scholarly journals Is Elevated Lipase in Covid-19 Patients Due to Acute Pancreatitis? - A Study from Punjab, India

2021 ◽  
Vol 10 (33) ◽  
pp. 2761-2764
Author(s):  
Shreya Garg ◽  
Sushil Garg ◽  
Anju Kansal ◽  
Afreen Kansal
Keyword(s):  
Acute Pancreatitis ◽  
Renal Function ◽  
Fluid Collection ◽  
Clinical Signs ◽  
Ct Scans ◽  
Antigen Test ◽  
Rt Pcr ◽  
Renal Function Test ◽  
Function Test ◽  
Extra Pulmonary

BACKGROUND Since the outbreak of coronavirus disease (Covid-19) many patients have presented with a variety of other symptoms along with primary respiratory symptoms. The increased reporting of these extra-pulmonary symptoms has made it necessary for the clinicians to establish a proper cause and relation between coronavirus disease 2019 (Covid-19) and extra-pulmonary symptoms. This study was undertaken to assess if the cause of elevated lipase levels in Covid-19 patients was due to acute pancreatitis. METHODS A retrospective observational study was performed at a local critical care ICU facility in Bathinda, India (MediWin Hospital, Bathinda, Punjab). RT - PCR, Rapid antigen test, CT scans were done to establish the Covid-19 status. Clinical signs and symptoms, CT scans were used to confirm the diagnosis of acute pancreatitis. MRI was preferred in patients with deranged renal function test. RESULTS Lipase test was done in 62 patients and the levels were found elevated in 52 patients. 40 patients were found to have symptoms of the spectrum of acute pancreatitis. 10 patients had symptoms along with signs of1 severe inflammatory response syndrome. Imaging was advised in these 10 patients with1 moderate to severe presentation of acute pancreatitis. 9 patients were advised CT scans which had no significant findings. 1 patient with deranged renal function test was advised2 MRI scan which showed mildly diffusely bulky pancreas. Mild peripancreatic fat stranding and fluid collection, suggestive of acute interstitial pancreatitis. It was associated with poor outcomes and lead to the patient’s death eventually. CONCLUSIONS Hyperlipasemia led to acute pancreatitis in 1 (1.6 %) patient. It was associated with poor outcome and caused eventual death of the patient. The prospects of a Covid-19 patient developing Hyperlipasemia due to acute pancreatitis were found to be statistically insignificant. KEY WORDS Coronavirus, Hyperlipasemia, Pancreatitis, Lipase, RT - PCR, Rapid Antigen Test.

scholarly journals Skin signs in acute pancreatitis: a case report

2013 ◽  
pp. 265-268
Author(s):  
Marco Bassi ◽  
Gelorma Belmonte ◽  
Paola Billi ◽  
Angelo Pasquale ◽  
Massimo Reta ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Case Report ◽  
Clinical Laboratory ◽  
Epigastric Pain ◽  
Multiorgan Failure ◽  
Fluid Collection ◽  
Clinical Signs ◽  
Pancreatic Fluid Collection ◽  
Retroperitoneal Hemorrhage ◽  
Skin Signs

Introduction: Subcutaneous manifestations of severe acute pancreatitis (Cullen’s sign, Gray- Turner’s sign, Fox’s sign, and Bryant’s sign) are often discussed in journals and textbooks, but seldom observed. Although historically associated with acute pancreatitis, these clinical signs have been described in various other conditions associated with retroperitoneal hemorrhage. Case report: We describe the case of a 61-year-old male with no history of alcohol intake, who was admitted for epigastric pain, vomiting, and increasing serum amylase and lipase levels. Five days after admission, ecchymotic skin discoloration was noted over both flanks (Gray-Turner’s sign) and the upper third of the thighs (Fox’s sign). Ten days later, he developed multiorgan failure and was transferred to the ICU for 5 days. Computed tomography revealed a large pancreatic fluid collection, which was subjected to EUS-guided drainage. Cholecystectomy was later performed for persistent obstructive jaundice. After more than 4 months of hospitalization, he died as a result of severe gastrointestinal bleeding. Discussion and conclusions: Skin manifestations of retroperitoneal hemorrhage in a patient with acute pancreatitis indicate a stormy disease course and poor prognosis. The severity of acute pancreatitis is currently estimated with validated scoring systems based on clinical, laboratory, and imaging findings. However, skin signs like the ones discussed above can represent a simple and inexpensive parameter for evaluating the severity and prognosis of this disease.

