Phytochemical and sub acute toxicity study of Bridelia ferruginea bark in white albino rats

2014 ◽  
Vol 1 (1) ◽  
pp. 3-9 ◽  
Author(s):  
E.J Araromi ◽  
E.U Etuk ◽  
S.O Bello ◽  
M.S Gwarzo ◽  
M.O Egua
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Albino Rats ◽  
Bridelia Ferruginea ◽  
Acute Toxicity Study

Acute Toxicity Study and Faecal Dropping Capability of Ethanolic Extract of Tecoma stans in Albino Rats

Pharmacologia ◽  
2013 ◽  
Vol 4 (7) ◽  
pp. 464-468 ◽  
Author(s):  
S. Kameshwara ◽  
C. Jothimaniv ◽  
R. Senthilkum ◽  
S. Thenmozhi ◽  
R. Sundaragan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Ethanolic Extract ◽  
Toxicity Study ◽  
Albino Rats ◽  
Acute Toxicity Study

scholarly journals ANTI ARTHRITIC ACTIVITY OF HERBO MINERAL SIDDHA PREPARATION ARUMUGA CHENDURAM AGAINST TYPE II COLLAGEN INDUCED ARTHRITIS IN EXPERIMENTAL RATS

2020 ◽  
pp. 28-36
Author(s):  
M. Ramamurthy ◽  
V. Thanigavelan ◽  
S. Elansekaran ◽  
V. Srinivasan ◽  
P. Shanmugapriya ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Type Ii Collagen ◽  
Toxicity Study ◽  
Albino Rats ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Immune Disorder ◽  
Animal Products ◽  
Acute Toxicity Study ◽  
Wistar Albino Rats

Siddha system of medicine is the eternal science of life. It is a system that has its extensive bonding with Dravidian culture, language and beliefs. The system of medicine mostly prevailed and prospered in the regions of Dravidian cultures by the great Siddhars. It’s unique as one only than other AYUSH traditional systems of medicine across India with its distinctive abundant usage of medicinal plants, metals, minerals and animal products. Siddhars used the steps of Alchemy to prepare various medicines from metallic and mineral origin for attainment elixir and various rare diseases. Siddha medicine is classified into 32 types of internal and external medicine each. Among the 32 types of internal medicine Chendhuram is a medicine shelf life of 75 years usually from herbo-mineral combinations. Arumuga Chendhuram (ARC) is a herbo-mineral formulation cited in Siddha literature ‘Siddha Vaithiya Thirattu’. ARC was orally administered at higher dose 2gm/kg to the Wistar Albino rats in acute toxicity study and during 28 days of repeated (sub acute) toxicity study, at daily doses of 12, 24 & 48mg/kg of body weight to the Wistar Albino rats. Type II collagen arthritis is another model for developing autoimmune arthritis. The immune pathogenesis mediated by T cell and B cell response to collagen. By this model, nearly 100% arthritis can be achieved. In our study, ARC after 42 days treatment reduced the arthritic swelling significantly and degree of inflammation evident to act against auto immune disorder.

An experiemental study to evaluate the principle Trini Dravyani Nati Upayunjita w.s.r. to Kshara (Alkali)

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Amrita Paul ◽  
Umapati C. Baragi ◽  
Kashinath Hadimur ◽  
R. A. Deshmukh
Keyword(s):  
Acute Toxicity ◽  
Adverse Effects ◽  
Dose Level ◽  
Behavioral Changes ◽  
Toxicity Study ◽  
Fixed Dose ◽  
Albino Rats ◽  
Acute Administration ◽  
Acute Toxicity Study ◽  
Acute Study

