scholarly journals Immunohistochemical Study of BCL2 Protein, Oestrogen Receptor Alpha and Oestrogen Receptor Beta Expression in Adenocarcinoma Prostate and Benign Prostatic Hyperplasia

2021 ◽  
Vol 10 (4) ◽  
pp. 179-184
Author(s):  
Aria Jyothi Appukuttan
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Oestrogen Receptor ◽  
Immunohistochemical Study ◽  
Prostatic Hyperplasia ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Bcl2 Protein ◽  
Receptor Beta

A possible divergent role for the oestrogen receptor alpha and beta subtypes in clinical breast cancer

2000 ◽  
Vol 89 (2) ◽  
pp. 209-212 ◽  
Author(s):  
Janice M. Knowlden ◽  
Julia M.W. Gee ◽  
John F.R. Robertson ◽  
Ian O. Ellis ◽  
Robert I. Nicholson
Keyword(s):  
Breast Cancer ◽  
Oestrogen Receptor ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Clinical Breast

Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women

2015 ◽  
Vol 31 (4) ◽  
pp. 327-331
Author(s):  
Marcio Masashi Kajikawa ◽  
Zsuzsanna Ilona Katalin Jármy-Di Bella ◽  
Juliane Dornelas ◽  
Luciana Campanatti Crema ◽  
Cláudia Cristina Takano ◽  
...  
Keyword(s):  
Oestrogen Receptor ◽  
Premenopausal Women ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha

scholarly journals Detection of oestrogenic activity of steroids present during mammalian gestation using oestrogen receptor alpha- and oestrogen receptor beta-specific in vitro assays

2002 ◽  
Vol 174 (3) ◽  
pp. 435-446 ◽  
Author(s):  
JG Lemmen ◽  
CE van den Brink ◽  
J Legler ◽  
PT van der Saag ◽  
B van der Burg
Keyword(s):  
Steroid Hormones ◽  
Oestrogen Receptor ◽  
In Vitro Assays ◽  
Relative Preference ◽  
Oestrogen Receptor Alpha ◽  
Total Pool ◽  
Er Alpha ◽  
Receptor Beta

Numerous steroid hormones are present in the foetus but their potential to activate oestrogen receptor (ER) alpha and/or beta is largely unknown. In this study, in vitro assays were developed to rapidly and specifically detect ERalpha or ERbeta activation by these steroid hormones. Our results showed that several oestrogen precursors and androgens are able to activate both ERalpha and ERbeta. Of special interest is that some of these precursors are able to activate ERalpha and ERbeta at concentrations that are present during human gestation. Moreover, some precursors (dehydroepiandrosterone (DHEA) and 17-hydroxylated pregnenolone sulphate) and androgens (5-androsten-3beta,16alpha,17beta-triol and testosterone) showed a more than 100-fold relative preference for ERbeta transactivation over ERalpha transactivation when compared with 17beta-oestradiol. Due to their relatively high levels, the precursor steroids DHEA and pregnenolone may be of particular importance in the regulation of ERbeta activity in vivo. To obtain information about the oestrogenic activity of the total pool of steroid hormones present during mammalian gestation, steroids were extracted from mouse embryos at different prenatal stages and assayed for oestrogenic activity in the established in vitro assays. Oestrogenic activity was detected in steroid extracts from all stages tested. This study has demonstrated that oestrogen receptor agonists are present in the murine embryo and that oestrogen precursors may contribute to the total pool of agonists during foetal life.

scholarly journals Oestrogen's masculine side: mediation of mating in male mice

Reproduction ◽  
2002 ◽  
pp. 331-338 ◽  
Author(s):  
EM Scordalakes ◽  
DB Imwalle ◽  
EF Rissman
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Dopamine Agonist ◽  
Sexual Behaviour ◽  
Oestrogen Receptor ◽  
Neuronal Nitric Oxide Synthase ◽  
Receptor Alpha ◽  
Male Sexual Behaviour ◽  
Oestrogen Receptor Alpha ◽  
Oxide Synthase

This review focuses on the role of oestrogen in male sexual behaviour using oestrogen receptor alpha and beta knockout (ERalphaKO and ERbetaKO) mouse models. ERbetaKO mice are capable of mating and producing offspring, whereas ERalphaKO mice are unable to do either. When ERalphaKO males are treated with testosterone or dihydrotestosterone (DHT), < 50% display mounting behaviour, few intromit and none ejaculate. However, concurrent treatment with testosterone and a dopamine agonist instates masculine sexual behaviour in both male and female ERalphaKO mice. Dopamine content in the preoptic area and associated regions is not affected by oestrogen receptor alpha gene disruption. However, expression of neuronal nitric oxide synthase immunoreactivity is severely reduced in ERalphaKO males compared with wild-type males. These findings, together with studies conducted in aromatase knockout mice, are at odds with the dogma that oestrogen is required during development for expression of male sexual behaviour in adults. However, they do support a role for oestrogens, mediated by oestrogen receptor alpha, in regulation and production of neuronal nitric oxide synthase, which in turn may control dopamine agonist release. As has been shown in male rats, in mice dopamine agonist release is likely to be an essential component of the neural pathway that mediates male sexual behaviour.

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