scholarly journals Antidepressant activity of methanol stem bark extract of Ficus platyphylla Del (Moraceae) in mice

2018 ◽  
Vol 8 (4) ◽  
pp. 227-234
Author(s):  
Shehu Aishatu ◽  
Ngbara Ummi ◽  
Magaji Muhammad Garba ◽  
Yau Jamilu ◽  
Ahmed Abubakar
Keyword(s):  
Antidepressant Activity ◽  
Stem Bark ◽  
Bark Extract ◽  
Stem Bark Extract

scholarly journals Antidepressant effect of methanol stem bark extract of Adansonia digitata: involvement of monoaminergic, nitric oxide and cholinergic pathways

2020 ◽  
Vol 10 (1) ◽  
pp. 84-92
Author(s):  
Aishatu Shehu ◽  
Mohammed Garba Magaji ◽  
Jamilu Yau ◽  
Abubakar Ahmed
Keyword(s):  
Nitric Oxide ◽  
Receptor Antagonist ◽  
Antidepressant Activity ◽  
Stem Bark ◽  
Bark Extract ◽  
Antidepressant Effect ◽  
Adansonia Digitata ◽  
Receptor Antagonists ◽  
Cholinergic Pathways ◽  
Stem Bark Extract

Introduction: Hausa people of north-western Nigeria were reported to utilize the plant Adansonia digitata for the management of depressive illnesses in an ethnobotanical survey. Thus, this study aimed to establish the mechanism(s) via which methanol stem bark extract of A. digitata (MEAD) exhibits antidepressant activity in mice. Methods: Antidepressant activity of MEAD was evaluated using tail suspension test (TST) at doses of 250, 500 and 1000 mg/kg. For the mechanistic studies, mice were pre-treated with sulpiride (50 mg/kg), prazosin (1 mg/kg), yohimbine (1 mg/kg), metergoline (1 mg/kg), cyproheptadine (3 mg/kg), L-arginine (50 mg/kg), N omega-nitro-L-arginine (L-NNA; 50 mg/kg), atropine (1 mg/kg) and naloxone (2 mg/kg) 15 minutes prior to MEAD (1000 mg/kg) administration, then antidepressant activity was assessed using TST one hour later. Data were analyzed using one-way ANOVA followed by Bonferroni post hoc test. Results: The extract (at doses of 250, 500 and 1000 mg/kg) significantly (P < 0.05) and dose-dependently decreased the duration of immobility in the TST. Sulpiride (D2 receptor antagonist), prazosin and yohimbine (α1 and α2 receptor antagonists, respectively), metergoline and cyproheptadine (5-HT1 and 5-HT2 receptor antagonists, respectively) significantly (P < 0.05) reversed the antidepressant effect of MEAD. On the other hand, L-NNA (NOS inhibitor) augmented the antidepressant effect of MEAD while L-arginine (nitric oxide substrate) had no effect on MEAD. However, atropine (muscarinic receptor antagonist) significantly (P < 0.01) augmented the antidepressant effect of MEAD. Conclusion: The antidepressant activity of methanol stem bark extract of A. digitata was established to be via the monoaminergic, nitric oxide and cholinergic pathways.

scholarly journals Methanol Stem Bark Extract of Tamarindus indica Exhibited Antidepressant Activity in Mice

2021 ◽  
Vol 16 (2) ◽  
pp. 39-43
Author(s):  
S. Yunusa ◽  
I.D. Bidazun ◽  
S.Y. Magaji ◽  
F.H. Ashemi
Keyword(s):  
Lethal Dose ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Stem Bark ◽  
Bark Extract ◽  
Tamarindus Indica ◽  
Tail Suspension ◽  
Immobility Time ◽  
Stem Bark Extract ◽  
Suspension Test

Background: Depression is one of the most common psychiatric disorders affecting nearly 17% of the world population and the existing antidepressant drugs used in clinical settings are largely associated with serious side effects. Tamarindus indica (Fabaceae) is a plant that has been used ethno-medicinally as a remedy for depression.Objectives: The objective of this study was to determine the antidepressant activity of methanol stem bark extract of Tamarindus indica using mice, also to determine the LD50 and phytoconstituents of same extract.Methods: Fresh leaves of Tamarindus indica were collected, pulverised and extracted using 70% v/v methanol. Phyto-constituents of the extract were screened and Median lethal dose (LD50) was determined using standard protocols. Antidepressant effects of the extract were investigated using Tail suspension test (TST) and forced swimming test (FST) models.Results: The results of median lethal dose revealed the LD50 value of 470 mg/kg body weight and the phytochemical screening showed the presence of saponins, alkaloids and glycosides. The extract at the doses of 75 and 150 mg/kg body weight significantly (p<0.05) and dose-dependently decreased the immobility time in tail suspension test (TST) as compared to control. In forced swim test, the extract significantly (p<0.05) decreased the immobility time only at the highest tested dose (150 mg/kg) when compared to placebo group.Conclusion: Methanol stem bark extract of Tamarindus indica contains secondary metabolites that possess antidepressant action and thus, justifying the traditional use of this plant in the treatment of mental disorders including depression.

Sequestered uptake of chromium(VI) by Irvingia gabonensis stem bark extract anchored silica gel

2021 ◽  
Author(s):  
James F. Amaku ◽  
Segun A. Ogundare ◽  
Kovo G. Akpomie ◽  
Comfort M. Ngwu ◽  
Jeanet Conradie
Keyword(s):  
Silica Gel ◽  
Stem Bark ◽  
Bark Extract ◽  
Chromium Vi ◽  
Irvingia Gabonensis ◽  
Stem Bark Extract

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Effect of Carica papaya L. Stem Bark Extracts on Cholesterol Concentration in Rats Induced with Streptosozin

2020 ◽  
Vol 151 ◽  
pp. 01011
Author(s):  
Safrida Safrida ◽  
Mustafa Sabri
Keyword(s):  
Body Weight ◽  
Carica Papaya ◽  
Stem Bark ◽  
Negative Control ◽  
Diabetic Rats ◽  
Cholesterol Concentration ◽  
Bark Extract ◽  
Treatment Groups ◽  
Randomized Design ◽  
Stem Bark Extract

This study was designed to determine the effect of Carica papaya L. stem bark extracts on cholesterol concentration in rats induced with glibenclamide. A completely randomized design was used for the experiment which consisted of 6 treatment groups, each group consisted of four rats, as follows:1) KN (negative control, non-diabetic rats); KP, diabetic rats given glibenclamide 10 mg/kg body weight; EP 1, diabetic rats given 0 mg/kg body weight/day extract; EP2, diabetic rats given 100 mg/kg body weight/day extract; and EP3, diabetic rats given 200 mg/kg body weight/day extract, EP4, diabetic rats given 300 mg/kg body weight/day extract for 28 day. The results showed that C. papaya L. stem bark extract decreased (P<0.05) cholesterol levels in diabetic rats. It was concluded that C. papaya L. stem bark extract had potential as anti-hypercholesterolemic in diabetic rats.

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