Background: In Charaka Samhita it has been mentioned that three medicinal substances viz. Pippali (Piper longum), Kshara (alkali) and Lavana (salt) can be used as emergency medicine, but they should not be consumed in excess (Ati Upayunjita). If they are consumed in excess quantity they will cause several adverse effects in the body. Hence in the present study Kshara has been evaluated in experimental animals in two different phases viz. acute administration at graded doses as part of acute toxicity study and sub-acute administration at fixed dose level, as part of sub-acute toxicity study, to assess the possible adverse effects if any. Objectives: To evaluate the acute and sub-acute toxic effect of Kshara in albino rats to establish the principle of Trini Dravyani Nati Upayunjita. Materials and Methods: Wister strain albino rats of either sex weighing between 150 - 200g body weights were used for experimental study. The experiment was carried out as per ‘Ayush Guidelines’ after the IAEC clearance. For Acute Toxicity - 9 Albino rats were used and for Sub-Acute Toxicity - 12 Albino rats were used. The dose calculation was done on the basis of body surface area ratio using the table of ‘Paget and Barnes rule’. Results: In Acute toxicity study no mortality and behavioral changes were observed when the drug Kshara was studied after two dose level i.e. TED X 5 and TED X 10. In Sub-acute study some behavioral changes (including cage side behavior) were observed. No mortality was observed in any of the groups. Discussion: Acute toxicity study of Kshara showed no immediate and evident toxic signs and mortality within 24 hours of observation. In Sub-acute toxicity study in all four groups, no mortality or evident toxic effects were observed, however some mild histopathological changes were observed in sub-acute study.

scholarly journals Effect of Methanolic Fruit Extract of Piper guineense on Serum Biochemical Parameters and Histomorphology of the Liver and Kidney of Male Albino Rats (Rattus norvegicus)

2017 ◽  
Vol 9 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Chidozie N. OKOYE ◽  
Izuchukwu S. OCHIOGU ◽  
Onyinyechukwu A. AGINA ◽  
Ukamaka U. EZE ◽  
Nnenna O. NWACHUKWU ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Male Rats ◽  
Control Group ◽  
Albino Rats ◽  
Hepatocellular Injury ◽  
Fruit Extract ◽  
Biochemical Effect ◽  
Piper Guineense ◽  
Acute Toxicity Study

Piper guineense fruit is known for its nutritive and medicinal values. This study evaluated the biochemical effect of the methanol fruit extract of P. guineense on male albino rats. A total of thirty-eight (38) adult male Sprague-Dawley albino rats were used for the study. Eighteen of the male rats were used for the acute toxicity study, while twenty (20) male rats were randomly assigned into four groups (A, B, C and D) of 5 rats each, for the sub-acute toxicity study. Groups B, C and D were the treatment groups, while group A was the control group and received only distilled water (10 mg/ml). Groups B, C and D received 10 mg/kg, 200 mg/kg and 400 mg/kg body weight of the fruit extract respectively. Administration of the 100 mg/kg, 200 mg/kg and 400 mg/kg of methanol fruit extract of P. guineense led to a significant (P < 0.05) increase in the serum ALT and AP on day 7 of the experiment. Throughout the experimental period, 200 mg/kg of the extract caused a significant (P < 0.05) increase in serum total proteins and globulin. Group D rats had significantly (P < 0.05) lower serum total cholesterol on day 28 of the experiment. The 100 mg/kg of the extract caused a significant increase in serum urea and creatinine on day 21 of the experiment. Oral administration of methanol fruit extract of P. guineense caused mild hepatocellular injury, hyperproteinemia, hyperglobulinemia, hypocholesterolemia, and mild renal toxicity.

scholarly journals Acute and Repeated Dose Toxicity Study of Clevira Syrup – A Polyherbal Formulation

2021 ◽  
Vol 14 (3) ◽  
pp. 1459-1467
Author(s):  
Uma Narayanamurthy ◽  
Mirunalini .R ◽  
Subha. V ◽  
K. Manimekalai ◽  
Sakthibalan K ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Toxicity Study ◽  
Tinospora Cordifolia ◽  
Repeated Dose ◽  
Piper Nigrum ◽  
Albino Rats ◽  
Polyherbal Formulation ◽  
Acute Toxicity Study ◽  
Repeated Dose Toxicity ◽  
Wistar Albino Rats