Development of a Fetal Renal Function Test Using Endogenous Creatinine Clearance

1986 ◽  
Vol 135 (5) ◽  
pp. 1111-1112
Author(s):  
N.S. Adzick ◽  
M.R. Harrison ◽  
A.W. Flake ◽  
J.-M. Laberge
Keyword(s):  
Renal Function ◽  
Creatinine Clearance ◽  
Renal Function Test ◽  
Endogenous Creatinine Clearance ◽  
Function Test

scholarly journals KEUNTUNGAN DAN KERUGIAN PENJAMINAN MUTU BERDASARKAN UJI MEMASTIKAN KECERMATAN (POCT)

2018 ◽  
Vol 13 (1) ◽  
pp. 38
Author(s):  
Hartono Kahar
Keyword(s):  
Renal Function ◽  
Critical Care ◽  
Point Of Care ◽  
Occult Blood ◽  
Self Management ◽  
Renal Function Test ◽  
Advantages And Disadvantages ◽  
Function Test ◽  
Bedside Testing ◽  
Definition Of

Laboratory examination especially for critical care such as emergency care, intensive care has been developed near the site of patientcare which is referred to point-of-care testing (POCT). As to the definition of POCT, there are many synonyms such as ancillary testing,satellite testing, and bedside testing, near patient testing, home testing, self-management, patient self-management, remote testing andphysician’s office laboratories. Based on evidence-based POCT, the National Academy of Clinical Biochemistry (NACB) has recommendedsome POCT such as coagulation tests, transcutan bilirubin testing, marker for acute coronary syndromes, diabetes mellitus, drugsand ethanol, Infectious disease testing, occult blood test, pH testing, renal function test, intraoperative PTH, renal function test andreproduction test. Some researchers conclude that performing POCT for critical care is efficient, while others found it not efficient,therefore, careful assessment of the advantages and disadvantages is important when implementing POCT. Nurses are the personnelin the acute care unit who often perform POCT; however they desire that laboratory personnel take the responsibility, therefore it isimportant to discuss which personnel are appropriate to conduct quality control of POCT.

scholarly journals Eradication of Helicobacter Pylori with Triple Therapy Comprising Probiotic & Proton Pump Inhibitor

2021 ◽  
pp. 703-709
Author(s):  
Hina Amjad ◽  
Sadia Sundus ◽  
. Ata-ur-Rehman ◽  
Kiran Khan ◽  
Ghazala Nasim Pasha ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Renal Function ◽  
Combination Therapy ◽  
Triple Therapy ◽  
Antigen Test ◽  
Stool Antigen Test ◽  
Positive Stool ◽  
Antigen Assay ◽  
Function Test ◽  
Stool Antigen

Objectives: The current clinical trial compared the effects of conventional triple therapy and probiotic (Lactobacillus reuteri) plus omeprazole combination in peptic ulcer patients. The secondary objectives included estimating the effects of these regimens on safety and tolerability. Study Design: Randomized clinical trial Abode and Period of Study: This was a six month research study conducted at the National Medical Centre, Karachi, Pakistan in October 2020 – March 2021. Materials & Methods: A total of 100 patients were recruited, had baseline positive stool antigen test. All the participants were separated into dual groups: conventional triple remedy (group A1) and probiotic with omeprazole combination (group B1). The study's primary endpoint was stool antigen assay and secondary included change in Hb, LFTs and renal function test. Results: The primary endpoints for combination therapy led to significantly greater reductions in positive stool antigen assay than triple therapy. This means that combination therapy is far better than triple therapy. The stool antigen test showed 56.5% positive and 43.5% negative in group A1 while in group B1 34.8% positive while 65.2% negative after treatment were seen with statistically significant difference (p=0.036). Insignificant findings were observed for level of Hb, LFTs and renal function test between both groups during the entire study. Conclusion: This is the first randomized clinical trial in peptic ulcer patients of Pakistan treated with probiotic plus omeprazole combination. Combination therapy was generally well-tolerated and effective in eradicating the Helicobacter pylori after initiation of therapy.

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