scholarly journals Surgical treatment of lymph node metastases in stage IB cervical cancer. The laterally extended parametrectomy procedure: experience with a 5 year follow-up

2011 ◽  
Author(s):  
László Tarnai
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Surgical Treatment ◽  
Lymph Node Metastases ◽  
Stage Ib ◽  
Node Metastases

Surgical treatment of lymph node metastases in stage IB cervical cancer. The laterally extended parametrectomy (LEP) procedure: Experience with a 5year follow-up

2011 ◽  
Vol 123 (2) ◽  
pp. 337-341 ◽  
Author(s):  
László Ungár ◽  
László Pálfalvi ◽  
László Tarnai ◽  
Dániel Horányi ◽  
Zoltán Novák
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Surgical Treatment ◽  
Lymph Node Metastases ◽  
Stage Ib ◽  
Node Metastases

Multimodal Management of Locally Advanced Neuroendocrine Cervical Carcinoma: A Single Institution Experience

2018 ◽  
Vol 28 (5) ◽  
pp. 1013-1019 ◽  
Author(s):  
Pauline Castelnau-Marchand ◽  
Patricia Pautier ◽  
Catherine Genestie ◽  
Alexandra Leary ◽  
Enrica Bentivegna ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Complete Remission ◽  
Lymph Node Metastases ◽  
Locally Advanced ◽  
Tumor Stage ◽  
Complete Resection ◽  
Node Metastases ◽  
Multimodal Management

ObjectiveThe aim of this study was to report our institutional experience of a multimodal approach for treatment of locally advanced high-grade neuroendocrine cervical cancer.Methods and MaterialsPatients with primary locally advanced neuroendocrine cervical cancer diagnosed between 2001 and 2014 were included. The scheduled treatment sequence was as follows: pelvic +/− para-aortic radiotherapy (according to tumor stage), associated with chemotherapy based on platine-derivate and etoposide regimen, followed with a brachytherapy boost, then completion surgery if there was no progression +/− consolidation etoposide chemotherapy (for a total of 5–6 cycles). Disease-free survival (DFS) and overall survival (OS) were reported and prognostic factors were searched.ResultsA total of 24 patients fulfilled inclusion criteria. Median age was 48 (range 22–77 years). Fourteen patients (58%) had pelvic lymph node metastases. After chemoradiation/brachytherapy, a radical hysterectomy could be performed in 18 of 24 patients (75%). Histologically complete resection was achieved in 14 (78%) of 18 patients. Complete pathological response was reported in 7 (39%) of 18. With median follow-up of 29.7 months, 10 (42%) of 24 patients experienced tumor relapse, all associated with distant failure, including one local failure. The DFS and OS rates estimated at 3 years were 55% and 63%, respectively. Lymph node metastases and tumor stage were prognostic for DFS (P = 0.016 and P = 0.022, respectively). Complete resection was associated with a lower incidence of relapses, as compared with microscopically incomplete resection (P = 0.04). A total of 12 (86%) of 14 patients with histologically complete resection were in complete remission at last follow-up. Apart from manageable acute hematological toxicities, most treatment complications were mild to moderate.ConclusionsThis series based on a multimodal management compares favorably with previously published data. Most patients could be eligible to surgery, and complete remission was achieved in 85% of those amenable to complete resection.

Surgical treatment of lymph node metastases in stage IB cervical cancer: The laterally extended parametrectomy (LEP) procedure

2003 ◽  
Vol 13 (5) ◽  
pp. 647-651 ◽  
Author(s):  
L. Ungar ◽  
L. Palfalvi
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Metastases ◽  
Early Stage ◽  
Pelvic Lymph Node ◽  
Significant Treatment ◽  
Stage Ib ◽  
Early Stage Cervical Cancer ◽  
Node Metastases

A surgical method has been introduced for the treatment of early stage cervical cancer patients with pelvic lymph node metastases. The procedure was used without any adjuvant treatment in 31 stage IB cervical cancer patients, where pelvic lymph node metastases were proven by intraoperative histology. Two patients were lost for follow-up. Twenty-nine patients were followed up for 24–105 months (mean 60 months). Twenty-five of 29 patients were alive and disease-free at the end of the study period. Kaplan-Meier 5 years cumulative proportion survival was 85% (SE 7%). Complications in four cases (16%) necessitated a second operation. One patient developed treatment-refractory grade II incontinence. All but the one incontinent patient are alive without significant treatment related symptoms. The results suggest that pelvic lymph node metastases can be cured by surgery alone. The LEP procedure seems to be a treatment alternative to chemoradiotherapy for early stage cervical cancer patients with pelvic lymph node metastases.

scholarly journals Imaging of lymph node metastases in cervical cancer

2008 ◽  
Vol 178 (7) ◽  
pp. 867-869 ◽  
Author(s):  
M. Q. Bernardini ◽  
A. Covens
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastases ◽  
Node Metastases
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