Aim and Objectives: This study evaluated the acute and repeated dose toxicity effects of Clevira Syrup Polyherbal formulation (CSPHF), which was prepared from ten different herbs, well known and widely used in traditional medicine for the management of viral infections and other inflammatory disease conditions. Individually these herbs (Carica papaya, Melia azedarach, Andrographis paniculata, Vetiveria zizanioides, Trichosanthes dioica, Cyperus rotundus, Zingiber officinale, Piper nigrum, Mollugo Cerviana and Tinospora cordifolia )were completely safe, but the polyherbal formulation effects were not known. Thus, this study was done for the investigation of toxicological profile of CSPHF in Wistar Albino rats. Methods: As per OECD(Organisation for Economic Co-operation and Development) guidelines 423 and 407, Acute and Repeated dose toxicity study were proceeded. In the acute toxicity study a single dose of CSPHF (2000mg/kg) was administered orally to female Wistar rats and in repeated dose toxicity study, CSPHF was administered orally in Control group and three different doses (1000, 500 and 250mg/kg body weight) to both male and female wistar albino rats for 28 days. At the end of the study, the animals were euthanized, observed the external and internal morphology (Acute Toxicity) and assessed the effect of CSPHF on histopathological and biochemical parameters (Repeated Dose toxicity study). Results: In acute toxicity study, there were no visual signs of toxicity of CSPHF (2000mg/kg) observed, whereas in Repeated dose toxicity study Ischaemia, inflammation and hematoma of the internal organs were observed at 1000mg/kg dose, but no such toxic features were seen at 500 and 250mg/kg dose of CSPHF. Conclusion: The results of the Acute and Repeated Dose toxicity study could be authenticated in future studies, which will be more useful and evidence based for the management of Viral infectionsduring pandemics.

An experimental study to evaluate the concept of Trividha Atisevana Varjya Dravya w.s.r. to Lavana

2019 ◽  
Vol 4 (04) ◽  
Author(s):  
Shilpa Nimbal ◽  
Umapati C. Baragi ◽  
Kashinath Hadimur ◽  
Jyothi Alias Jyostna
Keyword(s):  
Acute Toxicity ◽  
Dose Level ◽  
Equivalent Dose ◽  
Toxicity Study ◽  
Fixed Dose ◽  
Albino Rats ◽  
Acute Administration ◽  
Acute Toxicity Study ◽  
Wistar Strain ◽  
Acute Study

Background: Lavana is used as medicine as well as Ahara since ancient times. In Caraka Samhita it has been mentioned that three Dravyas viz. Pippali, Kshara (alkali) and Lavana (salt) can be used as emergency medicine, but they should not be consumed in excess (Ati Upayunjita). Hence in the present study Lavana has been evaluated in experimental animals in two different phases’ viz. Acute administration at graded doses as part of acute toxicity study and Sub-Acute administration at fixed dose level, as part of toxic Sub-Acute toxicity study, to assess the possible adverse effects. Materials andamp; Methods: Wistar strain albino rats of either sex weighing between 150 - 200g. body weights were used, The experiment was carried out in accordance with the direction of the Institutional animal ethics committee (IAEC) after obtaining its permission (Approval number IAEC – 138/k/2018). Results: Results were drawn based on histopathological reports and biochemical reports of each group of toxicity study. Acute toxicity study has been carried out in albino rats receiving the 2 dose level maximum at up to 10 times higher (855mg/kg) then the therapeutic equivalent dose (427.5mg/kg). In Sub-Chronic toxicity: dose given was five times higher than therapeutic equivalent dose and ten times the equivalent to human therapeutic dose for duration of 30 days. Discussion: Toxicity is not found in Acute study and in Sub-Acute study moderate to high toxicity is found.

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