scholarly journals Development of directly compressible ambroxol hydrochloride spherical crystals

2018 ◽  
Author(s):  
Orsolya Gyulai
Keyword(s):  
Ambroxol Hydrochloride ◽  
Spherical Crystals

An Overview of Optimization of Spherical Crystallisation Process

2013 ◽  
Vol 6 (4) ◽  
pp. 2203-2209
Author(s):  
N B Bhagat ◽  
A V Yadav ◽  
P R Mastud ◽  
R A Khutale
Keyword(s):  
Physical Phenomenon ◽  
Chemical Properties ◽  
Spherical Shape ◽  
Particle Engineering ◽  
Spherical Crystallization ◽  
Stirring Rate ◽  
Physico Chemical ◽  
Rate Selection ◽  
Pharmaceutical Agents ◽  
Spherical Crystals

In this article we describe the optimizing parameters in the process of spherical crystallisation. Particle engineering of active pharmaceutical agents is an innovative area of research in pharmaceutical industry because of several advantages. Spherical crystallization is one of the particle engineering technique in which drug directly gets crystallized and agglomerated into spherical shape. The spherical crystals can be obtained by different methods like solvent change, Quasi-emulsion droplet, ammonia diffusion and neutralisation. The optimization of process of spherical crystallization is important for obtaining the ideal spherical crystal agglomerates. It includes stirring rate, selection of solvent, pH, temperature etc. which affects on the physico-chemical properties of crystals. These optimizing parameters play its specific role in formation of spherical crystals. Stirring rate affects the shape as well as size of the final agglomerates and solvent selection helps in the formation of maximum amount of agglomerates in the system. The factors like pH and temperature should be maintained in case of drugs which show polymorphism. Apart from this, several others physical phenomenon or parameters like interfacial tension and rate of crystallisation are also important for thorough optimization of process.  

scholarly journals In vitro Release Kinetics Study of Ambroxol Hydrochloride Pellets Developed by Extrusion Spheronization Technique Followed by Acrylic Polymer Coating

1970 ◽  
Vol 7 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Ishtiaq Ahmed ◽  
Monzurul Amin Roni ◽  
Golam Kibria ◽  
Muhammad Rashedul Islam ◽  
Reza-ul Jalil
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
In Vitro Dissolution ◽  
Acrylic Polymer ◽  
Eudragit Rs ◽  
Methacrylate Copolymer ◽  
Ambroxol Hydrochloride ◽  
Eudragit Rl ◽  
Extrusion Spheronization

The aim of the present study was to investigate the effect of Ammonio Methacrylate Copolymer Dispersion Type A (Eudragit RL 30 D) and Ammonio Methacrylate Copolymer Dispersion Type B (Eudragit RS 30 D) combination in different weight ratios on the release kinetics of Ambroxol Hydrochloride from coated pellets. Microcrystalline cellulose, lactose, maize starch, hydroxypropyl methylcellulose and the drug was incorporated in the nuclei prepared by Extrusion-Spheronization technique which was coated with Eudragit RL 30D and Eudragit RS 30D in 1:1,1:1.5,1:2,1:2.5 and 1:3 ratios. The in vitro dissolution studies were carried out in 0.1N HCl for 1 hour followed by phosphate buffer (pH 6.8) for 11 h with USP dissolution apparatus Type-II. Drug release decreased with increasing amount of Eudragit RS 30 D in all cases. The drug release followed first order and Higuchi release kinetics. The Korsmeyer plot revealed n=0.50-0.61 or non-Fickian transport mechanism for drug release. From one way ANOVA it was found that the ratio of binary polymer mixer had significant (p < 0.05) effect on drug release. Key words: Aqueous coating, Eudragit, release kinetics, pellet, extrusion-spheronization  DOI = 10.3329/dujps.v7i1.1222 Dhaka Univ. J. Pharm. Sci. 7(1): 75-81, 2008 (June)

scholarly journals Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1910
Author(s):  
Dijana Jelić ◽  
Snežana Papović ◽  
Milan Vraneš ◽  
Slobodan Gadžurić ◽  
Silvia Berto ◽  
...  
Keyword(s):  
Thermal Stability ◽  
Active Compound ◽  
Degradation Kinetics ◽  
Practical Interest ◽  
Mechanistic Explanation ◽  
Compatibility Study ◽  
Order Kinetic ◽  
Order Kinetic Model ◽  
Synthetic Derivative ◽  
Ambroxol Hydrochloride

Ambroxol hydrochloride (AMB), used as a broncho secretolytic and an expectorant drug, is a semi-synthetic derivative of vasicine obtained from the Indian shrub Adhatoda vasica. It is a metabolic product of bromhexine. The paper provides comprehensive and detailed research on ambroxol hydrochloride, gives information on thermal stability, the mechanism of AMB degradation, and data of practical interest for optimization of formulation that contains AMB as an active compound. Investigation on pure AMB and in commercial formulation Flavamed® tablet (FT), which contains AMB as an active compound, was performed systematically using thermal and spectroscopic methods, along with a sophisticated and practical statistical approach. AMB proved to be a heat-stable and humidity-sensitive drug. For its successful formulation, special attention should be addressed to excipients since it was found that polyvinyl pyrrolidone and Mg stearate affect the thermal stability of AMB. At the same time, lactose monohydrate contributes to faster degradation of AMB and change in decomposition mechanism. It was found that the n-th order kinetic model mechanistically best describes the decomposition process of pure AMB and in Flavamed® tablets.

Tables of absorption factors for spherical crystals

1952 ◽  
Vol 5 (4) ◽  
pp. 540-542 ◽  
Author(s):  
H. T. Evans Jnr ◽  
M. G. Ekstein
Keyword(s):  
Spherical Crystals

scholarly journals Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents

2018 ◽  
Vol 31 (4) ◽  
pp. 255-265
Author(s):  
Shota Yoshida ◽  
Masanao Yokohira ◽  
Keiko Yamakawa ◽  
Yuko Nakano-Narusawa ◽  
Shohei Kanie ◽  
...  
Keyword(s):  
Chemically Induced ◽  
Neoplastic Lesions ◽  
Ambroxol Hydrochloride
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