scholarly journals The effect of new oral anticoagulants and tranexamic acid on perioperative blood loss and minor bleeding complications following total hip replacement

2021 ◽  
Author(s):  
Csaba Gombár
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Bleeding Complications ◽  
Minor Bleeding ◽  
Total Hip ◽  
Perioperative Blood Loss

scholarly journals A tranexámsav vérvesztést és kis vérzéses szövődményeket befolyásoló hatása cementes csípőprotézis beültetése után

2019 ◽  
Vol 160 (12) ◽  
pp. 456-463
Author(s):  
Csaba Gombár ◽  
Hristifor Gálity ◽  
Miklós Bácsi ◽  
Krisztián Sisák
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Hip Replacement ◽  
Large Scale ◽  
Transfusion Requirement ◽  
Skin Surface ◽  
Bleeding Complications ◽  
Control Group ◽  
Minor Bleeding ◽  
Long Term Outcome

Abstract: Introduction: Tranexamic acid (TXA) is widely used during elective joint replacement to reduce blood loss and decrease the transfusion requirement. Aim:This study assessed the efficacy of tranexamic acid in reducing minor bleeding complications following primary cemented total hip replacement, when rivaroxaban is used as thromboprophylaxis, the complicated wound healing effect of which has been published recently. Method: Consecutive patients undergoing hip replacement were studied. Patients receiving tranexamic acid perioperatively between January 2014 and November 2014 were designated as the TXA-group. We compared these data with those of a group of patients who underwent the same procedure between February 2012 and December 2012 (control group), before the introduction of tranexamic acid. The authors investigated the effect of tranexamic acid on surgical wound bleeding and discharge, area of hematoma on the skin surface, thigh volume changes, calculated perioperative blood loss and transfusion requirement. Results: 168 patients, 81 in the TXA-group and 87 in the control group were included. The extent of postoperative thigh swelling was significantly less in the TXA-group, 270.3 mL (129.1–449.0) as compared with the control group, 539.8 mL (350.0–864.8, p<0.001). Tranexamic acid significantly reduced wound bleeding during the first 24 hours postoperatively (p<0.001). The amount of calculated blood loss was significantly less in the TXA-group (1150 mL [780–1496] versus 1579 mL [1313–2074] in the control group, p<0.001). Transfusion requirement was remarkably lower in the TXA-group than in the control group (15% versus 39%). Conclusions: Tranexamic acid reduces postoperative thigh volume, wound bleeding and area of hematoma on the skin surface when rivaroxaban is used as the anticoagulant. Further large scale studies could help establish the clinical relevance and long-term outcome of minor bleeding complications. Orv Hetil. 2019; 160(12): 456–463.

Topical (Intra-Articular) Tranexamic Acid Reduces Blood Loss and Transfusion Rates Following Total Hip Replacement

2013 ◽  
Vol 95 (21) ◽  
pp. 1969-1974 ◽  
Author(s):  
Sattar Alshryda ◽  
James Mason ◽  
Praveen Sarda ◽  
Antoni Nargol ◽  
Nick Cooke ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Total Hip

scholarly journals Tranexamic Acid Reduces Blood Loss in Total Hip Replacement Surgery

2000 ◽  
Vol 91 (5) ◽  
pp. 1124-1130 ◽  
Author(s):  
Gustav Ekbäck ◽  
Kjell Axelsson ◽  
Lars Ryttberg ◽  
Bror Edlund ◽  
Jill Kjellberg ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Total Hip ◽  
Replacement Surgery ◽  
Hip Replacement Surgery

scholarly journals Efficacy and Safety of Enoxaparin versus New Oral Anticoagulants to Prevent Venous Thromboembolism after Total Hip Replacement: A Systematic Review and Meta-Analysis

2022 ◽  
Vol 12 (1) ◽  
pp. 107
Author(s):  
Mohammed Farhan A Alfarhan
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Meta Analysis ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Clinical Endpoint ◽  
Efficacy And Safety ◽  
Total Hip

Prophylactic anticoagulant therapy is recommended for reducing the risk of venous thromboembolism (VTE) after a total hip replacement (THR). However, it is not clear which anticoagulant is preferable. Hence, a systematic review and meta-analysis of randomized double-blind controlled trials (RDBCTs) were conducted to investigate the clinical efficacy and safety of enoxaparin in comparison with newer oral anticoagulants for the prevention of VTE after THR. The Cochrane Library, Scopus, Web of Science, Embase, and PubMed/Medline databases were used for PICO search strategy. Relative risks (RR) of symptomatic VTE, clinically relevant bleeding, mortality, and a net clinical endpoint were estimated employing a random effect meta-analysis. ITC and RevMan software were used for indirect and direct comparisons, respectively. Nine RDBCTs comprising 24,584 patients were included. As compared to enoxaparin, a reduced risk for symptomatic VTE was observed with rivaroxaban (confidence interval [CI]: 0.32–0.77; RR: 0.46%) and comparable with apixaban (0.12–1.26; 0.42%) and dabigatran (0.22–2.20; 0.70%). Contrarily to enoxaparin, a greater risk for clinically relevant bleeding was observed with rivaroxaban (1.03–1.48; 1.23%), comparable with dabigatran (0.96–1.33; 1.10%) and reduced with apixaban (0.19–5.66; 0.96%). In indirect or direct comparisons, the interventions did not differ on the net clinical endpoint. In conclusion, the findings of this meta-analysis revealed no significant difference in the efficacy and safety of new oral anticoagulants as compared to enoxaparin for the prevention of VTE after total hip replacement surgery.

Tranexamic acid reduces blood loss in total hip replacement operation

2000 ◽  
Vol 17 (Supplement 19) ◽  
pp. 79
Author(s):  
G. Ekbäck ◽  
K. Axelsson ◽  
J. Kjellberg ◽  
L. Ryttberg ◽  
U. Schött
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Total Hip Replacement ◽  
Hip Replacement ◽  
Total Hip ◽  
Replacement Operation
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