Bone Resorption in Tissue Culture and its Relevance to Periodontal Disease

1973 ◽  
Vol 87 (5) ◽  
pp. 1027-1033 ◽  
Author(s):  
Paul Goldhaber ◽  
Luka Rabadjija ◽  
William R. Beyer ◽  
Andrija Kornhauser
Keyword(s):  
Tissue Culture ◽  
Bone Resorption ◽  
Periodontal Disease

Determination of periodontal disease activity by a bone resorption assay

1984 ◽  
Vol 19 (6) ◽  
pp. 628-632 ◽  
Author(s):  
R. S. Feldman ◽  
D. L. Carnes ◽  
L. L. Key
Keyword(s):  
Bone Resorption ◽  
Periodontal Disease ◽  
Disease Activity

Inhibition of Bone Resorption in Tissue Culture by Membrane-Stabilizing Drugs*

Endocrinology ◽  
1979 ◽  
Vol 104 (6) ◽  
pp. 1644-1648 ◽  
Author(s):  
JOHN W. DIETRICH ◽  
GREGORY R. MUNDY ◽  
LAWRENCE G. RAISZ
Keyword(s):  
Tissue Culture ◽  
Bone Resorption

scholarly journals TRONCO RADICULAR E SUA IMPORTÂNCIA NO ESTABELECIMENTO E PROGRESSÃO DA DOENÇA PERIODONTAL. UMA DISCUSSÃO BASEADA EM EVIDÊNCIAS

2019 ◽  
Author(s):  
Eliane Dos Santos Porto Barboza
Keyword(s):  
Bone Resorption ◽  
Mortality Rate ◽  
Literature Review ◽  
Periodontal Disease ◽  
Lingual Surface ◽  
Pubmed Database ◽  
Furcation Involvement ◽  
Anatomical Area

RESUMOObjetivo: A lesão de furca é definida como a reabsorção óssea patológica na área anatômica onde as raízes de dentes multirradiculares divergem. Os molares são os dentes mais afetados pela doença periodontal e a maior taxa de mortalidade desses dentes pode ser explicada pela  morfologia que favorece o envolvimento de furca. Portanto, o dentista deve conhecer a anatomia da furca para diagnosticar precocemente seu envolvimento e tratar com precisão. O objetivo deste estudo é discutir, embasado em evidências científicas, a importância do tronco radicular no estabelecimento e progressão da doença periodontal. Materiais e métodos: uma revisão da literatura foi realizada na base de dados PubMed utilizando os termos tronco radicular, área de pré-furca, doença periodontal, envolvimento de furca em inglês. Resultados: Quarenta e três estudos foram selecionados e sete estudos foram incluídos nesta revisão.  O  tronco radicular na superfície lingual é maior do que na vestibular em molares inferiores. A área de pré-furca foi encontrada em todos os molares estudados. Os pré-molares superiores também apresentam área de pré-furca e 37% são bifurcados. A altura do tronco radicular e a concavidade da pré-furca interferem no tratamento. Conclusão: As características morfológicas do tronco radicular e a profundidade e largura da área de pré-furca podem favorecer o estabelecimento e progressão da doença periodontal.Palavras-chave: tronco radicular, área de pré-furca, doença periodontal, envolvimento de furca. ABSTRACTObjective: The furcation lesion is defined as pathological bone resorption in the anatomical area where the roots of multiradicular teeth differ. Molars are the teeth most affected by periodontal disease and the higher mortality rate of these teeth can be explained by the morphology that favors the furcation involvement. In this way, the dentist must know the anatomy of the furca to diagnose its involvement early and to treat with precision. The aim of this study is to discuss, based cientific evidences, the importance of the root trunk for the establishment and development of the periodontal disease. Material and Methods: A literature review was carried out in the PubMed database using the terms root trunk, pre furcation área, periodontal disease, furcation involvement in english. Results: Forty-three studies were selected and sextuplets were found at the time of the review. The root trunk at the lingual surface is larger than the buccal surface in lower molars. A pre-furcation area was found in all molars studied. Upper premolars also have a pre-furcation area and 37% are bifurcated. The height of the root trunk and the concavity of the pre-furcation area interfere in the treatment. Conclusion: Root trunks and concavity of the pre furcation area may favor the stablishment and progression of periodontal disease.Keywords: root trunk, pre furcation área, periodontal disease, furcation involvement.

Inhibition of Bone Resorption in Tissue Culture by Thyrocalcitonin

Calcitonin ◽  
1968 ◽  
pp. 215-222 ◽  
Author(s):  
LAWRENCE G. RAISZ ◽  
WILLIAM Y.W. AU ◽  
JUDITH FRIEDMAN ◽  
INGRID NIEMANN
Keyword(s):  
Tissue Culture ◽  
Bone Resorption

scholarly journals ON THE MECHANISMS OF BONE RESORPTION

1968 ◽  
Vol 39 (3) ◽  
pp. 676-697 ◽  
Author(s):  
Gilbert Vaes
Keyword(s):  
Tissue Culture ◽  
Alkaline Phosphatase ◽  
Protein Synthesis ◽  
Bone Resorption ◽  
Bone Mineral ◽  
Lysosomal Enzymes ◽  
Organic Matrix ◽  
Acid Hydrolases ◽  
New Synthesis ◽  
Stimulation Of

Bone resorption, characterized by the solubilization of both the mineral and the organic components of the osseous matrix, was obtained in tissue culture under the action of parathyroid hormone (PTH). It was accompanied by the excretion of six lysosomal acid hydrolases, which was in good correlation with the progress of the resorption evaluated by the release of phosphate, calcium 45 or hydroxyproline from the explants; there was no increased excretion of two nonlysosomal enzymes, alkaline phosphatase, and catalase. Balance studies and experiments with inhibitors of protein synthesis indicated that the intracellular stores of the acid hydrolases excreted were maintained by new synthesis. The release was not due to a direct disruption of the lysosomal membrane by PTH; it is presumed to result from an exocytosis of the whole lysosomal content and to involve mechanisms similar to those controlling the secretion of this content into digestive vacuoles. The resorbing explants acidified their culture fluids at a faster rate and released more lactate and citrate than the controls; this release was in good correlation, in the PTH-treated cultures, with the resorption of the bone mineral, but the amount of citrate released was considerably smaller than that of lactate. The acid released could account for the resorption of the mineral. It is proposed, as a working hypothesis, that the acid hydrolases of the lysosomes are active in the resorption of the organic matrix of bone and that acid, originating possibly from the stimulation of glycolysis, cares for the concomitant solubilization of bone mineral while also favoring the hydrolytic action of the lysosomal enzymes.

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