Effect of a novel kynurenic acid derivate on a model of trigeminovascular activation induced by chemical stimulation of rat dura mater

2017 ◽  
Author(s):  
Melinda Lukács
Keyword(s):  
Dura Mater ◽  
Kynurenic Acid ◽  
Chemical Stimulation ◽  
Acid Derivate ◽  
Stimulation Of

scholarly journals Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Klaudia Flóra Laborc ◽  
Eleonóra Spekker ◽  
Zsuzsanna Bohár ◽  
Mónika Szűcs ◽  
Gábor Nagy-Grócz ◽  
...  
Keyword(s):  
Dura Mater ◽  
Chemical Stimulation ◽  
Activation Patterns ◽  
Trigeminal Activation ◽  
Stimulation Of

Noxious Chemical Stimulation of Rat Facial Mucosa Increases Intracranial Blood Flow Through a Trigemino-Parasympathetic Reflex — An Experimental Model for Vascular Dysfunctions in Cluster Headache

Cephalalgia ◽  
2004 ◽  
Vol 24 (3) ◽  
pp. 206-214 ◽  
Author(s):  
R Gottselig ◽  
K Messlinger
Keyword(s):  
Blood Flow ◽  
Cluster Headache ◽  
Experimental Model ◽  
Dura Mater ◽  
Chemical Stimulation ◽  
Noxious Stimulation ◽  
Doppler Flowmetry ◽  
Release Of Acetylcholine ◽  
Flow Through ◽  
Stimulation Of

Cluster headache is characterized by typical autonomic dysfunctions including facial and intracranial vascular disturbances. Both the trigeminal and the cranial parasympathetic systems may be involved in mediating these dysfunctions. An experimental model was developed in the rat to measure changes in lacrimation and intracranial blood flow following noxious chemical stimulation of facial mucosa. Blood flow was monitored in arteries of the exposed cranial dura mater and the parietal cortex using laser Doppler flowmetry. Capsaicin (0.01-1 mM) applied to oral or nasal mucosa induced increases in dural and cortical blood flow and provoked lacrimation. These responses were blocked by systemic pre-administration of hexamethonium chloride (20 mg/kg). The evoked increases in dural blood flow were also abolished by topical pre-administration of atropine (1 mM) and [Lys1, Pro2,5, Arg3,4, Tyr6]-VIP (0.1 mM), a vasoactive intestinal polypeptide (VIP) antagonist, onto the exposed dura mater. We conclude that noxious stimulation of facial mucosa increases intracranial blood flow and lacrimation via a trigemino-parasympathetic reflex. The blood flow responses seem to be mediated by the release of acetylcholine and VIP within the meninges. Similar mechanisms may be involved in the pathogenesis of cluster headache.

Chemical Stimulation of the Brain Makes Stimulating Reading

1975 ◽  
Vol 20 (12) ◽  
pp. 923-924
Author(s):  
MADGE E. SCHEIBEL ◽  
ARNOLD B. SCHEIBEL
Keyword(s):  
Chemical Stimulation ◽  
The Brain ◽  
Stimulation Of
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