCC) and Guillain-Barré syndrome (GBS), published between 1 December 2019 to 15 July 2021. Results: Of the included 106 CNS manifestations in our study, CNS inflammatory disorders included transverse myelitis (17, 14.7%), AHNE (12, 10.4%), ADEM (11, 9.5%), CLOCC/MERS (10, 8.6%) and vasculitis (4, 3.4%). Others were nonspecific encephalopathy, encephalitis, seizures and stroke. Most patients were >50 years old (75, 70.8%) and male (64, 65.3%). Most (59, 63.4%) were severe cases of COVID-19 and 18 (18%) patients died. Of the included 94 PNS manifestations in our study, GBS (89, 92.7%) was the most common. Most of these patients were >50 years old (73, 77.7%) and male (59, 64.1%). Most (62, 67.4%) were non-severe cases of COVID-19, and ten patients died. Conclusion: Our comprehensive review of the clinical and paraclinical findings in CNS and PNS manifestations of COVID-19 provide insights on the pathophysiology of SARS-CoV-2 and its neurotropism. The higher frequency and severity of CNS manifestations should be noted by physicians for increased vigilance in particular COVID-19 cases.

Clinical and Radiologic Spectrum of Corpus Callosum Infarctions: A Case Series (P07.041)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P07.041-P07.041
Author(s):  
S. Murthy ◽  
M. Chmayssani ◽  
S. Shah ◽  
C. Goldsmith ◽  
J. Kass
Keyword(s):  
Corpus Callosum ◽  
Case Series

scholarly journals Pai syndrome: a review

2020 ◽  
Vol 36 (11) ◽  
pp. 2635-2640
Author(s):  
Francesca Olivero ◽  
Thomas Foiadelli ◽  
Sabino Luzzi ◽  
Gian Luigi Marseglia ◽  
Salvatore Savasta
Keyword(s):  
Corpus Callosum ◽  
Cleft Lip ◽  
Case Reports ◽  
Case Series ◽  
Rare Condition ◽  
Frontonasal Dysplasia ◽  
Pubmed Database ◽  
Median Cleft ◽  
The Central Nervous System

Abstract Background Pai syndrome is a rare idiopathic developmental condition characterized by midline craniofacial abnormalities. It was originally described as the presence of a median cleft lip, cutaneous polyps of the nasal mucosa and face, and midline lipomas of the central nervous system, mostly at the corpus callosum. However, there is great phenotypical variability and these characteristics are rarely all present at once. Objective The aim of this review was to analyze the available evidence regarding Pai syndrome in order to better delineate this rare condition and its features. Methods We analyzed the PubMed database using the words “Pai syndrome”, “frontonasal dysplasia”, “cleft lip”, “nasal polyp”, “facial polyp”, and “corpus callosum lipoma”, including reviews, case reports and case series. Conclusion There is no consensus regarding the diagnostic criteria of Pai syndrome up to date. It is usually diagnosed at birth, and its incidence is often underestimated. At present, the etiology of Pai syndrome is unknown. Several hypotheses regarding its genetic background have been made; however, there are not enough data yet to elucidate this point. An improved awareness could help in diagnosing the condition and performing the necessary investigations. These patients should have a multidisciplinary follow-up.

scholarly journals Mild cognitive impairment in novel SPG11 mutation-related sporadic hereditary spastic paraplegia with thin corpus callosum: case series

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Chuan Li ◽  
Qi Yan ◽  
Feng-ju Duan ◽  
Chao Zhao ◽  
Zhuo Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Corpus Callosum ◽  
Hereditary Spastic Paraplegia ◽  
Late Onset ◽  
Case Series ◽  
Spastic Paraplegia ◽  
Thin Corpus Callosum ◽  
Modeling Analysis ◽  
Multiple Domains

Abstract Background SPG11 mutation-related autosomal recessive hereditary spastic paraplegia with thin corpus callosum (HSP-TCC) is the most common cause in complicated forms of HSP, usually presenting comprehensive mental retardation on early-onset stage preceding spastic paraplegias in childhood. However, there are many instances of sporadic late-onset HSP-TCC cases with a negative family history, and potential mild cognitive deficits in multiple domains may be easily neglected and inaccurately described. Methods In this study, we performed next generation sequencing in four sporadic late-onset patients with HSP-TCC, and combined Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to evaluate cognition of the patients. Results By evolutionary conservation and structural modeling analysis, we have revealed 4 novel pathogenic SPG11 mutations, and firstly confirmed mild cognitive impairment (MCI) with normal MMSE scores (≥27) and decreased MoCA scores (< 26) in these SPG11 mutation-related HSP-TCC patients, predominantly presenting impairment of executive function, delayed recall, abstraction and language. Conclusions The results expand the mutational spectrum of SPG11-associated HSP-TCC from sporadic cases, and confirm MCI with combination of decreased MoCA and normal MMSE assessment, suggesting that clinicians should consider doing a MoCA to detect MCI in patients with HSP, particularly those with HSP-TCC.

scholarly journals Altered integrity of corpus callosum in generalized epilepsy in relation to seizure lateralization after corpus callosotomy

2020 ◽  
Vol 48 (4) ◽  
pp. E15 ◽  
Author(s):  
Po Ching Chen ◽  
Steven A. Messina ◽  
Eduardo Castillo ◽  
James Baumgartner ◽  
Joo Hee Seo ◽  
...  
Keyword(s):  
Corpus Callosum ◽  
Structural Damage ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Case Series ◽  
Structural Difference ◽  
The Body ◽  
Corpus Callosotomy ◽  
Major Pathway ◽  
Generalized Epilepsy

OBJECTIVEGeneralized-onset seizures are usually conceptualized as engaging bilaterally distributed networks with no clear focus. However, the authors previously reported a case series demonstrating that in some patients with generalized-onset seizures, focal seizure onset could be discovered after corpus callosotomy. The corpus callosum is considered to be a major pathway for seizure generalization in this group of patients. The authors hypothesized that, in patients with generalized-onset seizures, the structure of the corpus callosum could be different between patients who have lateralized seizures and those who have nonlateralized seizures after corpus callosotomy. The authors aimed to evaluate the structural difference through statistical analysis of diffusion tensor imaging (DTI) scalars between these two groups of patients.METHODSThirty-two patients diagnosed with generalized-onset motor seizures and without an MRI lesion were included in this study. Among them, 16 patients developed lateralized epileptic activities after corpus callosotomy, and the remaining 16 patients continued to have nonlateralized seizures after corpus callosotomy. Presurgical DTI studies were acquired to quantify the structural integrity of the corpus callosum.RESULTSThe DTI analysis showed significant reduction of fractional anisotropy (FA) and increase in radial diffusivity (RD) in the body of the corpus callosum in the lateralized group compared with the nonlateralized group.CONCLUSIONSThe authors’ findings indicate the existence of different configurations of bilateral epileptic networks in generalized epilepsy. Generalized seizures with focal onset relying on rapid spread through the corpus callosum might cause more structural damage related to demyelination in the corpus callosum, showing reduced FA and increased RD. This study suggests that presurgical DTI analysis of the corpus callosum might predict the seizure lateralization after corpus callosotomy.

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